Cytohesin-1 regulates β-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1

EMBO Journal

Volumn 19, Issue 11, 2000, Pages 2525-2536

  Geiger, Christiane ^a   Nagel, Wolfgang ^a   Boehm, Thomas ^a   Van Kooyk, Yvette ^c   Figdor, Carl G ^c   Kremmer, Elisabeth ^b   Hogg, Nancy ^d   Zeitlmann, Lutz ^a   Dierks, Henning ^a   Weber, Kim S C ^a   Kolanus, Waldemar ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

2 integrin; ARF GTPase; Cell adhesion; Cytohesin 1; LFA 1

Indexed keywords

CYTOHESIN 1; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INTEGRIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ARTICLE; CELL ADHESION; PRIORITY JOURNAL;

ADP-RIBOSYLATION FACTORS; ANIMALS; ANTIGENS, CD18; CELL ADHESION; CELL ADHESION MOLECULES; CELL SIZE; EPITOPES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HELA CELLS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROMOLECULAR SUBSTANCES; MICE; MODELS, MOLECULAR; RATS; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0034213074     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Carr, M.W., Alon, R. and Springer, T.A. (1996) The C-C chemokine MCP-1 differentially modulates the avidity of β1 and β2 integrins on T lymphocytes. Immunity, 4, 179-187.
2. Chan, A.S., Mobley, J.L., Fields, G.B. and Shimizu, Y. (1997) CD7-mediated regulation of integrin adhesiveness on human T cells involves tyrosine phosphorylation-dependent activation of phosphatidylinositol 3-kinase. J. Immunol., 159, 934-942.
3. Critchley, D.R., Holt, M.R., Barry, S.T., Priddle, H., Hemmings, L. and Norman, J. (1999) Integrin-mediated cell adhesion: the cytoskeletal connection. Biochem. Soc. Symp., 65, 79-99.
4. D'Souza, S.C., Boshans, R.L., McDonough, M., Stahl, P.D. and Van, A.L. (1997) A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements. EMBO J., 16, 5445-5454.
5. Diamond, M.S. and Springer, T.A. (1994) The dynamic regulation of integrin adhesiveness. Curr. Biol., 4, 506-517.
6. Dransfield, I., Cabanas, C., Craig, A. and Hogg, N. (1992) Divalent cation regulation of the function of the leukocyte integrin LFA-1. J. Cell Biol., 116, 219-226.
7. Du, X., Saido, T.C., Tsubuki, S., Indig, F.E., Williams, M.J. and Ginsberg, M.H. (1995) Calpain cleavage of the cytoplasmic domain of the integrin β3 subunit. J. Biol. Chem., 270, 26146-26151.
8. Dustin, M.L. (1998) Making a little affinity go a long way: a topological view of LFA-1 regulation. Cell Adhes. Commun., 6, 255-262.
9. Dustin, M.L. and Springer, T.A. (1989) T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature, 341, 619-624.
10. Fields, S. and Song, O. (1989) A novel genetic system to detect protein-protein interactions. Nature, 340, 245-246.
11. Fox, J.E., Taylor, R.G., Taffarel, M., Boyles, J.K. and Goll, D.E. (1993) Evidence that activation of platelet calpain is induced as a consequence of binding of adhesive ligand to the integrin. glycoprotein IIb-IIIa J. Cell Biol., 120, 1501-1507.
12. Franco, M., Peters, P.J., Boretto, J., van, D.E., Neri, A., D'Souza, S.C. and Chavrier, P. (1999) EFA6, a sec7 domain-containing exchange factor for ARF6, coordinates membrane recycling and actin cytoskeleton organization. EMBO J., 18, 1480-1491.
13. Frank, S.R., Hatfield, J.C. and Casanova, J.E. (1998) Remodeling of the actin cytoskeleton is coordinately regulated by protein kinase C and the ADP-ribosylation factor nucleotide exchange factor ARNO. Mol. Biol. Cell, 9, 3133-3146.
14. Goldberg, J. (1998) Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching. Cell, 95, 237-248.
15. Grotewiel, M.S., Beck, CD., Wu, K.H., Zhu, X.R. and Davis, R.L. (1998) Integrin-mediated short-term memory in Drosophila. Nature, 391, 455-460.
