Synthesis of new hexahydro- and octahydropyrido[1,2-c]pyrimidine derivatives with an arylpiperazine moiety as ligands for 5-HT1A and 5-HT2A receptors

Farmaco

Volumn 57, Issue 12, 2002, Pages 959-971

  Herold, Franciszek ^a   Kleps, Jerzy ^a   Wolska, Irena ^b   Nowak, Gabriel ^c,d  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b ADAM MICKIEWICZ UNIVERSITY   (Poland)

^c INSTITUTE OF PHARMACOLOGY   (Poland)

^d JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Hexahydro and octahydropyrido 1,2 c pyrimidine derivatives with an arylpiperazine moiety; Ligands for 5 HT1A and 5 HT2A receptors

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 1,4 DIBROMOBUTANE; ALKANE DERIVATIVE; ANXIOLYTIC AGENT; BUSPIRONE; FLESINOXAN; GEPIRONE; IMIDE; LIGAND; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; PIPERAZINE; PYRIMIDINE DERIVATIVE; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; TANDOSPIRONE; UNCLASSIFIED DRUG; ALPHA 1 ADRENERGIC RECEPTOR; PIPERAZINE DERIVATIVE; SEROTONIN 1 RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ALKYLATION; ARTICLE; BEHAVIOR; BINDING AFFINITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; LIGAND BINDING; POLYMERIZATION; STEREOCHEMISTRY; ANIMAL; BINDING COMPETITION; BRAIN CORTEX; IN VITRO STUDY; METABOLISM; RADIOASSAY; RAT; SYNTHESIS;

ANIMALS; BINDING, COMPETITIVE; CEREBRAL CORTEX; LIGANDS; PIPERAZINES; PYRIMIDINES; RADIOLIGAND ASSAY; RATS; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN ANTAGONISTS;

EID: 0036905786     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(02)01274-0     Document Type: Article

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