Novel CD47-dependent intercellular adhesion modulates cell migration

Journal of Cellular Physiology

Volumn 205, Issue 2, 2005, Pages 182-193

  Rebres, Robert A ^a,c   Kajihara, Kimberly ^a   Brown, Eric J ^a,b,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CD47 ANTIGEN; CELL MEMBRANE PROTEIN; CHEMOATTRACTANT; CLOSTRIDIUM DIFFICILE TOXIN B; GUANOSINE TRIPHOSPHATE; INTEGRIN; LIGAND; PERTUSSIS TOXIN; REGULATOR PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SCLEROPROTEIN; SIGNAL REGULATORY PROTEIN ALPHA1; THROMBOSPONDIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL ADHESION; CELL AGGREGATION; CELL MIGRATION; CELL STIMULATION; CELL TYPE; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOMODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; SERUM; SIGNAL TRANSDUCTION; UBIQUITINATION;

ANIMALS; ANTIGENS, CD47; BACTERIAL PROTEINS; BACTERIAL TOXINS; CELL ADHESION; CELL AGGREGATION; CELL MEMBRANE; CELL MOVEMENT; CELLS, CULTURED; CHEMOKINES, CXC; CHEMOTAXIS; FIBROBLASTS; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; JURKAT CELLS; LYMPHOCYTES; MICE; PERTUSSIS TOXIN; RAC GTP-BINDING PROTEINS; RECOMBINANT PROTEINS; THROMBOSPONDINS; TUMOR CELLS, CULTURED;

EID: 26444482058     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20379     Document Type: Article

References (60)

