Synthesis of new hexahydro- and octahydropyrido[1,2-c]pyrimidine derivatives with an arylpiperazine moiety as ligands for 5-HT1A and 5-HT2A receptors. Part 4

European Journal of Medicinal Chemistry

Volumn 41, Issue 1, 2006, Pages 125-134

  Herold, Franciszek ^a   Król, Marek ^a   Kleps, Jerzy ^a   Nowak, Gabriel ^b,c  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

^c JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

5 HT1A receptor ligand; 5 HT2A receptor ligand; Disubstituted piperazines; Pyrido 1,2 c pyrimidine

Indexed keywords

4 (2 CHLOROPHENYL) 2 [4 [4 (2 PYRIDYL) 1 PIPERAZINYL]BUTYL] 2H PYRIDO[1,2 C]PYRIMIDINE 1,3 DIONE; 4 (2 CHLOROPHENYL) 2 [4 [4 (2 PYRIMIDINYL) 1 PIPERAZINYL]BUTYL] 2H PYRIDO[1,2 C]PYRIMIDINE 1,3 DIONE; 4 (2 FLUOROPHENYL) 2 [ [4 (2 PYRIDYL) 1 PIPERAZINYL ]BUTYL] 2H PYRIDO[1,2 C]PYRIMIDINE 1,3 DIONE; 4 (2 FLUOROPHENYL) 2 [4 [4 (2 PYRIMIDYL) 1 PIPERAZINYL]BUTYL] 2H PYRIDO[1,2 C]PYRIMIDINE 1,3 DIONE; 4 (2 METHOXYPHENYL) 2 [4 [4 (2 PYRIDYL) 1 PIPERAZINYL]BUTYL] 2H PYRIDO[1,2 C]PYRIMIDINE 1,3 DIONE; 4 (2 METHOXYPHENYL) 2 [4 [4 (2 PYRIMIDINYL) 1 PIPERAZINYL]BUTYL] 2H PYRIDO[1,2 C]PYRIMIDINE 1,3 DIONE; 4 (2 TOLYL) 2 [4 [4 (2 PYRIDYL) 1 PIPERAZINYL]BUTYL] 2H PYRIDOL[1,2 C]PYRIMIDINE 1,3 DIONE; 4 (2 TOLYL) 2 [4 [4 (2 PYRIMIDINYL) 1 PIPERAZINYL]BUTYL] 2H PYRIDO[ 1,2 C]PYRIMIDINE 1,3 DIONE; 4 (4 FLUOROPHENYL) 2 [4 [4 (2 PYRIDYL) 1 PIPERAZINYL]BUTYL 2H PYRIDO[1,2 C]PYRIMIDINE 1,3 DIONE; 4 (4 FLUOROPHENYL) 2 [4 [4 (2 PYRIMIDINYL) 1 PIPERAZINYL]BUTYL] 2H PYRIDO[1,2 C]PYRIMIDINE 1,3 DIONE; 4 ARYL 2H PYRIDOL[1,2 C]PYRIMIDINE 1,3 DIONE DERIVATIVE; 4 PHENYL 2 [4 [4 (2 PYRIMIDINYL) 1 PIPERAZINYL]BUTYL] 2H PYRIDOL[1,2 C]PYRIMIDINE 1,3 DIONE; 4 PHENYL 2 [4 [4 (3 TRIFLUOROMETHYLPHENYL) 1 PIPERAZINYL]BUTYL] 2H PYRIDO[1,2 C]PYRIMIDINE 1,3 DIONE; 4 PHENYL 2[4 [4 (2 PYRIDYL) 1 PIPERAZINYL]BUTYL] 2H PYRIDOL[1,2 C]PYRIMIDINE 1,3 DIONE; ALPHA 1 ADRENERGIC RECEPTOR; PIPERAZINE DERIVATIVE; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; RAT; RECEPTOR AFFINITY;

ADRENAL CORTEX; ANIMALS; LIGANDS; MOLECULAR STRUCTURE; PIPERAZINES; PYRIMIDINES; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT2A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33244491223     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.09.003     Document Type: Article

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