Phosphatidylinositol transfer protein-α in netrin-1-induced PLC signalling and neurite outgrowth

Nature Cell Biology

Volumn 7, Issue 11, 2005, Pages 1124-1132

  Xie, Yi ^b   Ding, Yu Qiang ^c   Hong, Yan ^b   Feng, Zhu ^a   Navarre, Sammy ^a   Xi, Cai Xia ^a   Zhu, Xiao Juan ^a   Wang, Chun Lei ^c   Ackerman, S L ^d   Kozlowski, David ^a   Mei, Lin ^b   Xiong, Wen Cheng ^a,b  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b University of Alabama at Birmingham   (United States)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPID; MORPHOLINE DERIVATIVE; MUTANT PROTEIN; NEOGENIN; NETRIN 1; PHOSPHATE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA; PHOSPHOLIPASE C; PHOSPHOLIPID TRANSFER PROTEIN; RECEPTOR PROTEIN; TRIPHOSPHOINOSITIDE; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; DCC PROTEIN, HUMAN; MEMBRANE PROTEIN; NERVE GROWTH FACTOR; NETRIN-1; NEURITE INDUCING FACTOR; NEURITE-INDUCING FACTOR; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; TUMOR SUPPRESSOR PROTEIN; ZEBRAFISH PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL COUNT; CHICKEN; CONTROLLED STUDY; EMBRYO; EXPLANT; HYDROLYSIS; LIPID TRANSPORT; MOTONEURON; MOUSE; MOUSE MUTANT; NERVE CELL; NERVE FIBER; NERVE FIBER GROWTH; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPINAL CORD NERVE CELL; ZEBRA FISH; ANIMAL; CELL CULTURE; CHICK EMBRYO; CYTOLOGY; DRUG EFFECT; GENETIC TRANSFECTION; HUMAN; LIPID METABOLISM; METABOLISM; NEURITE; PHYSIOLOGY; PRENATAL DEVELOPMENT;

ANIMALIA; DANIO RERIO;

ANIMALS; CELLS, CULTURED; CHICK EMBRYO; HUMANS; LIPID METABOLISM; MEMBRANE PROTEINS; NERVE GROWTH FACTORS; NEURITES; NEURONS; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHOLIPID TRANSFER PROTEINS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 33644832752     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1321     Document Type: Article

References (35)

