Lung-specific transgenic expression of KC enhances resistance to Klebsiella pneumoniae in mice

Journal of Immunology

Volumn 161, Issue 5, 1998, Pages 2435-2440

  Tsai, Wan C ^a   Strieter, Robert M ^a   Wilkowski, Jodi M ^a   Bucknell, Kathy A ^a   Burdick, Marie D ^a   Lira, Sergio A ^b   Standiford, Theodore J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; MACROPHAGE INFLAMMATORY PROTEIN 2;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENTEROBACTER INFECTION; FEMALE; INFECTION RESISTANCE; KLEBSIELLA PNEUMONIAE; LEUKOCYTE ACTIVATION; LUNG; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL; TRANSGENIC MOUSE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CELL MOVEMENT; CHEMOKINES, CXC; CHEMOTACTIC FACTORS; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION; GROWTH SUBSTANCES; IMMUNITY, NATURAL; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTUBATION, INTRATRACHEAL; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; PNEUMONIA, BACTERIAL; TRANSGENES;

EID: 0032169656     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Doyle, R. 1997. U.S. deaths from pneumonia. Sci. Am. 276:29.
2. Davies, J. 1994. Inactivation of antibiotics and dissemination of resistance genes. Science 264:375.
3. Svarva, P. L., R. V. Lyng, and J. A. Maeland. 1985. Emergence of β-lactam multiresistant variants of gram-negative bacilli in the presence of cefotaxime. Scand. J. Infect. Dis. 17:387.
4. Toews, G. B., G. N. Gross, and A. K. Pierce. 1979. The relationship of inoculum size to lung bacterial clearance and phagocytic cell response in mice. Am. Rev. Respir. Dis. 120:55.
5. Standiford, T. J. 1997. Cytokines and Pulmonary Host Defenses. Current Opinion in Pulm Medicine. Rapid Science Publishers. 3:81.
6. 3C motif. Nature 385:640.
7. Schall, T. J. 1997. Fratalkine-a strange attractor in the chemokine landscape. Immunol. Today 18:147.
8. Matsushima, K., and J. J. Oppenheim. 1989. Interleukin-8 and MCAF: novel inflammatory cytokines inducible by interleukin-1 and TNF. Cytokine 1:2.
9. Oppenheim, J. J., C. O. C. Zachariae, N. Mukaida, and K. Matsushima. 1991. Properties of the novel proinflammatory supergene intercrine cytokine family. Annu. Rev. Immunol. 9:617.
10. Huffnagle, G. B., R. M. Strieter, S. L. Kunkel, G. B. Toews. and T. J. Standiford. 1996. The role of chemokines in pneumonia. In Chemokines in Disease. A. Koch and R. Strieter, eds. R. G. Landis, Austin, Texas, p. 151.
11. + T cells during a pulmonary Cryptococcus neoformans infection. J. Immunol. 155:4790.
12. Huffnagle, G., R. M. Strieter, T. J. Standiford, R. McDonald, L. K. McNeil, M. D. Burdick, S. L. Kunkel, and G. B. Toews. 1997. Macrophage inflammatory protein-1α (MIP-1α) is required for the efferent phase of pulmonary cell-mediated immunity to a Cryptococcus neoformans infection. J. Immunol. 159:318.
13. Greenberger, M. J., R. M. Strieter, S. L. Kunkel, J. M., Danforth, L. L. Laichalk, D. C. McGillicudy, and T. J. Standiford. 1996. Neutralization of MIP-2 attenuates neutrophil recruitment and bacterial clearance in murine Klebsiella pneumonia. J. Infect. Dis. 173:159.
14. Ryseck, R.-P., H. MacDonald-Bravo, M. G. Mattei, and R. Bravo. 1989. Cloning and sequence of a secretory protein induced by growth factors in mouse fibroblasts. Exp. Cell Res. 180:266.
15. Wen, D.Z., A. Rowland, and R. Derynck. 1989. Expression and secretion of GRO/MGSA by stimulated human endothelial cells. EMBO J. 8:1761.
16. Introna, M., R. C. Bast, Jr., C. S. Tannebaum, T. A. Hamilton, and D. O. Adams. 1987. The effect of LPS on expression of the early "competence" genes JE and KC in murine peritoneal macrophages. J. Immunol. 138:3891.
