Effects of leptin on endothelial function with OB-Rb gene transfer in Zucker fatty rats

Atherosclerosis

Volumn 169, Issue 2, 2003, Pages 225-233

  Jin, Xueqing ^a   Fukuda, Noboru ^a   Su, Jinzi ^a   Takagi, Hiroto ^a   Lai, Yimu ^a   Lin, Zhihong ^a   Kanmatsuse, Katsuo ^a   Wang, Zhuo Wei ^b   Unger, Roger H ^b  

^a NIHON UNIVERSITY   (Japan)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Adenovirus; Endothelial cells; Gene transfer; Leptin; OB Rb; Receptor

Indexed keywords

ADENOVIRUS VECTOR; JANUS KINASE; LEPTIN; LEPTIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; STAT3 PROTEIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CELL CULTURE; CELL FUNCTION; CELL GROWTH; CONTROLLED STUDY; CORNEA; DNA SYNTHESIS; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; ESCHERICHIA COLI; GENE TRANSFER; GENETIC CODE; GENETIC TRANSFECTION; LEPTIN RECEPTOR B GENE; METABOLIC SYNDROME X; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RAT STRAIN; RECEPTOR GENE; SIGNAL TRANSDUCTION;

EID: 0142029106     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(03)00159-X     Document Type: Article

References (35)

