A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 20, 2003, Pages 11594-11599

  Shaw, Michael H ^a   Boyartchuk, Victor ^b   Wong, Sandy ^a   Karaghiosoff, Marina ^d   Ragimbeau, Josiane ^e   Pellegrini, Sandra ^e   Muller, Mathias ^d   Dietrich, William F ^b,c   Yap, George S ^a  

^a BROWN UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^e INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CYTOKINE; INTERFERON; INTERLEUKIN 12; INTERLEUKIN 23; JANUS KINASE; TYK2 PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; AUTOIMMUNITY; CHROMOSOME 9; CONTROLLED STUDY; GENE; GENE LOCUS; GENE MUTATION; IMMUNE RESPONSE; INFECTION SENSITIVITY; LYMPHOCYTE; MISSENSE MUTATION; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTOZOAL INFECTION; SIGNAL TRANSDUCTION; TOXOPLASMA GONDII; TYK2 GENE;

ANIMALS; AUTOIMMUNITY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC COMPLEMENTATION TEST; GENETIC PREDISPOSITION TO DISEASE; INFECTION; MICE; MICE, INBRED BALB C; MUTAGENESIS; MUTATION; POINT MUTATION; PROTEIN-TYROSINE KINASES; PROTEINS; TYK2 KINASE;

ANIMALIA; JANUS; PROTOZOA; TOXOPLASMA GONDII;

EID: 0141482051     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1930781100     Document Type: Article

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