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Volumn 7, Issue 3 SUPPL., 2006, Pages

Current status and future promise of pharmacotherapeutic strategies for Alzheimer's disease

Author keywords

Alzheimer's disease; Future treatment; Pharmacotherapy

Indexed keywords

ACETYLCHOLINESTERASE; ALPHA TOCOPHEROL; ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN ANTIBODY; AMYLOID PRECURSOR PROTEIN; ASCORBIC ACID; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINESTERASE; DONEPEZIL; GALANTAMINE; GLYCOPROTEIN P; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IBUPROFEN; INDOMETACIN; MEMANTINE; NONSTEROID ANTIINFLAMMATORY AGENT; PACLITAXEL; RIVASTIGMINE; SULINDAC; TAXANE DERIVATIVE; TX 67; UNCLASSIFIED DRUG;

EID: 33144460377     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2005.12.015     Document Type: Article
Times cited : (8)

References (56)
  • 1
    • 0042023711 scopus 로고    scopus 로고
    • Alzheimer disease in the US population
    • Prevalence estimates using the 2000 census
    • L.E. Hebert P.A. Scherr J.L. Bienias et al. Alzheimer disease in the US population Prevalence estimates using the 2000 census Arch Neurol 60 2003 1119-1122
    • (2003) Arch Neurol , vol.60 , pp. 1119-1122
    • Hebert, L.E.1    Scherr, P.A.2    Bienias, J.L.3
  • 2
    • 0031695197 scopus 로고    scopus 로고
    • Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset
    • R. Brookmeyer S. Gray C. Kawas Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset Am J Public Health 88 1998 1337-1342
    • (1998) Am J Public Health , vol.88 , pp. 1337-1342
    • Brookmeyer, R.1    Gray, S.2    Kawas, C.3
  • 3
    • 0037042299 scopus 로고    scopus 로고
    • Alzheimer disease
    • J.L. Cummings G. Cole Alzheimer disease JAMA 287 2002 2335-2338
    • (2002) JAMA , vol.287 , pp. 2335-2338
    • Cummings, J.L.1    Cole, G.2
  • 4
    • 0242490526 scopus 로고    scopus 로고
    • End-of-life care and the effects of bereavement on family caregivers of persons with dementia
    • Resources for Enhancing Alzheimer's Caregiver Health (REACH) Investigator
    • R. Schulz A.B. Mendelsohn W.E. Haley Resources for Enhancing Alzheimer's Caregiver Health (REACH) Investigators End-of-life care and the effects of bereavement on family caregivers of persons with dementia N Engl J Med 349 2003 1936-1942
    • (2003) N Engl J Med , vol.349 , pp. 1936-1942
    • Schulz, R.1    Mendelsohn, A.B.2    Haley, W.E.3
  • 5
    • 33144457002 scopus 로고    scopus 로고
    • Author's guide. American Academy of Family Physicians Web site. Available at. Accessed October 24
    • Author's guide. American Academy of Family Physicians Web site. Available at http://www.aafp.org/x17444.xml. Accessed October 24, 2004.