1. Cioffi J.A., Shafer A.W., Zupancic T.J., Smith-Gbur J., Mikhail A., Platika D., Snodgrass H.R. Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nat. Med. 2:1996;585-589.
2. Takaya K., Ogawa Y., Isse N., Okazaki T., Satoh N., Masuzaki H., Mon K., Tamura N., Hosoda K., Nakao K. Molecular cloning of rat leptin receptor isoform complementary DNAs - identification of a missense mutation in Zucker fatty (fa/fa) rats. Biochem. Biophys. Res. Commun. 225:1996;75-83.
3. Murakami T., Yamashita T., Iida M., Kuwajima M., Shima K. A short form of leptin receptor performs signal transduction. Biochem. Biophys. Res. Commun. 231:1997;26-29.
4. Lollmann B., Gruninger S., Stricker-Krongrad A., Chiesi M. Detection and quantification of the leptin receptor splice variants Ob-Ra, b, and, e in different mouse tissues. Biochem. Biophys. Res. Commun. 238:1997;648-652.
5. Chen H., Charlat O., Tartaglia L.A., Woolf E.A., Weng X., Ellis S.J., Lakey N.D., Culpepper J., Moore K.J., Breitbart R.E., Duyk G.M., Tepper R.I., Morgenstern J.P. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 84:1996;491-495.
6. Tartaglia L.A. The leptin receptor. J. Biol. Chem. 272:1997;6093-6906.
7. Rett K. The relation between insulin resistance and cardiovascular complications of the insulin resistance syndrome. Diabetes Obes. Metab. 1:(Suppl. 1):1999;S8-S16.
8. Landsberg L. Insulin resistance and hypertension. Clin. Exp. Hypertens. 21:1999;885-894.
9. Argiles J.M. The obese Zucker rat: a choice for fat metabolism 1968-1988: 20 years of research on the insights of the Zucker mutation. Prog. Lipid Res. 28:1989;53-66.
10. Zucker T.F., Zucker L.M. Fat accretion and growth in the rat. Obes. Res. 4:1996;102-108.
11. Sierra-Honigmann M.R., Nath A.K., Murakami C., Garcia-Cardena G., Papapetropoulos A., Sessa W.C., Madge L.A., Schechner J.S., Schwabb M.B., Polverini P.J., Flores-Riveros J.R. Biological action of leptin as an angiogenic factor. Science. 281:1998;1683-1686.
12. Bouloumie A., Drexler H.C., Lafontan M., Busse R. Leptin, the product of Ob gene, promotes angiogenesis. Circ. Res. 83:1998;1059-1066.
13. Gainsford T., Alexander W.S. A role for leptin in hemopoieses. Mol. Biotechnol. 11:1999;149-158.
14. Wang M.Y., Koyama K., Shimabukuro M., Newgard C.B., Unger R.H. OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype. Proc. Natl. Acad. Sci. USA. 95:1998;714-718.
15. Kanegae Y., Miyake S., Sato Y., Lee G., Saito I. Adenovirus vector technology: an efficient method for constructing recombinant adenovirus and on/off switching of gene expression. Acta Paediatr. Jpn. 38:1996;182-188.
16. Yamane A., Seetharam L., Yamaguchi S., Gotoh N., Takahashi T., Neufeld G., Shibuya M. A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular endothelial growth factor and Flt tyrosine kinase receptor family (Flt-1 and KDR/Flk-1). Oncogene. 9:1994;2683-2690.
17. Frank D.J., Plamondon J., Hamet P. An increase in adenylate cyclase activity precedes DNA synthesis in cultured vascular smooth muscle cells. J. Cell. Physiol. 119:1984;41-45.
18. Mocharla H., Mocharla R., Hocks M.E. Coupled reverse transcription- polymerase chain reaction (RT-PCR) as a sensitive and rapid method for isozyme genotyping. Gene. 93:1990;271-275.
19. Whitehead T.P., Kricka L.J., Carter T.J., Thorpe G.H. Analytical luminescence: its potential in the clinical laboratory. Clin. Chem. 25:1979;1531-1546.
20. Pinkney J.H., Stehouwer C.D., Coppack S.W., Yudkin J.S. Endothelial dysfunction: cause of the insulin resistance syndrome. Diabetes. 46:(Suppl. 2):1997;S9-S13.
21. Walker A.B., Chattington P.D., Buckingham R.E., Williams G. The thiazolidinedione rosiglitazone (BRL-49653) lowers blood pressure and protects against impairment of endothelial function in Zucker fatty rats. Diabetes. 48:1999;1448-1453.
22. Winters B., Mo Z., Brooks-Asplund E., Kim S., Shoukas A., Li D., Nyhan D., Berkowitz D.E. Reduction of obesity, as induced by leptin, reverses endothelial dysfunction in obese (Lep(ob)) mice. J. Appl. Physiol. 89:2000;2382-2390.
23. Tobelem G. Endothelial cell growth: biology and pharmacology in relation to angiogenesis. Blood Coagul. Fibrinol. 1:1990;703-705.
24. Trayhurn P., Hoggard N., Mercer J.G., Rayner D.V. Leptin: fundamental aspects. Int. J. Obes. Rlat. Metab. Disord. 1:1999;22-28.
25. Cao R., Brakenhielm E., Wahlestedt C., Thyberg J., Cao Y. Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF. Proc. Natl. Acad. Sci. USA. 98:2001;6390-6395.
26. Touw I.P., De Koning J.P., Ward A.C., Hermans M.H. Signaling mechanisms of cytokine receptors and their perturbances in disease. Mol. Cell. Endocrinol. 160:2000;1-9.
27. van den Brink G.R., O'Toole T., Hardwick J.C., van den Boogaardt D.E., Versteeg H.H., van Deventer S.J., Peppelenbosch M.P. Leptin signaling in human peripheral blood mononuclear cells, activation of p38 and p42/44 mitogen-activated protein (MAP) kinase and p70 S6 kinase. Mol. Cell. Biol. Res. Commun. 4:2000;144-150.
28. Bjøbæk C., Buchholz R.M., Davis S.M., Bates S.H., Pierroz D.D., Gu H., Neel B.G., MyersJr M.G., Flier J.S. Divergent roles of SHP-2 in ERK activation by leptin receptors. J. Biol. Chem. 276:2001;4747-4755.
29. Oda A., Taniguchi T., Yokoyama M. Leptin stimulates rat aortic smooth muscle cell proliferation and migration. Kobe J. Med. Sci. 47:2001;141-150.
30. Machinal-Quelin F., Dieudonne M.N., Leneveu M.C., Pecquery R., Giudicelli Y. Proadipogenic effect of leptin on rat preadipocytes in vitro: activation of MAPK and STAT3 signaling pathways. Am. J. Physiol. Cell Physiol. 284:2002;C853-C863.
31. Alessi M.C., Morange P., Iuhan-Vague I. Fat cell function and fibrinolysis. Horm. Metab. Res. 32:2000;504-508.
32. Wang X., Reape T.J., Li X., Rayner K., Webb C.L., Burnand K.G., Lysko P.G. Induced expression of adipophilin mRNA in human macrophages stimulated with oxidized low-density lipoprotein and in atherosclerotic lesions. FEBS Lett. 462:1999;145-150.
33. Layne M.D., Patel A., Chen Y.H., Rebel V.I., Carvajal T.M., Pellacani A., Ith B., Zhao D., Schreiber B.M., Yet S.F., Lee M.E., Storch J., Perrella M.A. Role of macrophage-expressed adipocyte fatty acid binding protein in the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J. 15:2001;2733-2735.
34. Bjorback C., Elmquist J.K., Frantz J.D., Shoelson S.E., Flier J.S. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell. 1:1998;619-625.
35. Bjorback C., El-Haschimi K., Frantz J.D., Flier J.S. The role of SOCS-3 in leptin signaling and leptin resistance. J. Biol. Chem. 274:1999;30059-30065.