Influence of serotonin transporter gene polymorphisms on cognitive decline and cognitive abilities in a nondemented elderly population

Molecular Psychiatry

Volumn 10, Issue 12, 2005, Pages 1133-1139

  Payton, A ^a   Gibbons, L ^a   Davidson, Y ^a   Ollier, W ^a   Rabbitt, P ^a   Worthington, J ^a   Pickles, A ^a   Pendleton, N ^a   Horan, M ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Association; Cognition; Genes; Memory; Polymorphism; Serotonin transporter

Indexed keywords

ADULT; AGED; ALLELE; ARTICLE; COGNITION; COGNITIVE DEFECT; COHORT ANALYSIS; DISEASE ASSOCIATION; DNA POLYMORPHISM; FEMALE; FOLLOW UP; GENE CONTROL; GERIATRICS; HOMOZYGOSITY; HUMAN; INTELLIGENCE; MAJOR CLINICAL STUDY; MALE; MEMORY; PRIORITY JOURNAL; PROBLEM SOLVING; SEMANTICS; VOLUNTEER;

AGED; AGED, 80 AND OVER; AGING; COGNITION; FEMALE; HUMANS; MALE; MEMORY; MIDDLE AGED; MINISATELLITE REPEATS; POLYMORPHISM, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 32844466706     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/sj.mp.4001733     Document Type: Article

References (54)

