A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H) -quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia

Journal of Pharmacology and Experimental Therapeutics

Volumn 310, Issue 2, 2004, Pages 425-436

  Iwashita, Akinori ^a   Tojo, Nobuteru ^a   Matsuura, Shigeru ^a   Yamazaki, Syunji ^a   Kamijo, Kazunori ^a   Ishida, Junya ^a   Yamamoto, Hirofumi ^a   Hattori, Kouji ^a   Matsuoka, Nobuya ^a   Mutoh, Seitaro ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOBENZAMIDE; 5 CHLORO 2 [3 [4 PHENYL 3,6 DIHYDRO 1(2H) PYRIDINYL]PROPYL] 4(3H) QUINAZOLINONE; FR 247304; HYDROGEN PEROXIDE; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; CELL DEATH; CELL STRAIN; CORPUS STRIATUM; DEGENERATIVE DISEASE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG RESEARCH; DRUG SCREENING; ENZYME ACTIVATION; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; RAT; REPERFUSION; STROKE;

ANIMALS; BRAIN; BRAIN ISCHEMIA; CELL DEATH; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; HYDROGEN PEROXIDE; MALE; MICE; NEURONS; PC12 CELLS; POLY(ADP-RIBOSE) POLYMERASES; PYRIDINES; QUINAZOLINES; QUINAZOLINONES; RATS; RATS, WISTAR;

EID: 3342986461     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.066944     Document Type: Article

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