    • (2004)
  • 6
    • 0035829592 scopus 로고    scopus 로고
    • A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity
    • S. Weggen J.L. Eriksen P. Das A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity Nature 414 2001 212-216
    • (2001) Nature , vol.414 , pp. 212-216
    • Weggen, S.1    Eriksen, J.L.2    Das, P.3
  • 7
    • 0038719688 scopus 로고    scopus 로고
    • Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation
    • Y. Takahashi I. Hayashi Y. Tominari et al. Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation J Biol Chem 278 2003 18664-18670
    • (2003) J Biol Chem , vol.278 , pp. 18664-18670
    • Takahashi, Y.1    Hayashi, I.2    Tominari, Y.3
  • 8
    • 0032559003 scopus 로고    scopus 로고
    • Apolipoprotein E and antioxidants have different mechanisms of inhibiting Alzheimer's beta-amyloid fibril formation in vitro
    • H. Naiki K. Hasegawa I. Yamaguchi et al. Apolipoprotein E and antioxidants have different mechanisms of inhibiting Alzheimer's beta-amyloid fibril formation in vitro Biochemistry 37 1998 17882-17889
    • (1998) Biochemistry , vol.37 , pp. 17882-17889
    • Naiki, H.1    Hasegawa, K.2    Yamaguchi, I.3
  • 9
    • 0346688728 scopus 로고    scopus 로고
    • Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: The Cache Country Study
    • P.P. Zandi J.C. Anthony A.S. Khachaturian Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: The Cache County Study Arch Neurol 61 2004 82-88
    • (2004) Arch Neurol , vol.61 , pp. 82-88
    • Zandi, P.P.1    Anthony, J.C.2    Khachaturian, A.S.3
  • 10
    • 0030967165 scopus 로고    scopus 로고
    • A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study
    • M. Sano C. Ernesto R.G. Thomas A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study N Engl J Med 336 1997 1216-1222
    • (1997) N Engl J Med , vol.336 , pp. 1216-1222
    • Sano, M.1    Ernesto, C.2    Thomas, R.G.3
  • 11
    • 0037319158 scopus 로고    scopus 로고
    • The role of cholesterol in pathogenesis of Alzheimer's disease: Dual metabolic interaction between amyloid bete-protein an cholesterol
    • M. Michikawa The role of cholesterol in pathogenesis of Alzheimer's disease: Dual metabolic interaction between amyloid beta-protein and cholesterol Mol Neurobiol 27 2003 1-12
    • (2003) Mol Neurobiol , vol.27 , pp. 1-12
    • Michikawa, M.1
  • 12
    • 0033780954 scopus 로고    scopus 로고
    • Is there a connection between the concentration of cholesterol circulating in plasma and the rate of neuritic plaque formation in Alzheimer disease?
    • R.W. Haley J.M. Dietschy Is there a connection between the concentration of cholesterol circulating in plasma and the rate of neuritic plaque formation in Alzheimer disease? Arch Neurol 57 2000 1410-1412
    • (2000) Arch Neurol , vol.57 , pp. 1410-1412
    • Haley, R.W.1    Dietschy, J.M.2
  • 13
    • 0037388527 scopus 로고    scopus 로고
    • Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease
    • G.L. Vega M.F. Weiner A.M. Lipton Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease Arch Neurol 60 2003 510-515
    • (2003) Arch Neurol , vol.60 , pp. 510-515
    • Vega, G.L.1    Weiner, M.F.2    Lipton, A.M.3
  • 14
    • 0036452144 scopus 로고    scopus 로고
    • Cholesterol in Alzheimer's disease and tauopathy
    • M. Burns K. Duff Cholesterol in Alzheimer's disease and tauopathy Ann N Y Acad Sci 977 2002 367-375
    • (2002) Ann N Y Acad Sci , vol.977 , pp. 367-375
    • Burns, M.1    Duff, K.2
  • 15
    • 0344688198 scopus 로고    scopus 로고
    • Galantamine prevents apoptosis induced by beta-amyloid and thapsigargin: Involvement of nicotinic acetylcholine receptors
