Factor V Leiden protects against blood loss and transfusion after cardiac surgery

Circulation

Volumn 107, Issue 7, 2003, Pages 1003-1008

  Donahue, Brian S ^a,b   Gailani, David ^a   Higgins, Michael S ^a   Drinkwater, Davis C ^a   George, Alfred L ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

Genetics; Hemorrhage; Surgery

Indexed keywords

ACETYLSALICYLIC ACID; AMINOCAPROIC ACID DERIVATIVE; ANTITHROMBOCYTIC AGENT; APROTININ; BLOOD CLOTTING FACTOR 5 LEIDEN; COUMARIN; HEPARIN; NONSTEROID ANTIINFLAMMATORY AGENT;

ADULT; AGED; ARTICLE; BLEEDING; BLOOD TRANSFUSION; CONTROLLED STUDY; ETHNOLOGY; FEMALE; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC TRAIT; GENETIC VARIABILITY; HEART SURGERY; HETEROZYGOTE; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; RISK FACTOR; TREATMENT OUTCOME; TUBE;

ADULT; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; CARDIOPULMONARY BYPASS; FACTOR V; FEMALE; HEMOSTASIS, SURGICAL; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 0037465345     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000051864.28048.01     Document Type: Article

References (28)

1. Laupacis A, Fergusson D. Drugs to minimize perioperative blood loss in cardiac surgery: meta- analyses using perioperative blood transfusion as the outcome: the International Study of Peri-operative Transfusion (ISPOT) Investigators. Anesth Analg. 1997;85:1258-1267.
2. Nuttall GA, Oliver WC, Ereth MH, et al. Comparison of blood-conservation strategies in cardiac surgery patients at high risk for bleeding. Anesthesiology. 2000;92:674-682.
3. Stover EP, Siegel LC, Body SC, et al. Institutional variability in red blood cell conservation practices for coronary artery bypass graft surgery: institutions of the MultiCenter Study of Perioperative Ischemia Research Group. J Cardiothorcic Vasc Anesth. 2000;14:171-176.
4. Shore-Lesserson L, Manspeizer HE, DePerio M, et al. Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesth Analg. 1999;88:312-319.
5. Magovern JA, Sakert T, Benckart DH, et al. A model for predicting transfusion after coronary artery bypass grafting. Ann Thorac Surg. 1996; 61:27-32.
6. Despotis GJ, Levine V, Saleem R, et al. Use of point-of-care test in identification of patients who can benefit from desmopressin during cardiac surgery: a randomised controlled trial. Lancet. 1999;354: 106-110.
7. Huet C, Salmi LR, Fergusson D, et al. A meta-analysis of the effectiveness of cell salvage to minimize perioperative allogeneic blood transfusion in cardiac and orthopedic surgery: International Study of Perioperative Transfusion (ISPOT) Investigators. Anesth Analg. 1999;89:861-869.
8. Jansen PG, Baufreton C, Le Besnerais P, et al. Heparin-coated circuits and aprotinin prime for coronary artery bypass grafting. Ann Thorac Surg. 1996;61:1363-1366.
9. Dahlback B. Activated protein C resistance and thrombosis: molecular mechanisms of hypercoagulable state due to FVR506Q mutation. Semin Thromb Hemost. 1999;25:273-289.
10. Svensson PJ, Dahlback B. Resistance to activated protein C as a basis for venous thrombosis. N Engl J Med. 1994;330:517-522.
11. Juul K, Tybjaerg-Hansen A, Steffensen R, et al. Factor V Leiden: the Copenhagen City Heart Study and 2 meta-analyses. Blood. 2002; 100:3-10.
12. Nowak-Gottl U, Strater R, Heinecke A, et al. Lipoprotein (a) and genetic polymorphisms of clotting factor V, prothrombin, and methylenetetrahydrofolate reductase are risk factors of spontaneous ischemic stroke in childhood. Blood. 1999;94:3678-3682.
13. Baranovskaya S, Kudinov S, Fomicheva E, et al. Age as a risk factor for myocardial infarction in Leiden mutation carriers. Mol Genet Metab. 1998;64:155-157.
14. Longstreth WT Jr, Rosendaal FR, Siscovick DS, et al. Risk of stroke in young women and two prothrombotic mutations: factor V Leiden and prothrombin gene variant (G20210A). Stroke. 1998;29:577-580.
15. Fanashawe MP, Shore-Lesserson L, Reich DL. Two cases of fatal thrombosis after aminocaproic acid therapy and deep hypothermic circulatory arrest. Anesthesiology. 2001;95:1525-1527.
16. Linden MD, Schneider M, Erber WN. Factor V(LEIDEN), and cardiopulmonary bypass: investigation of haemostatic parameters and the effect of aprotinin using an ex vivo model. Perfusion. 2001;16:476-484.
17. Moor E, Silveira A, van't Hooft F, et al. Coagulation factor V (Arg506->Gln) mutation and early saphenous vein graft occlusion after coronary artery bypass grafting. Thromb Haemost. 1998;80:220-224.
18. Sweeney JD, Blair AJ, Dupuis MP, et al. Aprotinin, cardiac surgery, and factor V Leiden. Transfusion. 1997;37:1173-1178.
19. Ong BC, Zimmerman AA, Zappulla DC, et al. Prevalence of factor V Leiden in a population of patients with congenital heart disease. Can J Anaesth. 1998;45:1176-1180.
20. Ridker PM, Hennekens CH, Lindpaintner K, et al. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction. stroke, and venous thrombosis in apparently healthy men. N Engl J Med. 1995;332:912-917.
21. Chan AK, Leaker M, Burrows FA, et al. Coagulation and fibrinolytic profile of paediatric patients undergoing cardiopulmonary bypass. Thromb Haemost. 1997;77:270-277.
22. Despotis GJ, Joist JH, Hogue CW, et al. More effective suppression of hemostatic system activation in patients undergoing cardiac surgery by heparin dosing based on heparin blood concentrations rather than ACT. Thromb Haemost. 1996;76:902-908.
23. Despotis GJ, Filos KS. Zoys TN, et al. Factors associated with excessive postoperative blood loss and hemostatic transfusion requirements: a multivariate analysis in cardiac surgical patients. Anesth Analg. 1996;82: 13-21.
24. Greilich PE, Brouse CF, Beckham J. et al. Reductions in platelet contractile force correlate with duration of cardiopulmonary bypass and blood loss in patients undergoing cardiac surgery. Thromb Res. 2002; 105:523-529.
25. Morris CD, Vega JD, Levy JH, et al. Warfarin therapy does not increase bleeding in patients undergoing heart transplantation. Ann Thorac Surg. 2001;72:714-718.
26. Dietrich W, Dilthey G, Spannagl M, et al. Warfarin pretreatment does not lead to increased bleeding tendency during cardiac surgery. J Cardiothorac Vasc Anesth. 1995;9:250-254.
27. Levy JH. Pharmacologic preservation of the hemostatic system during cardiac surgery. Ann Thorac Surg. 2001;72:S1814-S1820.
28. Grody WW, Griffin JH, Taylor AK, et al. American College of Medical Genetics consensus statement on factor V Leiden mutation testing. Genet Med. 2001;3:139-148.