FcγRIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of Sepsis

Journal of Experimental Medicine

Volumn 199, Issue 5, 2004, Pages 717-723

  Clatworthy, Menna R ^a   Smith, Kenneth G C ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Fc RIIb; Interleukin 6; Septic shock; Streptococcus pneumoniae; Tumor necrosis factor

Indexed keywords

CYTOKINE; FC RECEPTOR; INTERLEUKIN 6; PNEUMOCOCCUS VACCINE; TUMOR NECROSIS FACTOR ALPHA; FCGR2B PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; BACTERIAL PERITONITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNE RESPONSE; IN VITRO STUDY; INOCULATION; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PRIORITY JOURNAL; SEPTIC SHOCK; STREPTOCOCCUS PNEUMONIAE; SURVIVAL RATE; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; GENETICS; IMMUNIZATION; IMMUNOLOGY; MOUSE MUTANT; PATHOGENICITY; PERITONITIS; PHYSIOLOGY; SEPSIS; STREPTOCOCCUS INFECTION;

ANIMALS; CYTOKINES; IMMUNIZATION; INTERLEUKIN-6; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; PERITONITIS; PNEUMOCOCCAL INFECTIONS; RECEPTORS, IGG; SEPSIS; STREPTOCOCCUS PNEUMONIAE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 1542313883     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20032197     Document Type: Article

References (30)

