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Volumn 10, Issue 8, 2004, Pages 1251-1265

New tertiary constraints between the RNA components of active yeast spliceosomes: A photo-crosslinking study

Author keywords

4 thiouridine; 5 iodouridine; Crosslinking; Photoaffinity; Pre mRNA splicing; U6 snRNA

Indexed keywords

ARTICLE; CROSS LINKING; ENZYME ACTIVE SITE; GENE DISRUPTION; GENE SEQUENCE; PHOTOAFFINITY LABELING; PHOTOREACTIVITY; PRIORITY JOURNAL; RNA ANALYSIS; RNA GENE; RNA METABOLISM; RNA SPLICING; SACCHAROMYCES CEREVISIAE; SPLICEOSOME; STRUCTURE ANALYSIS; YEAST;

EID: 3342906885     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1261/rna.7060404     Document Type: Article
Times cited : (16)

References (53)
  • 1
    • 0028156865 scopus 로고
    • A convenient synthesis of S-cyanoethyl-protected 4-thiouridine and its incorporation into oligoribonucleotides
    • Adams, C.J., Murray, J.B., Arnold, J.R.P., and Stockley, P.G. 1994. A convenient synthesis of S-cyanoethyl-protected 4-thiouridine and its incorporation into oligoribonucleotides. Tetrahedron Lett. 35: 765-768.
    • (1994) Tetrahedron Lett. , vol.35 , pp. 765-768
    • Adams, C.J.1    Murray, J.B.2    Arnold, J.R.P.3    Stockley, P.G.4
  • 2
    • 0030696675 scopus 로고    scopus 로고
    • The splicing factor BBP interacts specifically with the pre-mRNA branchpoint sequence UACUACC
    • Berglund, J.A., Chua, K., Abovich, N., Reed, R., and Rosbash, M. 1997. The splicing factor BBP interacts specifically with the pre-mRNA branchpoint sequence UACUACC. Cell 89: 781-787.
    • (1997) Cell , vol.89 , pp. 781-787
    • Berglund, J.A.1    Chua, K.2    Abovich, N.3    Reed, R.4    Rosbash, M.5
  • 3
    • 0036948420 scopus 로고    scopus 로고
    • Allosteric cascade of spliceosome activation
    • Brow, D.A. 2002. Allosteric cascade of spliceosome activation. Annu. Rev. Genet. 36: 333-360.
    • (2002) Annu. Rev. Genet. , vol.36 , pp. 333-360
    • Brow, D.A.1
  • 4
    • 0023782352 scopus 로고
    • Spliceosomal RNA U6 is remarkably conserved from yeast to mammals
    • Brow, D.A. and Guthrie, C. 1988. Spliceosomal RNA U6 is remarkably conserved from yeast to mammals. Nature 334: 213-218.
    • (1988) Nature , vol.334 , pp. 213-218
    • Brow, D.A.1    Guthrie, C.2
  • 5
    • 0001468848 scopus 로고    scopus 로고
    • Splicing of precursors to mRNAs by the spliceosomes
    • (eds. R.F. Gestland, T.R. Cech, and J.F. Atkins), 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Burge, C.B., Tuschl, T., and Sharp, P.A. 1999. Splicing of precursors to mRNAs by the spliceosomes. In The RNA world (eds. R.F. Gestland, T.R. Cech, and J.F. Atkins), pp. 525-560, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • (1999) The RNA World , pp. 525-560
    • Burge, C.B.1    Tuschl, T.2    Sharp, P.A.3
  • 6
    • 0141924550 scopus 로고    scopus 로고
    • The Prp19p-associated complex in spliceosome activation
    • Chan, S.-P., Kao, D.-I., Tsai, W.-Y., and Cheng, S.-C. 2003. The Prp19p-associated complex in spliceosome activation. Science 302: 279-282.
