Cellular localization of the chemokine receptor CCR5: Correlation to cellular targets of HIV-1 infection

American Journal of Pathology

Volumn 151, Issue 5, 1997, Pages 1341-1351

  Rottman, James B ^a   Ganley, Kenneth P ^a   Williams, Kenneth ^b   Wu, Lijun ^a   Mackay, Charles R ^a   Ringler, Douglas J ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR;

ANTIBODY SPECIFICITY; ARTICLE; ASTROCYTE; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOREACTIVITY; LEUKOCYTE MIGRATION; MICROGLIA; PRIORITY JOURNAL; RECEPTOR UPREGULATION; T LYMPHOCYTE ACTIVATION; TARGET CELL; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOOD CELLS; BRAIN; HIPPOCAMPUS; HIV INFECTIONS; HIV-1; HUMANS; LEUKOCYTES; LYMPH NODES; MACACA; NEUROGLIA; NEURONS; RECEPTORS, CCR5; SPLEEN; THYMUS GLAND; TISSUE DISTRIBUTION;

EID: 0030698047     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Springer TA: Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994, 76:301-314
2. Furie MB, Randolph GJ: Chemokines and tissue injury. Am J Pathol 1995, 146:1287-1301
3. Baggiolini M, Dewald B, Moser B: Interleukin-8 and related chemotactic cytokines: C-X-C and C-C chemokines. Adv Immunol 1994, 55:97-179
4. Schall TJ, Bacon KB: Chemokines, leukocyte trafficking, and inflammation. Curr Opin Immunol 1994, 6:865-673
5. Horuk R: Molecular properties of the chemokine receptor family. Trends Pharmacol Sci 1994, 15:159-165
6. Raport CJ, Gosling J, Schweickart VL, Gray PW, Charo IF: Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1β, and MIP-1α. J Biol Chem 1996, 271:17161-17166
7. Combadiere C, Ahuja SK, Tiffany HL, Murphy PM: Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(α), MIP-1(β), and RANTES. J Leukocyte Biol 1996, 60:147-152
8. + T cells. Science 1995, 270:1811-1815
9. Alkhatib G, Combadiere C, Broder CC, Feng Y, Kennedy PE, Murphy PM, Berger EA: CC CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 1996, 272:1955-1958
10. Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, Di Marzio P, Marmon S, Sutton RE, Hill CM, Davis CB, Peiper SC, Schall TJ, Littman DR, Landau NR: Identification of a major co-receptor for primary isolates of HIV-1. Nature 1996, 381:661-666
11. + cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996, 381:667-673
12. Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J: The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 1996, 85:1135-48
13. Feng Y, Broder CC, Kennedy PE, Berger EA: HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 1996, 272:872-877
14. Zhu T, Mo H, Wang N, Nam DS, Cao Y, Koup RA, Ho DD: Genotypic and phenotypic characterization of HIV-1 patients with primary infection. Science 1993, 261:1179-1181
15. Liu R, Paxton WA, Choe S, Ceradini D, Martin SR, Horuk R, MacDonald ME, Stuhlmann H, Koup RA, Landau NR: Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996, 86:367-377
16. Marcon L, Choe H, Martin K, Farzan M, Ponath P, Wu L, Newman W, Gerard N, Gerard C, Sodroski J: Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239. J Virol 1997, 71:2522-2527
17. Edinger A, Amedee A, Miller K, Doranz B, Endres M, Sharron M, Samson M, Lu Z, Clements J, Murphey-Corb M, Peiper S, Parmentier M, Broder C, Doms R: Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains. Proc Natl Acad Sci USA 1997, 94:4005-4010
18. Chen Z, Zhou P, Ho D, Landau N, Pa M: Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry. J Virol 1997, 71:2705-2714
19. Samson M, Labbe O, Mollereau C, Vassart G, Parmentier M: Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry 1996, 35:3362-3367
20. Wu L, Paxton W, Kassam N, Ruffing N, Rottman J, Sullivan N, Choe H, Sodroski J, Newman W, Koup R, Mackay C: CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro. J Exp Med 1997, 185:1-11
