A Novel Potent Radical Scavenger, 8-(4-Fluorophenyl)-2-((2E)-3-phenyl-2-propenoyl)-1,2,3,4-tetrahydropyrazolo[5, 1-c] [1,2,4]triazine (FR210575), Prevents Neuronal Cell Death in Cultured Primary Neurons and Attenuates Brain Injury after Focal Ischemia in Rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 307, Issue 3, 2003, Pages 961-968

  Iwashita, Akinori ^a   Maemoto, Takuya ^a   Nakada, Hirohisa ^a   Shima, Ichiro ^a   Matsuoka, Nobuya ^a   Hisajima, Hiroshi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

8 (4 FLUOROPHENYL) 2 (3 PHENYL 2 PROPENOYL) 1,2,3,4 TETRAHYDROPYRAZOLO[5,1 C][1,2,4]TRIAZINE; FR210575; GROWTH FACTOR; INSULIN; NEUROPROTECTIVE AGENT; OXYGEN; PROGESTERONE; PUTRESCINE; REACTIVE OXYGEN METABOLITE; SCAVENGER; TRANSFERRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG EFFICACY; DRUG POTENCY; EMBRYO; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; STROKE;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BRAIN; BRAIN ISCHEMIA; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CINNAMATES; FREE RADICAL SCAVENGERS; ISCHEMIC ATTACK, TRANSIENT; NEURONS; NEUROPROTECTIVE AGENTS; OXYGEN; PHOTOCHEMISTRY; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TRIAZINES;

EID: 0344304748     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.056572     Document Type: Article

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