    • (2003) Science , vol.302 , pp. 279-282
    • Chan, S.-P.1    Kao, D.-I.2    Tsai, W.-Y.3    Cheng, S.-C.4
  • 7
    • 0023449728 scopus 로고
    • Spliceosome assembly in yeast
    • Cheng, S.-C. and Abelson, J. 1987. Spliceosome assembly in yeast. Genes & Dev. 1: 1014-1027.
    • (1987) Genes & Dev. , vol.1 , pp. 1014-1027
    • Cheng, S.-C.1    Abelson, J.2
  • 8
    • 0035037961 scopus 로고    scopus 로고
    • Yeast U1 snRNP-pre-mRNA complex formation without U1 snRNA-pre-mRNA base pairing
    • Du, H. and Rosbash, M. 2001. Yeast U1 snRNP-pre-mRNA complex formation without U1 snRNA-pre-mRNA base pairing. RNA 7: 133-142.
    • (2001) RNA , vol.7 , pp. 133-142
    • Du, H.1    Rosbash, M.2
  • 9
    • 0037026523 scopus 로고    scopus 로고
    • The U1 snRNP protein U1C recognizes the 5′ splice site in the absence of base pairing
    • -. 2002. The U1 snRNP protein U1C recognizes the 5′ splice site in the absence of base pairing. Nature 419: 86-92.
    • (2002) Nature , vol.419 , pp. 86-92
  • 10
    • 0025886930 scopus 로고
    • Conformation and structural fluctuations of a 218 nucleotides long rRNA fragment: 4-Thiouridine as an intrinsic photolabeling probe
    • Dubreuil, Y.L., Experts-Bezancon, A., and Favre, A. 1991. Conformation and structural fluctuations of a 218 nucleotides long rRNA fragment: 4-thiouridine as an intrinsic photolabeling probe. Nucl. Acids Res. 19: 3653-3660.
    • (1991) Nucl. Acids Res. , vol.19 , pp. 3653-3660
    • Dubreuil, Y.L.1    Experts-Bezancon, A.2    Favre, A.3
  • 11
    • 0025001918 scopus 로고
    • Two domains of yeast U6 small nuclear RNA required for both steps of nuclear precursor messenger RNA splicing
    • Fabrizio, P., and Abelson, J. 1990. Two domains of yeast U6 small nuclear RNA required for both steps of nuclear precursor messenger RNA splicing. Science 250: 404-409.
    • (1990) Science , vol.250 , pp. 404-409
    • Fabrizio, P.1    Abelson, J.2
  • 12
    • 0026654005 scopus 로고
    • Thiophosphates in yeast U6 snRNA specifically affect pre-mRNA splicing in vitro
    • -. 1992. Thiophosphates in yeast U6 snRNA specifically affect pre-mRNA splicing in vitro. Nucleic Acids Res. 20: 3659-3664.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 3659-3664
  • 13
    • 0024792715 scopus 로고
    • In vitro assembly of yeast U6 snRNP: A functional assay
    • Fabrizio, P., McPheeters, D.S., and Abelson, J. 1989. In vitro assembly of yeast U6 snRNP: A functional assay. Genes & Dev. 3: 2137-2150.
    • (1989) Genes & Dev. , vol.3 , pp. 2137-2150
    • Fabrizio, P.1    McPheeters, D.S.2    Abelson, J.3
  • 14
    • 0029979220 scopus 로고    scopus 로고
    • Functionally redundant interactions between U2 and U6 spliceosomal snRNAs
    • Field, D.J. and Friesen, J.D. 1996. Functionally redundant interactions between U2 and U6 spliceosomal snRNAs. Genes & Dev. 10: 489-501.
    • (1996) Genes & Dev. , vol.10 , pp. 489-501
    • Field, D.J.1    Friesen, J.D.2
  • 15
    • 0027514174 scopus 로고
    • Splice site choice and splicing efficiency are positively influenced by pre-mRNA intramolecular base pairing in yeast
    • Goguel, V. and Rosbash, M. 1993. Splice site choice and splicing efficiency are positively influenced by pre-mRNA intramolecular base pairing in yeast. Cell 72: 893-901.