17. Huang, S., J. D. Paulauskis, J. Godleski, and L. Kobzik. 1992. Expression of macrophage inflammatory protein-2 and KC mRNA in pulmonary inflammation. Am. J. Pathol. 141:981.
18. Yu, S.-F., T. J. Koerner, and D. O. Adams. 1990. Gene regulation in macrophage activation: differential regulation of genes encoding for tumor necrosis factor, interleukin-1, JE, and KC by interferon-γ and lipopolysaccharide. J. Leukocyte Biol. 48:412.
19. Oquendo, P., J. Alberta, D. Wen, J. L. Graycar, R. Derynck, and C. D. Stiles. 1989. The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet α-granule proteins. J. Biol. Chem. 264:4133.
20. Frevert, C. W., S. Huang, H. Danaee, J. D. Paulauskis, and L. Kobzik. 1995. Functional characterization of the rat chemokine KC and its importance in neutrophil recruitment in a rat model of pulmonary inflammation. J. Immunol. 154: 335.
21. Farone, A., S. Huang, J. Paulauskis, and L. Kobzik. 1995. Airway neutrophilia and chemokine mRNA expression in sulfur dioxide-induced bronchitis. Am. J. Respir. Cell Mol. Biol. 12:345.
22. Pierce, L. M., F. Allessandrini, J. J. Godleski, and J. D. Paulauskis. 1996. Vanadium-induced chemokine mRNA expression and pulmonary inflammation. Toxicol. Applied Pharmacol. 138:1.
23. Schwartz, D., A. Andalibi, L. Chaverri-Almada, J. A. Berliner, T. Kirchgessner, Z. T. Fang, P. Tekamp-Olson, A. J. Lusis, C. Gallegos, and A. M. Fogelman. 1994. Role of the GRO family of chemokines in monocyte adhesion to MM-LDL-stimulated endothelium. J. Clin. Invest. 94:1968.
24. Wakefield, T. W., R. M. Strieter, M. R. Prince, L. J. Downing, and L. J. Greenfield. 1997. Pathogenesis of venous thrombosis: a new insight. Cardiovasc. Surg. 5:6.
25. Lira, S., P. Zalamea, J. Heinrich, M. Fuentes, D. Carrasco, A. Lewin, D. Barton, S. Durham, and R. Bravo. 1994. Expression of the chemokine N51/KC in the thymus and epidermis of transgenic mice results in marked infiltration of a single class of inflammatory cells. J. Exp. Med. 180:2039.
26. Lira, S. A., M. E. Fuentes, R. M. Strieter, and S. K. Durham. 1997. Transgenic methods to study chemokine function in lung and CNS. Methods Enzymol. 287: 304.
27. Lira, S. 1996. Genetic approaches to study chemokine function. J. Leukocyte Biol. 59:45.
28. Greenberger, M. J., R. M. Strieter, S. L. Kunkel, J. M., Danforth, R. E. Goodman, and T. J. Standiford. 1995. Neutralization of IL-10 increases survival in a murine model of Klebsiella pneumonia. J. Immunol. 155:722.
29. Broug-Holub, E., G. B. Toews, J. Freek Van Iwaarden, R. M. Strieter, S. L. Kunkel, R. Paine, III, and T. J. Standiford. 1997. Alveolar macrophages are required for protective pulmonary defenses in murine Klebsiella pneumonia: elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival. Infect. Immun. 65:1139.
30. Lukacs N. W., S. W. Chensue, W. L. Karpus, P. Lincoln, C. Keefer, R. M. Strieter, and S. L. Kunkel. 1997. C-C chemokines differentially alter interleukin-4 production from lymphocytes. Am. J. Pathol. 150:1861.
31. Zisman, D. A., S. L. Kunkel, R. M. Strieter, W. C. Tsai, K. Bucknell, J. Wilkowski, and T. J. Standiford. 1997. MCP-1 protects mice in lethal endotoxemia. J. Clin. Invest. 99:2832.
32. Centers for Disease Control and Prevention. 1997. Update: Staphylococcus aureus with reduced susceptibility to vancomycin-United States, 1997. MMWR Morb. Mortal. Wkly. Rep. 46:813.
33. Greenberger, M., S. L. Kunkel, R. M. Strieter, N. W. Lukacs, J. Bramson, J. Gauldie, F. Graham, M. Hitt, J. Danforth, and T. J. Standiford. 1996. IL-12 gene therapy protects mice in lethal Klebsiella pneumonia. J. Immunol. 157:3006.