Engagement of CD47 inhibits the contact hypersensitivity response via the suppression of motility and B7 expression by Langerhans cells

Journal of Investigative Dermatology

Volumn 126, Issue 4, 2006, Pages 797-807

  Yu, Xijun ^a   Fukunaga, Atsushi ^a   Nagai, Hiroshi ^a   Oniki, Shuntaro ^a   Honma, Nakayuki ^b   Ichihashi, Masamitsu ^c   Matozaki, Takashi ^d   Nishigori, Chikako ^a   Horikawa, Tatsuya ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KIRIN BREWERY CO LTD   (Japan)

^c Sun Care Institute   (Japan)

^d GUNMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD47 ANTIGEN; CD86 ANTIGEN; HAPTEN; HYBRID PROTEIN; PERTUSSIS TOXIN; PROTEIN TYROSINE PHOSPHATASE SHP 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CELL FUNCTION; CELL MIGRATION; CELL MOTILITY; CHEMOTAXIS; CONTACT ALLERGY; CONTROLLED STUDY; CULTURE MEDIUM; DENDRITIC CELL; EPIDERMIS; EXPLANT; IMMUNE RESPONSE; IN VIVO STUDY; LANGERHANS CELL; LIGATION; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN; STATISTICAL SIGNIFICANCE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD47; ANTIGENS, CD80; ANTIGENS, CD86; CELL MOVEMENT; CHEMOTAXIS; DERMATITIS, CONTACT; DOWN-REGULATION; EPIDERMIS; FEMALE; HAPTENS; INTERLEUKIN-4; KERATINOCYTES; LANGERHANS CELLS; LIGANDS; LYMPH NODES; MICE; PERTUSSIS TOXIN; RECOMBINANT FUSION PROTEINS;

EID: 33645036612     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700176     Document Type: Article

References (49)

