Epithelium-specific adenoviral transfer of a dominant-negative mutant TGF-β type II receptor stimulates embryonic lung branching morphogenesis in culture and potentiates EGF and PDGF-AA

Mechanisms of Development

Volumn 72, Issue 1-2, 1998, Pages 89-100

  Zhao, Jingsong ^a   Sime, Patricia J ^b   Bringas Jr , Pablo ^a   Gauldie, Jack ^b   Warburton, David ^a,c  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b MCMASTER UNIVERSITY   (Canada)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Competitive PCR; Dominant negative TGF type II receptor; Epithelium specific gene transfer; Intra tracheal micro injection; Potentiation; Recombinant adenovirus

Indexed keywords

EPIDERMAL GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR AA; TRANSFORMING GROWTH FACTOR BETA;

ADENOVIRUS; ANIMAL CELL; ARTICLE; EMBRYO DEVELOPMENT; EPITHELIUM CELL; GENE TRANSFER; GENETIC RECOMBINATION; IMMUNOREACTIVITY; LUNG ALVEOLUS EPITHELIUM; LUNG DEVELOPMENT; MESENCHYME CELL; MORPHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM;

ADENOVIRIDAE; ANIMALS; CULTURE TECHNIQUES; DENSITOMETRY; EPIDERMAL GROWTH FACTOR; EPITHELIAL CELLS; FEMALE; HUMANS; LUNG; MICE; MORPHOGENESIS; PLATELET-DERIVED GROWTH FACTOR; PREGNANCY; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA;

ADENOVIRIDAE; ANIMALIA; MAMMALIA;

EID: 17444433871     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(98)00019-7     Document Type: Article

References (42)

