Inhibition of telomerase activity by fungus metabolites, CRM646-A and thielavin B

Bioscience, Biotechnology and Biochemistry

Volumn 65, Issue 3, 2001, Pages 651-653

  Togashi, Ken Ichi ^a,c   Ko, Hack Ryong ^a,b   Ahn, Jong Seog ^b   Osada, Hiroyuki ^a  

^a RIKEN   (Japan)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

CRM646 A; Reverse transcriptase; Screening; Telomerase; Thielavin B

Indexed keywords

FUNGI;

CRM646 A; ENZYME INHIBITOR; HYDROXYBENZOIC ACID DERIVATIVE; TELOMERASE; THIELAVIN B;

ARTICLE; CELL STRAIN U937; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; METABOLISM;

ENZYME INHIBITORS; HUMANS; HYDROXYBENZOIC ACIDS; MOLECULAR STRUCTURE; TELOMERASE; U937 CELLS;

EID: 0035294027     PISSN: 09168451     EISSN: None     Source Type: Journal    
DOI: 10.1271/bbb.65.651     Document Type: Article

References (12)

1. Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., and Shay, J. W., Specific association of human telomerase activity with cells and cancer. Science, 266, 2011-2015 (1994).
2. Shay, J. W. and Bacchetti, S., A survey of telomerase activity in human cancer. Eur. J. Cancer, 33, 787-791 (1997).
3. Feng, J., Funk, W. D., Wang, S. S., Weinrich, S. L., Avillon, A. A., Chiu, C. P., Adams, R. R., Chang, E., Allsopp, R. C., Yu, J., Le, S., West, M. D., Harley, C. B., Anderews, W. H., Greider, C. W., and Villeponteau, B., The RNA component of human telomerase. Science, 269, 1236-1241 (1995).
4. Kondo, S., Kondo, Y., Li, G., Silverman, R. H., and Cowell, J. K., Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA. Oncogene, 16, 3323-3330 (1998).
5. Yegorov, Y. E., Chernov, D. N., Akimov, S. S., Bolsheva, N. L., Krayevsky, A. A., and Zelenin, A. V., Reverse transcriptase inhibitors suppress telomerase function and induce senescence-like process in cultured mouse fibroblasts. FEBS Lett., 389, 115-118 (1996).
6. Strahl, C. and Blackburn, E. H., Effect of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines. Mol. Cell. Biol., 16, 53-65 (1996).
7. Togashi, K., Kakeya, H., Morishita, M., Song, Y.-X., and Osada, H., Inhibition of human telomerase activity by alterperylenol. Oncol. Res., 10, 449-453 (1998).
8. Tatematsu, K.-I., Nakayama, J.-I., Danbara, M., Shionoya, S., Sato, H., Omine, M., and Ishikawa, F., A novel quantitative "stretch PCR assay" that detects a dramatic increase in telomerase activity during the progression of myeloid leukemias. Oncogene, 13, 2265-2274 (1996).
9. Kitahara, N., Endo, A., Furuya, K., and Takahashi, S., Thielavin A and B, new inhibitors of prostaglandin biosynthesis produced by Thielavia terricola. J. Antibiot., 34, 1562-1568 (1981).
10. Mani, N., Sanchet, P., Jiang, Z.-D., McNaney, C., DeCenzo, M., Knighti, B., Stankis, M., Kuranda, M., and Rothstein, D. M., Screening systems for detecting inhibitors of cell wall transglycosylation in enterococcus. Cell wall transglycosylation inhibitors in enterococcus. J. Antibiot., 51, 471-479 (1998).
11. Ko, H. R., Kim, B. Y., Oh, W. K., Kang, D. O., Lee, H. S., Koshino, H., Osada, H., Mheen, T. I., and Ahn, J. S., CRM646-A and -B, novel fungal metabolites that inhibit heparinase. J. Antibiot., 53, 211-214 (2000).
12. Naasani, I., Seimiya, H., and Tsuruo, T., Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins. Biochem. Biophys. Res. Commun., 249, 391-396 (1998).