The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity

Nucleic Acids Research

Volumn 34, Issue 5, 2006, Pages 1393-1404

  Zhang, Deng Hong ^a   Zhou, Bo ^a   Huang, Yu ^a   Xu, Lu Xia ^a   Zhou, Jin Qiu ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI PROTEIN; HELICASE; PROTEIN PIF1; PROTEIN RECD; RNA DIRECTED DNA POLYMERASE; TELOMERASE; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATASE; DNA; EXODEOXYRIBONUCLEASE V; EXODEOXYRIBONUCLEASE V, E COLI; PIF1 PROTEIN, HUMAN; RNA;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; DNA PROTEIN COMPLEX; DNA RNA HYBRIDIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; EUKARYOTE; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENETIC STABILITY; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; TELOMERE; WILD TYPE; CHEMISTRY; DRUG ANTAGONISM; GENETICS; METABOLISM;

ESCHERICHIA COLI; EUKARYOTA;

ADENOSINE TRIPHOSPHATASES; DNA; DNA HELICASES; ESCHERICHIA COLI PROTEINS; EXODEOXYRIBONUCLEASE V; HUMANS; RNA; SEQUENCE HOMOLOGY, AMINO ACID; TELOMERASE; TELOMERE;

EID: 33645009269     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkl029     Document Type: Article

References (51)

