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Volumn 1057, Issue , 2005, Pages 145-164

Aging as a mitochondria-mediated atavistic program: Can aging be switched off?

Author keywords

Mitochondria; Programmed death; Reactive oxygen species

Indexed keywords

REACTIVE OXYGEN METABOLITE; SCAVENGER;

EID: 32244431625     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1356.009     Document Type: Conference Paper
Times cited : (77)

References (112)
  • 4
    • 32244437270 scopus 로고    scopus 로고
    • The evolution of aging
    • New York. Lincoln. Shanghai
    • GOLDSMITH, T.C. 2003. The Evolution of Aging. iUniverse. New York. Lincoln. Shanghai.
    • (2003) iUniverse
    • Goldsmith, T.C.1
  • 6
    • 0031690075 scopus 로고    scopus 로고
    • The evolution of aging: A new approach to an old problem of biology
    • BOWLES, J.T. 1998. The evolution of aging: a new approach to an old problem of biology. Med. Hypotheses 51: 179-221.
    • (1998) Med. Hypotheses , vol.51 , pp. 179-221
    • Bowles, J.T.1
  • 7
    • 0033922445 scopus 로고    scopus 로고
    • Sex, kings, serial killers and other group-selected human traits
    • BOWLES, J.T. 2000. Sex, kings, serial killers and other group-selected human traits. Med. Hypotheses 54: 864-894.
    • (2000) Med. Hypotheses , vol.54 , pp. 864-894
    • Bowles, J.T.1
  • 8
    • 13844273405 scopus 로고    scopus 로고
    • Aging and the programmed death phenomena
    • T. Nystrom & H.D. Osiewacz, Eds. Model systems in ageing. Springer-Verlag, Berlin
    • SKULACHEV, V.P. 2003. Aging and the programmed death phenomena. In Topics in Current Genetics. T. Nystrom & H.D. Osiewacz, Eds. 3: 191-238. Model systems in ageing. Springer-Verlag, Berlin.
    • (2003) Topics in Current Genetics , vol.3 , pp. 191-238
    • Skulachev, V.P.1
  • 9
    • 0034985743 scopus 로고    scopus 로고
    • The programmed death phenomena, aging, and the Samurai law of biology
    • SKULACHEV, V.P. 2001. The programmed death phenomena, aging, and the Samurai law of biology. Exp. Gerontol. 36: 995-1024.
    • (2001) Exp. Gerontol. , vol.36 , pp. 995-1024
    • Skulachev, V.P.1
  • 10
    • 0033453260 scopus 로고    scopus 로고
    • Age-specific survival in five populations of ungulates: Evidence of senescence
    • LOISON, A., M. FESTA-BLANCHET, J.M. GAILLARD, et al. 1999. Age-specific survival in five populations of ungulates: evidence of senescence. Ecology 80: 2539-2554.
    • (1999) Ecology , vol.80 , pp. 2539-2554
    • Loison, A.1    Festa-Blanchet, M.2    Gaillard, J.M.3
  • 11
    • 0037191787 scopus 로고    scopus 로고
    • Senescence: Rapid and costly ageing in wild male flies
    • BONDURIANSKY, R. & C.E. BRASSIL. 2002. Senescence: rapid and costly ageing in wild male flies. Nature 420: 377.
    • (2002) Nature , vol.420 , pp. 377
    • Bonduriansky, R.1    Brassil, C.E.2
  • 12
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • KERR, J.F., A.H. WYLLIE & A.R. CURRIE. 1972. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26: 239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 13
    • 0029950290 scopus 로고    scopus 로고
    • Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
    • SUSIN, S.A., N. ZAMZAMI, M. CASTEDO, et al. 1996. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J. Exp. Med. 184: 1331-1341.
    • (1996) J. Exp. Med. , vol.184 , pp. 1331-1341
    • Susin, S.A.1    Zamzami, N.2    Castedo, M.3
  • 14
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
    • LIU, X., C.N. KIM, J. YANG, et al. 1996. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86: 147-157.
    • (1996) Cell , vol.86 , pp. 147-157
    • Liu, X.1    Kim, C.N.2    Yang, J.3
  • 15
    • 0031036872 scopus 로고    scopus 로고
    • Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
    • YANG, J., X. LIU, K. BHALLA, et al. 1997. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275: 1129-1132.
    • (1997) Science , vol.275 , pp. 1129-1132
    • Yang, J.1    Liu, X.2    Bhalla, K.3
  • 16
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
    • KLUCK, R.M., E. BOSSY-WETZEL, D.D. GREEN & D.D. NEWMEYER. 1997. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275: 1132-1136.
    • (1997) Science , vol.275 , pp. 1132-1136
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.D.3    Newmeyer, D.D.4
  • 17
    • 0030580287 scopus 로고    scopus 로고
    • Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide-producing mitochondria and cell
    • SKULACHEV, V.R. 1996. Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide-producing mitochondria and cell. FEBS Lett. 397: 7-10.
    • (1996) FEBS Lett. , vol.397 , pp. 7-10
    • Skulachev, V.R.1
  • 18
    • 2342443000 scopus 로고    scopus 로고
    • Nobel lecture. Worms, life, and death
    • HORVITZ, H.R. 2003. Nobel lecture. Worms, life, and death. Biosci. Rep. 6: 239-303.
    • (2003) Biosci. Rep. , vol.6 , pp. 239-303
    • Horvitz, H.R.1
  • 19
    • 0141636593 scopus 로고    scopus 로고
    • C. elegans: The cell lineage and beyond
    • SULSTON, J.E. 2003. C. elegans: the cell lineage and beyond. Biosci. Rep. 3: 49-66.