    • (1993) Cell , vol.72 , pp. 893-901
    • Goguel, V.1    Rosbash, M.2
  • 16
    • 0033965261 scopus 로고    scopus 로고
    • Metal ion catalysis during the exon-ligation step of nuclear pre-mRNA splicing: Extending the parallels between the spliceosome and group II introns
    • Gordon, P.M., Sontheimer, E.J., and Piccirilli, I.A. 2000. Metal ion catalysis during the exon-ligation step of nuclear pre-mRNA splicing: Extending the parallels between the spliceosome and group II introns. RNA 6: 199-205.
    • (2000) RNA , vol.6 , pp. 199-205
    • Gordon, P.M.1    Sontheimer, E.J.2    Piccirilli, I.A.3
  • 18
  • 19
    • 0027404721 scopus 로고
    • Stages in the second reaction of pre-mRNA splicing: The final step is ATP independent
    • Horowitz, D.S. and Abelson, J. 1993. Stages in the second reaction of pre-mRNA splicing: The final step is ATP independent. Genes & Dev 7: 320-329.
    • (1993) Genes & Dev. , vol.7 , pp. 320-329
    • Horowitz, D.S.1    Abelson, J.2
  • 20
    • 0036242097 scopus 로고    scopus 로고
    • Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis
    • Jurica, M.S., Licklider, L.J., Gygi, S.R., Grigorieff, N., and Moore M.J. 2002, Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. RNA 8: 426-439.
    • (2002) RNA , vol.8 , pp. 426-439
    • Jurica, M.S.1    Licklider, L.J.2    Gygi, S.R.3    Grigorieff, N.4    Moore, M.J.5
  • 21
    • 0002690513 scopus 로고    scopus 로고
    • Site-specific crosslinks of yeast U6 snRNA to the pre-mRNA near the 5′ splice site
    • Kim, C.H. and Abelson, J. 1996. Site-specific crosslinks of yeast U6 snRNA to the pre-mRNA near the 5′ splice site. RNA 2: 995-1010.
    • (1996) RNA , vol.2 , pp. 995-1010
    • Kim, C.H.1    Abelson, J.2
  • 22
    • 0029965552 scopus 로고    scopus 로고
    • Spliceosome activation by PRP2 ATPase prior to the first transesterification reaction of pre-mRNA splicing
    • Kim, S.-H. and Lin, R.-J. 1996. Spliceosome activation by PRP2 ATPase prior to the first transesterification reaction of pre-mRNA splicing. Mol. Cell. Biol. 16: 6810-6819.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 6810-6819
    • Kim, S.-H.1    Lin, R.-J.2
  • 23
    • 0032515969 scopus 로고    scopus 로고
    • The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro
    • Laggerbauer, B., Achsel, T., and Lührmann, R. 1998. The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro. Proc. Natl. Acad. Sci. 95: 4188-4192.
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 4188-4192
    • Laggerbauer, B.1    Achsel, T.2    Lührmann, R.3
  • 24
    • 0029312150 scopus 로고
    • RNA structural patterns and splicing: Molecular basis for an RNA-based enhancer
    • Libri, D., Stutz, F., McCarthy, T., and Rosbash, M. 1995. RNA structural patterns and splicing: Molecular basis for an RNA-based enhancer. RNA 1: 425-436.
    • (1995) RNA , vol.1 , pp. 425-436
    • Libri, D.1    Stutz, F.2    McCarthy, T.3    Rosbash, M.4
  • 26
    • 0026486883 scopus 로고
    • A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome
    • Madhani, H.D. and Guthrie, C. 1992. A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome. Cell 71: 803-817.
    • (1992) Cell , vol.71 , pp. 803-817
    • Madhani, H.D.1    Guthrie, C.2
  • 27
    • 0028175201 scopus 로고
    • Randomization-selection analysis of snRNAs in vivo: Evidence for a tertiary interaction in the spliceosome
    • -. 1994. Randomization-selection analysis of snRNAs in vivo: Evidence for a tertiary interaction in the spliceosome. Genes & Dev. 8: 1071-1086.
