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Volumn 28, Issue 7, 2003, Pages 377-383

Lysophosphatidic acid signaling: How a small lipid does big things

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; LIPID; LYSOPHOSPHATIDIC ACID; RECEPTOR SUBTYPE;

EID: 0038487319     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(03)00139-7     Document Type: Review
Times cited : (65)

References (49)
  • 1
    • 0034060152 scopus 로고    scopus 로고
    • Development of our current understanding of bioactive lysophospholipids
    • Moolenaar W.H. Development of our current understanding of bioactive lysophospholipids. Ann. N. Y. Acad. Sci. 905:2000;1-10.
    • (2000) Ann. N. Y. Acad. Sci. , vol.905 , pp. 1-10
    • Moolenaar, W.H.1
  • 2
    • 0035025354 scopus 로고    scopus 로고
    • Physiological responses to lysophosphatidic acid and related glycero-phospholipids
    • Tigyi G. Physiological responses to lysophosphatidic acid and related glycero-phospholipids. Prostaglandins. 64:2001;47-62.
    • (2001) Prostaglandins , vol.64 , pp. 47-62
    • Tigyi, G.1
  • 4
    • 0035976579 scopus 로고    scopus 로고
    • Lysophospholipids-receptor revelations
    • Hla T., et al. Lysophospholipids-receptor revelations. Science. 294:2001;1875-1878.
    • (2001) Science , vol.294 , pp. 1875-1878
    • Hla, T.1
  • 6
    • 0029836932 scopus 로고    scopus 로고
    • Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex
    • Hecht J.H., et al. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J. Cell Biol. 135:1996;1071-1083.
    • (1996) J. Cell Biol. , vol.135 , pp. 1071-1083
    • Hecht, J.H.1
  • 7
    • 0032568613 scopus 로고    scopus 로고
    • A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid
    • Fukushima N., et al. A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. Proc. Natl. Acad. Sci. U. S. A. 95:1998;6151-6156.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 6151-6156
    • Fukushima, N.1
  • 8
    • 0031584825 scopus 로고    scopus 로고
    • Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid
    • An S., et al. Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid. Biochem. Biophys. Res. Commun. 231:1997;619-622.
    • (1997) Biochem. Biophys. Res. Commun. , vol.231 , pp. 619-622
    • An, S.1
  • 9
    • 0028899593 scopus 로고
    • Characterization of edg-2, a human homologue of the Xenopus maternal transcript G10 from endothelial cells
    • Hla T., et al. Characterization of edg-2, a human homologue of the Xenopus maternal transcript G10 from endothelial cells. Biochim. Biophys. Acta. 1260:1995;227-229.
    • (1995) Biochim. Biophys. Acta , vol.1260 , pp. 227-229
    • Hla, T.1
  • 10
    • 0033600761 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid
    • Bandoh K., et al. Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J. Biol. Chem. 274:1999;27776-27785.
    • (1999) J. Biol. Chem. , vol.274 , pp. 27776-27785
    • Bandoh, K.1
  • 12
    • 0034700050 scopus 로고    scopus 로고
    • Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior
    • Contos J.J., et al. Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc. Natl. Acad. Sci. U. S. A. 97:2000;13384-13389.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 13384-13389
    • Contos, J.J.1
  • 13
    • 0036786445 scopus 로고    scopus 로고
    • Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: Signaling deficits without obvious phenotypic abnormality attributable to lpa(2)
    • Contos J.J., et al. Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2). Mol. Cell. Biol. 22:2002;6921-6929.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 6921-6929
    • Contos, J.J.1
  • 14
    • 0035895989 scopus 로고    scopus 로고
    • Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent
    • Hooks S.B., et al. Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent. J. Biol. Chem. 276:2001;4611-4621.
    • (2001) J. Biol. Chem. , vol.276 , pp. 4611-4621
    • Hooks, S.B.1
  • 15
    • 0037162084 scopus 로고    scopus 로고
    • Structure-activity relationships of lysophosphatidic acid analogs
    • Lynch K.R., Macdonald T.L. Structure-activity relationships of lysophosphatidic acid analogs. Biochim. Biophys. Acta. 1582:2002;289-294.