    • (2003) Biosci. Rep. , vol.3 , pp. 49-66
    • Sulston, J.E.1
  • 20
    • 0026588321 scopus 로고
    • Voltage activation of heart inner mitochondrial membrane channels
    • ZOROV, D.B., K.W. KINNALLY & H. TEDESCI. 1992. Voltage activation of heart inner mitochondrial membrane channels. J. Bioenerg. Biomembr. 24: 119-124.
    • (1992) J. Bioenerg. Biomembr. , vol.24 , pp. 119-124
    • Zorov, D.B.1    Kinnally, K.W.2    Tedesci, H.3
  • 21
    • 0000710844 scopus 로고
    • 2 as a special function of the cellular respiratory system
    • 2 as a special function of the cellular respiratory system. Biochem. Moscow 59: 1433-1434.
    • (1994) Biochem. Moscow , vol.59 , pp. 1433-1434
    • Skulachev, V.P.1
  • 22
    • 0029765443 scopus 로고    scopus 로고
    • Role of uncoupled and noncoupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants
    • SKULACHEV, V.P. 1996. Role of uncoupled and noncoupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants. Q. Rev. Biophys. 29: 169-202.
    • (1996) Q. Rev. Biophys. , vol.29 , pp. 169-202
    • Skulachev, V.P.1
  • 23
    • 0032564864 scopus 로고    scopus 로고
    • Uncoupling: New approaches to an old problem of bioenergetics
    • SKULACHEV, V.P. 1998. Uncoupling: new approaches to an old problem of bioenergetics. Biochim. Biophys. Acta 1363: 100-124.
    • (1998) Biochim. Biophys. Acta , vol.1363 , pp. 100-124
    • Skulachev, V.P.1
  • 24
    • 0035487007 scopus 로고    scopus 로고
    • The mitochondrial permeability transition initiates autophagy in rat hepatocytes
    • ELMORE, S.P., T. QIAN, S.F. GRISSOM & J.J. LEMASTERS. 2001. The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J. 15: 2286-2287.
    • (2001) FASEB J. , vol.15 , pp. 2286-2287
    • Elmore, S.P.1    Qian, T.2    Grissom, S.F.3    Lemasters, J.J.4
  • 26
    • 0034698759 scopus 로고    scopus 로고
    • Death commitment point is advanced by axotomy in sympathetic neurons
    • FLETCHER, G.C., L. XUE, S.K. PASSINOHAM & A.M. TOLKOVSKY. 2000. Death commitment point is advanced by axotomy in sympathetic neurons. J. Cell Biol. 150: 741-754.
    • (2000) J. Cell Biol. , vol.150 , pp. 741-754
    • Fletcher, G.C.1    Xue, L.2    Passinoham, S.K.3    Tolkovsky, A.M.4
  • 27
    • 0035814933 scopus 로고    scopus 로고
    • Mitochondria are selectively eliminated from eukaryotic cells after blockade of caspases during apoptosis
    • XUE, L., G.C. FLETCHER & A.M. TOLKOVSKY. 2001. Mitochondria are selectively eliminated from eukaryotic cells after blockade of caspases during apoptosis. Curr. Biol. 11: 361-365.
    • (2001) Curr. Biol. , vol.11 , pp. 361-365
    • Xue, L.1    Fletcher, G.C.2    Tolkovsky, A.M.3
  • 28
    • 0036743518 scopus 로고    scopus 로고
    • A mutation in the ATP2 gene abrogates the age asymmetry between mother and daughter cells of the yeast Saccharomyces cerevisiae
    • LAI, C.-Y., E. JARUGA, C. BOROHOUTS & S.M. JAZWINSKI. 2002. A mutation in the ATP2 gene abrogates the age asymmetry between mother and daughter cells of the yeast Saccharomyces cerevisiae. Genetics 162: 73-83.
    • (2002) Genetics , vol.162 , pp. 73-83
    • Lai, C.-Y.1    Jaruga, E.2    Borohouts, C.3    Jazwinski, S.M.4
  • 29
    • 11144345294 scopus 로고    scopus 로고
    • Mitochondria, metabolism, and aging in yeast
    • T. Nystrom & H.D. Osiewacz, Eds. Springer-Verlag. Berlin Heidelberg
    • JAZWINSKI, S.M. 2003. Mitochondria, metabolism, and aging in yeast. In Topics in Current Genetics: Model Systems in Aging. T. Nystrom & H.D. Osiewacz, Eds.: 39-59. Springer-Verlag. Berlin Heidelberg.
    • (2003) Topics in Current Genetics: Model Systems in Aging , pp. 39-59
    • Jazwinski, S.M.1
  • 30
    • 0033817972 scopus 로고    scopus 로고
    • Clustering of apoptotic cells via bystander killing by peroxides
    • REZNIKOV, K., A.L. KOLESNIKOVA, A. PRAMANIK, et al. 2000. Clustering of apoptotic cells via bystander killing by peroxides. FASEB J. 14: 1754-1764.
    • (2000) FASEB J. , vol.14 , pp. 1754-1764
    • Reznikov, K.1    Kolesnikova, A.L.2    Pramanik, A.3
  • 31
    • 27344451573 scopus 로고    scopus 로고
    • Long-distance apoptotic killing of cells is mediated by hydrogen peroxide in a mitochondrial ROS-dependent fashion
    • PLETJUSHKINA, O.Y., E.K. FETISOVA, K.D. LYAMZAEV, et al. 2005. Long-distance apoptotic killing of cells is mediated by hydrogen peroxide in a mitochondrial ROS-dependent fashion. Cell Death Diff. 12: 1442-1444.
    • (2005) Cell Death Diff. , vol.12 , pp. 1442-1444
    • Pletjushkina, O.Y.1    Fetisova, E.K.2    Lyamzaev, K.D.3
  • 32
    • 0032254389 scopus 로고    scopus 로고
    • Possible role of reactive oxygen species in antiviral defence
    • SKULACHEV, V.P. 1998. Possible role of reactive oxygen species in antiviral defence. Biochem. Moscow 63: 1438-1440.
