All in the family: The BTB/POZ, KRAB, and SCAN domains

Molecular and Cellular Biology

Volumn 21, Issue 11, 2001, Pages 3609-3615

  Collins, Tucker ^a   Stone, James R ^a   Williams, Amy J ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONE RECEPTOR; HYBRID PROTEIN; PROTEIN; PROTEIN BTB; PROTEIN KRAB; PROTEIN POZ; PROTEIN SCAN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; DROSOPHILA MELANOGASTER; GENE DELETION; GENE DISRUPTION; GENETIC PROCEDURES; GENETIC TRANSCRIPTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN ISOLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SHORT SURVEY; SMITH MAGENIS SYNDROME; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; DNA-BINDING PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; ZINC FINGERS;

DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 0034999879     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.11.3609-3615.2001     Document Type: Short Survey

References (56)

1. Ahmad, K. F., C. K. Engel, and G. G. Prive. 1998. Crystal structure of the BTB domain from PLZF. Proc. Natl. Acad. Sci. USA 95:12123-12128.
2. Albagli, O., P. Dhordain, C. Deweindt, G. Lecocq, and D. Leprince. 1995. The BTB/POZ domain: a new protein-protein interaction motif common to DNA-and actin-binding proteins. Cell Growth Differ. 6:1193-1198.
3. Alders, M., A. Ryan, M. Hodges, J. Bliek, A. P. Feinberg, O. Privitera, A. Westerveld, P. F. R. Little, and M. Mannens. 2000. Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome. Am. J. Hum. Genet. 66:1473-1484.
4. Babior, B. M., and Y. Matzner. 1997. The familial Mediterranean fever gene - cloned at last. N. Engl. J. Med. 337:1548-1549.
5. Bardwell, V. J., and R. Treisman. 1994. The POZ domain: a conserved protein-protein interaction motif. Genes Dev. 8:1664-1677.
6. Barna, M., N. Hawe, L. Niswander, and P. P. Pandolfi. 2000. Plzf regulates limb and axial skeletal patterning. Nat. Genet. 25:166-172.
7. Bellefroid, E. J., D. A. Poncelet, P. J. Lecocq, O. Relevant, and J. A. Martial. 1991. The evolutionary conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. Proc. Natl. Acad. Sci. USA 88:3608-3612.
8. Bellefroid, E. J., J. C. Marine, T. Ried, P. J. Lecocq, M. Riviere, C. Amemiya, D. A. Poncelet, P. G. Coulie, P. de Jong, and C. Szpirer. 1993. Clustered organization of homolgous KRAB zinc-finger genes with enhanced expression in human T cells. EMBO J. 12:1363-1374.
9. Bibel, M., and Y. A. Barde. 2000. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev. 14:2919-2937.
10. NTR and participates in programmed cell death. EMBO J. 18: 6050-6061.
11. Castillo, G., R. P. Brun, J. K. Rosenfield, S. Hauser, C. W. Park, A. E. Troy, M. E. Wright, and B. M. Spiegelman. 1999. An adipogenic cofactor bound by the differentiation domain of PPARγ. EMBO J. 18:3676-3687.
12. Chen, K. S., L. Potocki, and J. R. Lupski. 1996. The Smith-Magenis syndrome [del(17)p11.2]: clinical review and molecular advances. Ment. Retard. Dev. Disabil. Res. Rev. 2:122-129.
13. Chen, X., M. Hamon, Z. Deng, M. Centola, R. Sood, K. Taylor, D. L. Kastner, and N. Fischel-Ghodsian. 1999. Identification and characterization of a zinc finger gene (ZNF213) from 16p13.3. Biochim. Biophys. Acta 1444: 218-230.
14. Cook, M., A. Gould, N. Brand, J. Davies, P. Strutt, R. Shaknovich, J. Licht, S. Waxman, Z. Chen, and S. Gluecksohn-Waelsch. 1995. Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain. Proc. Natl. Acad. Sci. USA 92:2249-2253.
15. David, G., L. Alland, S. H. Hong, C. W. Wong, R. A. DePinho, and A. Dejean. 1998. Histone deacetylase associated with mSin3A mediates represion by the acute promyelocytic leukemia-associated PLZF protein. Oncogene 16:2549-2556.
16. Desjarlais, J. R., and J. M. Berg. 1992. Toward rules relating zinc finger protein sequences and DNA binding site preferences. Proc. Natl. Acad. Sci. USA 89:7345-7349.
17. Dong, S., J. Zhu, A. Reid, P. Strutt, F. Guidez, H. J. Zhong, Z. Y. Wang, J. Licht, S. Waxman, and C. Chomienne. 1996. Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein. Proc. Natl. Acad. Sci. USA 93:3624-3629.
