Local protein dynamics and catalysis: Detection of segmental motion associated with rate-limiting product release by a glutathione transferase

Biochemistry

Volumn 41, Issue 51, 2002, Pages 15161-15172

  Codreanu, Simona G ^a   Ladner, Jane E ^b   Xiao, Gaoyi ^b   Stourman, Nina V ^a   Hachey, David L ^a   Gilliland, Gary L ^b   Armstrong, Richard N ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; CATALYSIS; CRYSTALLOGRAPHY; PROTEINS;

SEGMENTAL MOTION;

BIOCHEMISTRY;

1 CHLORO 2,4 DINITROBENZENE; AMIDE; GLUTATHIONE TRANSFERASE; HYDROXYL GROUP; MUTANT PROTEIN;

ADDITION REACTION; ARTICLE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME MECHANISM; HYDROGEN BOND; MOLECULAR DYNAMICS; MOTION; MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTON TRANSPORT;

AMIDES; AMINO ACID SUBSTITUTION; ANIMALS; CATALYSIS; CIRCULAR DICHROISM; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DEUTERIUM OXIDE; DINITROCHLOROBENZENE; GLUTATHIONE TRANSFERASE; KINETICS; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; PROTEIN CONFORMATION; PROTONS; RATS; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THERMODYNAMICS; TYROSINE;

EID: 0347997288     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi026776p     Document Type: Article

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