    • (1998) Biochem. Moscow , vol.63 , pp. 1438-1440
    • Skulachev, V.P.1
  • 33
    • 0032749848 scopus 로고    scopus 로고
    • Mitochondrial physiology and pathology: Concepts of programmed death of organelles, cells, and organisms
    • SKULACHEV, V.P. 1999. Mitochondrial physiology and pathology: concepts of programmed death of organelles, cells, and organisms. Mol. Asp. Med. 20: 139-184.
    • (1999) Mol. Asp. Med. , vol.20 , pp. 139-184
    • Skulachev, V.P.1
  • 34
    • 0032921558 scopus 로고    scopus 로고
    • Thyroxine enhancement and the role of reactive oxygen species in tadpole tail apoptosis
    • KASHIWAGI, A., H. KANADA, M. YABUKI, et al. 1999. Thyroxine enhancement and the role of reactive oxygen species in tadpole tail apoptosis. Free Radic. Biol. Med. 26: 1001-1009.
    • (1999) Free Radic. Biol. Med. , vol.26 , pp. 1001-1009
    • Kashiwagi, A.1    Kanada, H.2    Yabuki, M.3
  • 35
    • 3543046206 scopus 로고    scopus 로고
    • "Wages of fear": Transient threefold decrease in intracellular ATP level imposes apoptosis
    • IZYUMOV, D.S., A.V. AVETISYAN, O.Y. PLETJUSHKINA, et al. 2004. "Wages of fear": transient threefold decrease in intracellular ATP level imposes apoptosis. Biochim. Biophys. Acta 1658: 141-147.
    • (2004) Biochim. Biophys. Acta , vol.1658 , pp. 141-147
    • Izyumov, D.S.1    Avetisyan, A.V.2    Pletjushkina, O.Y.3
  • 36
    • 0033936158 scopus 로고    scopus 로고
    • Mitochondria in the programmed death phenomena: A principle of biology: "It is better to die than to be wrong"
    • SKULACHEV, V.P. 2000. Mitochondria in the programmed death phenomena: a principle of biology: "It is better to die than to be wrong." IUBMB Life 49: 365-373.
    • (2000) IUBMB Life , vol.49 , pp. 365-373
    • Skulachev, V.P.1
  • 37
    • 0033819140 scopus 로고    scopus 로고
    • Programmed death in bacteria
    • LEWIS, K. 2000. Programmed death in bacteria. Microbiol. Mol. Biol. Rev. 64: 503-514.
    • (2000) Microbiol. Mol. Biol. Rev. , vol.64 , pp. 503-514
    • Lewis, K.1
  • 38
    • 0037174142 scopus 로고    scopus 로고
    • Programmed death in yeast as adaptation?
    • SKULACHEV, V.P. 2002. Programmed death in yeast as adaptation? FEBS Lett. 528: 23-26.
    • (2002) FEBS Lett. , vol.528 , pp. 23-26
    • Skulachev, V.P.1
  • 40
    • 10644251298 scopus 로고    scopus 로고
    • Yeast as a model for aging and apoptosis research
    • T. Nystrom & H.D. Osiewacz, Eds. Springer-Verlag. Berlin
    • BREITENBACH, M., F. MADEO, P. LAUN, et al. 2003. Yeast as a model for aging and apoptosis research. In Topics in Current Genetics: Model Systems in Aging. T. Nystrom & H.D. Osiewacz, Eds.: 61-96. Springer-Verlag. Berlin.
    • (2003) Topics in Current Genetics: Model Systems in Aging , pp. 61-96
    • Breitenbach, M.1    Madeo, F.2    Laun, P.3
  • 41
    • 0345643515 scopus 로고    scopus 로고
    • Oxygen stress: A regulator of apoptosis in yeast
    • MADEO, F., E. FRÖHLICH, M. LIOR, et al. 1999. Oxygen stress: a regulator of apoptosis in yeast. J. Cell Biol. 145: 757-767.
    • (1999) J. Cell Biol. , vol.145 , pp. 757-767
    • Madeo, F.1    Fröhlich, E.2    Lior, M.3
  • 42
    • 0034807841 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae commits to a programmed cell death process in response to acetic acid
    • LUDOVICO, P., M.J. SOUSA, M.T. SILVA, et al. 2001. Saccharomyces cerevisiae commits to a programmed cell death process in response to acetic acid. Microbiology 147: 2409-2415.
    • (2001) Microbiology , vol.147 , pp. 2409-2415
    • Ludovico, P.1    Sousa, M.J.2    Silva, M.T.3
  • 43
    • 18344374857 scopus 로고    scopus 로고
    • A caspase-related protease regulates apoptosis in yeast
    • MADEO, F., E. HERKER, C. MALDENER, et al. 2002. A caspase-related protease regulates apoptosis in yeast. Mol. Cell 9: 911-917.
    • (2002) Mol. Cell , vol.9 , pp. 911-917
    • Madeo, F.1    Herker, E.2    Maldener, C.3
  • 44
    • 0347917233 scopus 로고    scopus 로고
    • The S. cerevisiae HtrA-like protein Nma111p is a nuclear serine protease that mediates yeast apoptosis
    • FAHRENKROG, B., SAUDER, U. & AEBI U. 2004. The S. cerevisiae HtrA-like protein Nma111p is a nuclear serine protease that mediates yeast apoptosis. J. Cell Sci. 117: 115-126.
    • (2004) J. Cell Sci. , vol.117 , pp. 115-126
    • Fahrenkrog, B.1    Sauder, U.2    Aebi, U.3
  • 45
    • 11844276610 scopus 로고    scopus 로고
    • Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae
    • AHN, S.-H., W.L. CHEUNG, J.-Y HSU, et al. 2005. Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae. Cell 120: 25-36.
