Neuroprotection by 2-h postischemia administration of two free radical scavengers, α-phenyl-n-tert-butyl-nitrone (PBN) and N-tert-butyl-(2- sulfophenyl)-nitrone (S-PBN), in rats subjected to focal embolic cerebral ischemia

Experimental Neurology

Volumn 163, Issue 1, 2000, Pages 39-45

  Yang, Yi ^a   Li, Qiu ^a   Shuaib, Ashfaq ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Focal cerebral ischemia; Free radical scavengers; Neuroprotection; PBN; Rats; S PBN

Indexed keywords

ALPHA PHENYL N TERT BUTYL NITRONE; N TERT BUTYL (2 SULFOPHENYL)NITRONE; OXYGEN RADICAL; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG ABSORPTION; DRUG EFFICACY; DRUG MECHANISM; MALE; MIDDLE CEREBRAL ARTERY; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME;

EID: 0034073967     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2000.7364     Document Type: Article

References (40)

1. Bakker M. H., Foster A. C. An investigation of the mechanisms of delayed neurodegeneration caused by direct injection of quinolinate into the rat striatum in vivo. Neuroscience. 42:1991;387-395.
2. Canevari L., Kuroda S., Bates T. E., Clark J. B., Siesjo B. K. Activity of mitochondrial respiratory chain enzymes after transient focal ischemia in the rat. J. Cereb. Blood Flow Metab. 17:1997;1166-1169.
3. Cao W., Carney J. M., Duchon A., Floyd R., Chevion M. Oxygen free radical involvement in ischemia and reperfusion injury to brain. Neurosci. Lett. 88:1988;233-238.
4. Cao X., Phillis J. α-Phenyl-tert-butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia. Brain Res. 644:1994;267-272.
5. Carney J. M., Floyd R. A. Protection against oxidative damage to CNS by α-phenyl-tert-butyl-nitrone (PBN) and other spin-trapping agents: A novel series of nonlipid free radical scavengers. J. Mol. Neurosci. 3:1991;47-57.
6. Cheng H. Y., Liu T., Feuerstein G., Barone F. C. Distribution of spin-trapping compounds in rat blood and brain: In vivo microdialysis determination. Free Radical Biol. Med. 14:1993;243-250.
7. Coyle J. T., Puttfarcken P. Oxidative stress, glutamate and neurodegenerative disorders. Science. 262:1993;689-695.
8. Dietrich W. D., Prado R., Halley M., Watson B. D. Microvascular and neuronal consequences of common carotid artery thrombosis and platelet embolization in rats. J. Neuropathol. Exp. Neurol. 52:1993;351-360.
9. Facchinetti F., Dawson V. L., Dawson T. M. Free radicals as mediators of neuronal injury. Cell. Mol. Neurobiol. 18:1998;667-682.
10. Fallon J., Matthews R. T., Hyman B. T., Beal M. F. MPP+ produces progressive neuronal degeneration which is mediated by oxidative stress. Exp. Neurol. 144:1997;193-198.
11. Ferger B., Spratt C., Teismann P., Seitz G., Kuschinsky K. Effects of cytisine on hydroxyl radicals in vitro and MPTP-induced dopamine depletion in vivo. Eur. J. Pharmacol. 360:1998;155-163.
12. Floyd R. A., Carney J. M. Free radical damage to protein and DNA: Mechanisms involved relevant observations on brain undergoing oxidative stress. Ann. Neurol. 32:1992;S22-S27.
13. Foster A. C., Gill R., Woodruff G. N. Neuroprotective effects of MK-801 in vivo: Selectivity and evidence for delayed degeneration mediated by NMDA receptor activation. J. Neurosci. 8:1988;4745-4754.
14. Halliwell B. Reactive oxygen species and the central nervous system. J. Neurochem. 59:1992;1609-1623.
15. He Q. P., Smith M. L., Li P. A., Siesjö B. K. Necrosis of the substantia nigra, pars reticulate, in flurothyl-induced status epilepticus is ameliorated by the spin trap α-phenyl-tert-butyl-nitrone. Free Radical Biol. Med. 22:1997;917-922.
16. Irving E. A., Yatsushiro K., McCulloch J., Dewar D. Rapid alteration of tau in oligodendrocytes after focal ischemic injury in the rat: Involvement of free radicals. J. Cereb. Blood Flow Metab. 17:1997;612-622.
17. Klocker N., Cellerino A., Bahr M. Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects of brain-derived neurotrophic factor on axotomized retinal ganglion cells In vivo. J. Neurosci. 18:1998;1038-1046.
18. Knecht K. T., Mason R. P. In vivo spin trapping of xenobiotic free radical metabolites. Arch. Biochem. Biophys. 303:1993;185-194.