    • E. Arias E. Ales N.H. Gabilan et al. Galantamine prevents apoptosis induced by beta-amyloid and thapsigargin: Involvement of nicotinic acetylcholine receptors Neuropharmacology 46 2004 103-114
    • (2004) Neuropharmacology , vol.46 , pp. 103-114
    • Arias, E.1    Ales, E.2    Gabilan, N.H.3
  • 16
    • 0037622682 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons
    • Y. Takada A. Yonezawa T. Kume et al. Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons J Pharmacol Exp Ther 306 2003 772-777
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 772-777
    • Takada, Y.1    Yonezawa, A.2    Kume, T.3
  • 17
    • 0027973241 scopus 로고
    • Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia
    • M.M. Mesulam C. Geula Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia Ann Neurol 36 1994 722-727
    • (1994) Ann Neurol , vol.36 , pp. 722-727
    • Mesulam, M.M.1    Geula, C.2
  • 18
    • 0038618612 scopus 로고    scopus 로고
    • Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex
    • T. Rees P.I. Hammond H. Soreq et al. Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex Neurobiol Aging 24 2003 777-787
    • (2003) Neurobiol Aging , vol.24 , pp. 777-787
    • Rees, T.1    Hammond, P.I.2    Soreq, H.3
  • 19
    • 0037817311 scopus 로고    scopus 로고
    • Amyloid-beta increases acetylcholinesterase expression in neuroblastoma cells by reducing enzyme degradation
    • W. Hu N.W. Gray S. Brimijoin Amyloid-beta increases acetylcholinesterase expression in neuroblastoma cells by reducing enzyme degradation J Neurochem 86 2003 470-478
    • (2003) J Neurochem , vol.86 , pp. 470-478
    • Hu, W.1    Gray, N.W.2    Brimijoin, S.3
  • 20
    • 0037234423 scopus 로고    scopus 로고
    • The role of acetylcholinesterase in the pathogenesis of Alzheimer's disease
    • T.M. Rees S. Brimijoin The role of acetylcholinesterase in the pathogenesis of Alzheimer's disease Drugs Today (Barc) 39 2003 75-83
    • (2003) Drugs Today (Barc) , vol.39 , pp. 75-83
    • Rees, T.M.1    Brimijoin, S.2
  • 21
    • 0036993145 scopus 로고    scopus 로고
    • Butyrylcholinesterase: An important new target in Alzheimer's disease therapy
    • N.H. Greig D.K. Lahiri K. Sambamurti Butyrylcholinesterase: An important new target in Alzheimer's disease therapy Int Psychogeriatr 14 Suppl 1 2002 77-91
    • (2002) Int Psychogeriatr , vol.14 , Issue.SUPPL. 1 , pp. 77-91
    • Greig, N.H.1    Lahiri, D.K.2    Sambamurti, K.3
  • 22
  • 23
    • 0029863697 scopus 로고    scopus 로고
    • Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: Possible role of the peripheral site of the enzyme
    • N.C. Inestrosa A. Alvarez C.A. Perez et al. Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils Possible role of the peripheral site of the enzyme Neuron 16 1996 881-891
    • (1996) Neuron , vol.16 , pp. 881-891
    • Inestrosa, N.C.1    Alvarez, A.2    Perez, C.A.3
  • 24
    • 12444257779 scopus 로고    scopus 로고
    • 3-(4- Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone ( AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: A dual function lead for Alzheimer's disease therapy
    • L. Piazzi A. Rampa A. Bisi et al. 3-(4- Benzyl(methyl)amino]methyl]pheny l)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation A dual function lead for Alzheimer's disease therapy J Med Chem 46 2003 2279-2282
    • (2003) J Med Chem , vol.46 , pp. 2279-2282
    • Piazzi, L.1    Rampa, A.2    Bisi, A.3
  • 25
    • 0034467344 scopus 로고    scopus 로고
    • Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro
    • H. Ogura T. Kosasa Y. Kuriya Y. Yamanishi Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro Methods Find Exp Clin Pharmacol 22 2000 609-613
    • (2000) Methods Find Exp Clin Pharmacol , vol.22 , pp. 609-613
    • Ogura, H.1    Kosasa, T.2    Kuriya, Y.3    Yamanishi, Y.4