    • (2005) Cell , vol.120 , pp. 25-36
    • Ahn, S.-H.1    Cheung, W.L.2    Hsu, J.-Y.3
  • 46
    • 0034764911 scopus 로고    scopus 로고
    • A plant defense response effector induces microbial apoptosis
    • NARASIMHAN, M.L., B. DAMSZ, M.A. COCA, et al. 2001. A plant defense response effector induces microbial apoptosis. Mol. Cell 8: 921-930.
    • (2001) Mol. Cell , vol.8 , pp. 921-930
    • Narasimhan, M.L.1    Damsz, B.2    Coca, M.A.3
  • 47
    • 19944430433 scopus 로고    scopus 로고
    • Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor
    • NARASIMHAN, M.L., M.A. COCA, J. JIN, et al. 2005. Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor. Mol. Cell 17: 171-180.
    • (2005) Mol. Cell , vol.17 , pp. 171-180
    • Narasimhan, M.L.1    Coca, M.A.2    Jin, J.3
  • 48
    • 0037007151 scopus 로고    scopus 로고
    • Pheromone induces programmed cell death in S. cerevisiae
    • SEVERIN, F.F. & A.A. HYMAN. 2002. Pheromone induces programmed cell death in S. cerevisiae. Curr. Biol. 12: 233-235.
    • (2002) Curr. Biol. , vol.12 , pp. 233-235
    • Severin, F.F.1    Hyman, A.A.2
  • 49
    • 13844294270 scopus 로고    scopus 로고
    • Role of mitochondria in the pheromone- and amiodarone-induced programmed death of yeast
    • POZNIAKOVSKY, A.I., D.A. KNORRE, O.V. MARKOVA, et al. 2005. Role of mitochondria in the pheromone- and amiodarone-induced programmed death of yeast. J. Cell Biol. 168: 257-269.
    • (2005) J. Cell Biol. , vol.168 , pp. 257-269
    • Pozniakovsky, A.I.1    Knorre, D.A.2    Markova, O.V.3
  • 50
    • 0020070207 scopus 로고
    • Cytogerontology since 1881: A reappraisal of August Weismann and a review of modern progress
    • KIRKWOOD, T.B.L. & T. CREMER. 1982. Cytogerontology since 1881: a reappraisal of August Weismann and a review of modern progress. Hum. Genet. 60: 101-121.
    • (1982) Hum. Genet. , vol.60 , pp. 101-121
    • Kirkwood, T.B.L.1    Cremer, T.2
  • 51
    • 0008915076 scopus 로고    scopus 로고
    • Cruel love among the squids
    • A.V. Byalko, Ed. Nauka-Physmatlit. Moscow
    • NESIS, K.N. 1997. Cruel love among the squids. In Russian Science: Withstand and Revive. A.V. Byalko, Ed.: 358-372. Nauka-Physmatlit. Moscow.
    • (1997) Russian Science: Withstand and Revive , pp. 358-372
    • Nesis, K.N.1
  • 52
    • 0017741637 scopus 로고
    • Hormonal inhibition of feeding and death in the Octopus: Control by optic gland secretion
    • WODINSKY, J. 1977. Hormonal inhibition of feeding and death in the Octopus: control by optic gland secretion. Science 198: 948-951.
    • (1977) Science , vol.198 , pp. 948-951
    • Wodinsky, J.1
  • 53
    • 0000506602 scopus 로고
    • Histological changes in the organs and tissues of senile castrated kokanee salmon (Oncorhynchus nerka kennerlyi)
    • ROBERTSON, O.H. & B.C. WEXLER. 1962. Histological changes in the organs and tissues of senile castrated kokanee salmon (Oncorhynchus nerka kennerlyi). Gen. Comp. Endocrinol. 2: 458-472.
    • (1962) Gen. Comp. Endocrinol. , vol.2 , pp. 458-472
    • Robertson, O.H.1    Wexler, B.C.2
  • 54
    • 29144442988 scopus 로고    scopus 로고
    • Long-lived parasite extending the life span of his host. The pearl mussel Margaritifera margaritifera turns out the program of rapid senescence in Atlantic salmon Salmo salar
    • ZIUGANOV, V.V. 2005. Long-lived parasite extending the life span of his host. The pearl mussel Margaritifera margaritifera turns out the program of rapid senescence in Atlantic salmon Salmo salar. Doklady RAS (in Russian) 403: 701-705.
    • (2005) Doklady RAS (In Russian) , vol.403 , pp. 701-705
    • Ziuganov, V.V.1
  • 55
    • 13844261177 scopus 로고    scopus 로고
    • Inhibitory effects of anticancer peptide from Mercenaria on the BGC-823 cells and several enzymes
    • LENG, B., X.D. LIU & Q.X. CHEN. 2005. Inhibitory effects of anticancer peptide from Mercenaria on the BGC-823 cells and several enzymes. FEBS Lett. 579: 1187-1190.
    • (2005) FEBS Lett. , vol.579 , pp. 1187-1190
    • Leng, B.1    Liu, X.D.2    Chen, Q.X.3
  • 56
    • 0023856536 scopus 로고
    • What is the cause of the aging atrophy? Total number, size, and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men
    • LEXELL, J., C.C. TAYLOR & M. SJÖSTRÖM. 1988. What is the cause of the aging atrophy? Total number, size, and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men. J. Neurol. Sci. 84: 275-294.
    • (1988) J. Neurol. Sci. , vol.84 , pp. 275-294
    • Lexell, J.1    Taylor, C.C.2    Sjöström, M.3
  • 57
    • 0018356090 scopus 로고
    • Muscle strength and speed of movement in relation to age and muscle morphology
    • LARSSON, L., G. GRIMBY & J. KARLSSON. 1979. Muscle strength and speed of movement in relation to age and muscle morphology. J. Appl. Physiol. 46: 451-456.