18. Espinas, M. L., E. Jimenez-Garcia, A. Vaquero, S. Canudas, J. Bernues, and F. Azorin. 1999. The N-terminal POZ domain of GAGA mediates the formation of oligomers that bind DNA with high affinity and specificity. J. Biol. Chem. 274:16461-16469.
19. Farkas, G., J. Gausz, M. Galloni, G. Reuter, H. Gyurkovics, and F. Karch. 1994. The trithorax-like gene encodes the Drosophila GAGA factor. Nature 371:806-808.
20. Friedman, J. R., W. J. Fredericks, D. E. Jensen, D. W. Speicher, X. P. Huang, E. G. Neilson, and F. J. Rauscher III. 1996. KAP-1, a novel corepressor for the highly conserved KRAB repression domain. Genes Dev. 10:2067-2078.
21. Grignani, F., S. DeMatteis, C. Nervi, L. Tomassoni, V. Gelmetti, M. Cioce, M. Fanelli, M. Ruthardt, F. F. Ferrara, I. Zamir, C. Seiser, F. Grignani, M. A. Lazar, S. Minucci, and P. G. Pelicci. 1998. Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukemia. Nature 391:815-818.
22. Han, Z. G., Q. H. Zhang, M. Ye, L. X. Kan, B. W. Gu, K. L. He, S. L. Shi, J. Zhou, G. Fu, M. Mao, S. J. Chen, L. Yu, and Z. Chen. 1999. Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoetic cells and identification of a novel transregulator domain KRNB. J. Biol. Chem. 274:35741-35748.
23. Hoatlin, M. E., Y. Zhi, H. Ball, K. Silvey, A. Melnick, S. Stone, S. Arai, N. Hawe, G. Owen, A. Zelent, and J. D. Licht. 1999. A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. Blood 94:3737-3747.
24. Hong, S. H., G. David, C. W. Wong, A. Dejean, and M. L. Privalsky. 1997. SMRT corepressor protein interacts with PLZF and with the PML-retinoic acid receptor alpha (PARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia. Proc. Natl. Acad. Sci. USA 95: 9028-9033.
25. Hromas, R., B. Davis, F. J. Rauscher, M. Klemsz, D. Tenen, S. Hoffman, D. Xu, and J. F. Morris. 1996. Hematopoietic transcriptional regulation by the myeloid zinc finger gene MZF-1. Curr. Top. Microbiol. Immunol. 211:159-164.
26. Katsani, K. R., M. A. N. Hajibagheri, and C. P. Verrijzer. 1999. Co-operative DNA binding by GAGA transcription factor requires the conserved BTB/ POZ domain and reorganizes promoter topology. EMBO J. 18:698-708.
27. Kim, S. S., Y. M. Chen, E. O'Leary, R. Witzgall, M. Vidal, and J. V. Bonventre. 1996. A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins. Proc. Natl. Acad. Sci. USA 93:15299-15304.
28. Klug, A., and J. W. Schwabe. 1995. Protein motifs 5. Zinc fingers. FASEB J. 9:597-604.
29. Kort, E. N., D. G. Ballinger, W. Ding, S. C. Hunt, B. R. Bowen, V. Abkevich, K. Bulka, B. Campbell, C. Capener, A. Gutin, K. Harshman, M. McDermott, T. Thorne, H. Wang, B. Wardell, J. Wong, P. N. Hopkins, S. Skolnick, and M. Samuels. 2000. Evidence of linkage of familial hypoalphalipoproteinemia to a novel locus on chromosome 11q23. Am. J. Hum. Genet. 66:1845-1856.
30. Li, X., H. Peng, D. C. Schultz, J. M. Lopez-Guisa, F. J. Rauscher III, and R. Marmorstein. 1999. Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein. Cancer Res. 59:5275-5282.
31. Lin, R. J., L. Nagy, S. Inoue, W. Shao, W. H. Miler, and R. M. Evans. 1998. Role of the histone deacetylase complex in acute promyelocytic leukemia. Nature 391:811-814.
32. Margolin, J. F., J. R. Friedman, W. K. Meyer, H. Vissing, H. J. Thiesen, and F. J. Rauscher III. 1994. Kruppel-associated boxes are potent transcriptional repression domains. Proc. Natl. Acad. Sci. USA 91:4509-4513.
33. Melnick, A., K. F. Ahmad, S. Arai, A. Polinger, H. Ball, K. L. Borden, G. W. Carlile, G. G. Prive, and J. D. Licht. 2000. In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions. Mol. Cell. Biol. 20:6550-6567.
34. Moosmann, P., O. Georgiev, B. Le Douarin, J. P. Bourquin, and W. Schaffner. 1996. Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1. Nucleic Acids Res. 24:4859-4867.
35. Morris, J. F., R. Hromas, and F. J. Rauscher. 1994. Characterization of the DNA-binding properties of the myeloid zinc finger protein MZF1: two independent DNA-binding domains recognize two DNA consensus sequences with a common G-rich core. Mol. Cell. Biol. 14:1786-1795.
