Genomics and the circulation

British Journal of Anaesthesia

Volumn 93, Issue 1, 2004, Pages 140-148

  Podgoreanu, M V ^a   Schwinn, D A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cardiovascular system,genomics

Indexed keywords

APOLIPOPROTEIN E; CALSEQUESTRIN; CD68 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 2; NITRIC OXIDE SYNTHASE; PHOSPHOLAMBAN; TISSUE INHIBITOR OF METALLOPROTEINASE;

ATHEROGENESIS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR FUNCTION; DNA POLYMORPHISM; DNA SEQUENCE; FAMILIAL HYPERCHOLESTEROLEMIA; GENE EXPRESSION PROFILING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENETICS; GENOMICS; GENOTYPE ENVIRONMENT INTERACTION; HEART FAILURE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; LINKAGE ANALYSIS; LONG QT SYNDROME; PRIORITY JOURNAL; REVIEW;

EID: 3242749829     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/aeh168     Document Type: Article

References (119)

1. Abbott A. A post-genomic challenge: learning to read patterns of protein synthesis. Nature 1999; 402: 715-20
2. Adams LD, Geary RL, McManus B, Schwartz SM. A comparison of aorta and vena cava medial message expression by cDNA array analysis identifies a set of 68 consistently differentially expressed genes, all in aortic media. Circ Res 2000; 87: 623-31
3. Agema WR, Jukema JW, Pimstone SN, Kastelein JJ. Genetic aspects of restenosis after percutaneous coronary interventions: towards more tailored therapy. Eur Heart J 2001; 22: 2058-74
4. Archacki SR, Angheloiu G, Tian XL, et al. Identification of new genes differentially expressed in coronary artery disease by expression profiling. Physiol Genomics 2003; 15: 65-74
5. Aronow BJ, Toyokawa T, Canning A, et al. Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy. Physiol Genomics 2001; 6: 19-28
6. Barrans JD, Stamatiou D, Liew C. Construction of a human cardiovascular cDNA microarray: portrait of the failing heart. Biochem Biophys Res Commun 2001; 280: 964-9
7. Bassingthwaighte JB, Qian H, Li Z. The Cardiome Project. An integrated view of cardiac metabolism and regional mechanical function. Adv Exp Med Biol 1999; 471: 541-53
8. Birukov KG, Jacobson JR, Flores AA, et al. Magnitude-dependent regulation of pulmonary endothelial cell barrier function by cyclic stretch. Am J Physiol Lung Cell Mol Physiol 2003; 285: L785-97
9. Borecki IB, Suarez BK. Linkage and association: basic concepts. In: Rao DC, Province MA, eds. Genetic Dissection of Complex Traits. San Diego: Academic Press, 2001; 45-66
10. Botstein D, Risch N. Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nature Genet 2003; 33 Suppl: 228-37
11. Botstein D, White RL, Skolnick M, Davis RW. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet 1980; 32: 314-31
12. Brand T, Sharma HS, Fleischmann KE, et al. Proto-oncogene expression in porcine myocardium subjected to ischemia and reperfusion. Circ Res 1992; 71: 1351-60
13. Broeckel U, Hengstenberg C, Mayer B, et al. A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nature Genet 2002; 30: 210-14
14. Brull DJ, Montgomery HE, Sanders J, et al. Interleukin-6 gene - 174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery. Arterioscler Thromb Vasc Biol 2001; 21: 1458-63
15. Cardon LR, Bell JI. Association study designs for complex diseases. Nature Rev Genet 2001; 2: 91-9
16. Cardon LR, Palmer LJ. Population stratification and spurious allelic association. Lancet 2003; 361: 598-604
17. Chen BP, Li YS, Zhao Y, et al. DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress. Physiol Genomics 2001; 7: 55-63
18. Chew ST, Newman MF, White WD, et al. Preliminary report on the association of apolipoprotein E polymorphisms, with postoperative peak serum creatinine concentrations in cardiac surgical patients. Anesthesiology 2000; 93: 325-31
19. Chien KR. Genomic circuits and the integrative biology of cardiac diseases. Nature 2000; 407: 227-32
20. Cho RJ, Huang M, Campbell MJ, et al. Transcriptional regulation and function during the human cell cycle. Nature Genet 2001; 27: 48-54
