N-Oxide analogs of WAY-100635: New high affinity 5-HT 1A receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 3, 2005, Pages 883-893

  Marchais Oberwinkler, Sandrine ^a,e   Nowicki, Bartek ^a   Pike, Victor W ^b   Halldin, Christer ^c   Sandell, Johan ^c   Chou, Yuan Hwa ^c   Gulyas, Balazs ^c   Brennum, Lise T ^d   Farde, Lars ^c   Wikström, Håkan V ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

^d H LUNDBECK A S   (Denmark)

^e SAARLAND UNIVERSITY   (Germany)

Author keywords

5 HT 1A Receptor antagonist; Aromatic nucleophilic substitution; High affinity; PET; Pyridinyl N oxide; WAY 100635

Indexed keywords

CARBON 11; CYCLOHEXANE DERIVATIVE; N [2 [1 [4 (2 METHOXYPHENYL)PIPERAZINYL]ETHYL]] N (2 PYRIDINYL N OXIDE) CYCLOHEXANECARBOXAMIDE; N [2 [1 [4 (2 METHOXYPHENYL)PIPERAZINYL]ETHYL]] N [2 (6 CHLORO)PYRIDINYL N OXIDE]CYCLOHEXANECARBOXAMIDE; N [2 [1 [4 (2 PYRIDINYL N OXIDE)PIPERAZINYL]ETHYL]] N (2 PYRIDINYL)CYCLOHEXANECARBOXAMIDE; PIPERAZINE DERIVATIVE; SEROTONIN 1A ANTAGONIST; UNCLASSIFIED DRUG;

ACYLATION; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DEACETYLATION; DRUG METABOLISM; DRUG PENETRATION; LIGAND BINDING; LIPOPHILICITY; MALE; MONKEY; MOUSE; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; RECEPTOR AFFINITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SUBSTITUTION REACTION;

ANIMALS; MACACA FASCICULARIS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; OXIDES; PIPERAZINES; POSITRON-EMISSION TOMOGRAPHY; PYRIDINES; SEROTONIN ANTAGONISTS; SPECTROPHOTOMETRY, INFRARED;

MACACA FASCICULARIS;

EID: 19944429281     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.10.033     Document Type: Article

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