Early entry and widespread cellular involvement of HIV-1 DNA in brains of HIV-1 positive asymptomatic individuals

Journal of Neuropathology and Experimental Neurology

Volumn 58, Issue 11, 1999, Pages 1156-1162

  An, Shu F ^a   Groves, Michael ^a   Gray, Françoise ^b   Scaravilli, Francesco ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b RAYMOND POINCARÉ HOSPITAL   (France)

Author keywords

Asymptomatic individuals; Cellular localization; CNS; HIV 1 DNA; Polymerase chain reaction in situ

Indexed keywords

CYTOKINE; VIRUS DNA;

ARTICLE; ASTROCYTE; BRAIN; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MICROGLIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0032708190     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199911000-00005     Document Type: Article

References (40)

1. Bredesen DE, Messing R. Neurological syndromes heralding the acquired immunodeficiency syndrome. Ann Neurol 1983;14:141
2. Gisslen M, Hagberg L, Norkrans G, Lekman A, Fredman P. Increased cerebrospinal fluid ganglioside GM1 concentrations indicating neuronal involvement in all stages of HIV-1 infection. J Neurovirol 1997;3:148-52
3. Silva AA, Camara V, Quirico Santos T. Intrathecal reactivity for myelin components precedes development of neurological symptoms in AIDS patients. Arch Med Res 1997;28:391-96
4. Wilkinson ID, Miller RF, Miszkiel KA, et al. Cerebral proton magnetic resonance spectroscopy in asymptomatic HIV infection. AIDS 1997;11:289-95
5. Stout JC, Ellis RJ, Jernigan TL, et al. Progressive cerebral volume loss in human immunodeficiency virus infection: A longitudinal volumetric magnetic resonance imaging study. HIV Neurobehavioral Research Center Group. Arch Neurol 1998;55:161-68
6. An SF, Giometto B, Scaravilli F. HIV-1 DNA in brains in AIDS and pre-AIDS: Correlation with the stage of disease. Ann Neurol 1996;40:611-17
7. An SF, Ciardi A, Giometto B, Scaravilli T, Gray F, Scaravilli F. Investigation on the expression of major histocompatibility complex class II and cytokines and detection of HIV-1 DNA within brains of asymptomatic and symptomatic HIV-1-positive patients. Acta Neuropathol Berl 1996;91:494-503
8. An SF, Giometto B, Scaravilli T, Tavolato B, Gray F, Scaravilli F. Programmed cell death in brains of HIV-1-positive AIDS and pre-AIDS patients. Acta Neuropathol Berl 1996;91:169-73
9. An SF, Giometto B, Groves M, Miller RF, et al. Axonal damage revealed by accumulation of beta-APP in HIV-positive individuals without AIDS. J Neuropathol Exp Neurol 1997;56:1262-68
10. An SF, Groves M, Giometto B, Beckett AAJ, Scaravilli F. Detection and localisation of HIV-1 DNA and RNA in fixed adult AIDS brain by polymerase chain reaction-in situ technique. Acta Neuropathologica Berl 1999;98:481-87
11. Sharer LR, Saito Y, Epstein LG, Blumberg BM. Detection of HIV-1 DNA in pediatric AIDS brain tissue by two-step ISPCR. Adv Neuroimmunol 1994;4:283-85
12. Long AA, Komminoth P, Lee E, Wolfe HJ. Comparison of indirect in-situ polymerase chain reaction in cell preparation and tissue sections. Detection of viral DNA, gene rearrangements and chromosomal translocations. Histochemistry 1993;99:151-62
13. Walker F, Bedel C, Boucher O, Dauge MC, Vissuzaine C, Potet F. In situ gene amplification on tissue section (in situ PCR). A new technique for pathologists. Ann Pathol 1995;15:459-65
14. Davis LE, Hjelle BL, Miller VE, et al. Early viral brain invasion in iatrogenic human immunodeficiency virus infection. Neurology 1992;42:1736-39
15. Sinclair E, Gray F, Scaravilli F. PCR detection of HIV proviral DNA in the brain of an asymptomatic HIV-positive patient. J Neurol 1992;239:469-70
16. Gray F, Hurtrel M, Hurtrel B. Early central nervous system changes in human immunodeficiency virus (HIV)-infection. Neuropathol Appl Neurobiol 1993;19:3-9
17. Williams KC, Hickey WF. Traffic of lymphocytes into the CNS during inflammation and HIV infection. J Neuro AIDS 1996;1: 31-55
