Use of gene transfer to study lung: Cytokine biology

Gene Therapy in Lung Disease

Volumn , Issue , 2002, Pages 171-191

  Gauldie, Jack ^a   Xing, Zhou ^a   Kolb, Martin ^b   Sime, Patricia J ^c   Warburton, David ^d  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 30644462585     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (96)

1. Rankin JA, Picarella DE, Geba GP, Temann U-A, Prasad B, DiCosmo B, Tarallo A, Stripp B, Whitsett J, Flavell RA. Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity. Proc Natl Acad Sci USA 1996; 93: 7821-7825.
2. Korfhagen TR, Swantz RJ, Wert SE, McCarty JM, Keriakian CB, Glasser SW, Whitsett JA. Respiratory epithelial cell expression of human transforming growth factor- a induces lung fibrosis in transgenic mice. J Clin Invest 1994; 93:1691-1699.
3. Tang W, Geba GP, Zheng T, Ray P, Homer RJ, Kuhn III C, Flavell RA, Elias JA. Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction. J Clin Invest 1996; 98:2845-2853.
4. Ray P, Tang W, Wang P, Homer R, Kuhn III C, Flavell RA, Elias JA. Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes. J Clin Invest 1997; 100:2501-2511.
5. Bramson JL, Graham FL, Gauldie J. The use of adenoviral vectors for gene therapy and gene transfer in vivo. Curr Opin Biotechnol 1995; 6:590-595.
6. Gauldie J, Graham F, Xing Z, Braciak T, Foley R, Sime PJ. Adenovirus vector mediated cytokine gene transfer to lung tissue. Ann NY Acad Sci 1996; 796:235-244.
7. Hitt MM, Gauldie J. Gene vectors for cytokine expression in vivo. Curr Pharm Des 2000; 6:613-632.
8. Sime PJ, Xing Z, Foley R, Graham FL, Gauldie J. Transient gene transfer and expression in the lung. Chest 1997; 111:89S-94S.
9. Xing Z, Braciak T, Ohkawara Y, Sallenave JM, Foley R, Sime PJ, Jordana M, Graham FL, Gauldie J. Gene transfer for cytokine functional studies in the lung: the multifunctional role of GM-CSF in pulmonary inflammation. J Leukoc Biol 1996; 59:481-488.
10. Xing Z, Stmpfli MR, Gauldie J. Transient transgenic approaches for investigating the role of GM-CSF in pulmonary inflammatory and immune diseases. In: Chung KF, Adcock I, eds. Methods in Molecular Medicine. Totowa, NJ: Humana Press, 2000:161-178.
11. Huang S, Paulauskis JD, Goodleski JJ, Kobzik L. Expression of MIP-2 and KC mRNA in pulmonary inflammation. Am J Pathol 1992; 141:981-988.
12. Friedland JS, Griffin GE. Cytokines and bacterial infection. In: Kunkel SL, Remick DG, eds. Cytokines in Health and Disease, New York: Marcel Dekker, 1992:165-180.
13. Xing Z, Gauldie, J, Cox G, Baumann H, Jordana M, Lei XF, Achong MK. IL-6 is an anti-inflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest 1998; 101:311-320.
14. Bachofen M, Weibel ER. Alterations of the gas exchange apparatus in adult respiratory insufficiency associated with septicemia. Am Rev Respir Dis 1977; 116:589-615.
15. Braciak TA, Bacon K, Xing Z, Torry DJ, Graham FL, Schall TJ, Richards CD, Croitoru K, Gauldie J. Overexpression of RANTES using a recombinant adenovirus vector induces the tissue-directed recruitment of monocytes to the lung. J Immunol 1996; 157:5076-5084.
16. Palmer K, Emtage PCR, Strieter RM, Gauldie J. Transient gene transfer of non-ELR chemokines to rodent lung induces mononuclear cell accumulation and activation. J Interferon Cytokine Res 1999; 19:1381-1390.
17. Foley R, Driscoll K, Wan Y, Braciak T, Howard B, Xing Z, Graham F, Gauldie J. Adenoviral gene transfer of macrophage inflammatory protein-2 in rat lung. Am J Pathol 1996; 149:1395-1403.
18. Cox G, Crossley J, Xing Z. Macrophage engulfment of apoptotic neutrophils contributes to the resolution of acute pulmonary inflammation in vivo. Am J Respir Cell Mol Biol 1995; 12:232-237.
19. Savill J, Fadok V, Henson PM, Haslett C. Phagocyte recognition of cells undergoing apoptosis. Immunol Today 1993; 14:131-136.