1. Abitorabi MA, Pachynski RK, Ferrando RE, Tidswell M, Erle DJ. 1997. Presentation of integrins on leukocyte microvilli: A role for the extracellular domain in determining membrane localization. J Cell Biol 139:563-571.
2. Brittain JE, Mlinar KJ, Anderson CS, Orringer EP, Parise LV. 2001a. Activation of sickle red blood cell adhesion via integrin-associated protein/CD47-induced signal transduction. J Clin Invest 107:1555-1562.
3. Brittain JE, Mlinar KJ, Anderson CS, Orringer EP, Parise LV. 2001b. Integrin-associated protein is an adhesion receptor on sickle red blood cells for immobilized thrombospondin. Blood 97:2159-2164.
4. Brown EJ, Frazier WA. 2001. Integrin-associated protein (CD47) and its ligands. Trends Cell Biol 11:130-135.
5. Brown EJ, Hooper L, Ho T, Gresham HD. 1990. Integrin-associated protein: A 50-kD plasma membrane antigen physically and functionally associated with integrins. J Cell Biol 111:2785-2794.
6. Cant CA, Ullrich A. 2001. Signal regulation by family conspiracy. Cell Mol Life Sci 58:117-124.
7. Chung J, Gao AG, Frazier WA. 1997. Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3. J Biol Chem 272:14740-14746.
8. Comu S, Weng W, Olinsky S, Ishwad P, Mi Z, Hempel J, Watkins S, Lagenaur CF, Narayanan V. 1997. The murine P84 neural adhesion molecule is SHPS-1, a member of the phosphatase-binding protein family. J Neurosci 17:8702-8710.
9. Constantin G, Majeed M, Giagulli C, Piccio L, Kim JY, Butcher EC, Laudanna C. 2000. Chemokines trigger immediate beta2 integrin affinity and mobility changes: Differential regulation and roles in lymphocyte arrest under flow. Immunity 13:759-769.
10. Cooper D, Lindberg FP, Gamble JR, Brown EJ, Vadas MA. 1995. The transendothelial migration of neutrophils involves integrin associated protein (CD47). Proc Natl Acad Sci USA 92:3978-3982.
11. Dahl KN, Westhoff CM, Discher DE. 2003. Fractional attachment of CD47 (IAP) to the erythrocyte cytoskeleton and visual colocalization with Rh protein complexes. Blood 101:1194-1199.
12. Dahl KN, Parthasarathy R, Westhoff CM, Layton DM, Discher DE. 2004. Protein 4.2 is critical to CD47-membrane skeleton attachment in human red cells. Blood 103:1131-1136.
13. DeLisser HM, Chilkotowsky J, Yan HC, Daise ML, Buck CA, Albelda SM. 1994. Deletions in the cytoplasmic domain of platelet-endothelial cell adhesion molecule-1 (PECAM-1, CD31) result in changes in ligand binding properties. J Cell Biol 124:195-203.
14. W149 antibodies recognize a clustered subset of CD47 molecules associated with cytoplasmic signaling molecules. Tissue Antigens 56:258-267.
15. Famiglietti J, Sun J, DeLisser HM, Albelda SM. 1997. Tyrosine residue in exon 14 of the cytoplasmic domain of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) regulates ligand binding specificity. J Cell Biol 138:1425-1435.
16. Frazier WA, Gao AG, Dimitry J, Chung J, Brown EJ, Lindberg FP, Linder ME. 1999. The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric Gi. J Biol Chem 274:8554-8560.
17. Fujimoto TT, Katsutani S, Shimomura T, Fujimura K. 2003. Thrombospondin-bound integrin-associated protein (CD47) physically and functionally modifies integrin alphaIIbbeta3 by its extracellular domain. J Biol Chem 278:26655-26665.
18. Gao AG, Frazier WA. 1994. Identification of a receptor candidate for the carboxyl-terminal cell binding domain of thrombospondins. J Biol Chem 269:29650-29657.
19. Gao AG, Lindberg FP, Finn MB, Blystone SD, Brown EJ, Frazier WA. 1996. Integrin associated protein is a receptor for the carboxy terminal domain of thrombospondin. J Biol Chem 271:21-24.
20. Green JM, Zhelezniak A, Chung J, Lindberg FP, Sarfati M, Frazier WA, Brown EJ. 1999. Role of cholesterol in formation and function of a signaling complex involving alpha-v beta-3, integrin associated protein (IAP, CD47), and heterotrimeric G proteins. J Cell Biol 146:673-682.
21. Gresham HD, Adams SP, Brown EJ. 1992. Ligand binding specificity of the leukocyte response integrin expressed by human neutrophils. J Biol Chem 267:13895-13902.