    • (2002) Biochim. Biophys. Acta , vol.1582 , pp. 289-294
    • Lynch, K.R.1    Macdonald, T.L.2
  • 16
    • 0037422595 scopus 로고    scopus 로고
    • From the cover: Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist
    • McIntyre T.M., et al. From the cover: identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist. Proc. Natl. Acad. Sci. U. S. A. 100:2003;131-136.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 131-136
    • McIntyre, T.M.1
  • 17
    • 0036183630 scopus 로고    scopus 로고
    • The mechanisms of action of PPARs
    • Berger J., Moller D.E. The mechanisms of action of PPARs. Annu. Rev. Med. 53:2002;409-435.
    • (2002) Annu. Rev. Med. , vol.53 , pp. 409-435
    • Berger, J.1    Moller, D.E.2
  • 18
    • 0036399805 scopus 로고    scopus 로고
    • PPAR(γ) and glucose homeostasis
    • Picard F., Auwerx J. PPAR(γ) and glucose homeostasis. Annu. Rev. Nutr. 22:2002;167-197.
    • (2002) Annu. Rev. Nutr. , vol.22 , pp. 167-197
    • Picard, F.1    Auwerx, J.2
  • 19
    • 0021099118 scopus 로고
    • Intracellular translocation and metabolism of a fluorescent phosphatidic acid analogue in cultured fibroblasts
    • Pagano R.E., et al. Intracellular translocation and metabolism of a fluorescent phosphatidic acid analogue in cultured fibroblasts. J. Biol. Chem. 258:1983;2034-2040.
    • (1983) J. Biol. Chem. , vol.258 , pp. 2034-2040
    • Pagano, R.E.1
  • 20
    • 0034710631 scopus 로고    scopus 로고
    • Role of phosphatidic acid phosphatase 2a in uptake of extracellular lipid phosphate mediators
    • Roberts R.Z., Morris A.J. Role of phosphatidic acid phosphatase 2a in uptake of extracellular lipid phosphate mediators. Biochim. Biophys. Acta. 1487:2000;33-49.
    • (2000) Biochim. Biophys. Acta , vol.1487 , pp. 33-49
    • Roberts, R.Z.1    Morris, A.J.2
  • 21
    • 0024495699 scopus 로고
    • Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin
    • Gerrard J.M., Robinson P. Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin. Biochim. Biophys. Acta. 1001:1989;282-285.
    • (1989) Biochim. Biophys. Acta , vol.1001 , pp. 282-285
    • Gerrard, J.M.1    Robinson, P.2
  • 22
    • 0028986238 scopus 로고
    • Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells
    • Fourcade O., et al. Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells. Cell. 80:1995;919-927.
    • (1995) Cell , vol.80 , pp. 919-927
    • Fourcade, O.1
  • 23
    • 0032037561 scopus 로고    scopus 로고
    • α2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes. A paracrine signal for preadipocyte growth
    • Valet P., et al. α2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes. A paracrine signal for preadipocyte growth. J. Clin. Invest. 101:1998;1431-1438.
    • (1998) J. Clin. Invest. , vol.101 , pp. 1431-1438
    • Valet, P.1
  • 24
    • 0037189488 scopus 로고    scopus 로고
    • Expression of ectolipid phosphate phosphohydrolases in 3T3F442A preadipocytes and adipocytes. Involvement in the control of lysophosphatidic acid production
    • Simon M.F., et al. Expression of ectolipid phosphate phosphohydrolases in 3T3F442A preadipocytes and adipocytes. Involvement in the control of lysophosphatidic acid production. J. Biol. Chem. 277:2002;23131-23136.
    • (2002) J. Biol. Chem. , vol.277 , pp. 23131-23136
    • Simon, M.F.1
  • 25
    • 0034083409 scopus 로고    scopus 로고
    • Constitutive and lysophosphatidic acid (LPA)-induced LPA production: Role of phospholipase D and phospholipase A2
    • Eder A.M., et al. Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2. Clin. Cancer Res. 6:2000;2482-2491.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2482-2491
    • Eder, A.M.1
  • 26
    • 0037031878 scopus 로고    scopus 로고
    • Role for 18:1 lysophosphatidic acid as an autocrine mediator in prostate cancer cells
    • Xie Y., et al. Role for 18:1 lysophosphatidic acid as an autocrine mediator in prostate cancer cells. J. Biol. Chem. 277:2002;32516-32526.