20. Baumann H, Gauldie J. The acute phase response. Immunol Today 1994; 15:7480.
21. Xing Z, Braciak T, Jordana M, Croitoru K, Graham FL, Gauldie J. Adenovirus- mediated cytokine gene transfer at tissue sites: overexpression of IL-6 induces lymphocytic hyperplasia in the lung. J Immunol 1994; 153:4059-4069.
22. Braciak TA, Gallichan WS, Graham FL, Richards CD, Ramsay AJ, Rosenthal KL, Gauldie J. Recombinant adenovirus vectors expressing interleukin-5 and -6 specifically enhance mucosal immunoglobulin A responses in the lung. Immunology 2000; 101:388-396.
23. Xing Z, Braciak T, Chong D, Feng X, Schroeder JA, Gauldie J. Adenoviral-mediated gene transfer of interleukin-6 in rat lung enhances antiviral immunoglobulin A and G responses in distinct tissue compartments. Biochem Biophys Res Commun 1999; 258:332-335.
24. Ramsay AJ, Husband AJ, Ranshaw IA, Bao S, Matthaei KI, Koehler G, Kopf M. The role of interleukin-6 in mucosal IgA antibody responses in vivo. Science 1994; 264:561-563.
25. Lukacs NW, Addison CL, Gauldie J, Graham F, Simpson K, Strieter RM, Warming- ton K, Chensue SW, Kunkel SL. Transgene-induced production of IL-4 alters the development and collagen expression of T helper cell 1-type pulmonary granulomas. J Immunol 1997; 158:4478-4484.
26. Itano H, Mora BN, Zhang W, Ritter JH, McCarthy TJ, Yew NS, Mohanakumar T, Patterson GA. Lipid-mediated ex vivo gene transfer of viral interleukin 10 in rat lung allotransplantation. J Thorac Cardiovasc Surg 2001; 122:29-38.
27. Mora BN, Boasquevisque CH, Boglione M, Ritter JM, Scheule RK, Yew NS, Debruyne L, Qin L, Bromberg JS, Patterson GA. Transforming growth factor-P1 gene transfer ameliorates acute lung allograft rejection. J Thorac Cardiovasc Surg 2000; 119:913-920.
28. Dokka S, Malanga CJ, Shi X, Chen F, Castranova V, Rojanasakul Y. Inhibition of endotoxin-induced lung inflammation by interleukin-10 gene transfer in mice. Am J Physiol Lung Cell Mol Physiol 2000; 279:L872-877.
29. Xing Z, Ohkawara Y, Jordana M, Graham FL, Gauldie J. Adenoviral vector-mediated IL-10 expression in vivo: intramuscular gene transfer inhibits cytokine responses in endotoxemia. Gene Ther 1997; 4:140-149.
30. McCoy RD, Davidson BL, Roessler BJ, Huffnagle GB, Simon RH. Expression of human interleukin-1 receptor antagonist in mouse lungs using a recombinant adenovirus: effects on vector-induced inflammation. Gene Ther 1995; 2:437-442.
31. Worth LL, Jia SF, Zhou Z, Chen L, Kleinerman ES. Intranasal therapy with an adenoviral vector containing the murine interleukin-12 gene eradicates osteosarcoma lung metastases. Clin Cancer Res 2000; 6:3713-3718.
32. Partovian C, Adnot S, Raffestin B, Louzier V, Levame M, Mavier IM, Lemarchand P, Eddahibi S. Adenovirus-mediated lung vascular endothelial growth factor overexpression protects against hypoxic pulmonary hypertension in rats. Am J Respir Cell Mol Biol 2000; 23:762-771.
33. Gyorffy S, Palmer K, Gauldie J. Adenoviral vector expressing murine angiostatin inhibits a model of breast cancer metastatic growth in the lungs of mice. Am J Pathol 2001; 159:1137-1147.
34. Huffman JA, Hull WM, Dranoff G, Mulligan RC, Whitsett JA. Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice. J Clin Invest 1996; 97:649-655.
35. Huffman Reed JA, Rice WR, Zsengeller ZK, Wert SE, Dranoff G, Whitsett JA. GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice. Am J Physiol 1997; 273:L715-L725.
36. Santosuosso M, Divangahi M, Zganiacz A, Xing Z. Reduced tissue macrophage population in the lung by anti-cancer agent cyclophosphamide: restoration by local GM-CSF gene transfer. Blood 2002; 99:1246-1252.