22. Gresham HD, Lowrance JH, Caver TE, Wilson BS, Cheung AL, Lindberg FP. 2000. Survival of staphylococcus aureus inside neutrophils contributes to infection. J Immunol 164:3713-3722.
23. Jiang P, Lagenaur CF, Narayanan V. 1999. Integrin-associated protein is a ligand for the P84 neural adhesion molecule. J Biol Chem 274:559-562.
24. Kosfeld MD, Frazier WA. 1992. Identification of active peptide sequences in the carboxyl-terminal cell binding domain of human thrombospondin-1. J Biol Chem 267:16230-16236.
25. Kosfeld MD, Frazier WA. 1993. Identification of a new cell adhesion motif in two homologous peptides from the COOH-terminal cell binding domain of human thrombospondin. J Biol Chem 268:8808-8814.
26. Kunz B, Lierheimer R, Rader C, Spirig M, Ziegler U, Sonderegger P. 2002. Axonin-1/TAG-1 mediates cell-cell adhesion by a cis-assisted trans-interaction. J Biol Chem 277:4551-4557.
27. Lagadec P, Dejoux O, Ticchioni M, Cottrez F, Johansen M, Brown EJ, Bernard A. 2003. Involvement of a CD47-dependent pathway in platelet adhesion on inflamed vascular endothelium under flow. Blood 101:4836-4843.
28. Laudanna C, Kim JY, Constantin G, Butcher E. 2002. Rapid leukocyte integrin activation by chemokines. Immunol Rev 186:37-46.
29. Lindberg FP, Gresham HD, Schwarz E, Brown EJ. 1993. Molecular cloning of integrin-associated protein: An immunoglobulin family member with multiple membrane spanning domains implicated in alpha-v, beta-3-dependent ligand binding. J Cell Biol 123:485-496.
30. Lindberg FP, Bullard DC, Caver TE, Gresham HD, Beaudet AL, Brown EJ. 1996a. Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice. Science 274:795-798.
31. Lindberg FP, Gresham HD, Reinhold MI, Brown EJ. 1996b. Integrin-associated protein immunoglobulin domain is necessary for efficient vitronectin bead binding. J Cell Biol 134:1313-1322.
32. Liu Y, Merlin D, Burst SL, Pochet M, Madara JL, Parkos CA. 2001. The role of CD47 in neutrophil transmigration. Increased rate of migration correlates with increased cell surface expression of CD47. J Biol Chem 276:40156-40166.
33. Liu Y, Buhring HJ, Zen K, Burst SL, Schnell FJ, Williams IR, Parkos CA. 2002. Signal regulatory protein (SIRPα), a cellular ligand for CD47, regulates neutrophil transmigration. J Biol Chem 277:10028-10036.
34. Liu Y, O'Connor MB, Mandell KJ, Zen K, Ullrich A, Buhring HJ, Parkos CA. 2004. Peptide-mediated inhibition of neutrophil transmigration by blocking CD47 interactions with signal regulatory protein alpha. J Immunol 172:2578-2585.
35. Maile LA, Badley-Clarke J, Clemmons DR. 2003. The association between integrin-associated protein and SHPS-1 regulates insulin-like growth factor-I receptor signaling in vascular smooth muscle cells. Mol Biol Cell 14:3519-3528.
36. Manna PP, Frazier WA. 2003. The mechanism of CD47-dependent killing of T cells: Heterotrimeric Gi-dependent inhibition of protein kinase A. J Immunol 170:3544-3553.
37. McDonald JF, Dimitry JM, Frazier WA. 2003. An amyloid-like C-terminal domain of thrombospondin-1 displays CD47 agonist activity requiring both VVM motifs. Biochemistry 42:10001-10011.
38. Miyashita M, Ohnishi H, Okazawa H, Tomonaga H, Hayashi A, Fujimoto TT, Furuya N, Matozaki T. 2004. Promotion of neurite and filopodium formation by CD47: Roles of integrins, Rac, and Cdc42. Mol Biol Cell 15:3950-3963.
39. Nelissen JM, Peters IM, de Grooth BG, van Kooyk Y, Figdor CG. 2000. Dynamic regulation of activated leukocyte cell adhesion molecule-mediated homotypic cell adhesion through the actin cytoskeleton. Mol Biol Cell 11:2057-2068.
40. Ozaki H, Ishii K, Horiuchi H, Arai H, Kawamoto T, Okawa K, Iwamatsu A, Kita T. 1999. Cutting edge: Combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. J Immunol 163:553-557.
41. Parkos CA, Colgan SP, Liang TW, Nusrat A, Bacarra AE, Carnes DK, Madara JL. 1996. CD47 mediates post-adhesive events required for neutrophil migration across polarized intestinal epithelia. J Cell Biol 132:437-450.
