Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy

Physiological Genomics

Volumn 6, Issue 1, 2001, Pages 19-28

  Aronow, Bruce J ^a   Toyokawa, Tsuyoshi ^b   Canning, Amy ^b   Haghighi, Kobra ^b   Delling, Ulrike ^a   Kranias, Evangelia ^b   Molkentin, Jeffery D ^a   Dorn II, Gerald W ^b,c  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Cardiac hypertrophy; DNA microarray; Gene expression; Transgenic mouse

Indexed keywords

MUS MUSCULUS;

EID: 0346606833     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.2001.6.1.19     Document Type: Article

References (26)

1. Adams JW, Sakata Y, Davis MG, Sah VP, Wang Y, Liggett SB, Chien KR, Brown JH, and Dorn GW II. Enhanced Gαq signaling: a common pathway mediates cardiac hypertrophy and heart failure. Proc Natl Acad Sci USA 95: 10140-10145, 1998.
2. Brown LA, Nunez DJ, and Wilkins MR. Differential regulation of natriuretic peptide receptor messenger RNAs during the development of cardiac hypertrophy in the rat. J Clin Invest 92: 2702-2712, 1993.
3. Chien KR, Knowlton KU, Zhu H, and Chien S. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response. FASEB J 5: 3037-3046, 1991.
4. D'Angelo DD, Sakata Y, Lorenz JN, Boivin G, Walsh RA, Liggett SB, and Dorn GW II. Transgenic Gαq overexpression induces cardiac contractile failure in mice. Proc Natl Acad Sci USA 94: 8121-8126, 1997.
5. De Windt LJ, Lim HW, Taigen T, Wencker D, Condorelli G, Dorn GW II, Kitsis RN, and Molkentin JD. Calcineurin mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: an apoptosis independent model of dilated heart failure. Circ Res 86: 255-263, 2000.
6. Dorn GW II, Robbins J, Ball N, and Walsh RA. Myosin heavy chain regulation and myocyte contractile depression after left ventricular hypertrophy in aortic banded mice. Am J Physiol Heart Circ Physiol 267: H400-H405, 1994.
7. Dorn GW II, Souroujon MC, Liron T, Chen CH, Gray MO, Zhou HZ, Csukai M, Wu G, Lorenz JN, and Mochly-Rosen D. Sustained in vivo cardiac protection by a rationally designed peptide that causes e protein kinase C translocation. Proc Natl Acad Sci USA 96: 12798-12803, 1999.
8. Dorn GW II, Tepe NM, Lorenz JN, Koch WJ, and Liggett SB. Low- and high-level transgenic expression of β2-adrenergic receptors differentially affects cardiac hypertrophy and function in Gαq overexpressing mice. Proc Natl Acad Sci USA 96: 6400-6405, 1999.
9. Friddle CJ, Koga T, Rubin EM, and Bristow J. Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy. Proc Natl Acad Sci USA 97: 6745-6750, 2000.
10. Hama N, Itoh H, Shirakami G, Nakagawa O, Suga S, Ogawa Y, Masuda I, Nakanishi K, Yoshimasa T, Hashimoto Y, Yamaguchi M, Hori R, Yasue H, and Nakao K. Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction. Circulation 92: 1558-1564, 1995.
11. Hunter JJ, Tanaka N, Rockman HA, Ross J Jr, and Chien KR. Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice. J Biol Chem 270: 23173-23178, 1995.
12. Hwang DM, Dempsey AA, Lee CY, and Liew CC. Identification of differentially expressed genes in cardiac hypertrophy by analysis of expressed sequence tags. Genomics 66: 1-14, 2000.
13. Johnatty SE, Dyck JR, Michael LH, Olson EN, and Abdellatif M. Identification of genes regulated during mechanical load-induced cardiac hypertrophy. J Mol Cell Cardiol 32: 805-915, 2000.
14. Jones WK, Grupp IL, Doetschman T, Grupp G, Osinski H, Hewett TE, Boivin G, Gulick J, Ng WA, and Robbins J. Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart. J Clin Invest 98: 1906-1917, 1996.
15. Kumar A, Crawford K, Close L, Madison M, Lorenz J, Doetschman T, Pawlowski S, Duffy J, Neumann J, Robbins J, Boivin GP, O'Toole BA, and Lessard JL. Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin. Proc Natl Acad Sci USA 94: 4406-4411, 1997.
16. Miyata S, Minobe W, Bristow MR, and Leinwand LA. Myosin heavy chain isoform expression in the failing and nonfailing human heart. Circ Res 86: 386-390, 2000.
17. Mochly-Rosen D, Wu G, Hahn HS, Osinska H, Liron T, Lorenz JN, Yatani A, Robbins J, and Dorn GW II. Cardiotrophic effects of e protein kinase C: analysis by in vivo modulation of εPKC translocation. Circ Res 86: 1173-1179, 2000.
18. Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, and Oilson EN. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93: 215-228, 1998.
19. Rothermel B, Vega RB, Yang J, Wu H, Bassel-Duby R, and Williams RS. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J Biol Chem 275: 8719-8725, 2000.
20. Sakata Y, Lorenz JN, Hoit BD, Liggett SB, Walsh RA, and Dorn GW II. Decompensation of pressure overload hypertrophy in Gαq overexpressing mice. Circulation 97: 1488-1495, 1998.
21. Sato Y, Ferguson DG, Sako H, Dorn GW II, Kadambi VJ, Yatani A, Hoit BD, Walsh RA, and Kranias EG. Cardiac-specific overexpression of mouse cardiac calsequestrin is associated with depressed cardiovascular function and hypertrophy in transgenic mice. J Biol Chem 273: 28470-28477, 1998.
22. Subramaniam A, Gulick J, Neumann J, Knotts S, and Robbins J. Transgenic analysis of the thyroid-responsive elements in the alpha-cardiac myosin heavy chain gene promoter. J Biol Chem 268: 4331-4336, 1993.
23. Takeishi Y, Ping P, Bolli R, Kirkpatrick DL, Hoit BD, and Walsh RA. Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy. Circ Res 86: 1218-1223, 2000.
24. Taylor LA, Carthy CM, Yang D, Saad K, Wong D, Schreiner G, Stanton LW, and McManus BM. Host gene regulation during coxsackievirus B3 infection in mice, assessment by microarrays. Circ Res 87: 328-334, 2000.
25. Wu CF, Bishopric NH, and Pratt RE. Atrial natriuretic peptide induces apoptosis in neonatal rat cardiac myocytes. J Biol Chem 272: 14860-14866, 1997.
26. Wu G, Toyokawa T, Hahn H, and Dorn GW II. Epsilon protein kinase C in pathological myocardial hypertrophy: analysis by combined transgenic expression of translocation modifiers and Gαq. J Biol Chem 275: 29927-29930, 2000.