Effect of altered gastric emptying and gastrointestinal motility on metformin absorption

British Journal of Clinical Pharmacology

Volumn 50, Issue 4, 2000, Pages 325-332

  Marathe, Punit H ^a,b   Wen, Yandong ^a,b   Norton, Jean ^a,b   Greene, Douglas S ^a,b   Barbhaiya, Rashmi H ^a,b   Wilding, Ian R ^c  

^a Department of Metabolism and Pharmacokinetics ^*  (United Kingdom)

^b BRISTOL MYERS SQUIBB   (United States)

^c PHARMACEUTICAL PROFILES LTD   (United Kingdom)

Author keywords

Absorption; Gamma scintigraphy; Gastrointestinal motility; Metformin

Indexed keywords

METFORMIN; METOCLOPRAMIDE; PENTETATE TECHNETIUM TC 99M; PROPANTHELINE BROMIDE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG DOSAGE FORM; DRUG SAFETY; DRUG TOLERANCE; FEMALE; GAMMA SCINTIGRAPHY; GASTROINTESTINAL MOTILITY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; INTESTINE TRANSIT TIME; ISOTOPE LABELING; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH EMPTYING;

ADULT; CROSS-OVER STUDIES; DOPAMINE AGONISTS; DRUG INTERACTIONS; FEMALE; GASTRIC EMPTYING; GASTROINTESTINAL MOTILITY; HUMANS; HYPOGLYCEMIC AGENTS; INTESTINAL ABSORPTION; MALE; METFORMIN; METOCLOPRAMIDE; MUSCARINIC ANTAGONISTS; PROPANTHELINE;

EID: 0033775109     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2000.00264.x     Document Type: Article

References (15)

1. Metformin kinetics in healthy subjects and patients with diabetes mellitus
2. Clinical pharmacokinetics of metformin
3. Pharmacokinetic drug interactions with gastrointestinal motility modifying agents
4. Influence of propantheline and metoclopramide on the bioavailability of chlorothiazide
5. Metoclopramide. A review of its pharmacological properties and clinical use
6. Effect of metoclopramide and loperamide on the pharmacokinetics of didanosine in HIV seropositive male and female patients
7. Pharmacokinetic interactions of cefprozil with food, propantheline, metoclopramide, and probenecid in healthy volunteers
8. In vivo evaluation of enteric-coated naproxen tablets using gamma scintigraphy
9. Localization of drug release sites from an oral sustained-release formulation of 5-ASA (Pentasa(®)) in the gastrointestinal tract using gamma scintigraphy
10. Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects
11. Absorption, gastrointestinal transit, and tablet erosion of felodipine extended-release (ER) tablets
12. The importance of gamma scintigraphy in pharmaceutical development
13. An exact confidence interval from untransformed data for the ratio of two treatment means