21. Chung TP, Laramie JM, Province M, Cobb JP. Functional genomics of critical illness and injury. Crit Care Med 2002; 30: S51-7
22. Cobb JP, Brownstein BH, Watson MA, et al. Injury in the era of genomics. Shock 2001; 15: 165-70
23. Cohn JN, Ferrari R, Sharpe N. Cardiac remodeling - concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J Am Coll Cardiol 2000; 35: 569-82
24. Collins FS. Positional cloning moves from perditional to traditional. Nature Genet 1995; 9: 347-50
25. Collins FS, Guyer MS, Charkravarti A. Variations on a theme: cataloging human DNA sequence variation. Science 1997; 278: 1580-1
26. Cowley AW, Jr. Genomics and homeostasis. Am J Physiol Regul Integr Comp Physiol 2003; 284: R611-27
27. Daley GQ, Cargill M. The heart SNPs a beat: polymorphisms in candidate genes for cardiovascular disease. Trends Cardiovasc Med 2001; 11: 60-6
28. de Vries CJ, van Achterberg TA, Horrevoets AJ, ten Cate JW, Pannekoek H. Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes. J Biol Chem 2000; 275: 23 939-47
29. de Waard V, van den Berg BM, Veken J, Schultz-Heienbrok R, Pannekoek H, van Zonneveld AJ. Serial analysis of gene expression to assess the endothelial cell response to an atherogenic stimulus. Gene 1999; 226: 1-8
30. Deindl E, Schaper W. Gene expression after short periods of coronary occlusion. Mol Cell Biochem 1998; 186: 43-51
31. Dempsey AA, Dzau VJ, Liew CC. Cardiovascular genomics: estimating the total number of genes expressed in the human cardiovascular system. J Mol Cell Cardiol 2001; 33: 1879-86
32. Dempsey AA, Ton C, Liew CC. A cardiovascular EST repertoire: progress and promise for understanding cardiovascular disease. Mol Med Today 2000; 6: 231-7
33. Depre C, Tomlinson JE, Kudej RK, et al. Gene program for cardiac cell survival induced by transient ischemia in conscious pigs. Proc Natl Acad Sci USA 2001; 98: 9336-41
34. Donahue BS, Gailani D, Higgins MS, Drinkwater DC, George AL, Jr. Factor V Leiden protects against blood loss and transfusion after cardiac surgery. Circulation 2003; 107: 1003-8
35. Faber BC, Cleutjens KB, Niessen RL, et al. Identification of genes potentially involved in rupture of human atherosclerotic plaques. Circ Res 2001; 89: 547-54
36. Feng Y, Yang JH, Huang H, et al. Transcriptional profile of mechanically induced genes in human vascular smooth muscle cells. Circ Res 1999; 85: 1118-23
37. Frass O, Sharma HS, Knoll R, et al. Enhanced gene expression of calcium regulatory proteins in stunned porcine myocardium. Cardiovasc Res 1993; 27: 2037-43
38. Friddle CJ, Koga T, Rubin EM, Bristow J. Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy. Proc Natl Acad Sci USA 2000; 97: 6745-50
39. Garcia-Cardena G, Comander J, Anderson KR, Blackman BR, Gimbrone MA, Jr. Biomechanical activation of vascular endothelium as a determinant of its functional phenotype. Proc Natl Acad Sci USA 2001; 98: 4478-85
40. Ge H, Walhout AJ, Vidal M. Integrating 'omic' information: a bridge between genomics and systems biology. Trends Genet 2003; 19: 551-60
41. Geary RL, Wong JM, Rossini A, Schwartz SM, Adams LD. Expression profiling identifies 147 genes contributing to a unique primate neointimal smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol 2002; 22: 2010-16
42. Goldstein JL, Hobbs HH, Brown MS. Familial hypercholesterolemia. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Bases of Inherited Disease, 8th Edn. New York: McGraw-Hill, 2001; 2863-913
43. Gretarsdottir S, Sveinbjornsdottir S, Jonsson HH, et al. Localization of a susceptibility gene for common forms of stroke to 5q12. Am J Hum Genet 2002; 70: 593-603
44. Heinke MY, Wheeler CH, Yan JX, et al. Changes in myocardial protein expression in pacing-induced canine heart failure. Electrophoresis 1999; 20: 2086-93
45. Hilker M, Langin T, Hake U, et al. Gene expression profiling of human stenotic aorto-coronary bypass grafts by cDNA array analysis. Eur J Cardiothorac Surg 2003; 23: 620-5
46. Hiltunen MO, Tuomisto TT, Niemi M, et al. Changes in gene expression in atherosclerotic plaques analyzed using DNA array. Atherosclerosis 2002; 165: 23-32