37. Xing Z, Ohkawara Y, Jordana M, Graham FL, Gauldie J. Transfer of granulocyte- macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis and fibrotic reactions. J Clin Invest 1996; 97:1102-1110.
38. Xing Z, Tremblay GM, Sime PJ, Gauldie J. Overexpression of granulocyte-macro- phage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-β1 and myofibroblast accumulation. Am J Pathol 1997; 150:59-66.
39. Temann U-A, Prasad G, Gallup MW, Basbaum C, Ho SB, Flavell RA, Rankin JA. A novel role for murine IL-4 in vivo: induction of MUC5AC gene expression and mucin hypersecretion. Am J Respir Cell Mol Biol 1997; 16:471-478.
40. Lee JJ, McGarry MP, Farmer SC, Denzler KL, Larson KA, Carrigan PE, Brenneise IE, Horton MA, Haczku A, Gelfand EW, Leikauf GD, Lee NA. Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. J Exp Med 1997; 185:2143-2156.
41. DiCosmo BF, Geba GP, Picarella D, Elias JA, Rankin JA, Stripp BR, Whitsett JA, Flavell RA. Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity. J Clin Invest 1994; 94:2028-2035.
42. Wang J, Palmer K, Lotvall J, Milan S, Lei XF, Matthaei KI, Gauldie J, Inman MD, Jordana M, Xing Z. Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia. J Clin Invest 1998; 102:1132-1141.
43. Hamelmann E, Takeda K, Haczku A, Cieslewicz G, Shultz L, Hamid Q, Xing Z, Gauldie J, Gelfand EW. Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice. Am J Respir Cell Mol Biol 2000; 23:327-334.
44. Ohkawara Y, Xing Z, Gauldie J, Jordana M. Adenovirus vector-mediated gene transfer of murine IL-10 inhibits antigen-induced airways inflammation in sensitized mice. Am J Respir Crit Care Med 1996; 153:A143.
45. Wiley R, Palmer K, Gajewska B, Stampfli M, Alvarez D, Coyle A, Gutierrez-Ramos J, Jordana M. Expression of the Th1 chemokine IFN-gamma-inducible protein 10 in the airway alters mucosal allergic sensitization in mice. J Immunol 2001; 166: 2750-2759.
46. Walter DM, Wong CP, DeKruyff RH, Berry GJ, Levy S, Umetsu DT. IL-18 gene transfer by adenovirus prevents the development of and reverses established allergen-induced airway hyperreactivity. J Immunol 2001; 166:6392-6398.
47. Foster PS, Hogan SP, Ramsay AJ, Matthaei KI, Young IG. IL-5 deficiency abolishes eosinophilia, airways hyperreactivity and lung damage in a mouse asthma model. J Exp Med 1996; 183:195-201.
48. Lei XF, Ohkawara Y, Stampfli MR, Gauldie J, Croitoru K, Jordana M, Xing Z. Compartmentalized transgene expression of granulocyte-macrophage colony- stimulating factor (GM-CSF) in mouse lung enhances allergic airways inflammation. Clin Exp Immunol 1998; 113:157-165.
49. Wang J, Snider D, Hewlett B, Lukacs N, Gauldie J, Liang H, Xing Z. Transgenic expression of GM-CSF induces the differentiation and activation of a novel dendritic cell population in the lung. Blood 2000; 95:2337-2345.
50. Stampfli MR, Wiley RE, Neigh GS, Gajewska BU, Lei X-F, Snider DP, Xing Z, Jordana M. GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice. J Clin Invest 1998; 102:1704-1714.
51. Stampfli MR, Cwiartka M, Gajewska BU, Alvarez D, Ritz SA, Inman MD, Xing Z, Jordana M. Interleukin-10 gene transfer to the airway regulates allergic mucosal sensitization in mice. Am J Respir Cell Mol Biol 1999; 21:586-596.
52. Stampfli MR, Neigh SG, Wiley RE, Cwiartka M, Ritz SA, Hitt MM, Xing Z, Jordana M. Regulation of allergic mucosal sensitization by interleukin-12 gene transfer to the airway. Am J Respir Cell Mol Biol 1999; 21:317-326.
53. Lei XF, Ohkawara Y, Stampfli MR, Mastruzzo C, Marr RA, Snider D, Xing Z, Jordana M. Disruption of antigen-induced inflammatory responses in CD40 ligand knock-out mice. J Clin Invest 1998; 101:1342-1353.