    • (1979) J. Appl. Physiol. , vol.46 , pp. 451-456
    • Larsson, L.1    Grimby, G.2    Karlsson, J.3
  • 58
    • 0033382342 scopus 로고    scopus 로고
    • Effects of aging on muscle strength and functional ability of healthy Saudi Arabian males
    • AL-ABDULWAHAB, S.S. 1999. Effects of aging on muscle strength and functional ability of healthy Saudi Arabian males. Ann. Saudi Med. 19: 211-215.
    • (1999) Ann. Saudi Med. , vol.19 , pp. 211-215
    • Al-Abdulwahab, S.S.1
  • 59
    • 21644479467 scopus 로고    scopus 로고
    • Arctic and southern freshwater pearl mussel Margaritifera margaritifera with long and short life span as a model system for testing longevity mechanisms
    • ZIUGANOV, V.V. 2004. Arctic and southern freshwater pearl mussel Margaritifera margaritifera with long and short life span as a model system for testing longevity mechanisms. Adv. Gerontol. Russ. 14: 21-30.
    • (2004) Adv. Gerontol. Russ. , vol.14 , pp. 21-30
    • Ziuganov, V.V.1
  • 60
    • 0347359103 scopus 로고    scopus 로고
    • Reduced free-radical production and extreme longevity in the little brown bat (Myotis lucifugus) vs. two nonflying mammals
    • BRUNET-ROSSINNI, A.K. 2004. Reduced free-radical production and extreme longevity in the little brown bat (Myotis lucifugus) vs. two nonflying mammals. Mech. Ageing Dev. 125: 11-20.
    • (2004) Mech. Ageing Dev. , vol.125 , pp. 11-20
    • Brunet-Rossinni, A.K.1
  • 61
    • 4644342867 scopus 로고    scopus 로고
    • Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae
    • FABRIZIO, P., L. BATTISTELLA, R. VARDAVAS, et al. 2004. Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae. J. Cell Biol. 166: 1055-1067.
    • (2004) J. Cell Biol. , vol.166 , pp. 1055-1067
    • Fabrizio, P.1    Battistella, L.2    Vardavas, R.3
  • 62
    • 10744230830 scopus 로고    scopus 로고
    • Chronological aging leads to apoptosis in yeast
    • HERKER, E., H. JUNGWIRTH, K.A. LEHMANN, et al. 2004. Chronological aging leads to apoptosis in yeast. J. Cell Biol. 164: 501-507.
    • (2004) J. Cell Biol. , vol.164 , pp. 501-507
    • Herker, E.1    Jungwirth, H.2    Lehmann, K.A.3
  • 63
    • 0142030521 scopus 로고    scopus 로고
    • To what end does nature produce superoxide? NADPH oxidase as an autocrine modifier of membrane phospholipids generating paracrine lipid messengers
    • SARAN, M. 2003. To what end does nature produce superoxide? NADPH oxidase as an autocrine modifier of membrane phospholipids generating paracrine lipid messengers. Free Radic. Res. 37: 1045-1059.
    • (2003) Free Radic. Res. , vol.37 , pp. 1045-1059
    • Saran, M.1
  • 64
    • 0035853552 scopus 로고    scopus 로고
    • Regulation of longevity and stress resistance by Sch9 in yeast
    • FABRIZIO, P., F. POZZA, S.D. PLETCHER, et al. 2001. Regulation of longevity and stress resistance by Sch9 in yeast. Science 292: 288-290.
    • (2001) Science , vol.292 , pp. 288-290
    • Fabrizio, P.1    Pozza, F.2    Pletcher, S.D.3
  • 65
    • 0037280096 scopus 로고    scopus 로고
    • SOD2 functions downstream of Sch9 to extend longevity in yeast
    • FABRIZIO, P., L.L. LIOU, V.N. MOY, et al. 2003. SOD2 functions downstream of Sch9 to extend longevity in yeast. Genetics 163: 35-46.
    • (2003) Genetics , vol.163 , pp. 35-46
    • Fabrizio, P.1    Liou, L.L.2    Moy, V.N.3
  • 66
    • 0037011958 scopus 로고    scopus 로고
    • p53 mutant mice that display early aging-associated phenotypes
    • TYNER, S.D., S. VENKATACHALAM, J. CHOI, et al. 2002. p53 mutant mice that display early aging-associated phenotypes. Nature 415: 45-53.
    • (2002) Nature , vol.415 , pp. 45-53
    • Tyner, S.D.1    Venkatachalam, S.2    Choi, J.3
  • 67
    • 0037112844 scopus 로고    scopus 로고
    • "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant, and age normally
    • GARCIA-CAO, I., M. GARCIA-CAO, J. MARTIN-CABALLERO, et al. "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant, and age normally. EMBO J. 21: 6225-6235.
    • EMBO J. , vol.21 , pp. 6225-6235
    • Garcia-Cao, I.1    Garcia-Cao, M.2    Martin-Caballero, J.3
  • 68
    • 1042266548 scopus 로고    scopus 로고
    • Modulation of mammalian life span by the short isoform of p53
    • MAIER, B., W. GLUBA, B. BERNIER, et al. 2004. Modulation of mammalian life span by the short isoform of p53. Genes Dev. 18: 306-319.
    • (2004) Genes Dev. , vol.18 , pp. 306-319
    • Maier, B.1    Gluba, W.2    Bernier, B.3
  • 69
    • 0036678040 scopus 로고    scopus 로고
    • Cytochrome c release and mitochondria involvement in programmed cell death induced by acetic acid in Saccharomyces cerevisiae
    • LUDOVICO, P., F. RODRIGUES, A. ALMEIDA, et al. 2002. Cytochrome c release and mitochondria involvement in programmed cell death induced by acetic acid in Saccharomyces cerevisiae. Mol. Biol. Cell 13: 2598-2606.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 2598-2606
    • Ludovico, P.1    Rodrigues, F.2    Almeida, A.3
  • 71
    • 25844468410 scopus 로고    scopus 로고
    • Aging and mitochondrial dysfunction in the filamentous fungus Podospora anserine
    • T. Nystrom & H.D. Osiewacz, Eds. Springer-Verlag. Berlin
    • OSIEWACZ, H.D. 2003. Aging and mitochondrial dysfunction in the filamentous fungus Podospora anserine. In Topics in Current Genetics: Model Systems in Aging, Vol. 3. T. Nystrom & H.D. Osiewacz, Eds.: 17-38. Springer-Verlag. Berlin.