19. MacDonald R. L., Stoodley M. Pathophysiology of cerebral ischemia. Neurol. Medico-Chirurg. 38:1998;1-11.
20. Maiese K. From the bench to the bedside: The molecular management of cerebral ischemia. Clin. Neuropharmacol. 21:1998;1-7.
21. Malinski T., Bailey F., Zhang Z. G., Chopp M. Nitric oxide measured by a porphyrinic microsensor in rat brain after transient middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 13:1993;355-358.
22. Massieu L., Thedinga K. H., McVey M., Fagg G. E. A comparative analysis of the neuroprotective properties of competitive and uncompetitive N-methyl-d-aspartate receptor antagonists in vivo: Implications for the process of excitotoxic degeneration and its therapy. Neuroscience. 55:1993;883-892.
23. Mayhan W. G., Didion S. P. Glutamate-induced disruption of the blood-brain barrier in rats. Role of nitric oxide. Stroke. 27:1996;965-969.
24. Nelson C. W., Wei E. P., Povlishock J. T., Kontos H. A., Moskowitz M. A. Oxygen radicals in cerebral ischemia. Am. J. Physiol. 263:1992;H1356-H1362.
25. Oliver C., Starke-Reed P., Stadtman E., Liu G., Carney J. M., Floyd R. A. Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain. Proc. Natl. Acad. Sci. USA. 87:1990;5144-5147.
26. Park C. K., Hall E. D. Dose-response analysis of the effect of 21-aminosteroid tirilazad mesylate (U-74006F) upon neurological outcome and ischemic brain damage in permanent focal cerebral ischemia. Brain Res. 645:1994;157-163.
27. Peeling J., Yan H. J., Chen S. G., Campbell M., Del Bigio M. R. Protective effects of free radical inhibitors in intracerebral hemorrhage in rat. Brain Res. 795:1998;63-70.
28. Phillis J., Clough-Helfman C. Protection from cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl-α-phenylnitrone (PBN). Neurosci. Lett. 116:1990;315-319.
29. Phillis J. W., Sen S., Cao X. Amflutizole, a xanthine oxidase inhibitor, inhibits free radical generation in the ischemic/reperfused rat cerebral cortex. Neurosci. Lett. 169:1994;188-190.
30. Preston E., Foster D. O. Evidence for pore-like opening of the blood-brain barrier following forebrain ischemia in rats. Brain Res. 761:1997;4-10.
31. Schulz J. B., Henshaw D. R., MacGarvey U., Beal M. F. Involvement of oxidative stress in 3-nitropropionic acid neurotoxicity. Neurochem. Int. 29:1996;167-171.
32. Schulz J. B., Henshaw D. R., Siwek D., Jenkins B. G., Ferrante R. J., Cipolloni P. B., Kowall N. W., Rosen B. R., Beal M. F. Involvement of free radicals in excitotoxicity in vivo. J. Neurochem. 64:1995;2239-2247.
33. Schulz J. B., Matthews R. T., Henshaw D. R., Beal M. F. Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: Implications for neurodegenerative diseases. Neuroscience. 71:1996;1043-1048.
34. Schulz J. B., Matthews R. T., Jenkins B. G., Brar P., Beal M. F. Improved therapeutic window for treatment of histotoxic hypoxia with a free radical spin trap. J. Cereb. Blood Flow Metab. 15:1995;948-952.
35. Yamamoto M., Shima T., Uozumi T., Sogabe T., Yamada K., Kawasaki T. A possible role of lipid peroxidation in cellular damages caused by cerebral ischemia and the protective effect of alpha-tocopherol administration. Stroke. 14:1983;977-982.
36. Yang Y., Shuaib A., Li Q. Neuroprotection by two-hour delayed administration of topiramate in the middle cerebral artery embolization model of rat. Brain Res. 804:1998;169-176.
37. Yang Y., Shuaib A., Li Q. Quantification of infarct size on focal cerebral ischemia modal of rats using a simple and economical method. J. Neurosci. Methods. 84:1998;9-16.
38. Yue T. L., Gu J. L., Lysko P. G., Cheng H. Y., Barone F. C., Feuerstein G. Neuroprotective effects of phenyl-t-butyl-nitrone in gerbil global brain ischemia and in cultured rat cerebellar neurons. Brain Res. 574:1992;193-197.
39. Zhang J., Piantadosi C. A. Prolonged production of hydroxyl radical in rat hippocampus after brain ischemia-reperfusion is decreased by 21-aminosteroids. Neurosci. Lett. 177:1994;127-130.
40. Zhao Q., Pahlmark K., Smith M. L., Siesjö B. K. Delayed treatment with the spin trap α-phenyl-tert-butyl-nitrone (PBN) reduces infarct size following trasient middle cerebral artery occlusion in rats. Acta Physiol. Scand. 152:1994;349-350.