18. Nottet HS, Persidsky Y, Sasseville VG, et al. Mechanisms for the transendothelial migration of HIV-1 infected monocytes into brain. J Immunol 1996;156:1284-95
19. Persidsky Y, Stins M, Way D, et al. A model for monocyte migration through the blood-brain barrier during HTV-1 encephalitis. J Immunol 1997;158:3499-510
20. Vazeux R, Brousse N, Jarry A, et al. AIDS subacute encephalitis. Am J Pathol 1987;126:403-10
21. Wiley CA, Shrier RD, Nelson JA, Lampert PW, Oldstone MB. Cellular localisation of human immune deficieny virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sci USA 1986;83:7089-93
22. Bagasra O, Lavi E, Bobroski L, et al. Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: Identification by the combination of in situ polymerase chain reaction and immunohistochemistry. AIDS 1996;10:573-85
23. Moses AV, Bloom FE, Pauza CD and Nelson JA. Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism. Proc Natl Acad Sci USA 1993;90:10474-8
24. Shapshak P, Nagano I, Xin K, et al. HIV-1 heterogeneity and cytokines. Neuropathogenesis. Adv Exp Med Biol 1995;373:225-38
25. Smith TW, DeGirolami U, Hénin D, Bolgert F, Hauw JJ. Human immunodeficiency virus (HIV) leukoencephalopathy and the microcirculation. J Neuropathol Exp Neurol 1990;49:357-70
26. Moses AV and Nelson JA. HIV infection of human brain capillary endothelial cells: Implications for AIDS dementia. Adv Neuroimmunol 1994;4:239-47
27. Tornatore C, Chandra R, Berger JR, Major EO. HIV-1 infection of subcortical astrocytes in the pediatric central nervous system. Neurology 1994;44:481-87
28. Saito Y, Sharer LR, Epstein LG, et al. Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues. Neurology 1994;44:474-81
29. Neumann M, Felberg BK, Kleinshmidt A, et al. Restriction of human immunodeficiency virus type 1 production in a human astrocytoma cell line is associated with a cellular block in Rev function. J Virol 1995;69:2159-67
30. Nath A, Hartloper VH, Furer M, Fowke KR. Infection of human fetal cells with HIV-1: Viral tropism and the role of cell to cell contact in viral transmission. J Neuropathol Exp Neurol 1995;54: 320-30
31. Brack-Werner R. Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis. AIDS 1999;13:1-22
32. Merrill JI and Benveniste EN. Cytokines in inflammatory brain lesions: Helpful and harmful. TINS 1996;19:331-38
33. Aloisi F, Ceccherini-Silberstein F, Levi G. Cytokines and growth factor synthesis in human astrocytes. In: Jeserich G, Althaus HH, Richter-Landsberg C, Heumann R eds Molecular signalling and regulation in glial cells: A key to remyelination and functional repair. Berlin: Springer-Verlag, 1997:11-19
34. Tornatore C, Nath A, Amemiya K, Mayor EO. Persistent human immunodeficiency virus type 1 infection in human fetal glial cells reactivated by T-cell factor(s) or by the cytokines tumor necrosis factor-alpha and interleukin-1-beta. J Virol 1995;65:6094-100
35. Lokensgard JR, Gekker G, Ehrlick LK, Hu S, Chao CC, Peterson PK. Proinflammatory cytokines inhibit HIV-1 (SF162) expression in acutely infected human brain cell cultures. J Immunol 1997;158: 2449-55
36. Fiala M, Rhodes RH, Shapshak P, et al. Regulation of HIV-1 infection in astrocytes: Expression of nef, TNF-alpha and IL-6 is enhanced in co-culture of astrocytes with macrophages. J Neurovirol 1996;2:158-66
37. Nuovo GJ, Gallery F, MacConnell P, Braun A. In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids and tumor necrosis factor-alpha RNA in the central nervous system. Am J Pathol 1994;144:659-66
38. Takahashi K, Wesselingh SL, Griffin DE, McArthur JC, Johnson RT, Glass JD. Localization of HIV-1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry. Ann Neurol 1996;39:705-11
39. Brew BJ, Rosenblum M, Cronin K, Price RW. AIDS dementia complex and HIV-1 brain infection: Clinical-virological correlation. Ann Neurol 1995;38:563-70
40. Johnson RT, Glass JD, McArthur JC, Chesebro BW. Quantitation of human immunodeficiency virus in brains of demented and non-demented patients with acquired immunodeficiency syndrome. Ann Neurol 1996;39:392-95