  • 26
    • 10744232323 scopus 로고    scopus 로고
    • Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors
    • M. Samochocki A. Hoffle A. Fehrenbacher et al. Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors J Pharmacol Exp Ther 305 2003 1024-1036
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 1024-1036
    • Samochocki, M.1    Hoffle, A.2    Fehrenbacher, A.3
  • 27
    • 0001788650 scopus 로고    scopus 로고
    • Neuroprotective and symptomatic action of memantine relevant for Alzheimer's disease: A unified glutamatergic hypothesis on the mechanism of action
    • W. Danysz C.G. Parsons H.J. Möbius Neuroprotective and symptomatic action of memantine relevant for Alzheimer's disease: A unified glutamatergic hypothesis on the mechanism of action Neurotoxicity Res 2 2000 85-98
    • (2000) Neurotoxicity Res , vol.2 , pp. 85-98
    • Danysz, W.1    Parsons, C.G.2    Möbius, H.J.3
  • 28
    • 0345872128 scopus 로고    scopus 로고
    • Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil
    • for the Memantine Study Group
    • P.N. Tariot M.R. Farlow G.T. Grossberg et al. Memantine Study Group Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil JAMA 291 2004 317-324
    • (2004) JAMA , vol.291 , pp. 317-324
    • Tariot, P.N.1    Farlow, M.R.2    Grossberg, G.T.3
  • 29
    • 2942542795 scopus 로고    scopus 로고
    • Pharmacotherapeutic approaches to the treatment of Alzheimer's disease
    • J.B. Standridge Pharmacotherapeutic approaches to the treatment of Alzheimer's disease Clin Ther 26 2004 615-630
    • (2004) Clin Ther , vol.26 , pp. 615-630
    • Standridge, J.B.1
  • 30
    • 0037425565 scopus 로고    scopus 로고
    • Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: A meta-analysis
    • N.H. Trinh J. Hoblyn S. Mohanty K. Yaffe Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: A meta-analysis JAMA 289 2003 210-216
    • (2003) JAMA , vol.289 , pp. 210-216
    • Trinh, N.H.1    Hoblyn, J.2    Mohanty, S.3    Yaffe, K.4
  • 31
    • 3242775357 scopus 로고    scopus 로고
    • The efficacy of donepezil in the treatment of neuropsychiatric symptoms in Alzheimer disease
    • C. Holmes D. Wilkinson C. Dean The efficacy of donepezil in the treatment of neuropsychiatric symptoms in Alzheimer disease Neurology 63 2004 214-219
    • (2004) Neurology , vol.63 , pp. 214-219
    • Holmes, C.1    Wilkinson, D.2    Dean, C.3
  • 32
    • 0141763668 scopus 로고    scopus 로고
    • Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: A meta-analysis
    • K.L. Lanctot N. Herrmann K.K. Yau Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: A meta-analysis CMAJ 169 2003 557-564
    • (2003) CMAJ , vol.169 , pp. 557-564
    • Lanctot, K.L.1    Herrmann, N.2    Yau, K.K.3
  • 33
    • 0037707465 scopus 로고    scopus 로고
    • Donepezil is associated with delayed nursing home placement in patients with Alzheimer's disease
    • D.S. Geldmacher G. Provenzano T. McRae Donepezil is associated with delayed nursing home placement in patients with Alzheimer's disease J Am Geriatr Soc 51 2003 937-944
    • (2003) J Am Geriatr Soc , vol.51 , pp. 937-944
    • Geldmacher, D.S.1    Provenzano, G.2    McRae, T.3
  • 34
    • 3042567016 scopus 로고    scopus 로고
    • Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): Randomized double-blind trial Lancet 363 2004 2105-2115
    • AD2000 Collaborative Group Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): Randomized double-blind trial Lancet 363 2004 2105-2115
    • (2004) Lancet , vol.363 , pp. 2105-2115
  • 35
    • 0037371279 scopus 로고    scopus 로고
    • Use of cholinesterase inhibitors in clinical practice Evidence-based recommendations
