The lupus-susceptibility locus, Sle3, mediates enhanced: Resistance to bacterial infections

Journal of Immunology

Volumn 176, Issue 5, 2006, Pages 3233-3239

  Mehrad, Borna ^a,b   Park, Stacy J ^a   Akangire, Gangaram ^a   Standiford, Theodore J ^c   Wu, Tianfu ^b   Zhu, Jiankun ^b   Mohan, Chandra ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; BACTERIAL INFECTION; GENE; GENE LOCATION; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; INNATE IMMUNITY; MOUSE; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN FAMILY; SLE3 GENE; SYSTEMIC LUPUS ERYTHEMATOSUS; WILD TYPE;

EID: 33644541430     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.5.3233     Document Type: Article

References (49)

1. Nath, S. K., J. Kilpatrick, and J. B. Harley. 2004. Genetics of human systemic lupus erythematosus: the emerging picture. Curr. Opin. Immunol. 16: 794-800.
2. Jorgensen, T. N., M. R. Gubbels, and B. L. Kotzin. 2004. New insights into disease pathogenesis from mouse lupus genetics. Curr. Opin. Immunol. 16: 787-793.
3. Morel, L., and E. K. Wakeland. 2000. Lessons from the NZM2410 model and related strains. Int. Rev. Immunol. 19: 423-446.
4. Mohan, C. 2001. Murine lupus genetics: lessons learned. Curr. Opin. Rheumatol. 13: 352-360.
5. Mohan, C., E. Alas, L. Morel, P. Yang, and E. K. Wakeland. 1998. Genetic dissection of SLE pathogenesis: Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes. J. Clin. Invest. 101: 1362-1372.
6. Mohan, C., L. Morel, P. Yang, and E. K. Wakeland. 1997. Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity. J. Immunol. 159: 454-465.
7. Mohan, C., Y. Yu, L. Morel, P. Yang, and E. K. Wakeland. 1999. Genetic dissection of Sle pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation, and cell death. J. Immunol. 162: 6492-6502.
8. Sobel, E. S., L. Morel, R. Baert, C. Mohan, J. Schiffenbauer, and E. K. Wakeland. 2002. Genetic dissection of systemic lupus erythematosus pathogenesis: evidence for functional expression of Sle3/5 by non-T cells. J. Immunol. 169: 4025-4032.
9. Zhu, J., X. Liu, C. Xie, M. Yan, Y. Yu, E. S. Sobel, E. K. Wakeland, and C. Mohan. 2005. T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells. J. Clin. Invest. 115: 1869-1878.
10. Tsai, W. C., R. M. Stricter, J. M. Wilkowski, K. A. Bucknell, M. D. Burdick, S. A. Lira, and T. J. Standiford. 1998. Lung-specific transgenic expression of KC enhances resistance to Klebsiella pneumoniae in mice. J. Immunol. 161: 2435-2440.
11. Steinhauser, M. L., C. M. Hogaboam, S. L. Kunkel, M. W. Lukacs, R. M. Strieter, and T. J. Standiford. 1999. IL-10 is a major mediator of sepsis-induced impairment in lung antibacterial host defense. J. Immunol. 162: 392-399.
12. Mehrad, B., R. M. Strieter, T. A. Moore, W. C. Tsai, S. A. Lira, and T. J. Standiford. 1999. CXC chemokine receptor-2 ligands are necessary components of neutrophil-mediated host defense in invasive pulmonary aspergillosis. J. Immunol. 163: 6086-6094.
13. Morrison, B. E., S. J. Park, J. M. Mooney, and B. Mehrad. 2003. Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis. J. Clin. Invest. 112: 1862-1870.
14. Hotchkiss, R. S., K. W. Tinsley, P. E. Swanson, K. C. Chang, J. P. Cobb. T. G. Buchman, S. J. Korsmeyer, and I. E. Karl. 1999. Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc. Natl. Acad. Sci. USA 96: 14541-14546.
15. Rodriguez, I., K. Matsuura, C. Ody, S. Nagata, and P. Vassalli. 1996. Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death. J. Exp. Med. 184: 2067-2072.
