Incorporation of [3H]valproic acid into lipids in GT1-7 neurons

Biochemical Pharmacology

Volumn 56, Issue 2, 1998, Pages 207-212

  Siafaka Kapadai, Athanassia ^b   Patiris, Marinis ^b   Bowden, Charles ^a   Javors, Martin ^a,c  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITY OF ATHENS   (Greece)

^c NONE   (United States)

Author keywords

Epilepsy; GT1 7; Hypothalamus; Lipid; Mania; Neuron; Phospholipid; Valproic acid

Indexed keywords

LIPID; PHOSPHOLIPID; VALPROIC ACID; ANTICONVULSIVE AGENT; TRITIUM;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; HYPOTHALAMUS; MOUSE; NERVE CELL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; CELL LINE; METABOLISM; NERVE CELL; THIN LAYER CHROMATOGRAPHY;

ANTICONVULSANTS; CELL LINE, TRANSFORMED; CHROMATOGRAPHY, THIN LAYER; NEURONS; PHOSPHOLIPIDS; TRITIUM; VALPROIC ACID;

EID: 0031596233     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00148-8     Document Type: Article

References (30)

1. Chapman A, Keane PE, Meldrum BS, Simiand J and Vernieres JC, Mechanism of anticonvulsant action of valproate. Prog Neurobiol 19: 315-359, 1982.
2. Bowden CL, Brugger AM, Swann AC, Calabrese JR, Janicak PG, Petty R, Dilsaver SC, Davis JM, Rush AJ, Small JG, Garza-Trevino ES, Risch SC, Goodnick PJ and Morris DD, Efficacy of divalproex vs lithium and placebo in the treatment of mania. JAMA 271: 918-924, 1994.
3. Loscher W, Effects of the antiepileptic drug valproate on metabolism and function of inhibitory and excitatory amino acids in the brain. Neurochem Res 18: 485-502, 1993.
4. Javors MA and Erwin VG, Effects of benzodiazepines and valproic acid on brain aldehyde reductase and a proposed mechanism of anticonvulsant action. Biochem Pharmacol 29: 1703-1708, 1980.
5. Chen G, Manji HK, Hawver DB, Wright CB and Potter WZ, Chronic sodium valproate selectively decreases protein kinase C α and ε in vitro. J Neurochem 63: 2361-2364, 1994.
6. Petty F, Rush AJ, Davis JM, Calabrese JR, Small JG, Swann AC, Kramer GL, Orsulak PJ, Blake M and Bowden CL, Plasma GABA predicts acute response to divalproex in mania. Biol Psychiatry 39: 278-284, 1996.
7. Bolaños JP and Medina JM, Effect of valproate on lipogenesis in neonatal rat brain. Biochem Pharmacol 45: 1283-1288, 1993.
8. Dellantonio R, Guratola G, Angeleri F, Paladini D, Recchioni MA, Sirocchi G, Angeleri VA and Giannini L, Effect of valproic acid on fluidity of brain mitochondrial membranes. Adv Epileptol 17: 101-104, 1989.
9. Brown NA, Clarke DO and McCarthy A, Adaptation of postimplantation embryos to culture: Membrane lipid synthesis and response to valproate. Reprod Toxicol 5: 245-253, 1991.
10. Binaglia L, Effect of pyridoxal-5′-phosphate and valproic acid on phospholipid synthesis in neuroblastoma NA. Biochem Pharmacol 38: 3407-3413, 1989.
11. Bellringer ME, Rahman K and Coleman R, Sodium valproate inhibits the movement of secretory vesicles in rat hepatocytes. Biochem J 249: 513-519, 1988.
12. Mellon PL, Windle JJ, Goldsmith PC, Padula CA, Roberts JL and Weiner RI, Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron 5: 1-10, 1990.
13. Mellon PL, Windle JJ and Weiner RI, Immortalization of neuroendocrine cells by targeted oncogenesis. Recent Prog Horm Res 47: 69-93, 1991.
14. Mellon PL, Wetzel WC, Windle JJ, Valenca MM, Goldsmith PC, Whyte DB, Eraly SA, Negro-Vilar A and Weiner RI, Immortalized hypothalamic gonadotropin-releasing hormone neurons. Ciba Found Symp 168: 104-126, 1992.
15. Krsmanovic LZ, Stojilkovic SS, Balla T, al-Damluji S, Weiner RI and Catt KJ, Receptors and neurosecretory actions of endothelin in hypothalamic neurons. Proc Natl Acad Sci USA 88: 11124-11128, 1991.
16. Milenković L, D'Angelo G, Kelly PA and Weiner RI, Inhibition of gonadotropin hormone-releasing hormone release by prolactin from GT1 neuronal cell lines through prolactin receptors. Proc Natl Acad Sci USA 91: 1244-1247, 1994.
17. 1)-receptors coupled to adenylyl cyclase activation in GT1 gonadotropin-releasing hormone neurosecretory cells. Endocrinology 132: 682-688, 1993.
18. Hales TG, Kim H, Longoni B, Olsen RW and Tobin AJ, Immortalized hypothalamic GT1-7 neurons express functional GABA type A receptors. Mol Pharmacol 42: 197-202, 1992.
19. Hales TG, Sanderson MJ and Charles AC, GABA has excitatory actions on GnRH-secreting immortalized hypothalamic (GT1-7) neurons. Neuroendocrinology 59: 297-308, 1994.
20. 2A-adrenergic receptors in GT1 neurosecretory cells. Neuroendocrinology 62: 215-225, 1995.
21. Bligh EG and Dyer WJ, A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37: 911-917, 1959.
22. Siafaka-Kapadai A and Hanahan DJ, An endogenous inhibitor of PAF-induced platelet aggregation isolated from rat liver has been identified as free fatty acid. Biochim Biophys Acta 1166: 217-221, 1993.
23. 2+ mobilization in human platelets: Is oleic acid an intracellular messenger? J Lipid Mediat Cell Signal 15: 215-232, 1997.
24. 2+/ ascorbate/EDTA-induced lipid peroxidation. Biochim Biophys Acta 1166: 264-274, 1993.
25. Aly MI and Abdel-Latif AA, Studies of distribution and metabolism of valproate in rat brain, liver, and kidney. Neurochem Res 5: 1231-1242, 1980.
26. Becker C-M and Harris RA, Influence of valproic acid on hepatic carbohydrate and lipid metabolism. Arch Biochem Biophys 223: 381-392, 1983.
27. Aas M, Organ and subcellular distribution of fatty acid activating enzymes in the rat. Biochim Biophys Acta 231: 32-47, 1971.
28. Koltai M, Hosford D, Guinot P, Esanu A and Braquet P, Platelet activating factor (PAF): A review of its effects, antagonists, and possible future clinical implications. Drugs 42: 9-29, 1991.
29. Koumanov KS, Momchilova-Pankova AB, Markovska TT, Quinn PJ and Wolf C, Phospholipids with a short acyl-chain modulate phospholipase and acyltransferase activities. J Lipid Mediat Cell Signal 12: 59-76, 1995.
30. Bolaños JP and Medina JM, Effect of valproate on the metabolism of the central nervous system. Life Sci 60: 1933-1942, 1997.