Death commitment point is advanced by axotomy in sympathetic neurons

Journal of Cell Biology

Volumn 150, Issue 4, 2000, Pages 741-754

  Fletcher, G C ^a   Xue, L ^a   Passingham, S K ^a   Tolkovsky, A M ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Apoptosis; Caspases; Mitochondria; NGF; Survival signaling

Indexed keywords

CASPASE; CYTOCHROME C OXIDASE; NERVE GROWTH FACTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; MITOCHONDRION; NERVE CELL NECROSIS; NERVE FIBER TRANSECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SYMPATHETIC NERVE CELL;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; ASPARTIC ACID; AXOTOMY; CASPASES; CELL DIVISION; CELL SURVIVAL; CELLS, CULTURED; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE GROWTH FACTOR; NEURITES; NEURONS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; SUPERIOR CERVICAL GANGLION;

ANIMALIA;

EID: 0034698759     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.150.4.741     Document Type: Article

References (55)

1. A role for MAPK/ERK in sympathetic neuron survival: Protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside
2. Neuroprotection by a caspase inhibitor in acute bacterial meningitis
3. Nerve growth-factor is required for induction of c-fos immunoreactivity by serum, depolarization, cyclic-AMP or trauma in cultured rat sympathetic neurons
4. A hierarchy of ATP-consuming processes in mammalian cells
5. Caspase inhibitors block the retinal ganglion cell death following optic nerve transection
6. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia
7. Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury
8. Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons
9. The survival of sympathetic neurons promoted by potassium depolarization, but not by cyclic AMP, requires phosphatidylinositol 3-kinase and Akt
10. Temporal analysis of events associated with programmed cell-death (apoptosis) of sympathetic neurons deprived of nerve growth factor
11. Evidence of a novel event during neuronal death: Development of competence-to-die in response to cytoplasmic cytochrome c
12. Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases
13. Analysis of the mechanism of loss of trophic factor dependence associated with neuronal maturation: A phenotype indistinguishable from Bax deletion
14. Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal
15. Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons
16. Establishment of a cell-free system of neuronal apoptosis: Comparison of premitochondrial, mitochondrial, and postmitochondrial phases
17. Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis
18. Prolonged therapeutic window for ischemic brain damage caused by delayed caspase activation
19. Control of neuronal size homeostasis by trophic factor-mediated coupling of protein degradation to protein synthesis
20. Function of caspases in regulating apoptosis caused by erythropoietin deprivation in erythroid progenitors
21. A c-jun dominant-negative mutant protects sympathetic neurons against programmed cell death
22. Inhibition of interleukin 1 β-converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage
23. The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death
24. Contribution of p53-dependent caspase activation to neuronal cell death declines with neuronal maturation
25. Long-term effect of inhibition of ced 3-like caspases on the survival of axotomized retinal ganglion cells in vivo
26. Regulation of caspase activation in apoptosis: Implications in pathogenesis and treatment of disease
27. Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
28. The mitochondrial permeability transition in cell death: A common mechanism in necrosis, apoptosis and autophagy
29. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death
30. Induction of apoptotic programme in cell free extracts: Requirement for dATP and cytochrome c
31. The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event
32. Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak
33. Characterization of caspase processing and activation in HL-60 cell cytosol under cell-free conditions: Nucleotide requirement and inhibitor profile
34. Lack of apoptosis in mice with ALS
35. Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death
36. Blocking cytochrome c activity within intact neurons inhibits apoptosis
37. Neutralizing anti-p21ras Fabs suppress rat sympathetic neuron survival induced by NGF, LIF, CNTF and cyclic AMP
38. Active p21Ras is sufficient for rescue of rat sympathetic neurons
39. A suicide note from Alzheimer disease neurons?
40. Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons
41. Programmed cell death of embryonic motoneurons triggered through the Fas death receptor
42. Caspase inhibition reduces apoptosis and increases survival of nigral transplants
43. Caspases as treatment targets in stroke and neurodegenerative diseases
44. In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease
45. Caspase-dependent and -independent death of camptothecin-treated embryonic cortical neurons
46. Substrate specificities of caspase family proteases
47. Calpain inhibitors, but not caspase inhibitors, prevent actin proteolysis and DNA fragmentation during apoptosis
48. Activation of p44 and p42 MAP kinases is not essential for the survival of rat sympathetic neurons
49. Comparison between the timing of JNK activation, c-Jun phosphorylation, and onset of death commitment in sympathetic neurones
50. Nerve growth factor-induced PKB/Akt activity is sustained by phosphoinositide 3-kinase dependent and independent signals in sympathetic neurons
51. The anti-apoptotic protein ITA is essential for NGF-mediated survival of embryonic chick neurons
52. Bax involvement in p53-mediated neuronal cell death
53. Autophagy is activated by apoptotic signalling in sympathetic neurons: An alternative mechanism of death execution
54. The Ras/PI3K and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signalling pathway in sympathetic neurons
55. Activation of CPP32-like caspases contributes to neuronial apoptosis and neurological dysfunction after traumatic brain injury