Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice

Journal of Clinical Investigation

Volumn 97, Issue 3, 1996, Pages 649-655

  Huffman, Jacquelyn A ^a   Hull, William M ^a   Dranoff, Glenn ^b   Mulligan, Richard C ^c   Whitsett, Jeffrey A ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

alveolar proteinosis; gene correction; granulocyte macrophage colony stimulating factor (GM CSF); surfactant homeostasis; transgenic mice

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; LUNG SURFACTANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; GENE MUTATION; GENE TARGETING; GENETIC RECOMBINATION; IMMUNOPATHOGENESIS; IMMUNOREGULATION; LUNG ALVEOLUS PROTEINOSIS; LUNG ALVEOLUS SURFACE TENSION; LUNG CLEARANCE; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 0030038425     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118461     Document Type: Article

References (32)

1. Burgess, A.W., J. Camakans, and D. Metcalf. 1977. Purification and properties of colony-stimulating factor from mouse lung-conditioned medium. J. Biol. Chem. 252:1998-2003.
2. Gough, N.M., D. Metcalf, J. Gough, D. Grail, and A.R. Dunn. 1985. Structure and expression of the mRNA for murine granulocyte-macrophage colony stimulating factor. EMBO (Eur. Mol. Biol. Organ.) J. 4:645-653.
3. Gasson, J.C. 1991 Molecular physiology of granulocyte-macrophage colony-stimulating factor. Blood. 77:1131-1145.
4. Metcalf, D 1993. Hematopoietic regulators: redundancy or subtlety? Blood. 82:3515-3523.
5. Tazi, A., F. Bouchonnet, M. Grandsaigne, L. Boumsell, A.J. Hance, and P. Soler. 1993. Evidence that granulocyte-macrophage colony-stimulating factor regulates the distribution and differentiated state of dendritic cells/Langerhans cells in human lung and lung cancers. J. Clin. Invest. 91:566-576.
6. Churchill, L., B. Friedman, R.P. Schleimer, and D Proud. 1992. Production of granulocyte-macrophage colony-stimulating factor by cultured human tracheal epithelial cells. Immunology, 75:189-195.
7. Blau, H., S. Riklis, V. Kravtsov, and M Kalina. 1994. Secretion of cytokines by rat alveolar epithelial cells: possible regulatory role for SP-A. Am. J. Physiol. 266:L148-L155.
8. Metcalf, D. 1991. Transgenic mice as models of hemopoiesis. Cancer (Phila.) 67(Suppl. 10):2695-2699.
9. Mantel, C., Z Luo, P. Hendrie, and H.E. Broxmeyer 1993. Steel factor and granulocyte-macrophage colony stimulating factor act together to enhance choline-lipid turnover during synergistically stimulated proliferation of the human factor dependent cell line, MO7e. Biochem. Biophys. Res. Commun. 197: 978-984.
10. Dranoff, G., E. Jaffee, A. Lazenby, P Golumbek, H. Levitsky, K Brose, V. Jackson, H. Hamada, D. Pardoll, and R. Mulligan. 1993 Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl. Acad Sci. USA. 90:3539-3543.
11. Bussolino, F., F. Colotta, E. Bocchietto, A. Guglielmetti, and A Mantovani. 1993. Recent developments in the cell biology of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor: activities on endothelial cells. Int. J. Clin & Lab. Res. 23:8-12.
12. Dexter, T.M., J. Garland, D. Scott, E. Scolnick, and D. Metcalf. 1980. Growth of factor-dependent hemopoietic precursor cell lines J Exp. Med. 152: 1036-1047.
13. Greenberger, J.S., M. Sakakeeny, R.K Humphries, C J. Eaves, and R. J. Eckner. 1983. Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cells lines. Proc Natl Acad. Sci. USA. 80:2931-2935.
14. Donahue, R.E., E A. Wang, D.K. Stone, R. Kamen, G.G. Wong, P.K. Sehgal, D.G. Nathan, and S C. Clark. 1986. Stimulation of hematopoiesis in primates by continuous infusion of recombinant human GM-CSF. Nature (Lond.). 321:872-875.