16. 1 and S phase protein phosphatase that associates with Cdk2. Cell, 75, 791-803.
17. Hemler, M.E. (1998) Integrin associated proteins. Curr. Opin. Cell Biol., 10, 578-585.
18. Hmama, Z., Knutson, K.L., Herrera, V.P., Nandan, D. and Reiner, N.E. (1999) Monocyte adherence induced by lipopolysaccharide involves CD14, LFA-1 and cytohesin-1. Regulation by Rho and phosphatidylinositol 3-kinase. J. Biol. Chem., 274, 1050-1057.
19. Huang, Y. and Wu, C. (1999) Integrin-linked kinase and associated proteins. Int. J. Mol. Med., 3, 563-572.
20. Hughes, P.E. and Pfaff, M. (1998) Integrin affinity modulation. Trends Cell Biol., 8, 359-364.
21. Hughes, P.E., O'Toole, T.E., Ylanne, J., Shattil, S.J. and Ginsberg, M.H. (1995) The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity. J. Biol. Chem., 270, 12411-12417.
22. Hynes, R.O. (1992) Integrins: versatility, modulation and signaling in cell adhesion. Cell, 69, 11-25.
23. Knorr, T., Nagel, W. and Kolanus, W. (2000) Phosphoinositides determine specificity of the guanine-nucleotide exchange activity of cytohesin-1 for ADP-ribosylation factors derived from a mammalian expression system. Eur. J. Biochem., in press.
24. Kohler, G. and Milstein, C. (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature, 256, 495-497.
25. Kolanus, W. and Seed, B. (1997) Integrins and inside-out signal transduction: converging signals from PKC and PIP3. Curr. Opin. Cell Biol., 9, 725-731.
26. Kolanus, W., Romeo, C. and Seed, B. (1993) T cell activation by clustered tyrosine kinases. Cell, 74, 171-183.
27. Kolanus, W., Nagel, W., Schiller, B., Zeitlmann, L., Godar, S., Stockinger, H. and Seed, B. (1996) αLβ2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule. Cell, 86, 233-242.
28. Kremmer, E., Ohst, K., Kiefer, J., Brewis, N. and Walter, G. (1997) Separation of PP2A core enzyme and holoenzyme with monoclonal antibodies against the regulatory A subunit: abundant expression of both forms in cells. Mol. Cell. Biol., 17, 1692-1701.
29. 2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils. Nature, 377, 75-79.
30. Lub, M., van Kooyk, Y. and Figdor, C.F. (1995) Ins and outs of LFA-1. Immunol. Today, 16, 479-483.
31. Lub, M., van Kooyk, Y., van Vliet, S. and Figdor, C.G. (1997a) Dual role of the actin cytoskeleton in regulating cell adhesion mediated by the integrin lymphocyte function-associated molecule-1. Mol. Biol. Cell, 8, 341-351.
32. Lub, M., van Vliet, S., Oomen, S.P., Pieters, R.A., Robinson, M., Figdor, C.G. and van Kooyk, Y. (1997b) Cytoplasmic tails of β1, β2 and β7 integrins differentially regulate LFA-1 function in K562 cells. Mol. Biol. Cell, 8, 719-728.
33. Meacci, E., Tsai, S.C., Adamik, R., Moss, J. and Vaughan, M. (1997) Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor. Proc. Natl Acad Sci. USA, 94, 1745-1748.
34. Moss, J. and Vaughan, M. (1998) Molecules in the ARF orbit. J. Biol. Chem., 273, 21431-21434.
35. Mossessova, E., Gulbis, J.M. and Goldberg, J. (1998) Structure of the guanine nucleotide exchange factor Sec7 domain of human ARNO and analysis of the interaction with ARF GTPase. Cell, 92, 415-423.
36. Nagel, W., Schilcher, P., Zeitlmann, L. and Kolanus, W. (1998a) The PH domain and the polybasic C domain of cytohesin-1 cooperate specifically in plasma membrane association and cellular function. Mol. Biol. Cell. 9, 1981-1994.
37. Nagel, W., Zeitlmann, L., Schilcher, P., Geiger, C., Kolanus, J. and Kolanus, W. (1998b) Phosphoinositide 3-OH kinase activates the β2 integrin adhesion pathway and induces membrane recruitment of cytohesin-1. J. Biol. Chem., 273, 14853-14861.