16. Goldblum, S. E., K. M. Wu, and M. Jay. 1985. Lung myeloperoxidase as a measure of pulmonary leukostasis in rabbits. J. Appl. Physiol. 59: 1978-1985.
17. + T cells in the protective inflammatory response to a pulmonary cryptococcal infection. J. Leukocyte Biol. 55: 35-42.
18. Luo, Y., and M. E. Dorf. 2002. Isolation of mouse neutrophils. In Current Protocols in Immunology. John Wiley & Sons, Hoboken, pp. 3.20.1-3.20.6.
19. Boxio, R., C. Bossenmeyer-Pourie, N. Steinckwich, C. Doumon, and O. Nusse. 2004. Mouse bone marrow contains large numbers of functionally competent neutrophils. J. Leukocyte Biol. 75: 604-611.
20. Nick, J. A., S. K. Young, K. K. Brown, N. J. Avdi, P. G. Arndt, B. T. Suratt, M. S. Janes, P. M. Henson, and G. S. Worthen. 2000. Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation. J. Immunol. 164: 2151-2159.
21. Li, Y., A. Karlin, J. D. Loike, and S. C. Silverstein. 2002. A critical concentration of neutrophils is required for effective bacterial killing in suspension. Proc. Natl. Acad. Sci. USA 99: 8289-8294.
22. Li, Y., J. D. Loike, J. A. Ember, P. P. Cleary, E. Lu, S. Budhu, L. Cao, and S. C. Silverstein. 2002. The bacterial peptide N-formyl-Met-Leu-Phe inhibits killing of Staphylococcus epidermidis by human neutrophils in fibrin gels. J. Immunol. 168: 816-824.
23. Broug-Holub, E., G. B. Toews, J. F. van Iwaarden, R. M. Strieter, S. L. Kunkel, R. Paine III, and T. J. Standiford. 1997. Alveolar macrophages are required for protective pulmonary defenses in murine Klebsiella pneumonia: elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival. Infect. Immun. 65: 1139-1146.
24. Tsai, W. C., R. M. Strieter, B. Mehrad, M. W. Newstead, X. Zeng, and T. J. Standiford. 2000. CXC chemokine receptor CXCR2 is essential for protective innate host response in murine Pseudomonas aeruginosa pneumonia. Infect. Immun. 68: 4289-4296.
25. Vidal, S., M. L. Tremblay, G. Govoni, S. Gauthier, G. Sebastiani, D. Malo, E. Skamene, M. Olivier, S. Jothy, and P. Gros. 1995. The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. J. Exp. Med. 182: 655-666.
26. MacMicking, J. D., G. A. Taylor, and J. D. McKinney. 2003. Immune control of tuberculosis by IFN-γ-inducible LRG-47. Science 302: 654-659.
27. Kramnik, I., W. F. Dietrich, P. Demant, and B. R. Bloom. 2000. Genetic control of resistance to experimental infection with virulent Mycobacierium tuberculosis. Proc. Natl. Acad. Sci. USA 97: 8560-8565.
28. Poltorak, A., X. He, I. Smirnova, M. Y. Liu, C. Van Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, et al. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282: 2085-2088.
29. Sorensen, T. I., G. G. Nielsen, P. K. Andersen, and T. W. Teasdale. 1988. Genetic and environmental influences on premature death in adult adoptees. N. Engl. J. Med. 318: 727-732.
30. Wunderink, R. G., and G. W. Waterer. 2003. Genetics of sepsis and pneumonia. Curr. Opin. Crit. Care 9: 384-389.
31. Weinmann, P., K. Scharffetter-Kochanek, S. B. Forlow, T. Peters, and B. Walzog. 2003. A role for apoptosis in the control of neutrophil homeostasis in the circulation: insights from CD18-deficient mice. Blood 101: 739-746.
32. McLoughlin, R. M., J. Witowski, R. L. Robson, T. S. Wilkinson, S. M. Hurst, A. S. Williams, J. D. Williams, S. Rose-John, S. A. Jones, and N. Topley. 2003. Interplay between IFN-γ and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J. Clin. Invest. 112: 598-607.