54. Ward PA, Hunninghake GW. Lung inflammation and fibrosis. Am J Respir Crit Care Med 1998; 157:S123-S129.
55. Piguet PF, Collart MA, Grau GE, Sappino A-P, Vassalli P. Requirements of TNF for development of silica-induced pulmonary fibrosis. Nature 1990; 344:245-247.
56. Selman M, King TE, Pardo A. Idiopathic pulmonary fibrosis: prevailing and evolving hypothesis about its pathogenesis and implications for therapy. Ann Intern Med 2001; 134:136-151.
57. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. Am J Respir Crit Care Med 2000; 161:646-664.
58. Piguet PF, Collart MA, Grau GE, Kapanci Y, Vassalli P. TNF/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J Exp Med 1989; 170: 655-663.
59. Piguet PF. Pulmonary fibrosis induced by silica, asbestos and bleomycin. In: Schook LB, Laskin DL, eds. Xenobiotics and Inflammation. New York: Academic Press, 1994:283-300.
60. Phan SH, Kunkel SL. Lung cytokine production in bleomycin-induced pulmonary fibrosis. Exp Lung Res 1992, 18:29-43.
61. Raghow R, Irish P, Kang AH. Coordinate regulation of TGF beta gene expression and cell proliferation in hamster lungs undergoing bleomycin-induced pulmonary fibrosis. J Clin Invest 1989; 84:1836-1842.
62. Santana A, Saxena B, Noble NA, Gold LI, Marshall BC. Increased expression of TGF beta isoforms (beta1, beta2, beta3) in bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol 1995; 13:34-44.
63. Broekelmann TJ, Limper AH, Colby TV, McDonald JA. Transforming growth factor β1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc Natl Acad Sci USA 1991; 88:6642-6646.
64. Coker RK, Laurent GJ, Shahzeidi S, Lympany PA, du Bois RM, Jeffery PK, McAnulty RJ. TGFβ1, β2, β3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis. Am J Pathol 1997; 150:981-991.
65. Khalil N, O’Connor RN, Flanders KC, Unruh H. TGF-β1, but not TGF-β2 or TGF- β3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study. Am J Respir Cell Mol Biol 1996; 14:131-138.
66. Miyazaki Y, Araki K, Vesin C, Garcia I, Kapanci Y, Whitsett JA, Piguet P-F, Vas- salli P. Expression of a tumor necrosis factor-a transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis. J Clin Invest 1995; 96:250-259.
67. Kelly J. TGFβ. In: Kelly, J, ed. Cytokines of the Lung. New York: Marcel Dekker, 1993:101-137.
68. Letterio JJ, Roberts AB. Molecule of the month. TGFβ: A key modulator of immune cell function. Clin Immunol Immunopathol 1997; 84:244-250.
69. Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G. Transforming growth factor- β1 induces α-smooth actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 1993; 122:103-111.
70. Sime PJ, Marr RA, Gauldie D, Xing Z, Hewlett BR, Graham FL, Gauldie J. Transfer of TNFa to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of TGF-β1 and myofibroblasts. Am J Pathol 1998; 153: 825-832.
71. Kolb M, Margetts PJ, Anthony DC, Pitossi F, Gauldie J. Transient expression of IL-1β induces acute lung injury and chronic repair leading to pulmonary fibrosis. J Clin Invest 2001; 107:1529-1536.
72. Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J. Adenovector-mediated gene transfer of active TGF-β1 induces prolonged severe fibrosis in rat lung. J Clin Invest 1997; 100:768-776.
73. Nakao A, Fujii M, Matsumura R, Kumano K, Saito Y, Miyazono K. Iwamoto I. Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J Clin Invest 1999; 104:5-11.
74. Isaka Y, Brees DK, Ikegaya K, Kaneda Y, Imai E, Noble NA, Border WA. Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nat Med 1996; 2:418-423.
75. Kolb M, Margetts PJ, Galt T, Sime PJ, Xing Z, Schmidt M, Gauldie J. Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycin. Am J Respir Crit Care Med 2001; 163:770-777.
76. Kolb M, Margetts PJ, Sime PJ, Gauldie J. Proteoglycans decorin and biglycan differentially modulate TGF0-mediated fibrotic responses in the lung. Am J Physiol Lung Cell Mol Physiol 2001; 280:L1327-L1334.
77. Zhao J, Sime PJ, Bringas P, Tefft JD, Buckley S, Bu D, Gauldie J, Warburton D. Spatial-specific TGF-01 adenoviral expression determines morphogenetic phenotypes in embryonic mouse lung. Eur J Cell Biol 1999: 78:715-725.
