X-ray structures of free and leupeptin-complexed human αI-tryptase mutants: Indication for an α→β-tryptase transition

Journal of Molecular Biology

Volumn 357, Issue 1, 2006, Pages 195-209

  Rohr, Kerstin B ^a   Selwood, Trevor ^b,d   Marquardt, Ulf ^a,e   Huber, Robert ^a   Schechter, Norman M ^b   Bode, Wolfram ^a,c   Than, Manuel E ^a,c  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF MUNICH   (Germany)

^d FOX CHASE CANCER CENTER   (United States)

^e Partnerschaft Patent und Rechtsanwaltskanzlei   (Germany)

Author keywords

Active site flexibility; Asthma; Trypsin like serine proteinase; Tryptase; X ray crystallography

Indexed keywords

ALPHA TRYPTASE; AMINO ACID; BETA TRYPTASE; LEUPEPTIN; MONOMER; TETRAMER; TRYPTASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ANIMALIA;

EID: 33644776716     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.12.037     Document Type: Article

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