33. Rowe, S. J., L. Allen, V. C. Ridger, P. G. Hellewell, and M. K. Whyte. 2002. Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury. J. Immunol. 169: 6401-6407.
34. Kupfner, J. G., J. J. Arcaroli, H. K. Yum, S. G. Nadler, K. Y. Yang, and E. Abraham. 2001. Role of NF-κB in endotoxemia-induced alterations of lung neutrophil apoptosis. J. Immunol. 167: 7044-7051.
35. Feterowski, C., H. Weighardt, K. Emmanuilidis, T. Hartung, and B. Holzmann. 2001. Immune protection against septic peritonitis in endotoxin-primed mice is related to reduced neutrophil apoptosis. Eur. J. Immunol. 31: 1268-1277.
36. Kobayashi, S. D., K. R. Braughton, A. R. Whitney, J. M. Voyich, T. G. Schwan, J. M. Musser, and F. R. DeLeo. 2003. Bacterial pathogens modulate an apoptosis differentiation program in human neutrophils. Proc. Natl. Acad. Sci. USA 100: 10948-10953.
37. Allen, L., D. H. Dockrell, T. Pattery, D. G. Lee, P. Cornelis, P. G. Hellewell, and M. K. Whyte. 2005. Pyocyanin production by Pseudomonas aeruginosa induces neutrophil apoptosis and impairs neutrophil-mediated host defenses in vivo. J. Immunol. 174: 3643-3649.
38. Scaife, H., Z. Woldehiwet, C. A. Hart, and S. W. Edwards. 2003. Anaplasma phagocytophilum reduces neutrophil apoptosis in vivo. Infect. Immun. 71: 1995-2001.
39. Aga, E., D. M. Katschinski, G. van Zandbergen, H. Laufs, B. Hansen, K. Muller, W. Solbach, and T. Laskay. 2002. Inhibition of the spontaneous apoptosis of neutrophil granulocytes by the intracellular parasite Leishmania major. J. Immunol. 169: 898-905.
40. Dibbert, B., M. Weber, W. H. Nikolaizik, P. Vogt, M. H. Schoni, K. Blaser, and H. U. Simon. 1999. Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation. Proc. Natl. Acad. Sci. USA 96: 13330-13335.
41. Simon, H. U. 2003. Neutrophil apoptosis pathways and their modifications in inflammation. Immunol. Rev. 193: 101-110.
42. -/- mice. J. Exp. Med. 195: 1167-1174.
43. Clatworthy, M. R., and K. G. Smith. 2004. Fc-γRIIb balances efficient pathogen clearance and the cytokine-mediated consequences of sepsis. J. Exp. Med. 199: 717-723.
44. Shaw, M. H., V. Boyartchuk, S. Wong, M. Karaghiosoff, J. Ragimbeau, S. Pellegrini, M. Muller, W. F. Dietrich, and G. S. Yap. 2003. A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity. Proc. Natl. Acad. Sci. USA 100: 11594-11599.
45. Kelly, J. A., K. Thompson, J. Kilpatrick, T. Lam, S. K. Nath, C. Gray-McGuire, J. Reid, B. Namjou, C. E. Aston, G. R. Bruner, et al. 2002. Evidence for a susceptibility gene (SLEH1) on chromosome 11q14 for systemic lupus erythematosus (SLE) families with hemolytic anemia. Proc. Natl. Acad. Sci. USA 99: 11766-11771.
46. James, J. A., B. R. Neas, K. L. Moser, T. Hall, G. R. Bruner, A. L. Sestak, and J. B. Harley. 2001. Systemic lupus erythematosus in adults is associated with previous Epstein-Barr virus exposure. Arthritis Rheum. 44: 1122-1126.
47. Kang, I., T. Quan, H. Nolasco, S. H. Park, M. S. Hong, J. Crouch, E. G. Pamer, J. G. Howe, and J. Craft. 2004. Defective control of latent Epstein-Barr virus infection in systemic lupus erythematosus. J. Immunol. 172: 1287-1294.
48. Tsokos, G. C., I. T. Magrath, and J. E. Balow. 1983. Epstein-Barr virus induces normal B cell responses but defective suppressor T cell responses in patients with systemic lupus erythematosus. J. Immunol. 131: 1797-1801.
49. Sawalha, A. H., W. R. Schmid, S. R. Binder, D. K. Bacino, and J. B. Harley. 2004. Association between systemic lupus erythematosus and Helicobacter pylori seronegativity. J. Rheumatol. 31: 1546-1550.