Mammalian heparanase as mediator of tumor metastasis and angiogenesis

Israel Medical Association Journal

Volumn 2, Issue SUPPL. JULY, 2000, Pages 37-45

  Vlodavsky, I ^a   Elkin, M ^a   Pappo, O ^a   Aingorn, H ^a   Atzmon, R ^a   Ishai Michaeli, R ^a   Aviv, A ^a   Pecker, I ^a   Friedmann, Y ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Angiogenesis; Colon carcinoma; Extracellular matrix; Heparan sulfate; Metastasis

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; GLYCOSIDASE INHIBITOR; HEPARANASE; HEPARIN; MESSENGER RNA; PERLECAN; PROTEIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; BREAST CARCINOMA; CELL INVASION; COLON CARCINOMA; CONFERENCE PAPER; ENZYME PURIFICATION; GENE EXPRESSION; HEPATOMA CELL; HUMAN; HUMAN CELL; MAMMAL CELL; METASTASIS; MOLECULAR CLONING; NONHUMAN; PROTEIN EXPRESSION; T CELL LYMPHOMA;

ANIMALS; CLONING, MOLECULAR; ENDOTHELIUM, VASCULAR; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCURONIDASE; GLYCOSIDE HYDROLASES; HUMANS; MAMMALS; NEOPLASM METASTASIS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; RECOMBINANT PROTEINS; TUMOR CELLS, CULTURED;

EID: 0033861341     PISSN: 15651088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (40)

1. Proteoglycans: Structures and interactions
2. Functions of cell surface heparan sulfate proteoglycans
3. Integral membrane heparan sulfate proteoglycans
4. The role of proteoglycans in cell adhesion, migration and proliferation
5. The coordinated regulation of heparan sulfate, syndecans and cell behavior
6. Involvement of the extracellular matrix, heparan sulfate proteoglycans and heparan sulfate degrading enzymes in angiogenesis and metastasis
7. Extracellular matrix-bound growth factors, enzymes and plasma proteins
8. Matrix proteoglycans: From molecular design to cellular function
9. Cell biology of arterial proteoglycans
10. Enzymatic degradation of glycosaminoglycans
11. Lymphoma cell-mediated degradation of sulfated proteoglycans in the subendothelial extracellular matrix: Relationship to tumor cell metastasis
12. Heparanases and tumor metastasis
13. Substrate specificity of heparanases from human hepatoma and platelets
14. Partial purification and characterization of heparan sulfate specific endoglucuronidase
15. Inhibition of tumor metastasis by heparanase inhibiting species of heparin
16. Expression of heparanase by platelets and circulating cells of the immune system: Possible involvement in diapedesis and extravasation
17. Evidence that sulphated polysaccharides inhibit tumour metastasis by blocking tumour-cell-derived heparanases
18. Purification and characterization of placental heparanase and its expression by cultured cytotrophoblasts
19. Purification and properties of human platelet heparitinase
20. Human platelet heparanase: Purification, characterization and catalytic activity
21. CXC chemokines connective tissue activating peptide-III and neutrophil activating peptide-2 are heparin/heparan sulfate-degrading enzymes
22. Immunochemical localization of heparanase in mouse and human melanomas
23. Immunoselection of GRP94/endoplasmin from a KNRK cell-specific lambda gt11 library using antibodies directed against a putative heparanase amino-terminal peptide
24. Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis
25. Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis
26. Cloning and functional expression of a human heparanase gene
27. Human heparanase. Purification, characterization, cloning, and expression
28. Processing of the human heparanase precursor and evidence that the active enzyme is a heterodimer
29. Structural biochemistry and activation of matrix metalloproteases
30. Tumor invasion and the extracellular matrix
31. Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides
32. Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity
33. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
34. Involvement of heparan sulfate and related molecules in sequestration and growth promoting activity of fibroblast growth factor
35. Perlecan basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis
36. Extracellular sequestration and release of fibroblast growth factor: A regulatory mechanism?
37. Matrix metalloproteinases in angiogenesis: A moving target for therapeutic intervention
38. Lysolecithin-induced alteration of subendothelial heparan sulfate proteoglycans increases monocyte binding to matrix
39. Differential ability of heparan sulfate proteoglycans to assemble the fibroblast growth factor receptor complex in situ