47. Hirschhorn JN, Lohmueller K, Byrne E, Hirschhorn K. A comprehensive review of genetic association studies. Genet Med 2002; 4: 45-61
48. Hughes TR, Marton MJ, Jones AR, et al. Functional discovery via a compendium of expression profiles. Cell 2000; 102: 109-26
49. Hughes TR, Shoemaker DD. DNA microarrays for expression profiling. Curr Opin Chem Biol 2001; 5: 21-5
50. Hwang DM, Dempsey AA, Wang RX, et al. A genome-based resource for molecular cardiovascular medicine: toward a compendium of cardiovascular genes. Circulation 1997; 96: 4146-203
51. Hwang JJ, Dzau VJ, Liew CC. Genomics and the pathophysiology of heart failure. Curr Cardiol Rep 2001; 3: 198-207
52. Irish AB, Green FR, Gray DW, Morris PJ. The factor V Leiden (R506Q) mutation and risk of thrombosis in renal transplant recipients. Transplantation 1997; 64: 604-7
53. Jachymova M, Horky K, Bultas J, et al. Association of the Glu298Asp polymorphism in the endothelial nitric oxide synthase gene with essential hypertension resistant to conventional therapy. Biochem Biophys Res Commun 2001; 284: 426-30
54. Jin H, Yang R, Awad TA, et al. Effects of early angiotensin-converting enzyme inhibition on cardiac gene expression after acute myocardial infarction. Circulation 2001; 103: 736-42
55. Johnatty SE, Dyck JR, Michael LH, Olson EN, Abdellatif M. Identification of genes regulated during mechanical load-induced cardiac hypertrophy. J Mol Cell Cardiol 2000; 32: 805-15
56. Kan YW, Dozy AM. Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation. Proc Natl Acad Sci USA 1978; 75: 5631-5
57. Kastrati A, Dirschinger J, Schomig A. Genetic risk factors and restenosis after percutaneous coronary interventions. Herz 2000; 25: 34-46
58. Keating MT, Sanguinetti MC. Molecular and cellular mechanisms of cardiac arrhythmias. Cell 2001; 104: 569-80
59. Knecht M, Regitz-Zagrosek V, Pleissner KP, et al. Characterization of myocardial protein composition in dilated cardiomyopathy by two-dimensional gel electrophoresis. Eur Heart J 1994; 15 Suppl D: 37-44
60. Krenz M, Schwartzbauer G, Robbins J. Global genomic analyses of cardiovascular disease: a potential map or blind alley? In: Van Eyk JE, Dunn MJ, eds. Proteomic and Genomic Analysis of Cardiovascular Disease. Weinheim: Wiley-VCH Verlag, 2003; 27-44
61. Lander ES. The new genomics: global views of biology. Science 1996; 274: 536-9
62. Lander ES, Linton LM, Birren B, et al. Initial sequencing and analysis of the human genome. Nature 2001; 409: 860-921
63. Lasocki S, Iglarz M, Seince PF, et al. Involvement of renin-angiotensin system in pressure-flow relationship: role of angiotensin-converting enzyme gene polymorphism. Anesthesiology 2002; 96: 271-5
64. Lee RT, Yamamoto C, Feng Y, et al. Mechanical strain induces specific changes in the synthesis and organization of proteoglycans by vascular smooth muscle cells. J Biol Chem 2001; 276: 13 847-51
65. Levene AP, Morgan GJ, Davies FE. The use of genetic microarray analysis to classify and predict prognosis in haematological malignancies. Clin Lab Haematol 2003; 25: 209-20
66. Liang P, Pardee AB. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 1992; 257: 967-71
67. Liew CC, Hwang DM, Wang RX, et al. Construction of a human heart cDNA library and identification of cardiovascular based genes (CVBest). Mol Cell Biochem 1997; 172: 81-7
68. Lipardi C, Wei Q, Paterson BM. RNAi as random degradative PCR: siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs. Cell 2001; 107: 297-307
69. Liu T, Lai H, Wu W, Chinn S, Wang PH. Developing a strategy to define the effects of insulin-like growth factor-1 on gene expression profile in cardiomyocytes. Circ Res 2001; 88: 1231-8
70. Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nature Genet 2003; 33: 177-82
71. Lyn D, Liu X, Bennett NA, Emmett NL. Gene expression profile in mouse myocardium after ischemia. Physiol Genomics 2000; 2: 93-100
72. McCaffrey TA, Fu C, Du B, et al. High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis. J Clin Invest 2000; 105: 653-62
