His ··· Asp catalytic dyad of ribonuclease A: Histidine pK(a) values in the wild-type, D121N, and D121A enzymes

Biophysical Journal

Volumn 76, Issue 3, 1999, Pages 1571-1579

  Quirk, David J ^a   Raines, Ronald T ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; ASPARTIC ACID; HISTIDINE; PANCREATIC RIBONUCLEASE; URIDINE PHOSPHATE; LIGAND;

AMINO ACID ANALYSIS; AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME STRUCTURE; HYDROGEN BOND; IONIZATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PKA; PROTON TRANSPORT; RNA CLEAVAGE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ANIMAL; BIOPHYSICS; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; IN VITRO STUDY; KINETICS; METABOLISM; PANCREAS; POINT MUTATION; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS;

BOVINAE;

ANIMALS; ASPARTIC ACID; BIOPHYSICS; CATALYTIC DOMAIN; CATTLE; HISTIDINE; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; KINETICS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PANCREAS; POINT MUTATION; PROTEIN CONFORMATION; RIBONUCLEASE, PANCREATIC; URIDINE MONOPHOSPHATE;

EID: 0032589144     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(99)77316-9     Document Type: Article

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