42. Rebres RA, Green JM, Reinhold MI, Ticchioni M, Brown EJ. 2001a. Membrane raft association of CD47 is necessary for actin polymerization and protein kinase C theta translocation in its synergistic activation of T cells. J Biol Chem 276:7672-7680.
43. Rebres RA, Vaz LE, Green JM, Brown EJ. 2001b. Normal ligand binding and signaling by CD47 (integrin-associated requires a long range disulfide bond between the extracellular and membrane-spanning domains. J Biol Chem 276:34607-34616.
44. Reinhold MI, Lindberg FP, Kersh GJ, Allen PM, Brown EJ. 1997. Costimulation of T cell activation by integrin-associated protein (CD47) is an adhesion-dependent, CD28-independent signaling pathway. J Exp Med 185:1-11.
45. Reinhold MI, Green JM, Lindberg FP, Ticchioni M, Brown EJ. 1999. Cell spreading distinguishes the mechanism of augmentation of T cell activation by integrin-associated protein/CD47 and CD28. Int Immunol 11:707-718.
46. Rival Y, Del Maschio A, Rabiet MJ, Dejana E, Duperray A. 1996. Inhibition of platelet endothelial cell adhesion molecule-1 synthesis and leukocyte transmigration in endothelial cells by the combined action of TNF-alpha and IFN-gamma. J Immunol 157:1233-1241.
47. Rosales C, Gresham HD, Brown EJ. 1992. Expression of the 50 kD integrin associated protein on myeloid cells and erythrocytes. J Immunol 149:2759-2764.
48. Schenkel AR, Mamdouh Z, Chen X, Liebman RM, Muller WA. 2002. CD99 plays a major role in the migration of monocytes through endothelial junctions. Nat Immunol 3:143-150.
49. Senior RM, Gresham HD, Griffin GL, Brown EJ, Chung AE. 1992. Entactin stimulates neutrophil adhesion and chemotaxis through interactions between its Arg-Gly-Asp (RGD) domain and the leukocyte response integrin (LRI). J Clin Invest 90:2251-2257.
50. Shaw SK, Perkins BN, Lim YC, Liu Y, Nusrat A, Schnell FJ, Parkos CA, Luscinskas FW. 2001. Reduced expression of junctional adhesion molecule and platelet/endothelial cell adhesion molecule-1 (CD31) at human vascular endothelial junctions by cytokines tumor necrosis factor-alpha plus interferon-gamma does not reduce leukocyte transmigration under flow. Am J Pathol 159:2281-2291.
51. Taheri M, Saragovi U, Fuks A, Makkerh J, Mort J, Stanners CP. 2000. Self-recognition in the Ig superfamily. Identification of precise subdomains in carcinoembryonic antigen required for intercellular adhesion. J Biol Chem 275:26935-26943.
52. Ticchioni M, Raimondi V, Lamy L, Wijdenes J, Lindberg FP, Brown EJ, Bernard A. 2001. Integrin-associated protein (CD47/IAP) contributes to T cell arrest on inflammatory vascular endothelium under flow. FASEB J 15:341-350.
53. Vallejo AN, Mugge LO, Klimiuk PA, Weyand CM, Goronzy JJ. 2000. Central role of thrombospondin-1 in the activation and clonal expansion of inflammatory T cells. J Immunol 164:2947-2954.
54. van Kempen LC, Nelissen JM, Degen WG, Torensma R, Weidle UH, Bloemers HP, Figdor CG, Swart GW. 2001. Molecular basis for the homophilic activated leukocyte cell adhesion molecule (ALCAM)-ALCAM interaction. J Biol Chem 276:25783-25790.
55. van Kooyk Y, Figdor CG. 2000. Avidity regulation of integrins: The driving force in leukocyte adhesion. Curr Opin Cell Biol 12:542-547.
56. Wang XQ, Lindberg FP, Frazier WA. 1999. Integrin-associated protein stimulates alpha2beta1-dependent chemotaxis via Gi-mediated inhibition of adenylate cyclase and extracellular-regulated kinases. J Cell Biol 147:389-400.
57. Xie Y, Muller WA. 1993. Molecular cloning and adhesive properties of murine platelet/endothelial cell adhesion molecule 1. Proc Natl Acad Sci USA 90:5569-5573.
58. Yoshida H, Tomiyama Y, Ishikawa J, Oritani K, Matsumura I, Shiraga M, Yokota T, Okajima Y, Ogawa M, Miyagawa J, Nishiura T, Matsuzawa Y. 2000. Integrin-associated protein/CD47 regulates motile activity in human B-cell lines through CDC42. Blood 96:234-241.
59. Zen K, Parkos CA. 2003. Leukocyte-epithelial interactions. Curr Opin Cell Biol 15:557-564.
60. Zhou MJ, Brown EJ. 1993. Leukocyte response integrin and integrin associated protein act as a signal transduction unit in generation of a phagocyte respiratory burst. J Exp Med 178:1165-1174.