The heterogeneity of mast cell tryptase from human lung and skin: Differences in size, charge and substrate affinity

European Journal of Biochemistry

Volumn 270, Issue 2, 2003, Pages 270-283

  Peng, Qi ^a   McEuen, Alan R ^a   Benyon, R Christopher ^a   Walls, Andrew F ^a,b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

2D gel electrophoresis; Glycosylation; Lectin; Mast cell; Tryptase

Indexed keywords

CHROMOGENIC SUBSTRATE; SIALIDASE; TRYPTASE;

ARTICLE; CELL ISOLATION; CONTROLLED STUDY; DEGLYCOSYLATION; ENZYME ACTIVITY; ENZYME POLYMORPHISM; ENZYME PURIFICATION; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; LECTIN BINDING; LUNG; MAST CELL; MATHEMATICAL MODEL; MICHAELIS CONSTANT; MOLECULAR WEIGHT; NORMAL HUMAN; PH; PRIORITY JOURNAL; SIALYLATION; SKIN;

BLOTTING, WESTERN; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; LUNG; MAST CELLS; MODELS, MOLECULAR; PROTEIN ISOFORMS; SERINE ENDOPEPTIDASES; SKIN; SUBSTRATE SPECIFICITY; TRYPTASES;

EID: 0037244415     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2003.03385.x     Document Type: Article

References (56)