38. Nielsen, M., Svejgaard, A., Skov, S., Dobson, P., Bendtzen, K., Geisler, C. and Odum, N. (1996) IL-2 induces β2-integrin adhesion via a wortmannin/LY294002-sensitive, rapamycin-resistant pathway. Phosphorylation of a 125-kilodalton protein correlates with induction of adhesion, but not mitogenesis. J. Immunol., 157, 5350-5358.
39. Norman, J.C., Jones, D., Barry, S.T., Holt, M.R., Cockcroft, S. and Critchley, D.R. (1998) ARF1 mediates paxillin recruitment to focal adhesions and potentiates Rho-stimulated stress fiber formation in intact and permeabilized Swiss 3T3 fibroblasts. J. Cell Biol., 143, 1981-1995.
40. Palecek, S.P., Loftus, J.C., Ginsberg, M.H., Lauffenburger, D.A. and Horwitz, A.F. (1997) Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness. Nature, 385, 537-540.
41. Peter, K. and O'Toole, T.E. (1995) Modulation of cell adhesion by changes in αLβ2 (LFA-1, CD11a/CD18) cytoplasmic domain/cytoskeleton interaction. J. Exp. Med., 181, 315-326.
42. Radhakrishna, H., Al, A.O., Khachikian, Z. and Donaldson, J.G. (1999) ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements. J. Cell Sci., 112, 855-866.
43. Romeo, C., Kolanus, W., Amiot, M. and Seed, B. (1992) Activation of immune system effector function by T-cell or Fc receptor intracellular domains. Cold Spring Harb. Symp. Quant. Biol., 57, 117-125.
44. Sastry, S.K. and Horwitz, A.F. (1993) Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling. Curr. Opin. Cell Biol., 5, 819-831.
45. Shimizu, Y., Mobley, J.L., Finkelstein, L.D. and Chan, A.S. (1995) A role for phosphatidylinositol 3-kinase in the regulation of β1 integrin activity by the CD2 antigen. J. Cell Biol., 131, 867-880.
46. 2+-dependent protease, calpain. J. Cell Biol., 140, 699-707.
47. van Kooyk, Y., van de Wiel-van-Kemenade, P., Weder, P., Kuijpers, T.W. and Figdor, C.G. (1989) Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes. Nature, 342, 811-813.
48. van Kooyk, Y., van Vliet, S.J. and Figdor, C.G. (1999) The actin cytoskeleton regulates LFA-1 ligand binding through avidity rather than affinity changes. J. Biol. Chem., 274, 26869-26877
49. Venkateswarlu, K., Gunn, M.F., Tavar, J.M. and Cullen, P.J. (1999) EGF- and NGF-stimulated translocation of cytohesin-1 to the plasma membrane of PC12 cells requires PI 3-kinase activation and a functional cytohesin-1 PH domain. J. Cell Sci., 112, 1957-1965.
50. Vennegoor, C.J., van de Wiel-van Kemenade, E., Huijbens, R.J., Sanchez-Madrid, F., Melief, C.J. and Figdor, C. (1992) Role of LFA-1 and VLA-4 in the adhesion of cloned normal and LFA-1 (CD11/CD18)-deficient T cells to cultured endothelial cells. Indication for a new adhesion pathway. J. Immunol., 148, 1093-1101.
51. Weber, K.S., York, M.R., Springer, T.A. and Klickstein, L.B. (1997) Characterization of lymphocyte function-associated antigen 1 (LFA-1)-deficient T cell lines: the αL and β2 subunits are interdependent for cell surface expression. J. Immunol., 158, 273-279.
52. Woodside, D.G., Wooten, D.K. and McIntyre, B.W. (1998) Adenosine diphosphate (ADP)-ribosylation of the guanosine triphosphatase (GTPase) rho in resting peripheral blood human T lymphocytes results in pseudopodial extension and the inhibition of T cell activation. J. Exp. Med., 188, 1211-1221.
53. Zeitlmann, L., Knorr, T., Knoll, M., Romeo, C., Sirim, P. and Kolanus, W. (1998) T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70. J. Biol. Chem., 273, 15445-15452.
54. Zell, T., Hunt, S.R., Mobley, J.L., Finkelstein, L.D. and Shimizu, Y. (1996) CD28-mediated up-regulation of β1-integrin adhesion involves phosphatidylinositol 3-kinase. J. Immunol., 156, 883-886.
55. Zervos, A.S., Gyuris, J. and Brent, R. (1993) Mxil, a protein that specifically interacts with Max to bind Myc-Myx recognition sites. Cell, 72, 223-232.