HIV-1 tropism for the central nervous system: Brain-derived envelope glycoproteins with lower CD4 dependence and reduced sensitivity to a fusion inhibitor

Virology

Volumn 346, Issue 1, 2006, Pages 169-179

  Martín García, Julio ^a,b   Cao, Wei ^a   Varela Rohena, Angel ^a   Plassmeyer, Matthew L ^a   González Scarano, Francisco ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Brain; CCR5; CD4; Cell to cell fusion; Fusion inhibitor; gp120; gp41; HIV entry; Microglia

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 41; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; T 1249;

AMINO ACID SEQUENCE; ARTICLE; BRAIN; CELL FUSION; CENTRAL NERVOUS SYSTEM; DRUG BINDING; DRUG SENSITIVITY; GENE FUSION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IN VIVO STUDY; NEUROLOGIC DISEASE; NUCLEOTIDE SEQUENCE; PHENOTYPE; PHYLOGENY; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SPLEEN;

AIDS DEMENTIA COMPLEX; AMINO ACID SEQUENCE; ANTIGENS, CD4; BRAIN; DRUG RESISTANCE, VIRAL; HIV ENVELOPE PROTEIN GP120; HIV ENVELOPE PROTEIN GP41; HIV FUSION INHIBITORS; HIV INFECTIONS; HIV-1; HUMANS; MEMBRANE FUSION; MOLECULAR SEQUENCE DATA; RECEPTORS, HIV; SPLEEN;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 32844457281     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.virol.2005.10.031     Document Type: Article

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