    • J.L. Cummings Use of cholinesterase inhibitors in clinical practice: Evidence-based recommendations Am J Geriatr Psychiatry 11 2003 131-145
    • (2003) Am J Geriatr Psychiatry , vol.11 , pp. 131-145
    • Cummings, J.L.1
  • 36
    • 0037417238 scopus 로고    scopus 로고
    • Memantine in moderate-to-severe Alzheimer's disease
    • B. Reisberg R. Doody A. Stoffler et al. Memantine Study Group Memantine in moderate-to-severe Alzheimer's disease N Engl J Med 348 2003 1333-1341
    • (2003) N Engl J Med , vol.348 , pp. 1333-1341
    • Reisberg, B.1    Doody, R.2    Stoffler, A.3
  • 37
    • 0032983786 scopus 로고    scopus 로고
    • Memantine in severe dementia
    • Results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine)
    • B. Winblad N. Poritis Memantine in severe dementia Results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine) Int J Geriatr Psychiatry 14 1999 135-146
    • (1999) Int J Geriatr Psychiatry , vol.14 , pp. 135-146
    • Winblad, B.1    Poritis, N.2
  • 38
    • 0037369507 scopus 로고    scopus 로고
    • Drugs targeting Alzheimer's disease: Some things old and some things new
    • M.L. Michaelis Drugs targeting Alzheimer's disease: Some things old and some things new J Pharmacol Exp Ther 304 2003 897-904
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 897-904
    • Michaelis, M.L.1
  • 39
    • 0037442871 scopus 로고    scopus 로고
    • Comparative studies of active site-ligand interactions among various recombinant constructs of human beta-amyloid precursor protein cleaving enzyme
    • L.M. Kopcho J. Ma J. Marcinkeviciene Comparative studies of active site-ligand interactions among various recombinant constructs of human beta-amyloid precursor protein cleaving enzyme Arch Biochem Biophys 410 2003 307-316
    • (2003) Arch Biochem Biophys , vol.410 , pp. 307-316
    • Kopcho, L.M.1    Ma, J.2    Marcinkeviciene, J.3
  • 40
    • 0036861132 scopus 로고    scopus 로고
    • Emerging Alzheimer's disease therapies: Inhibition of beta-secretase
    • M. Citron Emerging Alzheimer's disease therapies: Inhibition of beta-secretase Neurobiol Aging 23 2002 1017-1022
    • (2002) Neurobiol Aging , vol.23 , pp. 1017-1022
    • Citron, M.1
  • 42
    • 0037431082 scopus 로고    scopus 로고
    • Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex
    • B. De Strooper Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex Neuron 38 2003 9-12
    • (2003) Neuron , vol.38 , pp. 9-12
    • De Strooper, B.1
  • 43
    • 0036050867 scopus 로고    scopus 로고
    • Are beta-sheet breaker peptides dissolving the therapeutic problem of Alzheimer's disease?
    • B. Permanne C. Adessi S. Fraga Are beta-sheet breaker peptides dissolving the therapeutic problem of Alzheimer's disease? J Neural Transm Suppl 62 2002 293-301
    • (2002) J Neural Transm Suppl , Issue.62 , pp. 293-301
    • Permanne, B.1    Adessi, C.2    Fraga, S.3
  • 44
    • 0036615884 scopus 로고    scopus 로고
    • Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide
    • B. Permanne C. Adessi G.P. Saborio et al. Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide FASEB J 16 2002 860-862
    • (2002) FASEB J , vol.16 , pp. 860-862
    • Permanne, B.1    Adessi, C.2    Saborio, G.P.3
  • 45
    • 0038529679 scopus 로고    scopus 로고
    • Pharmacological profiles of peptide drug candidates for the treatment of Alzheimer's disease
    • C. Adessi M.J. Frossard C. Boissard et al. Pharmacological profiles of peptide drug candidates for the treatment of Alzheimer's disease J Biol Chem 278 2003 13905-13911
    • (2003) J Biol Chem , vol.278 , pp. 13905-13911
    • Adessi, C.1    Frossard, M.J.2    Boissard, C.3
  • 46
    • 0037794384 scopus 로고    scopus 로고
    • The plasma membrane: A target and hurdle for the development of anti-Abeta drugs?