36. Morris, J. F., F. J. Rauscher, B. Davis, M. Klemsz, D. Xu, D. Tenen, and R. Hromas. 1995. The myeloid zinc finger gene MZF-1 regulates the CD34 promoter in vitro. Blood 186:3640-3647.
37. Peng, H., G. E. Begg, S. L. Harper, J. R. Friedman, D. W. Speicher, and F. J. Rauscher III. 2000. Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain. J. Biol. Chem. 275:18000-18010.
38. Peng, H., G. E. Begg, D. C. Schultz, J. R. Friedman, D. E. Jensen, D. W. Speicher, and F. J. Rauscher III. 2000. Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions. J. Mol. Biol. 295:1139-1162.
39. Perrotti, D., P. Melotti, T. Skorski, I. Casella, C. Peschle, and B. Calabretta. 1995. Overexpression of the zinc finger protein MZF1 inhibits hematopoietic development from embryonic stem cells: correlation with negative regulation of CD34 and c-myb promoter activity. Mol. Cell. Biol. 15:6075-6087.
40. Peterson, M. J., and J. F. Morris. 2000. Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein. Gene 22:105-118.
41. Read, A., A. Gould, N. Brand, M. Cook, P. Strutt, J. Li, J. Licht, S. Waxman, R. Krumlauf, and A. Zelent. 1995. Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors. Blood 83:4544-4552.
42. Ryan, R. F., D. C. Schultz, K. Ayyanathan, P. B. Singh, J. R. Friedman, W. J. Fredericks, and F. J. Rauscher III. 1999. KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Kruppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing. Mol. Cell. Biol. 19:4366-4378.
43. Sander, T. A., A. L. Haas, M. J. Peterson, and J. F. Morris. 2000. Identification of a novel SCAN box-related protein that interacts with MZF1B. J. Biol. Chem. 275:12857-12867.
44. Schumacher, C., H. Wang, C. Honer, W. Ding, J. Koehn, Q. Lawrence, C. M. Coulis, L. L. Wang, D. Ballinger, B. R. Bowen, and S. Wagner. 2000. The SCAN domain mediates selective oligomerization. J. Biol. Chem. 275:17173-17179.
45. Shaknovich, R., P. L. Yeyati, S. Ivins, A. Melnick, C. Lempert, S. Waxman, A. Zelent, and J. D. Licht. 1998. The promyelocytic leukemia zinc finger protein affects myeloid cell growth, differentiation and apoptosis. Mol. Cell. Biol. 18:5533-5545.
46. Sun, F. L., W. L. Dean, G. Kelsey, N. D. Allen, and W. Reik. 1997. Trans-activation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome. Nature 389:809-815.
47. Suzuki, M., M. Gerstein, and N. Yagi. 1994. Stereochemical basis of DNA recognition by Zn fingers. Nucleic Acids Res. 22:3397-3405.
48. Tenen, G. D., R. Hromas, J. D. Licht, and D. Zhag. 1997. Transcription factors, normal myeloid development and leukemia. Blood 90:489-519.
49. Venter, J. C., et al. 2001. The sequence of the human genome. Science 291:1304-1351.
50. Wagner, S., M. A. Hess, P. Ormonde-Hanson, J. Malandro, H. Hu, M. Chen, R. Kehrer, M. Frodsham, C. Schumacher, M. Beluch, C. Honer, M. Skolnick, D. Ballinger, and B. R. Bowen. 2000. A broad role for the zinc finger protein ZNF202 in human lipid metabolism. J. Biol. Chem. 275: 15685-15690.
51. Williams, A. J., S. C. Blacklow, and T. Collins. 1999. The zinc finger-associated SCAN box is a conserved oligomerization domain. Mol. Cell. Biol. 19:8526-8535.
52. Williams, A. J., L. M. Khachigian, T. Shows, and T. Collins. 1995. Isolation and characterization of a novel zinc-finger protein with transcriptional repressor activity. J. Biol. Chem. 270:22143-22152.
53. Witzgall, R., E. O'Leary, A. Leaf, D. Onaldi, and J. V. Bonventre. 1994. The Kruppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression. Proc. Natl. Acad. Sci. USA 91:4514-4518.
54. Yang, X. W., C. Wynder, M. L. Doughty, and N. Heintz. 1999. BAC-mediated gene-dosage analysis reveals a role for Ziprol (Ru49/Zfp38) in progenitor cell proliferation in cerebellum and skin. Nat. Genet. 22:327-335.
55. Yeyati, P. L., R. Shaknovich, S. Boterashvili, J. Li, H. J. Ball, S. Waxman, K. Nason-Burchenal, E. Dmitrovsky, A. Zelent, and J. D. Licht. 1999. Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A. Oncogene 18:925-934.
56. Zheng, L., H. Pan, S. Li, A. Flesken-Nikitin, P. Chen, T. G. Boyer, and W.-H. Lee. 2000. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. Mol. Cell 6:757-768.