1. Aiba S, Katz S (1990) Phenotypic and functional characteristics of in vivo-activated Langerhans cells. J Immunol 145:2791-6
2. Ando O, Suemoto Y, Kurimoto M, Horikawa T, Ichihashi M (2000) Deficient Th1-type immune responses via impaired CD28 signaling in ultraviolet B-induced systemic immunosuppression and the restorative effect of IL-12. J Dermatol Sci 24:190-202
3. 2 in the inhibition of epidermal Langerhans cell migration during schistosomiasis infection. J Exp Med 193:1135-47
4. Avice MN, Rubio M, Sergerie M, Delespesse G, Sarfati M (2001) Role of CD47 in the induction of human naive T cell anergy. J Immunol 167:2459-68
5. Babic I, Schallhorn A, Lindberg FP, Jirik FR (2000) SHPS-1 induces aggregation of Ba/F3 pro-B cells via an interaction with CD47. J Immunol 164:3652-8
6. Blazar BR, Lindberg FP, Ingulli E, Panoskaltsis-Mortari A, Oldenborg PA, Iizuka K et al. (2001) CD47 (integrin-associated protein) engagement of dendritic cell and macrophage counterreceptors is required to prevent the clearance of donor lymphohematopoietic cells. J Exp Med 194:541-9
7. Brown EJ, Frazier WA (2001) Integrin-associated protein (CD47) and its ligands. Trends Cell Biol 11:130-5
8. Cooper D, Lindberg FP, Gamble JR, Brown EJ, Vadas MA (1995) Transendothelial migration of neutrophils involves integrin-associated protein (CD47). Proc Natl Acad Sci USA 92:3978-82
9. Cumberbatch M, Dearman RJ, Antonopoulos C, Groves RW, Kimber I (2001) Interleukin (IL)-18 induces Langerhans cell migration by a tumour necrosis factor-alpha- and IL-1 beta-dependent mechanism. Immunology 102:323-30
10. Cumberbatch M, Dearman RJ, Kimber I (1997a) Interleukin-1 beta and the stimulation of Langerhans cell migration: comparisons with tumor necrosis factor alpha. Arch Dermatol Res 289:277-84
11. Cumberbatch M, Dearman RJ, Kimber I (1997b) Langerhans cells require signals from both tumour necrosis factor-α and interleukin-1β for migration. Immunology 92:388-95
12. Cumberbatch M, Gould SJ, Peters SW, Kimber I (1991) MHC class II expression by Langerhans cells and lymph node dendritic cells: possible evidence for maturation of Langerhans cells following contact sensitization. Immunology 74:414-9
13. Cumberbatch M, Kimber I (1992) Dermal tumor necrosis factor-alpha induces dendritic cell migration to draining lymph nodes, and possibly provides one stimulus for Langerhans cell migration. Immunology 75:257-63
14. Demeure CE, Tanaka H, Mateo V, Rubio M, Delespesse G, Sarfati M (2000) CD47 engagement inhibits cytokine production and maturation of human dendritic cells. J Immunol 164:2193-9
15. Doyen V, Rubio M, Braun D, Nakajima T, Abe J, Saito H et al. (2003) Thrombospondin 1 is an autocrine negative regulator of human dendritic cell activation. J Exp Med 198:1277-83
16. Frazier WA, Gao AG, Dimitry J, Chung J, Brown EJ, Lindberg FP et al. (1999) The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric Gi. J Biol Chem 274:8554-60
17. Fujioka Y, Matozaki T, Noguchi T, Iwamatsu A, Yamao T, Takahashi N et al. (1996) A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol Cell Biol 16:6887-99
18. Fukunaga A, Nagai H, Noguchi T, Okazawa H, Matozaki T, Yu X et al. (2004) Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the migration of Langerhans cells from the epidermis to draining lymph nodes. J Immunol 172:4091-9
19. Gamble JR, Vadas MA, Munoz JJ, Thomas WR, Miller JFAP (1983) Delayed hypersensitivity induced by anti-T-cell line antisera is enhanced by pertussigen and not restricted by histocompatibility genes. Proc Natl Acad Sci USA 80:2036-9
20. Grabbe S, Schwarz T (1998) Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity. Immunol Today 19:37-44
21. Jolles S, Christensen J, Holman M, Klaus GB, Ager A (2002) Systemic treatment with anti-CD40 antibody stimulates Langerhans cell migration from the skin. Clin Exp Immunol 129:519-26
22. Kabashima K, Sakata D, Nagamachi M, Miyachi Y, Inaba K, Narumiya S (2003) Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells. Nat Med 9:744-9
23. Kharitonenkov A, Chen Z, Sures I, Wang H, Schilling J, Ullrich A (1997) A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 386:181-6
24. Kimber I, Cumberbatch M, Dearman RJ, Bhushan M, Griffiths CEM (2000) Cytokines and chemokines in the initiation and regulation of epidermal Langerhans cell mobilization. Br J Dermatol 142:401-12
