A point mutation in CD45 may be associated with an increased risk of HIV-1 infection

AIDS

Volumn 15, Issue 14, 2001, Pages 1892-1894

  Tchilian, Elma Z ^a   Wallace, Diana L ^a   Dawes, Ritu ^a   Imami, Nesrina ^b   Burton, Catherine ^b   Gotch, Frances ^b   Beverley, Peter C L ^a  

^a EDWARD JENNER INST FOR VACC RES   (United Kingdom)

^b CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; EXON; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION RISK; INFECTION SENSITIVITY; LYMPHOCYTE; POINT MUTATION; PRIORITY JOURNAL; RNA SPLICING; SIGNAL TRANSDUCTION;

ALTERNATIVE SPLICING; ANTIGENS, CD45; EXONS; GENETIC PREDISPOSITION TO DISEASE; HIV INFECTIONS; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; POINT MUTATION;

EID: 0035964663     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200109280-00024     Document Type: Article

References (11)

1. Normal B lymphocyte development but impaired T cell maturation in CD45-exon 6 protein tyrosine phosphatase deficient mice
2. CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes and in B cell maturation
3. Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease
4. A deletion in the gene encoding the CD45 antigen in a patient with severe combined immunodeficiency
5. A point mutation in the human CD45 gene associated with defective splicing of exon A
6. A point mutation within CD45 exon A is the cause of variant CD45RA splicing in human
7. A point mutation in PTPRC is associated with the development of multiple sclerosis
8. A prospective study of CD45 isoform expression in haemophagocytic lymphohistiocytosis; an abnormal inherited immunophenotype in one family
9. Abnormal T cell phenotype in familial erythrophagocytic lymphohistiocytosis
10. T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45
11. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling