Diosgenin-3-O-α-L-rhamnopyranosyl-(1→4)-β -D-glucopyranoside obtained as a new anticancer agent from Dioscorea futschauensis induces apoptosis on human colon carcinoma HCT-15 cells via mitochondria-controlled apoptotic pathway

Journal of Asian Natural Products Research

Volumn 6, Issue 2, 2004, Pages 115-125

  Wang, San Long ^a,b   Cai, Bing ^a   Cui, Cheng Bin ^a,c   Liu, Hong Wei ^b   Wu, Chun Fu ^b   Yao, Xin Sheng ^b,d  

^a Tianjin Institute for Biomedicinal Research   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c OCEAN UNIVERSITY OF CHINA   (China)

^d Trad Chinese Med/Nat Prod R C   (China)

Author keywords

Apoptosis; Bax; Bcl 2; Cytochrome c; Dioscorea futschauensis; Diosgenin 3 O L rhamnopyranosyl (1 4) D glucopyranoside; HCT 15 cells; Mitochondrial transmembrane potential

Indexed keywords

CYTOCHROME C; DIOSCOREA FUTSCHAUENSIS EXTRACT; DIOSGENIN; DIOSGENIN 3 O ALPHA LEVO RHAMNOPYRANOSYL(1-4) BETA DEXTRO GLUCOPYRANOSIDE; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; COLON CARCINOMA; DIOSCOREA FUTSCHAUENSIS; DIOSCOREACEAE; DRUG STRUCTURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; RHIZOME;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; COLONIC NEOPLASMS; CYTOCHROMES C; DIOSCOREA; DIOSGENIN; DOWN-REGULATION; FLOW CYTOMETRY; HUMANS; MEMBRANE POTENTIALS; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SAPONINS;

DIOSCOREA; DIOSCOREACEAE;

EID: 0842268520     PISSN: 10286020     EISSN: None     Source Type: Journal    
DOI: 10.1080/1028602031000147357     Document Type: Article

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