21. Williams KC, Dooley NP, Ulvestad E, Waage A, Blain M, Yong VW, Antel JP: Antigen presentation by human fetal astrocytes with the cooperative effect of microglia or the microglial-derived cytokine IL-1. J Neurosci 1995, 15:1869-1878
22. Rand M, Warren J, Mansour M, Newman W, Ringler D: Inhibition of T cell recruitment and cutaneous delayed-type hypersensitivity-induced inflammation with antibodies to monocyte chemoattractant protein-1. Am J Pathol 1996, 148:855-864
23. Shezen E, Okon E, Ben Hur H, Abramsky O: Cytokeratin expression in human thymus: immunohistochemical mapping. Cell Tissue Res 1995, 279:221-231
24. Chesbro B, Buller R, Protis J, Wehrly K: Failure of human immunodeficiency virus entry and infection in CD4-positive human brain and skin cells. J Virol 1990, 64:215-221
25. Dalgleish A, Beverly P, Clapham P, Crawford D, Greaves M, Ra W: The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 1984, 312:763-767
26. Fauci A, Macher A, Longo D, Lane H, Rook A, Masur H, Gelmann E: Acquired immunodeficiency syndrome: epidemiologic, clinical, immunologic, and therapeutic considerations. Ann Int Med 1984, 100:92-106
27. Gartner S, Markovits P, Markovitz D, Kaplan M, Gallo R, Papovic M: The role of mononuclear phagocytes in HTLV-III/LAV infection. Science 1986, 233:215-219
28. Koenig S, Gendelman H, Orenstein J, DalCanto M, Pezeshkpour G, Yungbluth M, Janotta F, Aksamit A, Martin M, Fauci A: Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 1986, 233:1089-1092
29. Fox C, Tenner-Racz P, Firpo A, Pizzo P, Fauci A: Lymphoid germinal centers are reservoirs of human immunodeficiency virus type 1 RNA. J Infect Dis 1991, 164:1051-1057
30. Reimann KA, Tenner Racz K, Racz P, Montefiori DC, Yasutomi Y, Lin W, Ransil BJ, Letvin NL: Immunopathogenic events in acute infection of rhesus monkeys with simian immunodeficiency virus of macaques. J Virol 1994, 68:2362-2370
31. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M: Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995, 373:123-126
32. Perelson AS, Neumann AU, Markowitz M, Leonard JM, Ho DD: HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 1996, 271:1582-1586
33. Vazeux R, Brousse N, Jarry A, Henin D, Marche C, Vedrenne C, Mikol J, Wolff M, Michon C, Rozenbaum W: AIDS subacute encephalitis: identification of HIV-infected cells. Am J Pathol 1987, 126:403-410
34. Wiley C, Belman A, Dickson D, Rubinstein A, Nelson J: Human immunodeficiency virus within the brains of children with AIDS. Clin Neuropathol 1990, 9:1-6
35. Bhat S, Spitalnik S, Gonzalez-Scarano F, Silberberg D: Galactosyl ceramide or a derivative is an essential component of the neural receptor for human immunodeficiency virus type 1 envelope glycoprotein gp120. Proc Natl Acad Sci USA 1991, 88:7131-7134
36. Takahashi K, Wesselingh SL, Griffin DE, McArthur JC, Johnson RT, Glass JD: Localization of HIV-1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry. Ann Neurol 1996, 39:705-711
37. Horuk R, Martin A, Wang Z, Schweitzer L, Gerassimides A, Guo H, Lu Z, Hesselgesser J, Perez H, Kim J, Parker J, Hadley T, Peiper S: Expression of chemokine receptors by subsets of neurons in the central nervous system. J Immunol 1997, 158:2882-2890
38. Horuk R, Martin A, Hesselgesser J, Hadley T, Lu ZH, Wang ZX, Peiper SC: The Duffy antigen receptor for chemokines: structural analysis and expression in the brain. J Leukocyte Biol 1996, 59:29-38
39. Meyer A, Coyle AJ, Proudfoot AE, Wells TN, Power CA: Cloning and characterization of a novel murine macrophage inflammatory protein-1α receptor. J Biol Chem 1996, 271:14445-14451