    • P. Talaga L. Quere The plasma membrane: A target and hurdle for the development of anti-Abeta drugs? Curr Drug Target CNS Neurol Disord 1 2002 567-574
    • (2002) Curr Drug Target CNS Neurol Disord , vol.1 , pp. 567-574
    • Talaga, P.1    Quere, L.2
  • 48
    • 0036044614 scopus 로고    scopus 로고
    • Current drugs and future hopes in the treatment of Alzheimer's disease
    • M. Windisch B. Hutter-Paier E. Schreiner Current drugs and future hopes in the treatment of Alzheimer's disease J Neural Transm Suppl 62 2002 149-164
    • (2002) J Neural Transm Suppl , Issue.62 , pp. 149-164
    • Windisch, M.1    Hutter-Paier, B.2    Schreiner, E.3
  • 49
    • 0037375876 scopus 로고    scopus 로고
    • Cholinesterases: New roles in brain function and in Alzheimer's disease
    • E. Giacobini Cholinesterases: New roles in brain function and in Alzheimer's disease Neurochem Res 28 2003 515-522
    • (2003) Neurochem Res , vol.28 , pp. 515-522
    • Giacobini, E.1
  • 50
    • 0036931159 scopus 로고    scopus 로고
    • Tau neurofibrillary pathology and microtubule stability
    • M.L. Michaelis R.T. Dobrowsky G. Li Tau neurofibrillary pathology and microtubule stability J Mol Neurosci 19 2002 289-293
    • (2002) J Mol Neurosci , vol.19 , pp. 289-293
    • Michaelis, M.L.1    Dobrowsky, R.T.2    Li, G.3
  • 51
    • 0642309504 scopus 로고    scopus 로고
    • Overcoming the blood-brain barrier to taxane delivery for neurodegenerative diseases and brain tumors
    • A. Rice M.L. Michaelis G. Georg Overcoming the blood-brain barrier to taxane delivery for neurodegenerative diseases and brain tumors J Mol Neurosci 20 2003 339-343
    • (2003) J Mol Neurosci , vol.20 , pp. 339-343
    • Rice, A.1    Michaelis, M.L.2    Georg, G.3
  • 52
    • 0037606205 scopus 로고    scopus 로고
    • Vaccines for Alzheimer's disease: How close are we?
    • C. Janus Vaccines for Alzheimer's disease How close are we? CNS Drugs 17 2003 457-474
    • (2003) CNS Drugs , vol.17 , pp. 457-474
    • Janus, C.1
  • 53
    • 3042692322 scopus 로고    scopus 로고
    • Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet
    • C.A. Lemere A. Beierschmitt M. Iglesias Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet Am J Pathol 165 2004 283-297
    • (2004) Am J Pathol , vol.165 , pp. 283-297
    • Lemere, C.A.1    Beierschmitt, A.2    Iglesias, M.3
  • 54
    • 12444337654 scopus 로고    scopus 로고
    • Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach
    • N. Sergeant S. Bombois A. Ghestem Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach J Neurochem 85 2003 1581-1591
    • (2003) J Neurochem , vol.85 , pp. 1581-1591
    • Sergeant, N.1    Bombois, S.2    Ghestem, A.3
  • 55
    • 0036644989 scopus 로고    scopus 로고
    • Reversal of amyloid beta toxicity in Alzheimer's disease model Tg2576 by intraventricular antiamyloid beta antibody
    • N.B. Chauhan G.J. Siegel Reversal of amyloid beta toxicity in Alzheimer's disease model Tg2576 by intraventricular antiamyloid beta antibody J Neurosci Res 69 2002 10-23
    • (2002) J Neurosci Res , vol.69 , pp. 10-23
    • Chauhan, N.B.1    Siegel, G.J.2
  • 56
    • 0141758165 scopus 로고    scopus 로고
    • Intracerebroventricular passive immunization with anti-Abeta antibody in Tg2576
    • N.B. Chauhan G.J. Siegel Intracerebroventricular passive immunization with anti-Abeta antibody in Tg2576 J Neurosci Res 74 2003 142-147
    • (2003) J Neurosci Res , vol.74 , pp. 142-147
    • Chauhan, N.B.1    Siegel, G.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.