    • (1994) Genes & Dev. , vol.8 , pp. 1071-1086
  • 28
    • 0037073946 scopus 로고    scopus 로고
    • Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome
    • Makarov, E.M., Makarova, O.V., Urlaub, H., Gentzel, M., Will, C.L., Wilm, M., and Lührmann, R. 2002. Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome. Science 298: 2205-2208.
    • (2002) Science , vol.298 , pp. 2205-2208
    • Makarov, E.M.1    Makarova, O.V.2    Urlaub, H.3    Gentzel, M.4    Will, C.L.5    Wilm, M.6    Lührmann, R.7
  • 29
    • 0037627610 scopus 로고    scopus 로고
    • The U1 snRNP base pairs with the 5′ splice site within a penta-snRNP complex
    • Malca, H., Shomron, N., and Ast, G. 2003. The U1 snRNP base pairs with the 5′ splice site within a penta-snRNP complex. Mol. Cell. Biol. 23: 3442-3455.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 3442-3455
    • Malca, H.1    Shomron, N.2    Ast, G.3
  • 30
    • 0023651444 scopus 로고
    • Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates
    • Milligan, J.F., Groebe, D.R., Witherell, G.W., and Uhlenbeck, O.C. 1987. Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates. Nucleic Acids Res. 15: 8783-8798.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 8783-8798
    • Milligan, J.F.1    Groebe, D.R.2    Witherell, G.W.3    Uhlenbeck, O.C.4
  • 31
    • 0027364421 scopus 로고
    • Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicing
    • Moore, M.J. and Sharp, P.A. 1993. Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicing. Nature 365: 364-368.
    • (1993) Nature , vol.365 , pp. 364-368
    • Moore, M.J.1    Sharp, P.A.2
  • 32
    • 0028807644 scopus 로고
    • The roles of the conserved pyrimidine bases in hammerhead ribozyme catalysis. Evidence for a magnesium ion-binding site
    • Murray, J.B., Adams, C.J., Arnold, J.R.P., and Stockley, P.G. 1995. The roles of the conserved pyrimidine bases in hammerhead ribozyme catalysis. Evidence for a magnesium ion-binding site. Biochem. J. 311: 487-494.
    • (1995) Biochem. J. , vol.311 , pp. 487-494
    • Murray, J.B.1    Adams, C.J.2    Arnold, J.R.P.3    Stockley, P.G.4
  • 33
    • 0036896469 scopus 로고    scopus 로고
    • Sculpting of the spliceosomal branch site recognition motif by a conserved pseudouridine
    • Newby, M.I. and Greenbaum, N.L. 2002. Sculpting of the spliceosomal branch site recognition motif by a conserved pseudouridine. Nat. Struct. Biol. 9: 959-965.
    • (2002) Nat. Struct. Biol. , vol.9 , pp. 959-965
    • Newby, M.I.1    Greenbaum, N.L.2
  • 34
    • 0023481389 scopus 로고
    • Specific accessory sequences in Saccharomyces cerevisiae introns control assembly of pre-mRNAs into spliceosomes
    • Newman, A. 1987. Specific accessory sequences in Saccharomyces cerevisiae introns control assembly of pre-mRNAs into spliceosomes. EMBO J. 6: 3833-3839.
    • (1987) EMBO J. , vol.6 , pp. 3833-3839
    • Newman, A.1
  • 35
    • 0034637161 scopus 로고    scopus 로고
    • The structural basis of ribosome activity in peptide bond synthesis
    • Nissen, P., Hansen, J., Ban, N., Moore, P.B., and Steitz, T.A. 2000. The structural basis of ribosome activity in peptide bond synthesis. Science 289: 920-930.