1. McEachern,M.J., Krauskopf,A. and Blackburn,E.H. (2000) Telomeres and their control. Annu. Rev. Genet., 34, 331-358.
2. Cervantes,R.B. and Lundblad,V. (2002) Mechanisms of chromosome-end protection. Curr. Opin. Cell Biol., 14, 351-356.
3. Greider,C.W. and Blackburn,E.H. (1985) Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell, 43, 405-413.
4. Bryan,T.M., Englezou,A., Dalla-Pozza,L., Dunham,M.A. and Reddel,R.R. (1997) Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nature Med., 3, 1271-1274.
5. Greider,C.W. and Blackburn,E.H. (1989) A telomeerec sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature, 337, 331-337.
6. Kim,N.W. (1997) Clinical implications of telomerase in cancer. Eur. J. Cancer, 33, 781-786.
7. Harley,C.B., Kim,N.W., Prowse,K.R., Weinrich,S.L., Hirsch,K.S., West,M.D., Bacchetti,S., Hirte,H.W., Counter,C.M., Greider,C.W. et al. (1994) Telomerase, cell immortality, and cancer. Cold Spring Harb. Symp. Quant. Biol., 59, 307-315.
8. Hastie,N.D., Dempster,M., Dunlop,M.G., Thompson,A.M., Green,D.K. and Allshire,R.C. (1990) Telomere reduction in human colorectal carcinoma and with ageing. Nature, 346, 866-868.
9. Harley,C.B., Futcher,A.B. and Greider,C.W. (1990) Telomeres shorten during ageing of human fibroblasts. Nature, 345, 458-460.
10. Bodnar,A.G., Ouellette,M., Frolkis,M., Holt,S.E., Chiu,C.P., Morin,G.B., Harley,C.B., Shay,J.W., Lichtsteiner,S. and Wright,W.E. (1998) Extension of life-span by introduction of telomerase into normal human cells. Science, 279, 349-352.
11. Vaziri,H. and Benchimol,S. (1998) Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Biol., 8, 279-282.
12. Morales,C.P., Holt,S.E., Ouellette,M., Kaur,K.J., Yan,Y., Wilson,K.S., White,M.A., Wright,W.E. and Shay,J.W. (1999) Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nature Genet., 21, 115-118.
13. Hiyama,E., Hiyama,K., Yokoyama,T., Matsuura,Y., Piatyszek,M.A. and Shay,J.W. (1995) Correlating telomerase activity levels with human neuroblastoma outcomes. Nature Med., 1, 249-255.
14. Hahn,W.C., Stewart,S.A., Brooks,M.W., York,S.G., Eaton,E., Kurachi,A., Beijersbergen,R.L., Knoll,J.H., Meyerson,M. and Weinberg,R.A. (1999) Inhibition of telomerase limits the growth of human cancer cells. Nature Med., 5, 1164-1170.
15. Herbert,B., Pitts,A.E., Baker,S.I., Hamilton,S.E., Wright,W.E., Shay,J.W. and Corey,D.R. (1999) Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc. Natl Acad. Sci. USA, 96, 14276-14281.
16. Zhang,X., Mar,V., Zhou,W., Harrington,L. and Robinson,M.O. (1999) Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev., 13, 2388-2399.
17. Blasco,M.A. (2005) Telomeres and human disease: Ageing, cancer and beyond. Nature Rev. Genet., 6, 611-622.
18. Counter,C.M., Avilion,A.A., LeFeuvre,C.E., Stewart,N.G., Greider,C.W., Harley,C.B. and Bacchetti,S. (1992) Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J., 11, 1921-1929.
19. van Steensel,B. and de Lange,T. (1997) Control of telomere length by the human telomeric protein TRF1. Nature, 385, 740-743.
20. Smogorzewska,A., van Steensel,B., Bianchi,A., Oelmann,S., Schaefer,M.R., Schnapp,G. and de Lange,T. (2000) Control of human telomere length by TRF1 and TRF2. Mol. Cell Biol., 20, 1659-1668.
21. de Lange,T. (2005) Shelterin: The protein complex that shapes and safeguards human telomeres. Genes Dev., 19, 2100-2110.
22. Kim,S.H., Beausejour,C., Davalos,A.R., Kaminker,P., Heo,S.J. and Campisi,J. (2004) TIN2 mediates functions of TRF2 at human telomeres. J. Biol. Chem., 279, 43799-43804.
23. Li,B., Oestreich,S. and de Lange,T. (2000) Identification of human Rap1: implications for telomere evolution. Cell, 101, 471-483.
24. Griffith,J.D., Comeau,L., Rosenfield,S., Stansel,R.M., Bianchi,A., Moss,H. and de Lange,T. (1999) Mammalian telomeres end in a large duplex loop. Cell, 97, 503-514.
25. Greider,C.W. (1999) Telomeres do D-loop-T-loop. Cell, 97, 419-422.
26. Stansel,R.M., de Lange,T. and Griffith,J.D. (2001) T-loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang. EMBO J., 20, 5532-5540.
27. Loayza,D. and De Lange,T. (2003) POT1 as a terminal transducer of TRF1 telomere length control. Nature, 423, 1013-1018.
28. Zhou,J., Monson,E.K., Teng,S.C., Schulz,V.P. and Zakian,V.A. (2000) Pif1p helicase, a catalytic inhibitor of telomerase in yeast. Science, 289, 771-774.
29. Ivessa,A.S., Zhou,J.Q. and Zakian,V.A. (2000) The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA. Cell, 100, 479-489.
30. Ivessa,A.S., Zhou,J.Q., Schulz,V.P., Monson,E.K. and Zakian,V.A. (2002) Saccharomyces Rrm3p, a 5′ to 3′DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA. Genes Dev., 16, 1383-1396.
31. Boule,J.B., Vega,L.R. and Zakian,V.A. (2005) The yeast Pif1p helicase removes telomerase from telomeric DNA. Nature, 438, 57-61.
32. Bessler,J.B., Torredagger,J.Z. and Zakian,V.A. (2001) The Pif1p subfamily of helicases: Region-specific DNA helicases? Trends Cell Biol., 11, 60-65.
33. Zhou,J.Q., Qi,H., Schulz,V.P., Mateyak,M.K., Monson,E.K. and Zakian,V.A. (2002) Schizosaccharomyces pombe pfh1+ encodes an essential 5′ to 3′DNA helicase that is a member of the PIF1 subfamily of DNA helicases. Mol. Biol. Cell, 13, 2180-2191.
34. Li,B. and de Lange,T. (2003) Rap1 affects the length and heterogeneity of human telomeres. Mol. Biol. Cell, 14, 5060-5068.
35. West,S.C. (1996) DNA helicases: New breeds of translocating motors and molecular pumps. Cell, 86, 177-180.
36. Gorbalenya,A.E., Koonin,E.V., Donchenko,A.P. and Blinov,V.M. (1989) Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes. Nucleic Acids Res., 17, 4713-4730.
37. Tatusov,R.L., Koonin,E.V. and Lipman,D.J. (1997) A genomic perspective on protein families. Science, 278, 631-637.
38. Taylor,A.F. and Smith,G.R. (2003) RecBCD enzyme is a DNA helicase with fast and slow motors of opposite polarity. Nature, 423, 889-893.
39. Dillingham,M.S., Spies,M. and Kowalczykowski,S.C. (2003) RecBCD enzyme is a bipolar DNA helicase. Nature, 423, 893-897.
40. Deloukas,P., Schuler,G.D., Gyapay,G., Beasley,E.M., Soderlund,C., Rodriguez-Tome,P., Hui,L., Matise,T.C., McKusick,K.B., Beckmann,J.S. et al. (1998) A physical map of 30 000 human genes. Science, 282, 744-746.
41. Klapper,W., Krams,M., Qian,W., Janssen,D. and Parwaresch,R. (2003) Telomerase activity in B-cell non-Hodgkin lymphomas is regulated by hTERT transcription and correlated with telomere-binding protein expression but uncoupled from proliferation. Br. J. Cancer, 89, 713-719.
42. Lahaye,A., Stahl,H., Thines-Sempoux,D. and Foury,F. (1991) PIF1: A DNA helicase in yeast mitochondria. EMBO J., 10, 997-1007.
43. Taneja,P., Gu,J., Peng,R., Carrick,R., Uchiumi,F., Ott,R.D., Gustafson,E., Podust,V.N. and Fanning,E. (2002) A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication. J. Biol. Chem., 277, 40853-40861.
44. Zhou,X.Z. and Lu,K.P. (2001) The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell, 107, 347-359.
45. Colgin,L.M., Baran,K., Baumann,P., Cech,T.R. and Reddel,R.R. (2003) Human POT1 facilitates telomere elongation by telomerase. Curr. Biol., 13, 942-946.
46. Zaug,A.J., Podell,E.R. and Cech,T.R. (2005) Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. Proc. Natl Acad. Sci. USA, 102, 10864-10869.
47. Johnson,F.B., Marciniak,R.A., McVey,M., Stewart,S.A., Hahn,W.C. and Guarente,L. (2001) The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase. EMBO J., 20, 905-913.
48. Cohen,H. and Sinclair,D.A.(2001) Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase. Proc. Natl Acad. Sci. USA, 98, 3174-3179.
49. Huang,P., Pryde,F.E., Lester,D., Maddison,R.L., Borts,R.H., Hickson,I.D. and Louis,E.J. (2001) SGS1 is required for telomere elongation in the absence of telomerase. Curr. Biol., 11, 125-129.
50. Crabbe,L., Verdun,R.E., Haggblom,C.I. and Karlseder,J. (2004) Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science, 306, 1951-1953.
51. Lee,J.W., Harrigan,J., Opresko,P.L. and Bohr,V.A. (2005) Pathways and functions of the Werner syndrome protein. Mech. Ageing Dev., 126, 79-86.