    • (2003) Topics in Current Genetics: Model Systems in Aging , vol.3 , pp. 17-38
    • Osiewacz, H.D.1
  • 72
    • 0029776793 scopus 로고    scopus 로고
    • Determination of life-span in Caenorhabditis elegans by four clock genes
    • LAKOWSKI, B. & S. HEKIMI. 1996. Determination of life-span in Caenorhabditis elegans by four clock genes. Science 272: 1010-1013.
    • (1996) Science , vol.272 , pp. 1010-1013
    • Lakowski, B.1    Hekimi, S.2
  • 73
    • 0037470539 scopus 로고    scopus 로고
    • Genetics and the specificity of the aging process
    • HEKIMI, S. & L. GUARENTE. 2003. Genetics and the specificity of the aging process. Science 299: 1351-1354.
    • (2003) Science , vol.299 , pp. 1351-1354
    • Hekimi, S.1    Guarente, L.2
  • 75
    • 0033581704 scopus 로고    scopus 로고
    • The p66shc adaptor protein controls oxidative stress response and life span in mammals
    • MIGLIACCIO, E., M. GIORGIO, S. MELE, et al. 1999. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402: 309-313.
    • (1999) Nature , vol.402 , pp. 309-313
    • Migliaccio, E.1    Giorgio, M.2    Mele, S.3
  • 76
    • 85047695800 scopus 로고    scopus 로고
    • A p53-p66Shc signaling pathway controls intracellular redox status, levels of oxidation-damaged DNA, and oxidative stress-induced apoptosis
    • TRINEI, M., M. GIORGIO, A. CICALESE, et al. 2002. A p53-p66Shc signaling pathway controls intracellular redox status, levels of oxidation-damaged DNA, and oxidative stress-induced apoptosis. Oncogene 21: 3872-3878.
    • (2002) Oncogene , vol.21 , pp. 3872-3878
    • Trinei, M.1    Giorgio, M.2    Cicalese, A.3
  • 77
    • 0037452461 scopus 로고    scopus 로고
    • Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet
    • NAPOLI, C., I. MARTIN-PADURA, F. DE NIGRIS, et al. 2003. Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet. Proc. Natl. Acad. Sci. USA 100: 2112-2116.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 2112-2116
    • Napoli, C.1    Martin-Padura, I.2    De Nigris, F.3
  • 78
    • 21144434217 scopus 로고    scopus 로고
    • Extension of murine life span by overexpression of catalase targeted to mitochondria
    • SCHRINER, S.E., N.J. LINFORD, G.M. MARTIN, et al. 2005. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 308: 1909-1911.
    • (2005) Science , vol.308 , pp. 1909-1911
    • Schriner, S.E.1    Linford, N.J.2    Martin, G.M.3
  • 79
    • 0015220921 scopus 로고
    • Age-associated elevation of hypothalamic threshold to feedback control, and its role in development, aging, and disease
    • DILMAN, V.M. 1971. Age-associated elevation of hypothalamic threshold to feedback control, and its role in development, aging, and disease. Lancet 1: 1211-1219.
    • (1971) Lancet , vol.1 , pp. 1211-1219
    • Dilman, V.M.1
  • 80
    • 0018077244 scopus 로고
    • Aging, metabolic immunodepression, and carcinogenesis
    • DILMAN, V.M. 1978. Aging, metabolic immunodepression, and carcinogenesis. Mech. Ageing Dev. 8: 153-173.
    • (1978) Mech. Ageing Dev. , vol.8 , pp. 153-173
    • Dilman, V.M.1
  • 81
    • 0018402590 scopus 로고
    • Hypothalamic mechanisms of aging and of specific age pathology. I. Sensitivity threshold of hypothalamo-pituitary complex to homeostatic stimuli in the reproductive system
    • DILMAN, V.M. & V.N. ANISIMOV. 1979. Hypothalamic mechanisms of aging and of specific age pathology. I. Sensitivity threshold of hypothalamo-pituitary complex to homeostatic stimuli in the reproductive system. Exp. Gerontol. 14: 161-174.
    • (1979) Exp. Gerontol. , vol.14 , pp. 161-174
    • Dilman, V.M.1    Anisimov, V.N.2
  • 83
    • 0343442106 scopus 로고
    • The pineal gland and melatonin: The aging clock? A concept and experimental evidence
    • G. Nappi, E. Martignoni, A.R. Genazzani & F. Petraglia, Eds. Raven Press. New York
    • PIERPAOLI, W. & C.X. YI. 1990. The pineal gland and melatonin: the aging clock? A concept and experimental evidence. In Stress and the Aging Brain. G. Nappi, E. Martignoni, A.R. Genazzani & F. Petraglia, Eds.: 172-175. Raven Press. New York.