1. Walls, A.F. (2000) The roles of neutral proteases in asthma and rhinitis. In Asthma and Rhinitis, 2nd edn. (Busse, W.W. & Holgate, S.T., eds), pp. 968-997. Blackwell, Boston, USA.
2. Walls, A.F. (2000) Structure and function of mast cell tryptase. In Mast Cells and Basophils in Physiology, Pathology and Host Defence (Marone, G., Lichtenstein, L.M. & Galli, S.J., eds), pp. 291-309. Academic Press, London, UK.
3. Tam, E.K. & Caughey, G.H. (1990) Degradation of airway neu-ropeptides by human lung tryptase. Am. Rev. Respir. Cell. Mol. Biol. 3, 27-32.
4. Walls, A.F., Brain, S.D., Desai, A., Jose, P.J., Hawkings, E., Church, M.K. & Williams, T.J. (1992) Human mast cell tryptase attenuates the vasodilator activity of calcitonin gene-related peptide (CGRP). Biochem. Pharmacol. 43, 1243-1248.
5. Walls, A.F., Bennett, A.F., Sueiras-Diaz, J. & Olsson, H. (1992) The kininogenase activity of human mast cell tryptase. Biochem. Soc. Trans. 20, 260S.
6. Thomas, V.A., Wheeless, C.J., Stack, M.S. & Johnson, D.A. (1998) Human mast cell tryptase fibrinogenolysis: kinetics, anticoagulation mechanism, and cell adhesion disruption. Biochemistry 37, 2291-2298.
7. Cairns, J.A. & Walls, A.F. (1996) Mast cell tryptase is a mitogen for epithelial cells. Stimulation of IL-8 production and inter-cellular adhesion molecule-1 expression. J. Immunol. 156, 275-283.
8. Cairns, J.A. & Walls, A.F. (1997) Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts. J. Clin. Invest. 99, 1313-1321.
9. He, S., Gaça, M.D.A. & Walls, A.F. (1998) A role for tryptase in the activation of human mast cells: modulation of histamine release by tryptase and inhibitors of tryptase. J. Pharmacol. Exp. Ther. 286, 289-297.
10. Compton, S.J., Cairns, J.A., Holgate, S.T. & Walls, A.F. (1998) The role of mast cell tryptase in regulating endothelial cell proliferation, cytokine release and adhesion molecule expression. Tryptase induces expression of mRNA for IL-1β and IL-8 and stimulates the selective release of IL-8 from HUVEC. J. Immunol. 161, 1939-1947.
11. Berger, P., Perng, D.-W., Thabrew, H., Compton, S.J., Cairns, J.A., McEuen, A.R., Marthan, R., Tunon-de-Lara, J.M. & Walls, A.F. (2001) Tryptase and agonists of protease activated receptor 2 induce the proliferation of human airway smooth muscle cells. J. Appl. Physiol. 91,1372-1379.
12. He, S., Peng, Q. & Walls, A.F. (1997) Potent induction of a neutrophil and eosinophil-rich infiltrate in vivo by human mast cell tryptase. Selective enhancement of eosinophil recruitment by histamine. J. Immunol. 159, 6216-6225.
13. Berger, P., Compton, S.J., Molimard, M., Walls, A.F., N'Guyen, C., Marthan, R. & Tunon de Lara, J.M. (1999) Mast cell tryptase as a mediator of hyperresponsiveness in human isolated bronchi. Clin. Exp. Allergy 29, 804-812.
14. Clark, J.M., Abraham, W.M., Fishman, C.E., Forteza, R., Ahmed, A., Cortes, A., Warne, R.L., Moore, W.R. & Tanaka, R.D. (1995) Tryptase inhibitors block allergen induced airway and inflammatory responses in allergic sheep. Am. J. Resp. Crit. Care Med. 152, 2076-2083.
15. Krishna, M.T., Chauhan, A., Little, L., Sampson, K., Hawksworth, R., Mant, T., Djukanovic, R., Lee, T. & Holgate, S. (2001) Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma. J. Allergy Clin. Immunol. 107, 1039-1045.
16. Schwartz, L.B., Lewis, R.A. & Austen, K.F. (1981) Tryptase from human pulmonary mast cells: purification and characterization. J. Biol. Chem. 256, 11939-11943.
17. Smith, T.J., Hougland, M.W. & Johnson, D.A. (1984) Human lung tryptase: purification and characterization. J. Biol. Chem. 259, 11046-11051.
18. 2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates. J. Biol. Chem. 262, 1363-1373.
19. Walls, A.F., Bennett, A.R., McBride, H.M., Glennie, M.J., Holgate, S.T. & Church, M.K. (1990) Production and characterization of monoclonal antibodies specific for human mast cell tryptase. Clin. Exp. Allergy 20, 581-589.
20. Benyon, R.C., Enciso, J.A. & Befus, A.D. (1993) Analysis of human skin mast cell proteins by two-dimensional gel electrophoresis. J. Immunol. 151, 2699-2706.
21. Tanaka, T., McRea, B.J., Cho, K., Cook, R., Fräki, J.E., Johnson, D.A. & Powers, J.C. (1983) Mammalian tissue trypsin-like enzymes. J. Biol. Chem. 258, 13552-13557.
22. Little, S.S. & Johnson, D.A. (1995) Human mast cell tryptase isoforms: separation and examination of substrate specificity differences. Biochem. J. 307, 341-346.
23. Pereira, P.J.B., Bergner, A., Macedo-Ribeiro, S., Huber, R., Matschiner, G., Fritz, H., Sommerhoff, C.P. & Bode, W. (1998) Human β-tryptase is a ring-like tetramer with active sites facing a central pore. Nature 392, 306-311.
24. Schwartz, L.B. (1985) Monoclonal antibodies against human mast cell tryptase demonstrate shared antigenic sites on subunits of tryptase and selective location of the enzyme to mast cells. J. Immunol. 134, 526-531.
25. Harvima, I.T., Schechter, N.M., Harvima, R.J. & Fräki, J.E. (1988) Human skin tryptase: purification, partial characterization and comparison with human lung tryptase. Biochim. Biophys. Acta 957, 71-80.
26. Miller, J.S., Westin, E.H. & Schwartz, L.B. (1989) Cloning and characterization of complementary DNA for human tryptase. J. Clin. Invest. 84, 1188-1195.
27. Miller, J.S., Moxley, G. & Schwartz, L.B. (1990) Cloning and characterization of a second complementary DNA for human tryptase. J. Clin. Invest. 86, 864-870.
28. Vanderslice, P., Barllinger, S.M., Tam, E.K., Goldstein, S.M., Craik, C.S. & Caughey, G.H. (1990) Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family. Proc. Natl Acad. Sci. USA 87, 3811-3815.