1. Keino-Masu, K. et al. Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Cell 87, 175-185 (1996).
2. Chan, S. S. et al. UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues. Cell 87, 187-195 (1996).
3. Kolodziej, P. A. et al. frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. Cell 87, 197-204 (1996).
4. Hiramoto, M., Hiromi, Y., Giniger, E. & Hotta, Y. The Drosophila Netrin receptor Frazzled guides axons by controlling Netrin distribution. Nature 406, 886-889 (2000).
5. Ren, X. R. et al. Focal adhesion kinase in netrin-1 signaling. Nature Neurosci. 7, 1204-1212 (2004).
6. Ming, G. et al. Phospholipase C-γ and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance. Neuron 23, 139-148 (1999).
7. Forcet, C. et al. Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. Nature 417, 443-447 (2002).
8. Li, X., Saint-Cyr-Proulx, E., Aktories, K. & Lamarche-Vane, N. Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (Deleted in Colorectal Cancer) in N1E-115 neuroblastoma cells. J. Biol. Chem. 277, 15207-15214 (2002).
9. Hu, G. et al. Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway. Genes Dev. 11, 2701-2714 (1997).
10. Culotti, J. G. & Merz, D. C. DCC and netrins. Curr. Opin. Cell Biol. 10, 609-613 (1998).
11. Kennedy, T. E. Cellular mechanisms of netrin function: Long-range and short-range actions. Biochem. Cell Biol. 78, 569-575 (2000).
12. Stein, E. & Tessier-Lavigne, M. Hierarchical organization of guidance receptors: Silencing of netrin attraction by slit through a Robo/DCC receptor complex. Science 291, 1928-1938 (2001).
13. Stein, E., Zou, Y., Poo, M. & Tessier-Lavigne, M. Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation. Science 291, 1976-1982 (2001).
14. Allen-Baume, V., Segui, B. & Cockcroft, S. Current thoughts on the phosphatidylinositol transfer protein family. FEBS Lett. 531, 74-80 (2002).
15. Hara, S., Swigart, P., Jones, D. & Cockcroft, S. The first 5 amino acids of the carboxyl terminus of phosphatidylinositol transfer protein (PITP) alpha play a critical role in inositol lipid signaling. Transfer activity of PITP is essential but not sufficient for restoration of phospholipase C signaling. J. Biol. Chem. 272, 14908-14913 (1997).
16. Graef, I. A. et al. Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell 113, 657-670 (2003).
17. Brose, K. & Tessier-Lavigne, M. Slit proteins: Key regulators of axon guidance, axonal branching, and cell migration. Curr. Opin. Neurobiol. 10, 95-102 (2000).
18. Finger, J. H. et al. The netrin 1 receptors Unc5h3 and Dcc are necessary at multiple choice points for the guidance of corticospinal tract axons. J. Neurosci. 22, 10346-10356 (2002).
19. Schouten, A. et al. Structure of apo-phosphatidylinositol transfer protein alpha provides insight into membrane association. EMBO J. 21, 2117-2121 (2002).
20. Yoder, M. D. et al. Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine. J. Biol. Chem. 276, 9246-9252 (2001).
21. Wang, Q. et al. Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolin. J. Cell Biol. 160, 565-575 (2003).
22. Van Paridon, P. A., Gadella, T. W. Jr & Wirtz, K. W. The effect of polyphosphoinositides and phosphatidic acid on the phosphatidylinositol transfer protein from bovine brain: A kinetic study. Biochim. Biophys. Acta 943, 76-86 (1988).
23. Hamilton, B. A. et al. The vibrator mutation causes neurodegeneration via reduced expression of PITPα: Positional complementation cloning and extragenic suppression. Neuron 18, 711-722 (1997).
24. Metin, C., Deleglise, D., Serafini, T., Kennedy, T. E. & Tessier-Lavigne, M. A role for netrin-1 in the guidance of cortical efferents. Development 124, 5063-5074 (1997).
25. Braisted, J. E. et al. Netrin-1 promotes thalamic axon growth and is required for proper development of the thalamocortical projection. J. Neurosci. 20, 5792-5801 (2000).
26. Serafini, T. et al. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78, 409-424 (1994).
27. Nasevicius, A. & Ekker, S. C. Effective targeted gene 'knockdown' in zebrafish. Nature Genet. 26, 216-220 (2000).
28. Mawdsley, D. J. et al. The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish. Dev. Biol. 269, 302-315 (2004).
29. Morgan, C. P. et al. Phosphorylation of a distinct structural form of PITP at Ser166 by protein kinase C disrupts receptor-mediated phospholipase C signalling by inhibiting delivery of phosphatidylinositol to membranes. J. Biol. Chem. 279, 47159-47171 (2004).
30. Takei, K., Shin, R. M., Inoue, T., Kato, K. & Mikoshiba, K. Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptors in growth cones. Science 282, 1705-1708 (1998).
31. Li, H. S. et al. Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. Cell 96, 807-818 (1999).
32. Ren, X. R. et al. Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. J. Cell Biol. 152, 971-984 (2001).
33. Niwa, H., Yamamura, K. & Miyazaki, J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108, 193-199 (1991).
34. Richards, L. J., Koester, S. E., Tuttle, R. & O'Leary, D. D. Directed growth of early cortical axons is influenced by a chemoattractant released from an intermediate target. J. Neurosci. 17, 2445-2458 (1997).
35. Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B. & Schilling, T. F. Stages of embryonic development of the zebrafish. Dev. Dyn. 203, 253-310 (1995).