The intestinal peptide carrier: A potential transport system for small peptide derived drugs

Advanced Drug Delivery Reviews

Volumn 20, Issue 1, 1996, Pages 33-58

  Walter, Elke ^a   Kissel, Thomas ^b   Amidon, Gordon L ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

ACE inhibitors; Basolateral membrane; Brush border membrane; Carrier mediated transport; Di tripeptide; Intestinal peptide transporter; Oral availability; Prodrug; Lactam antibiotics

Indexed keywords

ABSORPTION; AMINO ACIDS; BIOLOGICAL MEMBRANES; CONTROLLED DRUG DELIVERY; DRUG PRODUCTS; DRUG THERAPY; ENZYME INHIBITION; TISSUE; TRANSPORT PROPERTIES;

INTESTINAL PEPTIDE CARRIER; LIPOPHILIC INTESTINAL MEMBRANE; MUTUAL INHIBITION; PEPTIDE DERIVED DRUGS; PEPTIDE DRUG ABSORPTION; SMALL INTESTINE;

POLYPEPTIDES;

AMINO ACID; AMPICILLIN; BETA LACTAM ANTIBIOTIC; CAPTOPRIL; CARRIER PROTEIN; CEFACLOR; CEFADROXIL; CEFALEXIN; CEFALOTIN; CEFDINIR; CEFOXITIN; CEFRADINE; CEFTIBUTEN; CEPHALOSPORIN DERIVATIVE; DIPEPTIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; ENALAPRILAT; GLYCYLPROLINE; LATAMOXEF; LORACARBEF; PENICILLIN DERIVATIVE; PEPTIDE DERIVATIVE; PHENYLALANYLALANYLPROLINE; PIVAMPICILLIN; PRODRUG; PROTON; TRIPEPTIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACTIVE TRANSPORT; BASOLATERAL MEMBRANE; COMPETITIVE INHIBITION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG TRANSPORT; ENZYME SPECIFICITY; GASTROINTESTINAL TRACT; HUMAN; INTESTINE ABSORPTION; MEMBRANE TRANSPORT; MOLECULAR CLONING; NONHUMAN; NUTRIENT; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; TISSUE DISTRIBUTION;

EID: 0030581089     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0169-409X(95)00129-U     Document Type: Review

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