73. McCormick SM, Eskin SG, McIntire LV, et al. DNA microarray reveals changes in gene expression of shear stressed human umbilical vein endothelial cells. Proc Natl Acad Sci USA 2001; 98: 8955-60
74. Molkentin JD, Lu JR, Antos CL, et al. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 1998; 93: 215-28
75. Morgan T, Brunner HR. The renin-angiotensin system and the heart: beyond 2000. Heart 1996; 76: 98-103
76. Ohki R, Yamamoto K, Mano H, Lee RT, Ikeda U, Shimada K. Identification of mechanically induced genes in human monocytic cells by DNA microarrays. J Hypertens 2002; 20: 685-91
77. Ortlepp JR, Janssens U, Bleckmann F, et al. A chymase gene variant is associated with atherosclerosis in venous coronary artery bypass grafts. Coron Artery Dis 2001; 12: 493-7
78. Ozaki K, Ohnishi Y, Iida A, et al. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nature Genet 2002; 32: 650-4
79. Pass JM, Zheng Y, Wead WB, et al. PKCepsilon activation induces dichotomous cardiac phenotypes and modulates PKCepsilon-RACK interactions and RACK expression. Am J Physiol Heart Circ Physiol 2001; 280: H946-55
80. Philip I, Plantefeve G, Vuillaumier-Barrot S, et al. G894T polymorphism in the endothelial nitric oxide synthase gene is associated with an enhanced vascular responsiveness to phenylephrine. Circulation 1999; 99: 3096-8
81. Pleissner KP, Sander S, Oswald H, Regitz-Zagrosek V, Fleck E. The construction of the World Wide Web-accessible myocardial two-dimensional gel electrophoresis protein database 'HEART-2DPAGE': a practical approach. Electrophoresis 1996; 17: 1386-92
82. Podgoreanu MV, Booth JV, White WD, et al. Beta adrenergic receptor polymorphisms and risk of adverse events following cardiac surgery. Circulation 2003; 108: IV-434
83. Pola E, Gaetani E, Pola R, et al. Angiotensin-converting enzyme gene polymorphism may influence blood loss in a geriatric population undergoing total hip arthroplasty. J Am Geriatr Soc 2002; 50: 2025-8
84. Pratt RE, Dzau VJ. Genomics and hypertension: concepts, potentials, and opportunities. Hypertension 1999; 33: 238-47
85. Rifon J, Paramo JA, Panizo C, Montes R, Rocha E. The increase of plasminogen activator inhibitor activity is associated with graft occlusion in patients undergoing aorto-coronary bypass surgery. Br J Haematol 1997; 99: 262-7
86. Rinder CS, Mathew JP, Rinder HM, et al. Platelet PIA2 polymorphism and platelet activation are associated with increased troponin I release after cardiopulmonary bypass. Anesthesiology 2002; 97: 1118-22
87. Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science 1996; 273: 1516-17
88. Scheler C, Li XP, Salnikow J, Dunn MJ, Jungblut PR. Comparison of two-dimensional electrophoresis patterns of heat shock protein Hsp27 species in normal and cardiomyopathic hearts. Electrophoresis 1999; 20: 3623-8
89. Schinke M, Riggi L, Butte AJ, Izumo S. Large scale expression profiling in cardiovascular disease using microarrays: prospects and pitfalls. In: Van Eyk JE, Dunn MJ, eds. Proteomic and Genomic Analysis of Cardiovascular Disease. Weinheim: Wiley-VCH Verlag, 2003; 324
90. Schwartz SM, Duffy JY, Pearl JM, Nelson DP. Cellular and molecular aspects of myocardial dysfunction. Crit Care Med 2001; 29: S214-19
91. Sehl PD, Tai JT, Hillan KJ, et al. Application of cDNA microarrays in determining molecular phenotype in cardiac growth, development, and response to injury. Circulation 2000; 101: 1990-9
92. Seidman JG, Seidman C. The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms. Cell 2001; 104: 557-67
93. Shiffman D, Mikita T, Tai JT, et al. Large scale gene expression analysis of cholesterol-loaded macrophages. J Biol Chem 2000; 275: 37 324-32
94. Shimkets RA, Lowe DG, Tai JT, et al. Gene expression analysis by transcript profiling coupled to a gene database query. Nature Biotechnol 1999; 17: 798-803
95. Slavcheva E, Albanis E, Jiao Q, et al. Cytotoxic T-lymphocyte antigen 4 gene polymorphisms and susceptibility to acute allograft rejection. Transplantation 2001; 72: 935-40