    • (2002) J. Biol. Chem. , vol.277 , pp. 32516-32526
    • Xie, Y.1
  • 27
    • 0032568216 scopus 로고    scopus 로고
    • 2+ signaling pathways
    • 2+ signaling pathways. Curr. Biol. 8:1998;386-392.
    • (1998) Curr. Biol. , vol.8 , pp. 386-392
    • Van Dijk, M.C.1
  • 28
    • 0022623355 scopus 로고
    • Involvement of lysophospholipase D in the production of lysophosphatidic acid in rat plasma
    • Tokumura A., et al. Involvement of lysophospholipase D in the production of lysophosphatidic acid in rat plasma. Biochim. Biophys. Acta. 875:1986;31-38.
    • (1986) Biochim. Biophys. Acta , vol.875 , pp. 31-38
    • Tokumura, A.1
  • 29
    • 1542359873 scopus 로고    scopus 로고
    • Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production
    • Umezu-Goto M., et al. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J. Cell Biol. 158:2002;227-233.
    • (2002) J. Cell Biol. , vol.158 , pp. 227-233
    • Umezu-Goto, M.1
  • 30
    • 0026787698 scopus 로고
    • Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein
    • Stracke M.L., et al. Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein. J. Biol. Chem. 267:1992;2524-2529.
    • (1992) J. Biol. Chem. , vol.267 , pp. 2524-2529
    • Stracke, M.L.1
  • 31
    • 0028045941 scopus 로고
    • CDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases
    • Murata J., et al. cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases. J. Biol. Chem. 269:1994;30479-30484.
    • (1994) J. Biol. Chem. , vol.269 , pp. 30479-30484
    • Murata, J.1
  • 32
    • 0034490045 scopus 로고    scopus 로고
    • Nucleotide pyrophosphatases/phosphodiesterases on the move
    • Bollen M., et al. Nucleotide pyrophosphatases/phosphodiesterases on the move. Crit. Rev. Biochem. Mol. Biol. 35:2000;393-432.
    • (2000) Crit. Rev. Biochem. Mol. Biol. , vol.35 , pp. 393-432
    • Bollen, M.1
  • 33
    • 0029013367 scopus 로고
    • Autotaxin is an N-linked glycoprotein but the sugar moieties are not needed for its stimulation of cellular motility
    • Stracke M.L., et al. Autotaxin is an N-linked glycoprotein but the sugar moieties are not needed for its stimulation of cellular motility. Melanoma Res. 5:1995;203-209.
    • (1995) Melanoma Res. , vol.5 , pp. 203-209
    • Stracke, M.L.1
  • 34
    • 0034642507 scopus 로고    scopus 로고
    • Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells
    • Nam S.W., et al. Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells. Oncogene. 19:2000;241-247.
    • (2000) Oncogene , vol.19 , pp. 241-247
    • Nam, S.W.1
  • 35
    • 0035884290 scopus 로고    scopus 로고
    • Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor
    • Nam S.W., et al. Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor. Cancer Res. 61:2001;6938-6944.
    • (2001) Cancer Res. , vol.61 , pp. 6938-6944
    • Nam, S.W.1
  • 36
    • 0037073806 scopus 로고    scopus 로고
    • Serum lysophosphatidic acid is produced through diverse phospholipase pathways
    • Aoki J., et al. Serum lysophosphatidic acid is produced through diverse phospholipase pathways. J. Biol. Chem. 277:2002;48737-48744.
    • (2002) J. Biol. Chem. , vol.277 , pp. 48737-48744
    • Aoki, J.1
  • 37
    • 0037077199 scopus 로고    scopus 로고
    • Multiple mechanisms linked to platelet activation result in lysophosphatidic acid and sphingosine 1-phosphate generation in blood
    • Sano T., et al. Multiple mechanisms linked to platelet activation result in lysophosphatidic acid and sphingosine 1-phosphate generation in blood. J. Biol. Chem. 277:2002;21197-21206.
    • (2002) J. Biol. Chem. , vol.277 , pp. 21197-21206
    • Sano, T.1
  • 38
    • 0028135327 scopus 로고
    • Biochemical characterization of human PC-1, an enzyme possessing alkaline phosphodiesterase I and nucleotide pyrophosphatase activities
    • Belli S.I., Goding J.W. Biochemical characterization of human PC-1, an enzyme possessing alkaline phosphodiesterase I and nucleotide pyrophosphatase activities. Eur. J. Biochem. 226:1994;433-443.