40. Van Meir E, Ceska M, Effenberger F, Walz A, Grouzmann E, Desbaillets I, Frei K, Fontana A, de Tribolet N: Interleukin-8 is produced in neoplastic and infectious diseases of the human central nervous system. Cancer Res 1992, 52:4297-4305
41. Koch A, Polverini P, Kunkel S, Harlow L, DiPietro L, Einer V, Einer S, Strieter R: Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 1992, 258:1798-1801
42. Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH, Tosato G: Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med 1995, 182:155-162
43. Parmentier H, van Wichen D, Meyling F, Goudsmit J, Schuurman H: Epitopes of human immunodeficiency virus regulatory proteins tat, nef, and rev are expressed in normal tissue. Am J Pathol 1992, 141:1209-1216
44. Moses AV, Nelson JA: HIV infection of human brain capillary endothelial cells: implications for AIDS dementia. Adv Neuroimmunol 1994, 4:239-247
45. Conaldi PG, Serra C, Dolei A, Basolo F, Falcone V, Mariani G, Speziale P, Toniolo A: Productive HIV-1 infection of human vascular endothelial cells requires cell proliferation and is stimulated by combined treatment with interleukin-1β plus tumor necrosis factor-α. J Med Virol 1995, 47:355-363
46. Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo J, Newman W, Gutierrez-Ramos J, Mackay CR: Cloning of the human eosinophil chemoattractant, eotaxin. J Clin Invest 1996, 3:604-612
47. Becker S, Quay J, Koren HS, Haskill JS: Constitutive and stimulated MCP-1, GRO α, β, and γ expression in human airway epithelium and bronchoalveolar macrophages. Am J Physiol 1994, 266:L278-L286
48. Berkman N, Robichaud A, Krishnan VL, Roesems G, Robbins R, Jose PJ, Barnes PJ, Chung KF: Expression of RANTES in human airway epithelial cells: effect of corticosteroids and interleukin-4, -10 and -13. Immunology 1996, 87:599-603
49. Nelson J, Wiley C, Reynolds-Kohler C, Reese C, Margaretten W, Levy J: Human immunodeficiency virus detected in bowel epithelium from patients with gastrointestinal symptoms. Lancet 1988, 1:259-262
50. Adachi A, Koenig S, Gendelman H, Daugherty D, Gattoni-Celli S, Fauci A, Martin M: Productive, persistent infection of human colorectal cell lines with human immunodeficiency virus. J Virol 1987, 61:209-213
51. + T-helper cells. Am J Pathol 1992, 140:15-22
52. Tenner-Racz K, Racz P, Bofill M, Schulz-Meyer A, Dietrich M, Kern P, Weber J, Pinching A, Veronese-Dimarzo F, Popovic M, Klatzman D, Gluckman J, Janossy G: LAV viral antigens in lymph nodes of homosexual men with persistent generalized lymphadenopathy. Am J Pathol 1986, 125:436-442
53. Armstrong J, Home R: Follicular dendritic cells and virus-like particles in AIDS and AIDS-related lymphadenopathy. Lancet 1984, 2:370-372
54. Cameron PU, Lowe MG, Sotzik F, Coughlan AF, Crowe SM, Shortman K: The interaction of macrophage and non-macrophage tropic isolates of HIV-1 with thymic and tonsillar dendritic cells in vitro. J Exp Med 1996, 183:1851-1856
55. Ayehunie S, Groves RW, Bruzzese AM, Ruprecht RM, Kupper TS, Langhoff E: Acutely infected Langerhans cells are more efficient than T cells in disseminating HIV type 1 to activated T cells following a short cell-cell contact. AIDS Res Hum Retroviruses 1995, 11:877-884
56. Maher D, Hoffman I: Prevalence of genital infections in medical in patients in Blantyre, Malawi. J Infect 1995, 31:77-78
57. Laga M, Manoka A, Kivuvu M, Malele B, Tuliza M, Nzila N, Goeman J, Behets F, Batter V, Alary M: Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: results from a cohort study. AIDS 1993, 7:95-102
58. Craib KJ, Meddings DR, Strathdee SA, Hogg RS, Montaner JS, O'Shaughnessy MV, Schechter MT: Rectal gonorrhoea as an independent risk factor for HIV infection in a cohort of homosexual men. Genitourin Med 1995, 71:150-154