5-HT(1A)-versus D2-receptor selectivity of flesinoxan and analogous N4-substituted N1-arylpiperazines

Journal of Medicinal Chemistry

Volumn 40, Issue 3, 1997, Pages 300-312

  Kuipers, Wilma ^a   Kruse, Chris G ^a   Van Wijngaarden, Ineke ^a   Standaar, Piet J ^a   Tulp, Martin Th M ^b   Veldman, Nora ^c   Spek, Anthony L ^c   Ijzerman, Adriaan P ^d  

^a Department of Medicinal Chemistry ^*  (Netherlands)

^b Solvay Pharmaceuticals Inc   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 2 RECEPTOR STIMULATING AGENT; FLESINOXAN; N [2 [4 (2,3 DIHYDRO 1,4 BENZODIOXIN 5 YL) 2,6 DIMETHYL 1 PIPERAZINYL]ETHYL] 4 FLUOROBENZENECARBOXAMIDE; SEROTONIN 1A AGONIST; UNCLASSIFIED DRUG; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; PIPERAZINE DERIVATIVE; SEROTONIN 1 RECEPTOR; SEROTONIN AGONIST; SEROTONIN RECEPTOR; SPIPERONE;

ARTICLE; DRUG ACTIVITY; DRUG BINDING SITE; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; LIPOPHILICITY; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; ANIMAL; BINDING COMPETITION; BINDING SITE; BRAIN; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; CONFORMATION; HAMSTER; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; RAT; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; BRAIN; CHO CELLS; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PIPERAZINES; PROTEIN BINDING; RATS; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; SPIPERONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030614322     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960496o     Document Type: Article

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