Novel, flexible, and conformationally defined analogs of gepirone: Synthesis and 5-HT1A, 5-HT2A, and D2 receptor activity

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 4, 2005, Pages 1195-1200

  Paluchowska, Maria H ^a   Bugno, Ryszard ^a   Bojarski, Andrzej J ^a   Charakchieva Minol, Sijka ^a   Duszyńska, Beata ^a   Tatarczyńska, Ewa ^b   Kłodzińska, Aleksandra ^b   Stachowicz, Katarzyna ^b   Chojnacka Wójcik, Ewa ^b  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

^b Polska Akademia Nauk Oddzial w Krakowie   (Poland)

Author keywords

5 HT1A Receptor agonists and partial agonists; 5 HT1A 5 HT2A Receptor ligands; Flexible and conformationally defined gepirone analogs; Selective 5 HT 1A receptor ligands

Indexed keywords

1 [4 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]BUTYL] 4,4 DIMETHYLPIPERIDINE 2,6 DIONE; 1 [4 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]CYCLOHEXYL] 4,4 DIMETHYLPIPERIDINE 2,6 DIONE; 1 [4 [4 (3 CHLOROPHENYL)PIPERAZIN 1 YL]BUTYL] 4,4 DIMETHYLPIPERIDINE 2,6 DIONE; 1 [4 [4 (3 CHLOROPHENYL)PIPERAZIN 1 YL]CYCLOHEXYL] 4,4 DIMETHYLPIPERIDINE 2,6 DIONE; 1 [4 [4 (3 TRIFLUOROMETHYLPHENYL)PIPERAZIN 1 YL]BUTYL] 4,4 DIMETHYLPIPERIDINE 2,6 DIONE; 1 [4 [4 (3 TRIFLUOROMETHYLPHENYL)PIPERAZIN 1 YL]CYCLOHEXYL] 4,4 DIMETHYLPIPERIDINE 2,6 DIONE; DOPAMINE 2 RECEPTOR; DRUG ANALOG; GEPIRONE; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; STRUCTURE ANALYSIS;

ANIMALS; DOPAMINE AGONISTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; PYRIMIDINES; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, DOPAMINE D2; SEROTONIN AGONISTS;

STAPHYLOCOCCUS PHAGE 3A;

EID: 12844278851     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.11.019     Document Type: Article

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