25. Latour S, Tanaka H, Demeure C, Mateo V, Rubio M, Brown EJ et al. (2001) Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulatory protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation. J Immunol 167:2547-54
26. Li Z, Calzada MJ, Sipes JM, Cashel JA, Krutzsch HC, Annis DS et al. (2002) Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior. J Cell Biol 157:509-19
27. Lindberg FP, Bullard DC, Caver TE, Gresham HD, Beaudet AL, Brown EJ (1996) Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice. Science 274:795-8
28. Liu Y, Merlin D, Burst SL, Pochet M, Madara JL, Parkos CA (2001) The role of CD47 in neutrophil transmigration. Increased rate of migration correlates with increased cell surface expression of CD47. J Biol Chem 276:40156-66
29. Macatonia SE, Knight SC, Edwards AJ, Griffiths S, Fryer P (1987) Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. J Exp Med 166:1654-67
30. Motegi S, Okazawa H, Ohnishi H, Sato R, Kaneko Y, Kobayashi H et al. (2003) Role of the CD47-SHPS-1 system in regulation of cell migration. EMBO J 22:2634-44
31. Nuriya S, Yagita H, Okumura K, Azuma M (1996) The differential role of CD86 and CD80 co-stimulatory molecules in the induction and the effector phases of contact hypersensitivity. Int Immunol 8:917-26
32. Ohl L, Mohaupt M, Czeloth N, Hintzen G, Kiafard Z, Zwirner J et al. (2004) CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity 21:279-88
33. Ohnishi H, Kobayashi H, Okazawa H, Ohe Y, Tomizawa K, Sato R et al. (2004) Ectodomain shedding of SHPS-1 and its role in regulation of cell migration. J Biol Chem 279:27878-87
34. Oka M, Ogita K, Ando H, Horikawa T, Hayashibe K, Saito N et al. (1996) Deletion of specific protein kinase C subspecies in human melanoma cells. J Cell Physiol 167:406-12
35. Oldenburg PA (2004) Role of CD47 in erythroid cells and in autoimmunity. Leuk Lymphoma 45:1319-27
36. Oldenburg PA, Zheleznyak A, Fang YF, Lagenaur CF, Gresham HD, Lindberg FP (2000) Role of CD47 as a marker of self on red blood cells. Science 288:2051-4
37. Parkos CA, Colgan SP, Liang TW, Nusrat A, Bacarra AE, Carnes DK et al. (1996) CD47 mediates post-adhesive events required for neutrophil migration across polarized intestinal epithelia. J Cell Biol 132:437-50
38. Piccio L, Vermi W, Boles KS, Fuchs A, Strader CA, Facchetti F et al. (2005) Adhesion of human T cells to antigen-presenting cells through SIRP{beta}2-CD47 interaction costimulates T-cell proliferation. Blood 105:2421-7
39. Price AA, Cumberbatch M, Kimber I, Ager A (1997) Alpha 6 integrins are required for Langerhans cell migration from the epidermis. J Exp Med 186:1725-35
40. Ratzinger G, Stoitzner P, Ebner S, Lutz MB, Layton GT, Rainer C et al. (2002) Matrix metalloproteinases 9 and 2 are necessary for the migration of Langerhans cells and dermal dendritic cells from human and murine skin. J Immunol 168:4361-71
41. Rebres RA, Kajihara K, Brown EJ (2005) Novel CD47-dependent intercellular adhesion modulates cell migration. J Cell Physiol 205:182-93
42. Roberts LK, Spangrude GJ, Daynes RA, Krueger GG (1985) Correlation between keratinocyte expression of Ia and the intensity and duration of contact hypersensitivity responses in mice. J Immunol 135:2929-36
43. - hematopoietic cells. Blood 97:2741-9
44. Sewell WA, Munoz JJ, Vadas MA (1983) Enhancement of the intensity, persistence, and passive transfer of delayed-type hypersensitivity lesions by pertussigen in mice. J Exp Med 157:2087-96
45. Stoitzner P, Ratzinger G, Koch F, Janke K, Scholler T, Kaser A et al (2001) Interleukin-16 supports the migration of Langerhans cells, partly in a CD4-independent way. J Invest Dermatol 116:641-9
46. Wang B, Zhuang L, Fujisawa H, Shinder GA, Feliciani C, Shivji GM et al. (1999) Enhanced epidermal Langerhans cell migration in IL-10 knockout mice. J Immunol 162:277-83
47. Xu S, Ariizumi K, Caceres-dittmar G, Ebelbaum D, Hashimoto K, Bergstresser PR et al. (1995) Successive generation of antigen-presenting, dendritic cell-lines from murine epidermis. J Immunol 154:2697-705
48. + cell line (XS52) by IL-4, TNF-α, IL-1β, and agonistic anti-CD40 monoclonal antibody. J Immunol 163:5331-7
49. Zen K, Parkos CA (2003) Leukocyte-epithelial interactions. Curr Opin Cell Biol 15:557-64