Synthesis and structure-activity relationships of a new model of arylpiperazines. 3. 2-[ω-(4-arylpiperazin-1-yl)alkyl]perhydropyrrolo(1,2- c]imidazoles and -perhydroimidazo[1,5-α]pyridines: Study of the influences of the terminal amide fragment on 5-HT(1A) affinity/selectivity

Journal of Medicinal Chemistry

Volumn 40, Issue 16, 1997, Pages 2653-2656

  Lopez Rodriguez, M L ^a   Morcillo, M J ^a   Fernandez, E ^a   Porras, E ^a   Murcia, M ^a   Sanz, A M ^a   Orensanz, L ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; BUSPIRONE; FLESINOXAN; GEPIRONE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; SEROTONIN; SEROTONIN RECEPTOR;

ARTICLE; BINDING AFFINITY; BINDING SITE; LIGAND BINDING; RECEPTOR AFFINITY; RECEPTOR BINDING; SEROTONIN UPTAKE; STRUCTURE ACTIVITY RELATION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; ANTIHYPERTENSIVE AGENTS; CEREBRAL CORTEX; MODELS, CHEMICAL; PIPERAZINES; PRAZOSIN; RATS; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030835390     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970216k     Document Type: Article

References (34)