1. Devlin B, Daniels M, Roeder K. The heritability of IQ. Nature 1997; 388: 468-471.
2. McArdle JJ, Prescott CA, Hamagami F, Horn JL. A contempory method for developmental-genetic analysis of age changes in intellectual abilities. Dev Neuropsychol 1998; 14: 69-114.
3. Schmand B, Smit JH, Geerlings MI, Lindeboom J. The effects of intelligence and education on the development of dementia. A test of the brain reserve hypothesis. Psychol Med 1997; 27: 1337-1344.
4. Scarmeas N, Stern Y. Cognitive reserve: implications for diagnosis and prevention of Alzheimer's disease. Curr Neurol Neurosci Rep 2004; 4: 374-380.
5. Goldberg TE, Weinberger DR. Genes and the parsing of cognitive processes. Trends Cogn Sci 2004; 8: 325-335.
6. Comings DE, Johnson JP, Gonzalez NS, Huss M, Saucier G, McGue M et al. Association between the adrenergic alpha 2A receptor gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjects. Psychiatr Genet 2000; 10: 39-42.
7. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE et al. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 2001; 98: 6917-6922.
8. Bartres-Faz D, Junque C, Serra-Grabulosa JM, Lopez-Alomar A, Moya A, Bargallo N et al. Dopamine DRD2 Taq I polymorphism associates with caudate nucleus volume and cognitive performance in memory impaired subjects. Neuroreport 2002; 13: 1121-1125.
9. Tsai SJ, Yu YW, Lin CH, Chen TJ, Chen SP, Hong CJ. Dopamine D2 receptor and N-methyl-D-aspartate receptor 2B subunit genetic variants and intelligence. Neuropsychobiology 2002; 45: 128-130.
10. Comings DE, Wu S, Rostamkhani M, McGue M, Lacono WG, Cheng LS et al. Role of the cholinergic muscarinic 2 receptor (CHRM2) gene in cognition. Mol Psychiatr 2003; 8: 10-11.
11. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003; 112: 257-269.
12. Egan MF, Straub RE, Goldberg TE, Yakub I, Callicott JH, Hariri AR et al. Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. Proc Natl Acad Sci USA 2004; 101: 12604-12609.
13. DeQuervain DJ, Henke K, Aerni A, Coluccia D, Wollmer MA, Hock CA et al. A functional genetic variation of the 5-HT2a receptor affects human memory. Nat Neurosci 2003; 6: 1141-1142.
14. Feskens EJM, Havekes LM, Kalmijn S, de Knijff P, Launer LJ, Kromhout D. Apolipoprotein e4 allele and cognitive decline in elderly men. BMJ 1994; 309: 1202-1206.
15. Jonker C, Schmand B, Lindeboom J, Havekes LM, Launer LJ. Association between apolipoprotein E epsilon4 and the rate of cognitive decline in community-dwelling elderly individuals with and without dementia. Arch Neurol 1998; 55: 1065-1069.
16. Small BJ, Graves AB, McEvoy CL, Crawford FC, Mullan M, Mortimer JA. Is APOE epsilon4 a risk factor for cognitive impairment in normal aging? Neurology 2000; 54: 2082-2088.
17. Smith GE, Bohac DL, Waring SC, Kokmen E, Tangalos EG, Ivnik RJ et al. Apolipoprotein E genotype influences cognitive 'phenotype' in patients with Alzheimer's disease but not in healthy control subjects. Neurology 1998; 50: 355-362.
18. Mayeux R, Small SA, Tang M, Tycko B, Stern Y. Memory performance in healthy elderly without Alzheimer's disease: effects of time and apolipoprotein-E. Neurobiol Aging 2001; 22: 683-689.
19. Pendleton N, Payton A, van den Boogerd EH, Holland F, Diggle P, Rabbitt PM et al. Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults. Neurosci Lett 2002; 324: 74-76.
20. van Kesteren RE, Spencer GE. The role of neurotransmitters in neurite outgrowth and synapse formation. Rev Neurosci 2003; 14: 217-231.
21. Meneses A. 5-HT system and cognition. Neurosci Biobehav Rev 1999; 23: 1111-1125.
22. Rehman HU, Masson EA. Neuroendocrinology of ageing. Age Ageing 2001; 30: 279-287.
23. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274: 1527-1531.
24. Sen S, Burmeister M, Ghosh D. Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am J Med Genet 2004; 127B: 85-89.
25. Lin PY, Tsai G. Association between serotonin transporter gene promoter polymorphism and suicide: results of a meta-analysis. Biol Psychiatr 2004; 55: 1023-1030.
26. Ospina-Duque J, Duque C, Carvajal-Carmona L, Ortiz-Barrientos D, Soto I, Pineda N et al. An association study of bipolar mood disorder (type I) with the 5-HTTLPR serotonin transporter polymorphism in a human population isolate from Colombia. Neurosci Lett 2000; 292: 199-202.
27. Langley K, Payton A, Hamshere ML, Pay HM, Lawson DC, Turic D et al. No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder. Psychiatr Genet 2003; 13: 107-110.
28. Retz W, Retz-Junginger P, Supprian T, Thome J, Rosler M. Association of serotonin transporter promoter gene polymorphism with violence: relation with personality disorders, impulsivity, and childhood ADHD psychopathology. Behav Sci Law 2004; 22: 415-425.
29. Mata I, Arranz MJ, Patino A, Lai T, Beperet M, Sierrasesumaga L et al. Serotonergic polymorphisms and psychotic disorders in populations from North Spain. Am J Med Genet 2004; 126B: 88-94.
30. Munafo MR, Clark TG, Moore LR, Payne E, Walton R, Flint J. Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis. Mol Psychiatr 2003; 8: 471-484.
31. Feinn R, Nellissery M, Kranzler HR. Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence. Am J Med Genet B Neuropsychiatr Genet 2005; 133: 79-84.
32. Mendlewicz J, Massat I, Souery D, Del-Favero J, Oruc L, Nothen MM et al. Serotonin transporter SLC6A4LPR polymorphism and affective disorders: no evidence of association in a large European multicenter study. Eur J Hum Genet 2004; 12: 377-382.
33. Lotrich FE, Pollock BG. Meta-analysis of serotonin transporter polymorphisms and affective disorders. Psychiatr Genet 2004; 14: 121-129.
34. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D et al. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996; 66: 2621-2624.
35. Fiskerstrand CE, Lovejoy EA, Quinn JP. An intronic polymorphic domain often associated with susceptibility to affective disorders has allele dependent differential enhancer activity in embryonic stem cells. FEBS Lett 1999; 458: 171-174.
36. MacKenzie A, Quinn J. A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proc Natl Acad Sci USA 1999; 96: 15251-15255.
37. Hranilovic D, Stefulj J, Schwab S, Borrmann-Hassenbach M, Albus M, Jernej B et al. Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression. Biol Psychiatr 2004; 55: 1090-1094.
38. Heim AW. AH4 Group Test of General Intelligence. NFER-Nelson: Windsor UK, 1970.
39. Raven JC. The Mill Hill Vocabulary Scale. HK Lewis: London, 1965.
40. Rabbitt P, Diggle P, Horan M, Pendleton N, Bent N, Abson V et al. The University of Manchester Longitudinal Study of normal healthy old age 1983 through 2003. Aging Neuropsychol Cognition 2004; 11: 245-279.
41. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274: 1527-1531.
42. Ogilvie AD, Battersby S, Bubb VJ, Fink G, Harmar AJ, Goodwim GM et al. Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 1996; 347: 731-733.
43. Binder DA. On the variances of asymptotically normal estimators from complex surveys. Int Statist Rev 1983; 51: 279-292.
44. Brick JM, Kalton G. Handling missing data in survey research. Statist Methods Med Res 1996; 5: 215-238.
45. Rabbitt P, Diggle P, Holland F, Mclnnes L. Practice and drop-out effects during a 17-year longitudinal study of cognitive aging. J Gerontol B Psychol Sci Soc Sci 2004; 59: P84-P97.
46. Arivazhagan P, Panneerselvam C. Neurochemical changes related to ageing in the rat brain and the effect of DL-alpha-lipoic acid. Exp Gerontol 2002; 37: 1489-1494.
47. Mortensen OV, Thomassen M, Larsen MB, Whittemore SR, Wiborg O. Functional analysis of a novel human serotonin transporter gene promoter in immortalized raphe cells. Brain Res Mol Brain Res 1999; 68: 141-148.
48. Vandenberghe R. Language, ageing and neurodegenerative disease. Bull Mem Acad R Med Belg 2004; 159: 161-166.
49. Subbarao KV, Richardson JS, Ang LC. Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro. J Neurochem 1990; 55: 342-345.
50. Harmer CJ, Bhagwagar Z, Perrett DI, Vollm BA, Cowen PJ, Goodwin GM. Acute SSRI administration affects the processing of social cues in healthy volunteers. Neuropsychopharmacology 2003; 28: 148-152.
51. Siepmann M, Handel J, Mueck-Weymann M, Kirch W. The effects of moclobemide on autonomic and cognitive functions in healthy volunteers. Pharmacopsychiatry 2004; 37: 81-87.
52. Roth BL, Hanizavareh SM, Blum AE. Serotonin receptors represent highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders. Psychopharmacology 2004; 174: 17-24.
53. Bertram L, Tanzi RE. Alzheimer's disease: one disorder, too many genes? Hum Mol Genet 2004; 13: R135-R141.
54. Plomin R, McGuffin P. Psychopathology in the postgenomic era. Annu Rev Psychol 2003; 54: 205-228.