    • (2000) Science , vol.289 , pp. 920-930
    • Nissen, P.1    Hansen, J.2    Ban, N.3    Moore, P.B.4    Steitz, T.A.5
  • 36
    • 0030036934 scopus 로고    scopus 로고
    • Mechanistic studies of the 5-iodouracil chromophore relevant to its use in nucleoprotein photo-crosslinking
    • Norris, C.L., Meisenheimer, P.L., and Koch, T.H. 1996. Mechanistic studies of the 5-iodouracil chromophore relevant to its use in nucleoprotein photo-crosslinking. J. Am. Chem. Soc. 118: 5796-5803.
    • (1996) J. Am. Chem. Soc. , vol.118 , pp. 5796-5803
    • Norris, C.L.1    Meisenheimer, P.L.2    Koch, T.H.3
  • 37
    • 0028769660 scopus 로고
    • The stereochemical course of group II intron self-splicing
    • Padgett, R.A., Podar, M., Boulanger, S.C., and Perlman, P.S. 1994. The stereochemical course of group II intron self-splicing. Science 266: 1685-1688.
    • (1994) Science , vol.266 , pp. 1685-1688
    • Padgett, R.A.1    Podar, M.2    Boulanger, S.C.3    Perlman, P.S.4
  • 38
    • 0003736129 scopus 로고
    • Architecture of fungal introns: Implications for spliceosome assembly
    • (eds. B. Dudock and M. Inouye), Academic Press, New York
    • Parker, R. and Patterson, B. 1987. Architecture of fungal introns: Implications for spliceosome assembly. In Molecular biology of RNA: New perspectives (eds. B. Dudock and M. Inouye), pp. 133-149. Academic Press, New York.
    • (1987) Molecular Biology of RNA: New Perspectives , pp. 133-149
    • Parker, R.1    Patterson, B.2
  • 39
    • 0032537739 scopus 로고    scopus 로고
    • RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2
    • Raghunathan, P.L. and Guthrie, C. 1998. RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2. Curr. Biol. 8: 847-855.
    • (1998) Curr. Biol. , vol.8 , pp. 847-855
    • Raghunathan, P.L.1    Guthrie, C.2
  • 40
    • 0036674269 scopus 로고    scopus 로고
    • Large-scale proteomic analysis of the human spliceosome
    • Rappsilber, J., Ryder, U., Lamond, A.I., and Mann, M. 2002. Large-scale proteomic analysis of the human spliceosome. Genome Res. 12: 1231-1245.
    • (2002) Genome Res. , vol.12 , pp. 1231-1245
    • Rappsilber, J.1    Ryder, U.2    Lamond, A.I.3    Mann, M.4
  • 41
    • 0036676886 scopus 로고    scopus 로고
    • The conserved central domain of yeast U6 snRNA: Importance of U2-U6 helix Ia in spliceosome assembly
    • Ryan, D.E. and Abelson, J. 2002. The conserved central domain of yeast U6 snRNA: Importance of U2-U6 helix Ia in spliceosome assembly. RNA 8: 997-1010.
    • (2002) RNA , vol.8 , pp. 997-1010
    • Ryan, D.E.1    Abelson, J.2
  • 42
    • 0036667321 scopus 로고    scopus 로고
    • The 5′ and 3′ domains of yeast U6 snRNA: Lsm proteins facilitate binding of Prp24 protein to the U6 telestem region
    • Ryan, D.E., Stevens, S.W., and Abelson, J. 2002. The 5′ and 3′ domains of yeast U6 snRNA: Lsm proteins facilitate binding of Prp24 protein to the U6 telestem region. RNA 8: 1011-1033.
    • (2002) RNA , vol.8 , pp. 1011-1033
    • Ryan, D.E.1    Stevens, S.W.2    Abelson, J.3
  • 43
    • 0028465429 scopus 로고
    • Site-specific RNA crosslinking with 4-thiouridine
    • Sontheimer, E.J. 1994. Site-specific RNA crosslinking with 4-thiouridine. Mol. Biol. Rep. 20: 35-44.