15. Aglietta, M., W. Piacibello, P. Pasquino, F. Sanavio, A. Stacchini, C. Volta, A. Monteverde, L. Fubini, S. Morelli, and A. Severino. 1994. Rationale for the use of granulocyte-macrophage colony-stimulating factor in oncology. Semin. Oncol. 21(Suppl. 16):5-9.
16. Dranoff, G., A.D. Crawford, M. Sadelain, B. Ream, A. Rasbid, R.T. Bronson, G.R. Dickersin, C.J. Bachurski, E L Mark, J.A Whitsett, and R.C. Mulligan. 1994. Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis Science (Wash. DC). 264:713-716.
17. Stanley, E., G.J. Lieschke, D. Grail, D. Metcalf, G. Hodgson, J.A.M. Gall, D.W. Maher, J. Cebon, V Sinickas, and A.R. Dunn. 1994. Granulocyte/ macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc. Natl. Acad. Sci. USA. 91:5592-5596.
18. Lieschke, G.J., E. Stanley, D. Grail, G. Hodgson, V. Sinickas, J.A M. Gall, R.A. Sinclair, and A. R. Dunn. 1994 Mice lacking both macrophage- and granulocyte-macrophage colony-stimulating factor have macrophages and coexistent osteopetrosis and severe lung disease. Blood. 84:27-35.
19. Weaver, T E., and J.A. Whitsett. 1991. Function and regulation of expression of pulmonary surfactant-associated proteins. Biochem. J. 273:249-264.
20. Rider, D.D., M. Ikegami, and A.H. Jobe. 1992. Localization of alveolar surfactant clearance in rabbit lung cells. Am. J Physiol. 263 (Lung Cell. Mol. Physiol. 8):L201-L209.
21. Glasser, S.W., T.R. Korfhagen, S.E. Wert, M.D. Bruno, K.M. McWilliams, D.K Vorbroker, and J.A. Whitsett. 1991. Genetic element from human surfactant protein SP-C gene confers bronchiolar-alveolar cell specificity in transgenic mice. Am. J. Physiol. (Lung Cell. Mol. Physiol.) 261:L349-L356.
22. Korfhagen, T R., S W. Glasser, S.E. Wert, M.D. Bruno, C C. Daugherty, J.D. McNeish, J.L Stock, S.S. Potter, and J.A. Whitsett. 1990. Cis-acting sequences from a human surfactant protein gene confer pulmonary-specific gene expression in transgenic mice Proc. Natl Acad. Sci. USA. 87:6122-6126.
23. Wikenheiser, K.A., J.C. Clark, R.I. Linnoila, M.T. Stahlman, and J.A. Whitsett. 1992. Simian virus 40 large T antigen directed by transcriptional elements of the human surfactant protein C gene produces pulmonary adenocarcinomas in transgenic mice. Cancer Res. 52:5342-5352.
24. Buckingham, K.W., and W E Wyder. 1981. Rapid tracheal infusion method for routine lung fixation using rat and guinea pig. Toxicol. Pathol. 9:17-20.
25. Clark, J.C., SE. Wert, C.J. Bachurski, M.T. Stahlman, B R. Stripp, T.E Weaver, and J A. Whitsett. 1995. Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice Proc. Natl. Acad. Sci. USA. 92:7794-7798.
26. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
27. Lesur, O., R.A.W. Veldhuizen, J.A. Whitsett, W.M. Hull, F. Possmayer, A. Cantin, and R. Begin. 1993. Surfactant-associated proteins (SP-A, SP-B) are increased proportionally to alveolar phospholipids in sheep silicosis. Lung 171:63-74.
28. 27a Ikegami, M., T. Ueda, W. Hull, J.A. Whitsett, R.C. Mulligan, G. Dranoff, and A.H. Jobe. 1996. Surfactant metabolism in transgenic mice after granulocyte macrophage-colony stimulating factor ablation. Am. J. Physiol. (Lung Cell Mol Biol.). In press.
29. Mitruka, B M , and H.M Rawnsley. 1981. Clinical biochemical and hematological reference values in normal experimental animals and normal humans. Masson Publishing USA, Inc., New York, 60-61.
30. Gearing, A. J., D. Metcalf, J.G. Moore, and N.A. Nicola. 1989. Elevated levels of GM-CSF and IL-1 in the serum, peritoneal and pleural cavities of GM-CSF transgenic mice. Immunology 67:216-220.
31. Glasser, S.W., T.R. Korfhagen, S.E. Wert, and J.A. Whitsett. 1994. Transgenic models for study of pulmonary development and disease Am. J. Physiol. 267 (Lung Cell. Mol. Physiol.)267:L489-L497.
32. Hildebrand, F.L , E.C. Rosenow, T.M Habermann, and H.D. Tazelaar 1990. Pulmonary complications of leukemia Chest 98:1233-1239.