A BMAL1 mutant with arginine 91 substituted with alanine acts as a dominant negative inhibitor

Gene

Volumn 338, Issue 2, 2004, Pages 235-241

  Hosoda, Hiroshi ^a   Motohashi, Junko ^a   Kato, Haruno ^a   Masushige, Shoichi ^a   Kida, Satoshi ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

Author keywords

Arnt; aryl hydrocarbon receptor nuclear translocator; basic helix loop helix; bHLH; bHLH transcription factor; BMAL1; Brain Muscle Arnt Like protein 1; Circadian rhythm; CLOCK; E box; HIF; hypoxia inducible factor; NPAS2; PAS; Per Arnt Sim

Indexed keywords

ALANINE; ARGININE; PROTEIN BMAL1;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CIRCADIAN RHYTHM; DNA BINDING; E BOX ELEMENT; GENE CONSTRUCT; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; MUTATION; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN FUNCTION; REPORTER GENE; TRANSCRIPTION INITIATION;

ALANINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ARGININE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BINDING SITES; CERCOPITHECUS AETHIOPS; COS CELLS; DIMERIZATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HELIX-LOOP-HELIX MOTIFS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; NIH 3T3 CELLS; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 4143088113     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2004.05.022     Document Type: Article

References (25)

1. Benezra R., Davis R.L., Lockshon D., Turner D.L., Weintraub H. The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell. 61:1990;49-59
2. Bunger M.K., Wilsbacher L.D., Moran S.M., Clendenin C., Radcliffe L.A., Hogenesch J.B., Simon M.C., Takahashi J.S., Bradfield C.A. Mop3 is an essential component of the master circadian pacemaker in mammals. Cell. 103:2000;1009-1017
3. Carmeliet P., Dor Y., Herbert J.M., Fukumura D., Brusselmans K., Dewerchin M., Neeman M., Bono F., Abramovitch R., Maxwell P., Koch C.J., Ratcliffe P., Moons L., Jain R.K., Collen D., Keshert E., Keshet E. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 394:1998;485-490
4. Dudley C.A., Erbel-Sieler C., Estill S.J., Reick M., Franken P., Pitts S., McKnight S.L. Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Science. 301:2003;379-383
5. Dunlap J.C. Molecular bases for circadian clocks. Cell. 96:1999;271-290
6. Ellenberger T., Fass D., Arnaud M., Harrison S.C. Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer. Genes Dev. 8:1994;970-980
7. Ferre-D'Amare A.R., Prendergast G.C., Ziff E.B., Burley S.K. Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain. Nature. 363:1993;38-45
8. Garcia J.A., Zhang D., Estill S.J., Michnoff C., Rutter J., Reick M., Scott K., Diaz-Arrastia R., McKnight S.L. Impaired cued and contextual memory in NPAS2-deficient mice. Science. 288:2000;2226-2230
9. Gekakis N., Staknis D., Nguyen H.B., Davis F.C., Wilsbacher L.D., King D.P., Takahashi J.S., Weitz C.J. Role of the CLOCK protein in the mammalian circadian mechanism. Science. 280:1998;1564-1569
10. Hogenesch J.B., Gu Y.-X., Jain S., Bradfield A.C.A. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc. Natl. Acad. Sci. U. S. A. 95:1998;5474-5479
11. 2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 12:1998;149-162
12. Jin X., Shearman L.P., Weaver D.R., Zylka M.J., de Vries G.J., Reppert S.M. A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Cell. 96:1999;57-68
13. Kim J.B., Spotts G.D., Halvorsen Y.D., Shih H.M., Ellenberger T., Towle H.C., Spiegelman B.M. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain. Mol. Cell. Biol. 15:1995;2582-2588
14. King D.P., Zhao Y., Sangoram A.M., Wilsbacher L.D., Tanaka M., Antoch M.P., Steeves T.D., Vitaterna M.H., Kornhauser J.M., Lowrey P.L., Turek F.W., Takahashi J.S. Positional cloning of the mouse circadian clock gene. Cell. 89:1997;641-653
15. Kume K., Zylka M.J., Sriram S., Shearman L.P., Weaver D.R., Jin X., Maywood E.S., Hastings M.H., Reppert S.M. mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell. 98:1999;193-205
16. Ma P.C., Rould M.A., Weintraub H., Pabo C.O. Crystal structure of MyoD bHLH domain-DNA complex: perspectives on DNA recognition and implications for transcriptional activation. Cell. 77:1994;451-459
17. Okamura H., Miyake S., Sumi Y., Yamaguchi S., Yasui A., Muijtjens M., Hoeijmakers J.H., van der Horst G.T. Photic induction of mPer1 and mPer2 in cry-deficient mice lacking a biological clock. Science. 286:1999;2531-2534
18. Preitner N., Damiola F., Lopez-Molina L., Zakany J., Duboule D., Albrecht U., Schibler U. The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell. 110:2002;251-260
19. Ravi R., Mookerjee B., Bhujwalla Z.M., Sutter C.H., Artemov D., Zeng Q., Dillehay L.E., Madan A., Semenza G.L., Bedi A. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev. 14:2000;34-44
20. Reick M., Garcia J.A., Dudley C., McKnight S.L. NPAS2: an analog of clock operative in the mammalian forebrain. Science. 293:2001;506-509
21. Reppert S.M., Weaver D.R. Coordination of circadian timing in mammals. Nature. 418:2002;935-941
22. Rutter J., Reick M., Wu L.C., McKnight S.L. Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science. 293:2001;510-514
23. Shearman L.P., Sriram S., Weaver D.R., Maywood E.S., Chaves I., Zheng B., Kume K., Lee C.C., van der Horst G.T., Hastings M.H., Reppert S.M. Interacting molecular loops in the mammalian circadian clock. Science. 288:2000;1013-1019
24. Vitaterna M.H., Selby C.P., Todo T., Niwa H., Thompson C., Fruechte E.M., Hitomi K., Thresher R.J., Ishikawa T., Miyazaki J., Takahashi J.S., Sancar A. Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2. Proc. Natl. Acad. Sci. U. S. A. 96:1999;12114-12119
25. Voronova A., Baltimore D. Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains. Proc. Natl. Acad. Sci. U. S. A. 87:1990;4722-4726