    • (1990) Stress and the Aging Brain , pp. 172-175
    • Pierpaoli, W.1    Yi, C.X.2
  • 84
    • 0026377775 scopus 로고
    • The pineal control of aging. The effects of melatonin and pineal grafting on the survival of older mice
    • PIERPAOLI, W., A. DALL'ARA, E. PEDRINIS & W. REGELSON. 1991. The pineal control of aging. The effects of melatonin and pineal grafting on the survival of older mice. Ann. N.Y Acad. Sci. 621: 291-313
    • (1991) Ann. N.Y Acad. Sci. , vol.621 , pp. 291-313
    • Pierpaoli, W.1    Dall'Ara, A.2    Pedrinis, E.3    Regelson, W.4
  • 85
    • 0027952777 scopus 로고
    • Pineal control of aging: Effect of melatonin and pineal grafting on aging mice
    • PIERPAOLI, W. & W. REGELSON. 1994. Pineal control of aging: effect of melatonin and pineal grafting on aging mice. Proc. Natl. Acad. Sci. USA 91: 787-791.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 787-791
    • Pierpaoli, W.1    Regelson, W.2
  • 86
    • 0028341816 scopus 로고
    • Pineal cross-ransplantation (old-to-young and vice versa) as evidence for an endogenous "aging clock"
    • LESNIKOV, V.A. & W. PIERPAOLI. 1994. Pineal cross-ransplantation (old-to-young and vice versa) as evidence for an endogenous "aging clock." Ann. N.Y. Acad. Sci. 719: 456-460.
    • (1994) Ann. N.Y. Acad. Sci. , vol.719 , pp. 456-460
    • Lesnikov, V.A.1    Pierpaoli, W.2
  • 87
    • 0030878594 scopus 로고    scopus 로고
    • Circadian melatonin and young-to-old pineal grafting postpone aging and maintain juvenile conditions of reproductive functions in mice and rats
    • PIERPAOLI, W., D. BULIAN, A. DALL'ARA, et al. 1997. Circadian melatonin and young-to-old pineal grafting postpone aging and maintain juvenile conditions of reproductive functions in mice and rats. Exp. Gerontol. 32: 587-602.
    • (1997) Exp. Gerontol. , vol.32 , pp. 587-602
    • Pierpaoli, W.1    Bulian, D.2    Dall'Ara, A.3
  • 88
    • 0035035264 scopus 로고    scopus 로고
    • The pineal aging and death program. I. Grafting of old pineals in young mice accelerates their aging
    • PIERPAOLI, W. & D. BULIAN. 2001. The pineal aging and death program. I. Grafting of old pineals in young mice accelerates their aging. J. Anti-Aging Med. 4: 31-37.
    • (2001) J. Anti-Aging Med. , vol.4 , pp. 31-37
    • Pierpaoli, W.1    Bulian, D.2
  • 89
    • 0037942739 scopus 로고    scopus 로고
    • Extended longevity in mice lacking the insulin receptor in adipose tissue
    • BLÜHER, M., B.B. KAHN & C.R. KAHN. 2003. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299: 572-574.
    • (2003) Science , vol.299 , pp. 572-574
    • Blüher, M.1    Kahn, B.B.2    Kahn, C.R.3
  • 90
    • 0347664057 scopus 로고    scopus 로고
    • IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
    • HOLZENBERGER, M., J. DUPONT, B. DUCOS, et al. 2003. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421: 182-187.
    • (2003) Nature , vol.421 , pp. 182-187
    • Holzenberger, M.1    Dupont, J.2    Ducos, B.3
  • 91
    • 0037470488 scopus 로고    scopus 로고
    • Evolutionary medicine: From dwarf model systems to healthy centenarians
    • LONGO, V.D. & C.E. FINCH. 2003. Evolutionary medicine: from dwarf model systems to healthy centenarians. Science 299: 1342-1346.
    • (2003) Science , vol.299 , pp. 1342-1346
    • Longo, V.D.1    Finch, C.E.2
  • 92
    • 3142749712 scopus 로고    scopus 로고
    • Long-lived Drosophila with overexpressed dFOXO in adult fat body
    • GIANNAKOU, M.E., M. GOSS, M.A. JUNGER, et al. 2004. Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 305: 361.
    • (2004) Science , vol.305 , pp. 361
    • Giannakou, M.E.1    Goss, M.2    Junger, M.A.3
  • 93
    • 0027771804 scopus 로고
    • A C. elegans mutant that lives twice as long as wild type
    • KENYON, C., J. CHANG, E. GENSCH, et al. 1993. A C. elegans mutant that lives twice as long as wild type. Nature 366: 461-464.
    • (1993) Nature , vol.366 , pp. 461-464
    • Kenyon, C.1    Chang, J.2    Gensch, E.3
  • 94
    • 0042092531 scopus 로고    scopus 로고
    • Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    • MURPHY, C.T., S.A. MCCARROLL, C.I. BARGMANN, et al. 2003. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 434: 277-283.
    • (2003) Nature , vol.434 , pp. 277-283
    • Murphy, C.T.1    McCarroll, S.A.2    Bargmann, C.I.3
  • 95
    • 2642580016 scopus 로고    scopus 로고
    • Premature aging in mice expressing defective mitochondrial DNA polymerase
    • TRIFUNOVIC, A., A. WREEENBERG, M. FALKENBERG, et al. 2004. Premature aging in mice expressing defective mitochondrial DNA polymerase. Nature 429: 417-423.
    • (2004) Nature , vol.429 , pp. 417-423
    • Trifunovic, A.1    Wreeenberg, A.2    Falkenberg, M.3
  • 96
    • 2942576595 scopus 로고    scopus 로고
    • Cardiac disease due to random mitochondrial DNA mutations is prevented by cyclosporin A
    • MOTT, J.L., D. ZHANG, J.C. FREEMAN, et al. 2004. Cardiac disease due to random mitochondrial DNA mutations is prevented by cyclosporin A. Biochim. Biophys. Res. Commun. 319: 1210-1215.
    • (2004) Biochim. Biophys. Res. Commun. , vol.319 , pp. 1210-1215
    • Mott, J.L.1    Zhang, D.2    Freeman, J.C.3
  • 97
    • 0032972559 scopus 로고    scopus 로고
    • Positive correlation between mammalian life span and cellular resistance to stress
    • KAPAHI, P., M.E. BOULTON & T.B.L. KIRKWOOD. 1999. Positive correlation between mammalian life span and cellular resistance to stress. Free Radic. Biol. Med. 26: 495-500.