96. St Croix B, Rago C, Velculescu V, et al. Genes expressed in human tumor endothelium. Science 2000; 289: 1197-202
97. Stanton LW, Garrard LJ, Damm D, et al. Altered patterns of gene expression in response to myocardial infarction. Circ Res 2000; 86: 939-45
98. Steenbergen C, Afshari CA, Petranka JG, et al. Alterations in apoptotic signaling in human idiopathic cardiomyopathic hearts in failure. Am J Physiol Heart Circ Physiol 2003; 284: H268-76
99. Stoll M, Cowley AW, Jr, Tonellato PJ, et al. A genomic-systems biology map for cardiovascular function. Science 2001; 294: 1723-6
100. Stuber F, Petersen M, Bokelmann F, Schade U. A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-alpha concentrations and outcome of patients with severe sepsis. Crit Care Med 1996; 24: 381-4
101. Suzuki T, Hashimoto S, Toyoda N, et al. Comprehensive gene expression profile of LPS-stimulated human monocytes by SAGE. Blood 2000; 96: 2584-91
102. Tabor HK, Risch NJ, Myers RM. Opinion: Candidate-gene approaches for studying complex genetic traits: practical considerations. Nature Rev Genet 2002; 3: 391-7
103. Tang Z, Tracy RP. Candidate genes and confirmed genetic polymorphisms associated with cardiovascular diseases: a tabular assessment. J Thromb Thrombolysis 2001; 11: 49-81
104. Tardiff BE, Newman MF, Saunders AM, et al. Preliminary report of a genetic basis for cognitive decline after cardiac operations. The Neurologic Outcome Research Group of the Duke Heart Center. Ann Thorac Surg 1997; 64: 715-20
105. Taylor LA, Carthy CM, Yang D, et al. Host gene regulation during coxsackievirus B3 infection in mice: assessment by microarrays. Circ Res 2000; 87: 328-34
106. Thornton J, Striplin S, Liu GS, et al. Inhibition of protein synthesis does not block myocardial protection afforded by preconditioning. Am J Physiol 1990; 259: H1822-5
107. Velculescu VE, Zhang L, Vogelstein B, Kinzler KW. Serial analysis of gene expression. Science 1995; 270: 484-7
108. Venter JC, Adams MD, Myers EW, et al. The sequence of the human genome. Science 2001; 291: 1304-51
109. Volzke H, Engel J, Kleine V, et al. Angiotensin I-converting enzyme insertion/deletion polymorphism and cardiac mortality and morbidity after coronary artery bypass graft surgery. Chest 2002; 122: 31-6
110. Weekes J, Wheeler CH, Yan JX, et al. Bovine dilated cardiomyopathy: proteomic analysis of an animal model of human dilated cardiomyopathy. Electrophoresis 1999; 20: 898-906
111. Wienke A, Holm NV, Skytthe A, Yashin AI. The heritability of mortality due to heart diseases: a correlated frailty model applied to Danish twins. Twin Res 2001; 4: 266-74
112. Winkelmann BR, Hager J. Genetic variation in coronary heart disease and myocardial infarction: methodological overview and clinical evidence. Pharmacogenomics 2000; 1: 73-94
113. Wuttge DM, Sirsjo A, Eriksson P, Stemme S. Gene expression in atherosclerotic lesion of ApoE deficient mice. Mol Med 2001; 7: 383-92
114. Yamada Y, Izawa H, Ichihara S, et al. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. N Engl J Med 2002; 347: 1916-23
115. Yang J, Moravec CS, Sussman MA, et al. Decreased SLIMI expression and increased gelsolin expression in failing human hearts measured by high-density oligonucleotide arrays. Circulation 2000; 102: 3046-52
116. Zdravkovic S, Wienke A, Pedersen NL, Marenberg ME, Yashin AI, De Faire U. Heritability of death from coronary heart disease: a 36-year follow-up of 20 966 Swedish twins. J Intern Med 2002; 252: 247-54
117. Zee RY, Hoh J, Cheng S, et al. Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis of common complex disease. Pharmacogenomics J 2002; 2: 197-201
118. Ziegeler S, Tsusaki BE, Collard CD. Influence of genotype on perioperative risk and outcome. Anesthesiology 2003; 99: 212-19
119. Zotz RB, Klein M, Dauben HP, Moser C, Gams E, Scharf RE. Prospective analysis after coronary-artery bypass grafting: platelet GP IIIa polymorphism (HPA-Ib/PIA2) is a risk factor for bypass occlusion, myocardial infarction, and death. Thromb Haemost 2000; 83: 404-7