Chemical modifications of heparin that diminish its anticoagulant but preserve its heparanase-inhibitory, angiostatic, anti-tumor and anti-metastatic properties

Glycobiology

Volumn 6, Issue 3, 1996, Pages 355-366

  Lapierre, France ^a   Holme, Kevin ^a   Lam, Lim ^a   Tressler, Robert J ^a   Storm, Neil ^a   Wee, Jennifer ^a   Stack, Robert J ^a   Castellot, John ^b   Tyrrell, David J ^a  

^a Glycomed Inc   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; Cancer; Chemically modified heparins; Endoglycosidase; Heparan sulphate

Indexed keywords

2,3 DESULFATED HEPARIN; HEPARAN SULFATE; HEPARANASE; HEPARIN; HEPARIN DERIVATIVE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BIOASSAY; CHEMICAL MODIFICATION; CHICKEN; CHORIOALLANTOIS; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; LUNG METASTASIS; MALE; MELANOMA; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION; TUMOR CELL; TUMOR GROWTH;

ANIMALS; ANTICOAGULANTS; ANTINEOPLASTIC AGENTS; CHICK EMBRYO; CHONDROITIN SULFATES; ENZYME INHIBITORS; FEMALE; GLUCURONIDASE; GLYCOSIDE HYDROLASES; HEPARIN; HEPARITIN SULFATE; HUMANS; LUNG NEOPLASMS; MALE; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, NUDE; MOLECULAR STRUCTURE; NEOPLASM METASTASIS; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PHYSIOLOGIC; PANCREATIC NEOPLASMS;

ANIMALIA; GALLUS GALLUS; MUS MUSCULUS;

EID: 0030001467     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: 10.1093/glycob/6.3.355     Document Type: Article

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