    • (1994) Eur. J. Biochem. , vol.226 , pp. 433-443
    • Belli, S.I.1    Goding, J.W.2
  • 39
    • 0032544691 scopus 로고    scopus 로고
    • Mammalian lipid phosphate phosphohydrolases
    • Brindley D.N., Waggoner D.W. Mammalian lipid phosphate phosphohydrolases. J. Biol. Chem. 273:1998;24281-24284.
    • (1998) J. Biol. Chem. , vol.273 , pp. 24281-24284
    • Brindley, D.N.1    Waggoner, D.W.2
  • 40
    • 0034608826 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1-phosphate and induces cell death
    • Mandala S.M., et al. Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1-phosphate and induces cell death. Proc. Natl. Acad. Sci. U. S. A. 97:2000;7859-7864.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 7859-7864
    • Mandala, S.M.1
  • 41
    • 0033564681 scopus 로고    scopus 로고
    • Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters
    • Jasinska R., et al. Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters. Biochem. J. 340:1999;677-686.
    • (1999) Biochem. J. , vol.340 , pp. 677-686
    • Jasinska, R.1
  • 42
    • 0032693488 scopus 로고    scopus 로고
    • Sequential actions of phospholipase D and phosphatidic acid phosphohydrolase 2b generate diglyceride in mammalian cells
    • Sciorra V.A., Morris A.J. Sequential actions of phospholipase D and phosphatidic acid phosphohydrolase 2b generate diglyceride in mammalian cells. Mol. Biol. Cell. 10:1999;3863-3876.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 3863-3876
    • Sciorra, V.A.1    Morris, A.J.2
  • 43
    • 0034623053 scopus 로고    scopus 로고
    • 2+ control lysophosphatidate signaling through EDG-2 receptors
    • 2+ control lysophosphatidate signaling through EDG-2 receptors. J. Biol. Chem. 275:2000;27520-27530.
    • (2000) J. Biol. Chem. , vol.275 , pp. 27520-27530
    • Xu, J.1
  • 44
    • 85031146372 scopus 로고    scopus 로고
    • The human lipid phosphate phosphatase-3 (hLPP-3) decreases the growth, survival, and tumorigenesis of ovarian cancer cells: Validation of the LPA signaling cascade as a target for therapy in ovarian cancer
    • in press
    • Tanyi, J.L. et al. The human lipid phosphate phosphatase-3 (hLPP-3) decreases the growth, survival, and tumorigenesis of ovarian cancer cells: Validation of the LPA signaling cascade as a target for therapy in ovarian cancer. Cancer Res. (in press).
    • Cancer Res.
    • Tanyi, J.L.1
  • 45
    • 0033809110 scopus 로고    scopus 로고
    • Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile
    • Zhang N., et al. Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile. Genesis. 27:2000;137-140.
    • (2000) Genesis , vol.27 , pp. 137-140
    • Zhang, N.1
  • 46
    • 0031105524 scopus 로고    scopus 로고
    • Cell migration: Don't tread on me
    • Doren M.V., Lehmann R. Cell migration: don't tread on me. Curr. Biol. 7:1997;R148-R150.
    • (1997) Curr. Biol. , vol.7
    • Doren, M.V.1    Lehmann, R.2
  • 47
    • 0031021247 scopus 로고    scopus 로고
    • The Drosophila protein Wunen repels migrating germ cells
    • Zhang N., et al. The Drosophila protein Wunen repels migrating germ cells. Nature. 385:1997;64-67.
    • (1997) Nature , vol.385 , pp. 64-67
    • Zhang, N.1
  • 48
    • 0035071025 scopus 로고    scopus 로고
    • Spatially restricted activity of a Drosophila lipid phosphatase guides migrating germ cells
    • Starz-Gaiano M., et al. Spatially restricted activity of a Drosophila lipid phosphatase guides migrating germ cells. Development. 128:2001;983-991.
    • (2001) Development , vol.128 , pp. 983-991
    • Starz-Gaiano, M.1
  • 49
    • 0032480975 scopus 로고    scopus 로고
    • HMG-CoA reductase guides migrating primordial germ cells
    • Van Doren M., et al. HMG-CoA reductase guides migrating primordial germ cells. Nature. 396:1998;466-469.
    • (1998) Nature , vol.396 , pp. 466-469
    • Van Doren, M.1


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