29. Pallaoro, M., Fejzo, M.S., Shayesteh, L., Blount, J.L. & Caughey, G.H. (1999) Characterization of genes encoding known and novel human mast ecll tryptases on chromosome 16p13.3. J. Biol. Chem. 274, 3355-3362.
30. Caughey, G.H., Raymond, W.W., Blount, J.L., Hau, L.W.-T., Pallaoro, M., Wolters, P.J. & Verghese, G.M. (2000) Characterization of human c-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families. J. Immunol. 164, 6566-6575.
31. Wong, G.W., Tang, Y., Feyfant, E., Šali, A., Li, L., Li, Y., Huang, C., Friend, D.S., Krillis, S.A. & Stevens, R.L. (1999) Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension. J. Biol. Chem. 274, 30784-30793.
32. Wong, G.W., Yasuda, S., Madhusudhan, M.S., Li, L., Yang, Y., Krillis, S.A., Šali, A. & Stevens, R.L. (2001) Human tryptase ε (PRSS22), a novel member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells. J. Biol. Chem. 276, 49169-49182.
33. Min, H.-K., Kambe, N. & Schwartz, L.B. (2001) Human mouse mast cell protease 7-like tryptase genes are pseudogenes. J. Allergy Clin. Immunol. 107, 315-321.
34. Soto, D., Malmsten, C., Blount, J.L., Muilenburg, D.J. & Caughey, G.H. (2002) Genetic deficiency of human mast cell a-tryptase. Clin. Exp. Allergy 32, 1000-1006.
35. cεRIγ mRNAs in human mast cells and basophils by competitive reverse transcription-polymerase chain reaction. J. Immunol. 154, 5472-5480.
36. Schwartz, L.B., Sakai, K., Bradford, T.R., Ren, S., Zweiman, B., Worobic, A.S. & Metcalfe, D. (1995) The a form of human tryptase is the predominant type present in blood at baseline in normal subject and is elevated in those with systemic mastocytosis. J. Clin. Invest. 96, 2702-2710.
37. Sakai, K., Ren, S. & Schwartz, L.B. (1996) A novel heparin-dependent processing pathway for human tryptase autocatalysis followed by activation with dipeptidyl peptidase I. J. Clin. Invest. 97, 988-995.
38. Guida, M., Riedy, M., Lee, D. & Hall, J. (2000) Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog. Pharmaco-genetics 10, 389-396.
39. Okayama, Y., Hunt, T.C., Kassel, O., Ashman, L.K. & Church, M.K. (1993) Assessment of anti-c-kit monoclonal antibody YB5.B8 in affinity magnetic enrichment of human lung mast cells. J. Immunol. Methods 169, 153-161.
40. Benyon, R.C., Lowman, M. & Church, M.K. (1987) Human skin mast cells: their dispersion, purification and secretory characterization. J. Immunol. 138, 861-867.
41. McEuen, A.R., He, S., Brander, M.L. & Walls, A.F. (1996) Guinea pig lung tryptase: localisation to mast cells and characterisation of the partially purified enzyme. Biochem. Pharmacol. 52, 331-340.
42. Abe, T., Swieter, M., Imai, T., Hollander, N.D. & Befus, D.A. (1990) Mast cell heterogeneity: two-dimensional gel electrophoretic analysis of rat peritoneal and intestinal mucosal mast cells. Eur. J. Immunol. 20, 1941-1947.
43. McEuen, A.R., Sharma, B. & Walls, A.F. (1995) Regulation of the activity of human chymase during storage and release from mast cells: the contributions of inorganic cations, pH, heparin and histamine. Biochim. Biophys. Acta 1267, 115-121.
44. Ellis, K.J. & Morrison, J.F. (1982) Buffers of constant ionic strength for studying pH-dependent processes. Methods Enzymol.87, 405-426.
45. Goldsteine, I.J., Reichart, C. & Misaki, A. (1974) Interaction of concanavalin A with model substrates. Ann. NY Acad. Sci. 234, 283-296.
46. Kornfeld, R. & Kornfeld, S. (1980) The structure of glycoproteins and their oligosaccharide units. In The Biochemistry of Glyco-proteins and Proteoglycans (Lennarz, W.I., ed.), pp. 1-34. Plenum Press, New York, USA.
47. Allen, A.K., Neuberger, A. & Sharon, N. (1973) The purification and specificity of wheat germ agglutinin. Biochem. J. 131, 155-162.
48. Gallagher, J.T., Harding, M. & Dale, R.E. (1983) Sialic acid as a cell surface binding for wheat germ agglutinin. In Lectins, Biology, Biochemistry, Clinical Biochemistry (Bog-Hansen, T.C. & Spen-gler, G.A., eds), pp. 311-318. Walter de Gruyter, Berlin, Germany.
49. Debray, H., Decont, D., Strecker, G., Spik, G. & Monteuil, J. (1981) Specificity of twelve lectins towards oligosaccharides and glycopeptides related to N-glycosyl proteins. Eur. J. Biochem. 117, 41-55.
50. Cummings, R.D. & Kornfeld, S. (1982) Characterization of the structural determinants required for the high affinity interactions of asparagine-linked oligosaccharides with immobilized Phaseolus vulgaris leukoagglutinating and erythroagglutinating lectins. J. Biol. Chem. 257, 11230-11234.
51. Segel, I.H. (1975) Enzyme Kinetics: Behaviour and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems. John Wiley and Sons, New York, USA.
52. Picard, V., Ersal-Badju, E. & Bock, S.C. (1995) Partial glycosy-lation of antithrombin III asparagines-135 is caused by the serine in the third position of its N-glycosylation consensus sequence and is responsible for production of the β-antithrombin III isoforms with enhanced heparin affinity. Biochemistry 34, 8433-8440.
53. Kirkpatrick, C.J., Jones, C.J. & Stoddart, R.W. (1988) Lectin histochemistry of the mast cell: a light microscopical study. Histochem. J. 20, 139-146.
54. Buckley, M.G., Walters, C., Wong, W.M., Cawley, M.I.D., Ren, S., Schwartz, L.B. & Walls, A.F. (1997) Mast cell activation in arthritis: detection of α- and β-tryptase, histamine and eosinophil cationic protein in synovial fluid. Clin. Sci. 93, 363-370.
55. Schwartz, L.B., Irani, A.A., Roller, K., Castells, M.C. & Schechter, N.M. (1987) Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells. J. Immunol. 138, 2622-2615.
56. Alter, S.C. & Schwartz, L.B. (1989) Effect of histamine and divalent cations on the activity and stability of tryptase from human mast cells. Biochim. Biophys. Acta 991, 426-430.