78. Zhao J, Sime PJ, Bringas P, Gauldie J, Warburton D. Epithelium-specific adenoviral transfer of a dominant-negative mutant TGF-β type II receptor stimulates embryonic lung branching morphogenesis in culture and potentiates EGF and PDGF-AA. Mech Dev 1998; 72:89-100.
79. Warburton D, Schwartz M, Tefft D. Flores-Delgado G, Anderson KD, Cardoso WV. The molecular basis of lung morphogenesis. Mech Dev 2000; 92:55-81.
80. Holgate ST, Davies DE, Lackie PM, Wilson SJ, Puddicombe SM, Jordan JL. The epithelial-mesenchymal trophic unit. J Allergy Clin Immunol 2000; 105:193-204.
81. Zhao J, Sime PJ, Bringas P, Gauldie J, Warburton D. Adenovirus-mediated decorin gene transfer prevents TGF-β-induced inhibition of lung morphogenesis. Am J Physiol 1999; 277:L412-L422.
82. Cooper AM, Flynn JL. The protective immune response to Mycobacterium tuberculosis. Curr Opin Immunol 1995; 7:512-516.
83. Standiford TJ, Huffnagle GB. Cytokines in host defense against pneumonia. J Invest Med 1997; 45:335-345.
84. Xing Z, Wang J. Consideration of cytokines as therapeutic agents or targets. Curr Pharm Des 2000; 6:599-611.
85. Munk ME, Emoto M. Functions of T-cell subsets and cytokines in mycobacterial infections. Eur Respir J 1995; 8:668s-675s.
86. Condos R, Rom WN, Schluger NW. Treatment of multidrug-resistant pulmonary tuberculosis with IFN gamma via aerosol. Lancet 1997; 349:1513-1515.
87. Kolls JK, Lei D, Nelson S, Summer WR, Shellito JE. Adenoviral-mediated murine IFN gene transfer compartmentally activates alveolar macrophages and enhances bacterial clearance. Chest 1997; 111:104S.
88. Lei D, Lancaster JR Jr, Joshi MS, Nelson S, Stolz D, Bagby GJ, Odom G, Shellito JE, Kolls JK. Activation of alveolar macrophages and lung host defenses using transfer of the interferon-γ gene. Am J Physiol 1997; 272:L852-L859.
89. Kolls JK, Habetz S, Shean MK, Vazquez C, Brown JA, Lei D, Schwarzenberger P, Ye P, Nelson S, Summer WR, Shellito JE. IFN-y and CD8+ T cells restore host defenses against pneumocystis carinii in mice depleted of CD4+ T cells. J Immunol 1999; 162:2890-2894.
90. Kumar M, Behera AK, Matsuse H, Lockey RF, Mohapatra SS. Intranasal IFN-gamma gene transfer protects BALB/C mice against respiratory syncytial virus infection. Vaccine 1999; 18:558-567.
91. Xing Z, Zganiacz A, Wang J, Sharma SK. Enhanced protection against fatal mycobacterial infection in SCID beige mice by reshaping innate immunity with IFN-γ transgene. J Immunol 2001; 167:375-383.
92. Wang Z, Zheng T, Zhu Z, Homer RJ, Riese RJ, Chapman HA Jr, Shapiro SD, Elias JA. Interferon γ induction of pulmonary emphysema in the adult murine lung. J Exp Med 2000; 192:1587-1599.
93. Standiford TJ, Wilkowski JM, Sisson TH, Hattori N, Mehrad B, Bucknell KA, Moore TA. Intrapulmonary tumor necrosis factor gene therapy increases bacterial clearance and survival in murine gram-negative pneumonia. Hum Gene Ther 1999; 10:899-909.
94. Kolls JK, Lei D, Nelson S, Summer WR, Greenberg S, Beutler B. Adenovirus- mediated blockade of tumor necrosis factor in mice protects against endotoxic shock yet impairs pulmoary host defense. J Infect Dis 1995; 171:570-575.
95. Greenberger MJ, Kunkel SL, Strieter RM, Lukacs NW, Bramson J, Gauldie J, Graham FL, Hitt M, Danforth JM, Standiford TJ. IL-12 gene therapy protects mice in lethal Klebsiella pneumonia. J Immunol 1996; 157:3006-3012.
96. Erickson AM, de la Monte SM, Moore GW, Hutchins GM. The progression of morphological changes in bronchopulmonary dysplasia. Am J Pathol 1987; 127:474-484.