1. Takashima, K., K. Tateda, T. Matsumoto, Y. Iizawa, M. Nakao, and K. Yamaguchi. 1997. Role of TNF alpha in pathogenesis of pneumococcal pneumonia in mice. Infect. Immun. 65:257-260.
2. Wellmer, A., J. Gerber, J. Ragheb, G. Zysk, T. Kunst, A. Smirnov, W. Bruck, and R. Nau. 2001. Effect of deficiency of tumor necrosis factor alpha or both of its receptors on Streptococcus pneumoniae central nervous system infection and peritonitis. Infect. Immun. 69:6881-6886.
3. Hotchkiss, R.S., and I.E. Karl. 2003. The pathophysiology and treatment of sepsis. N. Engl. J. Med. 348:138-150.
4. Ravetch, J.V., and S. Bolland. 2001. IgG Fc receptors. Annu. Rev. Immunol. 19:275-290.
5. Pritchard, N.R., and K.G.C. Smith. 2003. B cell inhibitory receptors and autoimmunity. Immunology. 108:263-273.
6. Takai, T., M. Ono, M. Hikida, H. Ohmori, and J.V. Ravetch. 1996. Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature. 379:346-349.
7. Clynes, R., J.S. Maizes, R. Guinamard, M. Ono, T. Takai, and J.V. Ravetch. 1999. Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors. J. Exp. Med. 189: 179-185.
8. Wuorimaa, T., and H. Kayhty. 2002. Current state of pneumococcal vaccines. Scand. J. Immunol. 56:111-129.
9. Briles, D.E., M. Nahm, K. Schroer, J. Davie, P. Baker, J. Kearney, and R. Barletta. 1981. Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 Streptococcus pneumoniae. J. Exp. Med. 153:694-705.
10. Mold, C., B. Rodic-Polic, and T.W. Du Clos. 2002. Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc gamma receptors. J. Immunol. 168:6375-6381.
11. Brown, J.S., A.D. Ogunniyi, M.C. Woodrow, D.W. Holden, and J.C. Paton. 2001. Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection. Infect. Immun. 69:6702-6706.
12. 1994. Pain and distress in laboratory rodents and lagomorphs. Report of the Federation of European Laboratory Animal Science Associations (FELASA) Working Group on Pain and Distress accepted by the FELASA Board of Management November 1992. Lab. Anim. 28:97-112.
13. Martinez, J.E., S. Romero-Steiner, T. Pilishvili, S. Barnard, J. Schinsky, D. Goldblatt, and G.M. Carlone. 1999. A flow cytometric opsonophagocytic assay for measurement of functional antibodies elicited after vaccination with the 23-valent pneumococcal polysaccharide vaccine. Clin. Diagn. Lab. Immunol. 6:581-586.
14. Martin, F., A.M. Oliver, and J.F. Kearney. 2001. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity. 14:617-629.
15. Saeland, E., J.H. Leusen, G. Vidarsson, W. Kuis, E.A. Sanders, I. Jonsdottir, and J.G. van de Winkel. 2003. Role of leukocyte immunoglobuin G receptors in vaccine-induced immunity to Streptococcus pneumoniae. J. Infect. Dis. 187:1686-1693.
16. Gingles, N.A., J.E. Alexander, A. Kadioglu, P.W. Andrew, A. Kerr, T.J. Mitchell, E. Hopes, P. Denny, S. Brown, H.B. Jones, et al. 2001. Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains. Infect. Immun. 69:426-434.
17. Gjertsson, I., S. Kleinau, and A. Tarkowski. 2002. The impact of Fcgamma receptors on Staphylococcus aureus infection. Microb. Pathog. 33:145-152.
18. Tracey, K.J., B. Beutler, S.F. Lowry, J. Merryweather, S. Wolpe, I.W. Milsark, R.J. Hariri, T.J. Fahey III, A. Zentella, J.D. Albert, et al. 1986. Shock and tissue injury induced by recombinant human cachectin. Science. 234:470-474.
19. Casey, L.C., R.A. Balk, and R.C. Bone. 1993. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann. Intern. Med. 119:771-778.
20. Teti, G., G. Mancuso, F. Tomasello, and M.S. Chiofalo. 1992. Production of TNF-alpha and IL-6 in mice infected with group B streptococci. Circ. Shock. 38:138-144.
21. Suitters, A.J., R. Foulkes, S.M. Opal, J.E. Palardy, J.S. Emtage, M. Rolfe, S. Stephens, A. Morgan, A.R. Holt, L.C. Chaplin, et al. 1994. Differential effect of isotype on efficacy of anti-TNF-α chimeric antibodies in experimental septic shock. J. Exp. Med. 179:849-856.
22. Minskoff, S.A., K. Matter, and I. Mellman. 1998. Fc gamma RII-B1 regulates the presentation of B cell receptor-bound antigens. J. Immunol. 161:2079-2083.
23. Wayte, J., A.T. Silva, T. Krausz, and J. Cohen. 1993. Observations on the role of TNF-alpha in a murine model of shock due to Streptococcus pyogenes. Crit. Care Med. 21:1207-1212.
24. Abraham, E. 1999. Why immunomodulatory therapies have not worked in sepsis. Intensive Care Med. 25:556-566.
25. Pricop, L., P. Redecha,J.L. Teillaud, J. Frey, W.H. Fridman, C. Sautes-Fridman, and J.E. Salmon. 2001. Differential modulation of stimulatory and inhibitory Fc gamma receptors on human monocytes by Th1 and Th2 cytokines. J. Immunol. 166:531-537.
26. Rudge, E.U., A.J. Cutler, N.R. Pritchard, and K.G.C. Smith. 2002. Interleukin 4 reduces expression of inhibitory receptors on B cells and abolishes CD22 and FcγRII-mediated B cell suppression. J. Exp. Med. 195:1079-1085.
27. Kyogoku, C., H.M. Dijstelbloem, N. Tsuchiya, Y. Hatta, H. Kato, A. Yamaguchi, T. Fukazawa, M.D. Jansen, H. Hashimoto, J.G. van de Winkel, et al. 2002. Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility. Arthritis Rheum. 46:1242-1254.
28. Siriboonrit, U., N. Tsuchiya, M. Sirikong, C. Kyogoku, S. Bejrachandra, P. Suthipinittharm, K. Luangtrakool, D. Srinak, R. Thongpradit, K. Fujiwara, et al. 2003. Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais. Tissue Antigens. 61:374-383.
29. Pritchard, N.R., A.J. Cutler, S. Uribe, S.J. Chadban, B.J. Morley, and K.G.C. Smith. 2000. Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor FcgammaRII. Curr. Biol. 10:227-230.
30. Xiu, Y., K. Nakamura, M. Abe, N. Li, X.S. Wen, Y. Jiang, D. Zhang, H. Tsurui, S. Matsuoka, Y. Hamano, et al. 2002. Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responses. J. Immunol. 169:4340-4346.