    • (1994) Mol. Biol. Rep. , vol.20 , pp. 35-44
    • Sontheimer, E.J.1
  • 44
    • 0027739853 scopus 로고
    • The U5 and U6 small nuclear RNAs as active site components of the spliceosome
    • Sontheimer, E.J. and Steitz, J.A. 1993. The U5 and U6 small nuclear RNAs as active site components of the spliceosome. Science 262: 1989-1996.
    • (1993) Science , vol.262 , pp. 1989-1996
    • Sontheimer, E.J.1    Steitz, J.A.2
  • 45
    • 0030833215 scopus 로고    scopus 로고
    • Metal ion catalysis during splicing of pre-messenger RNA
    • Sonthiemer, E.J., Sun, S., Piccirilli, J.A. 1997. Metal ion catalysis during splicing of pre-messenger RNA. Nature 388:801-805.
    • (1997) Nature , vol.388 , pp. 801-805
    • Sonthiemer, E.J.1    Sun, S.2    Piccirilli, J.A.3
  • 46
    • 0033166446 scopus 로고    scopus 로고
    • Metal ion catalysis during group II intron self-splicing: Parallels with the spliceosomes
    • Sontheimer, E.J., Gordon, P.M., and Piccirilli, J.A. 1999. Metal ion catalysis during group II intron self-splicing: Parallels with the spliceosomes. Genes & Dev. 13: 1729-1741.
    • (1999) Genes & Dev. , vol.13 , pp. 1729-1741
    • Sontheimer, E.J.1    Gordon, P.M.2    Piccirilli, J.A.3
  • 47
    • 0027184481 scopus 로고
    • A general two-metal-ion mechanism for catalytic RNA
    • Steitz, T.A. and Steitz, J.A. 1993. A general two-metal-ion mechanism for catalytic RNA. Proc. Natl. Acad. Sci. 90: 6498-6502.
    • (1993) Proc. Natl. Acad. Sci. , vol.90 , pp. 6498-6502
    • Steitz, T.A.1    Steitz, J.A.2
  • 48
  • 49
    • 0027491331 scopus 로고
    • Yeast precursor mRNA processing protein PRP19 associates with the spliceosome concomitant with or just after dissociation of U4 small nuclear RNA
    • Tarn, W.-Y., Lee, K.-R., Cheng, S.-C. 1993. Yeast precursor mRNA processing protein PRP19 associates with the spliceosome concomitant with or just after dissociation of U4 small nuclear RNA. Proc. Natl. Acad. Sci. 22: 10821-10825.
    • (1993) Proc. Natl. Acad. Sci. , vol.22 , pp. 10821-10825
    • Tarn, W.-Y.1    Lee, K.-R.2    Cheng, S.-C.3
  • 50
    • 0033962271 scopus 로고    scopus 로고
    • A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast
    • Valadkhan, S. and Manley, J.L. 2000. A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast. RNA 6: 206-219.
    • (2000) RNA , vol.6 , pp. 206-219
    • Valadkhan, S.1    Manley, J.L.2
  • 52
    • 0034649666 scopus 로고    scopus 로고
    • Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome
    • Yean, S.-L., Wuenschell, G., Termini, J., and Lin, R.-J. 2000. Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome. Nature 408: 881-884.
    • (2000) Nature , vol.408 , pp. 881-884
    • Yean, S.-L.1    Wuenschell, G.2    Termini, J.3    Lin, R.-J.4
  • 53
    • 0037068447 scopus 로고    scopus 로고
    • Comprehensive proteomic analysis of the human spliceosome
    • Zhou, Z., Licklider, L.J., Gygi, S.P., and Reed, R. 2002. Comprehensive proteomic analysis of the human spliceosome. Nature 419: 182-185.
    • (2002) Nature , vol.419 , pp. 182-185
    • Zhou, Z.1    Licklider, L.J.2    Gygi, S.P.3    Reed, R.4


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