MCH-/- mice are resistant to aging-associated increases in body weight and insulin resistance

Diabetes

Volumn 55, Issue 2, 2006, Pages 428-434

  Jeon, Justin Y ^a,b,c,d   Bradley, Richard L ^a,b,c   Kokkotou, Efi G ^a,b,c   Marino, Francis E ^a,b   Wang, Xiaomei ^a   Pissios, Pavlos ^a,b,c   Maratos Flier, Eleftheria ^a,b,c  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b JOSLIN DIABETES CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d Yonsei University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

MELANIN CONCENTRATING HORMONE; PROTEIN P53; SILENT INFORMATION REGULATOR PROTEIN 2;

AGE DISTRIBUTION; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALORIC RESTRICTION; COMPARATIVE STUDY; CONTROLLED STUDY; ENERGY EXPENDITURE; FEMALE; GLUCOSE TOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LEAN BODY WEIGHT; LIFESPAN; MALE; METABOLISM; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; WEIGHT GAIN; WILD TYPE;

AGING; ANIMALS; ENERGY METABOLISM; FEMALE; GENE DELETION; HYPOTHALAMIC HORMONES; INSULIN RESISTANCE; MALE; MELANINS; MICE; MOTOR ACTIVITY; PHENOTYPE; PITUITARY HORMONES; TUMOR SUPPRESSOR PROTEIN P53; WEIGHT GAIN;

EID: 33644778822     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/diabetes.55.02.06.db05-0203     Document Type: Article

References (46)

1. Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, Koplan JP: The continuing epidemics of obesity and diabetes in the United States. JAMA 286:1195-1200, 2001
2. You T, Yang R, Lyles MF, Gong D, Nicklas BJ: Abdominal adipose tissue cytokine gene expression: relationship to obesity and metabolic risk factors. Am J Physiol Endocrinol Metab, 2005 288:E741-E747
3. Barbieri M, Rizzo MR, Manzella D, Paolisso G: Age-related insulin resistance: is it an obligatory finding? The lesson from healthy centenarians. Diabetes Metab Res Rev 17:19-26, 2001
4. Barzilai N, Banerjee S, Hawkins M, Chen W, Rossetti L: Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat. J Clin Invest 101:1353-1361, 1998
5. Barzilai N, She L, Liu BQ, Vuguin P, Cohen P, Wang J, Rossetti L: Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes 48:94-98, 1999
6. Shimada M, Tritos NA, Lowell BB, Flier JS, Maratos-Flier E: Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 396:670-674, 1998
7. Flier JS: Obesity wars: molecular progress confronts an expanding epidemic. Cell 116:337-350, 2004
8. Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, Fumagalli S, Allegrini PR, Kozma SC, Auwerx J, Thomas G: Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431:200-205, 2004
9. Pissios P, Maratos-Flier E: Melanin-concentrating hormone: from fish skin to skinny mammals. Trends Endocrinol Metab 14:243-248, 2003
10. Borowsky B, Durkin MM, Ogozalek K, Marzabadi MR, DeLeon J, Lagu B, Heurich R, Lichtblau H, Shaposhnik Z, Daniewska I, Blackburn TP, Branchek TA, Gerald C, Vaysse PJ, Forray C: Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist. Nat Med 8:825-830, 2002
11. Clegg DJ, Air EL, Benoit SC, Sakai RS, Seeley RJ, Woods SC: Intraventricular melanin-concentrating hormone stimulates water intake independent of food intake. Am J Physiol Regul Integr Comp Physiol 284:R494-R499, 2003
12. Gomori A, Ishihara A, Ito M, Mashiko S, Matsushita H, Yumoto M, Tanaka T, Tokita S, Moriya M, Iwaasa H, Kanatani A: Chronic intracerebroventricular infusion of MCH causes obesity in mice: melanin-concentrating hormone. Am J Physiol Endocrinol Metab 284:E583-E588, 2003
13. Ito M, Gomori A, Ishihara A, Oda Z, Mashiko S, Matsushita H, Yumoto M, Sano H, Tokita S, Moriya M, Iwaasa H, Kanatani A: Characterization of MCH-mediated obesity in mice. Am J Physiol Endocrinol Metab 284:E940-E945, 2003
14. Ludwig DS, Mountjoy KG, Tatro JB, Gillette JA, Frederich RC, Flier JS, Maratos-Flier E: Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus. Am J Physiol 274:E627-E633, 1998
15. Marsh DJ, Weingarth DT, Novi DE, Chen HY, Trumbauer ME, Chen AS, Guan XM, Jiang MM, Feng Y, Camacho RE, Shen Z, Frazier EG, Yu H, Metzger JM, Kuca SJ, Shearman LP, Gopal-Truter S, MacNeil DJ, Strack AM, MacIntyre DE, Van der Ploeg LH, Qian S: Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Proc Natl Acad Sci U S A 99:3240-3245, 2002
16. Segal-Lieberman G, Bradley RL, Kokkotou E, Carlson M, Trombly DJ, Wang X, Bates S, Myers MG Jr, Flier JS, Maratos-Flier E: Melaninconcentrating hormone is a critical mediator of the leptin-deficient phenotype. Proc Natl Acad Sci U S A 100:10085-10090, 2003
17. Pissios P, Trombly DJ, Tzameli I, Maratos-Flier E: Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways. Endocrinology 144:3514-3523, 2003
18. Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA: Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305:390-392, 2004
19. Lin SJ, Ford E, Haigis M, Liszt G, Guarente L: Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev 18:12-16, 2004
20. Ryan KM, Phillips AC, Vousden KH: Regulation and function of the p53 tumor suppressor protein. Curr Opin Cell Biol 13:332-337, 2001
21. Vogelstein B, Lane D, Levine AJ: Surfing the p53 network. Nature 408:307-310, 2000
22. Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, Lu X, Soron G, Cooper B, Brayton C, Hee Park S, Thompson T, Karsenty G, Bradley A, Donehower LA: p53 mutant mice that display early ageingassociated phenotypes. Nature 415:45-53, 2002
23. Dumble M, Gatza C, Tyner S, Venkatachalam S, Donehower LA: Insights into aging obtained from p53 mutant mouse models. Ann N Y Acad Sci 1019:171-177, 2004
24. Campisi J: Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120:513-522, 2005
25. Giese H, Snyder WK, van Oostrom C, van Steeg H, Dolle ME, Vijg J: Age-related mutation accumulation at a lacZ reporter locus in normal and tumor tissues of Trp53-deficient mice. Mutat Res 514:153-163, 2002
26. Lin SJ, Defossez PA, Guarente L: Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289:2126-2128, 2000
27. Rogina B, Helfand SL: Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A 101:15998-16003, 2004
28. Guarente L, Picard F: Calorie restriction: the SIR2 connection. Cell 120:473-482, 2005
29. Bellizzi D, Rose G, Cavalcante P, Covello G, Dato S, De Rango F, Greco V, Maggiolini M, Feraco E, Mari V, Franceschi C, Passarino G, De Benedictis G: A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics 85:258-263, 2005
30. Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107:149-159, 2001
31. Smith J: Human Sir2 and the "silencing" of p53 activity. Trends Cell Biol 12:404-406, 2002
32. Kokkotou E, Jeon JY, Wang X, Marino FE, Carlson M, Trombly DJ, Maratos-Flier E: Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms. Am J Physiol Regul Integr Comp Physiol 289:R117-R124, 2005
33. Astrand A, Bohlooly YM, Larsdotter S, Mahlapuu M, Andersen H, Tornell J, Ohlsson C, Snaith M, Morgan DG: Mice lacking melanin-concentrating hormone receptor 1 demonstrate increased heart rate associated with altered autonomic activity. Am J Physiol Regul Integr Comp Physiol 287:R749-R758, 2004
34. Barzilai N, Rossetti L: Age-related changes in body composition are associated with hepatic insulin resistance in conscious rats. Am J Physiol 270:E930-E936, 1996
35. Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS: A transgenic model of visceral obesity and the metabolic syndrome. Science 294:2166-2170, 2001
36. Hotamisligil GS: The role of TNFalpha and TNF receptors in obesity and insulin resistance. J Intern Med 245:621-625, 1999
37. Wang C, Weindruch R, Fernandez JR, Coffey CS, Patel P, Allison DB: Caloric restriction and body weight independently affect longevity in Wistar rats. Int J Obes Relat Metab Disord 28:357-362, 2004
38. Caloric restriction and longevity. Harv Mens Health Watch 2:6-7, 1998
39. Das M, Gabriely I, Barzilai N: Caloric restriction, body fat and ageing in experimental models. Obes Rev 5:13-19, 2004
40. Berrigan D, Perkins SN, Haines DC, Hursting SD: Adult-onset calorie restriction and fasting delay spontaneous tumorigenesis in p53-deficient mice. Carcinogenesis 23:817-822, 2002
41. Patel AC, Nunez NP, Perkins SN, Barrett JC, Hursting SD: Effects of energy balance on cancer in genetically altered mice. J Nutr 134:3394S-3398S, 2004
42. Lamming DW, Wood JG, Sinclair DA: Small molecules that regulate lifespan: evidence for xenohormesis. Mol Microbiol 53:1003-1009, 2004
43. DePinho RA: The age of cancer. Nature 408:248-254, 2000
44. Xiao ZQ, Yu Y, Khan A, Jaszewski R, Ehrinpreis MN, Majumdar AP: Induction of G(1) checkpoint in the gastric mucosa of aged rats. Am J Physiol 277:G929-G934, 1999
45. Xiao ZQ, Jaszewski R, Majumdar AP: Aging enhances G(1) phase in the colonic mucosa of rats. Mech Ageing Dev 116:1-14, 2000
46. Nitahara JA, Cheng W, Liu Y, Li B, Leri A, Li P, Mogul D, Gambert SR, Kajstura J, Anversa P: Intracellular calcium, DNase activity and myocyte apoptosis in aging Fischer 344 rats. J Mol Cell Cardiol 30:519-535, 1998