    • (1999) Free Radic. Biol. Med. , vol.26 , pp. 495-500
    • Kapahi, P.1    Boulton, M.E.2    Kirkwood, T.B.L.3
  • 98
    • 0032439245 scopus 로고    scopus 로고
    • Mitochondrial free radical production and aging in mammals and birds
    • BARJA, G. 1998. Mitochondrial free radical production and aging in mammals and birds. Ann. N.Y. Acad. Sci. 854: 224-238.
    • (1998) Ann. N.Y. Acad. Sci. , vol.854 , pp. 224-238
    • Barja, G.1
  • 99
    • 5444230868 scopus 로고    scopus 로고
    • Mitochondria, reactive oxygen species, and longevity: Some lessons from the Barja group
    • SKULACHEV, V.P. 2004. Mitochondria, reactive oxygen species, and longevity: some lessons from the Barja group. Aging Cell 3: 17-19.
    • (2004) Aging Cell , vol.3 , pp. 17-19
    • Skulachev, V.P.1
  • 100
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • KIRKWOOD, T. 2005. Understanding the odd science of aging. Cell 120: 437-447.
    • (2005) Cell , vol.120 , pp. 437-447
    • Kirkwood, T.1
  • 101
    • 2442679213 scopus 로고    scopus 로고
    • Aging and the mystery at Aries
    • NEMOTO, S. & T. FINKEL. 2004. Aging and the mystery at Aries. Nature 429: 149-152.
    • (2004) Nature , vol.429 , pp. 149-152
    • Nemoto, S.1    Finkel, T.2
  • 102
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • HARMAN, D. 1956. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11: 298-300.
    • (1956) J. Gerontol. , vol.11 , pp. 298-300
    • Harman, D.1
  • 103
    • 0141766912 scopus 로고    scopus 로고
    • Demography of dietary restriction and death in Drosophila
    • MAIR, W., P. GOYMER, S.D. PLETCHER & L. PARTRIDGE. 2003. Demography of dietary restriction and death in Drosophila. Science 301: 1731-1733.
    • (2003) Science , vol.301 , pp. 1731-1733
    • Mair, W.1    Goymer, P.2    Pletcher, S.D.3    Partridge, L.4
  • 104
    • 0031266238 scopus 로고    scopus 로고
    • Aging is a specific biological function rather than the result of a disorder in complex living systems: Biochemical evidence in support of Weismann's hypothesis
    • SKULACHEV, V.P. 1997. Aging is a specific biological function rather than the result of a disorder in complex living systems: biochemical evidence in support of Weismann's hypothesis. Biochem. Moscow 62: 1191-1195.
    • (1997) Biochem. Moscow , vol.62 , pp. 1191-1195
    • Skulachev, V.P.1
  • 105
    • 0034697626 scopus 로고    scopus 로고
    • Population viscosity and the evolution of altruism
    • MITTELDORF, J. & D.S. WILSON. 2000. Population viscosity and the evolution of altruism. J. Theor. Biol. 204: 481-496.
    • (2000) J. Theor. Biol. , vol.204 , pp. 481-496
    • Mitteldorf, J.1    Wilson, D.S.2
  • 106
    • 21644472973 scopus 로고    scopus 로고
    • Reflections on an unsolved problem of biology: The evolution of senescence and death
    • CLARK, W.R. 2004. Reflections on an unsolved problem of biology: the evolution of senescence and death. Adv. Gerontol. Russ. 14: 7-20.
    • (2004) Adv. Gerontol. Russ. , vol.14 , pp. 7-20
    • Clark, W.R.1
  • 107
    • 1842841003 scopus 로고    scopus 로고
    • The evolution of programmed death in a spatially structured population
    • TRAVIS, J.M.J. 2004. The evolution of programmed death in a spatially structured population. J. Gerontol. 59: 301-305.
    • (2004) J. Gerontol. , vol.59 , pp. 301-305
    • Travis, J.M.J.1
  • 108
    • 13844257506 scopus 로고    scopus 로고
    • The nonexistent aging program: How does it work?
    • BREDESEN, D.E. 2004. The nonexistent aging program: how does it work? Aging Cell 3: 255-259.
    • (2004) Aging Cell , vol.3 , pp. 255-259
    • Bredesen, D.E.1
  • 109
    • 0014674557 scopus 로고
    • Mechanism of coupling of oxidative phosphorylation and the membrane potential of mitochondria
    • LIBERMAN, E.A., V.P. TOPALI, L.M. TSOFINA, et al. 1969. Mechanism of coupling of oxidative phosphorylation and the membrane potential of mitochondria. Nature 222: 1076-1078.
    • (1969) Nature , vol.222 , pp. 1076-1078
    • Liberman, E.A.1    Topali, V.P.2    Tsofina, L.M.3
  • 110
    • 0036237241 scopus 로고    scopus 로고
    • Prevention of mitochondrial oxidative damage using targeted antioxidants
    • KELSO, G.F., C.M. PORTEOUS, G. HUGHES, et al. Prevention of mitochondrial oxidative damage using targeted antioxidants. Ann. N.Y. Acad. Sci. 959: 263-274.
    • Ann. N.Y. Acad. Sci. , vol.959 , pp. 263-274
    • Kelso, G.F.1    Porteous, C.M.2    Hughes, G.3
  • 111
    • 21344470348 scopus 로고    scopus 로고
    • How to clean the dirtiest place in the cell: Cationic antioxidants as intramitochondrial ROS scavengers
    • SKULACHEV, V.P. 2005. How to clean the dirtiest place in the cell: cationic antioxidants as intramitochondrial ROS scavengers. IUBMB Life 57: 305-310.
    • (2005) IUBMB Life , vol.57 , pp. 305-310
    • Skulachev, V.P.1


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