1. Alescio T., Cassini A. Induction in vitro of tracheal buds by pulmonary mesenchyme grafted onto tracheal epithelium. J. Exp. Zool. 150:1962;83-94.
2. Baldwin H.S., Mickanin C., Buck C. Adenovirus-mediated gene transfer during initial organogenesis in the mammalian embryo is promoter-dependent and tissue-specific. Gene Therapy. 4:1997;1142-1149.
3. Bonström H., Willetts K., Pekny M., Levéen P., Lindahl P., Hedstrand H., Pekna M., Hellström M., Gebre-Medhin S., Schalling M., Nilsson M., Kurland S., Törnell J., Heath J.K., Betsholtz C. PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell. 85:1996;863-873.
4. Böttinger E., Jakubczak J.L., Roberts I.S.D., Mumy M., Hemmati P., Bagnall K., Merline G., Wakefield L.M. Expression of a dominant-negative mutant TGF-β type II receptor in transgenic mice reveals essential roles for TGF-β in regulation of growth and differentiation in the exocrine pancreas. EMBO J. 16:1997;2621-2633.
5. Derynck R., Zhang Y. Intracellular signaling: the mad way to do it. Curr. Biol. 6:1996;1226-1229.
6. Graham, F.L., Prevec, L., 1990. Manipulation of adenovirus vectors. In: Murray, E.J., and Walker, J.M., (Eds.), Gene Transfer and Expression Protocols. Methods in molecular biology. Humana Press, Clifton, NJ, pp. 109-127.
7. Heldin C.-H., Miyazono K., ten Dijke P. TGF-β signaling from cell membrane to nucleus through Smad proteins. Nature. 390:1997;465-471.
8. Hilfer S.R. Morphogenesis of the lung: control of embryonic and fetal branching. Annu. Rev. Physiol. 58:1996;93-113.
9. Jaskoll T.F., Don Wheeler G., Johnson R., Slavkin H.C. Embryonic mouse lung morphogenesis and type II cytodifferentiation in serumless, chemically defined medium using prolonged in vitro cultures. Cell Differ. 24:1988;105-117.
10. Kawamoto M., Romberger D.J., Nakamura Y., Adachi Y., Tate L., Ertl R.F., Spurzem J.R., Rennard S.I. Modulation of fibroblast type I collagen and fibronectin production by bovine bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 12:1995;425-433.
11. Korfhagen T.R., Swantz R.J., Wert S.E., McCarty J.M., Kerlakian C.B., Glasser S.W., Whitsett J.A. Respiratory epithelial cell expression of human transforming growth factor-α induces lung fibrosis in transgenic mice. J. Clin. Invest. 93:1994;1691-1699.
12. Lagna G., Hata A., Hemmati-Brivanlou A., Massagué J. Partnership between DPC4 and Smad proteins in TGF-β signaling pathways. Nature. 383:1996;832-836.
13. Lee M., Hwang C., Lee J., Slavkin H., Warburton D. TGF-β isoforms differentially attenuate EGF mitogenicity and receptor activity in fetal lung mesenchymal cells. Am. J. Physiol. 273:1997;L374-L381.
14. Lin H.Y., Wang X.F., Ng-Eaton E., Weinberg R.A., Lodish H.F. Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. Cell. 68:1992;775-785.
15. Maniscalco W.M., Sinkin R.A., Watkins R.H., Campbell M.H. Transforming growth factor-beta1 modulates type II cell fibronectin and surfactant protein C expression. Am. J. Physiol. 267:1994;L569-577.
16. Massagué J., Cheifetz S., Boyd F.T., Andres J.L. TGF-beta receptors and TGF-beta binding proteoglycans: recent progress in identifying their functional properties. Ann. NY Acad. Sci. 593:1990;59-72.
17. Miettineen P.J., Warburton D., Bu D., Zhao J., Berger J.E., Minoo P., Koivisto T., Allen L., Dobbs L., Werb Z., Derynck R. Impaired lung branching morphogenesis in the absence of functional EGF receptor. Dev. Biol. 186:1997;224-236.
18. Miettinen P.J., Berger J.E., Meneses J., Phung Y., Pedersen R.A., Werb Z., Derynck R. Epithelial immaturity and failure in mice lacking epidermal growth factor receptor. Nature. 376:1995;337-341.
19. Niwa H., Yainamura K., Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene. 108:1991;193-199.
20. Prelich G., Tan C.K., Kostura M., Matthews M.B., So A.G., Downey K.M., Stillman B. Functional identity of proliferating cell nuclear antigen and a DNA polymerase-delta auxiliary protein. Nature. 326:1987;517-520.
21. Roberts A.B., Flanders K.C., Hein N.I., Jakowlew S.B., Kondaiah P., Kim S.J., Sporn M.B. Transforming growth factor-eta: multifunctional regulator of differentiation and development. Philos. Trans. R. Soc. London (Biol.). 327:1990;145-154.
22. Sanger R., Nickren S., Coulson R.R. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA. 74:1977;5463-5467.
23. Sekhon H.S., Larson J.L. In utero gene transfer into the pulmonary epithelium. Nature Med. 1:1995;1201-1203.
24. Serra R., Johnson M., Filvaroff E.H., LaBorde J., Sheehan D.M., Derynck R., Moses H.L. Expression of a truncated, kinase-defective TGF-β type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J. Cell Biol. 139:1997;541-552.
25. Serra R., Pelton R.W., Moses H.L. TGF beta 1 inhibits branching morphogenesis and N-myc expression in lung bud organ cultures. Development. 120:1994;2153-2161.
26. Shannon J.M. Induction of alveolar type II cell differentiation in fetal tracheal epithelium by grafted distal lung mesenchyme. Dev. Biol. 166:1994;600-614.
27. Sime P.J., Xing Z., Graham F.L., Csaky K.G., Gauldie J. Adenovector-mediated gene transfer of active TGF-β1 induces prolonged severe fibrosis in rat lung. J. Clin. Invest. 100:1997;768-776.
28. Souza P., Kuliszewski M., Wang J., Tseu I., Tanswell A.K., Post M. PDGF-AA and its receptor influence early lung branching via an epithelial-mesenchymal interaction. Development. 121:1995;2559-2567.
29. Tan C.K., Castillo C., So A.G., Downey K.M. An auxiliary protein for DNA polymerase-delta from fetal calf thymus. J. Biol. Chem. 261:1986;12310-12316.
30. Walter J., You Q., Hagstrom J.N., Sands M., High K.A. Successful expression of human factor IX following repeat administration of adenoviral vector in mice. Proc. Natl. Acad. Sci. USA. 93:1996;3056-3061.
31. Warburton D., Seth R., Shum L., Horcher P.G., Hall F.L., Werb Z., Slavkin H.C. Epigenetic role of epidermal growth factor expression and signaling in embryonic mouse lung morphogenesis. Dev. Biol. 149:1992;123-133.
32. Wrana J.L., Attisano L., Wieser R., Ventura F., Massagué J. Mechanism of activation of the TGF-beta receptor. Nature. 370:1994;341-347.
33. Xing Z., Braciak T., Jordana M., Croitoru K., Graham F.L., Gauldie J. Adenovirus-mediated cytokine gene transfer at tissue sites. Overexpression of IL-6 induces lymphocytic hyperplasia in the lung. J. Immunol. 153:1994;4059-4069.
34. Xing Z., Ohkawara Y., Jordana M., Graham F.L., Gauldie J. Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions. J. Clin. Invest. 97:1996;1102-1110.
35. Yamamoto H., Ueno H., Ooshima A., Takeshita A. Adenovirus-mediated transfer of a truncated transforming growth factor-D type II receptor completely and specifically abolishes diverse signaling by TGF-β in vascular wall cells in primary culture. J. Biol. Chem. 271:1996;16253-16259.
36. Zhao J., Araki N., Nishimoto S.K. Quantitation of matrix Gla protein mRNA by competitive polymerase chain reaction using glyceraldehyde-3-phosphate dehydrogenase as an internal control. Gene. 155:1995;159-165.
37. Zhao J., Bu D., Lee M., Slavkin H.C., Hall F.L., Warburton D. Abrogation of transforming growth factor-β type II receptor stimulates embryonic mouse lung branching morphogenesis in culture. Dev. Biol. 180:1996;242-257.
38. Zhao J., Lee M., Smith S., Warburton D. Abrogation of Smad3 and Smad2 or Smad4 gene expression positively regulate murine embryonic lung branching morphogenesis in culture. Dev. Biol. 194:1998;182-195.
39. Zhao J., Warburton D. Matrix Gla protein gene expression is induced by exogenous transforming growth factor-β in embryonic lung culture. Am. J. Physiol. 273:1997;L282-287.
40. Zhao Y., Young S.L. TGF-β regulates expression of tenascin alternative-splicing isoforms in fetal rat lung. Am. J. Physiol. 268:1995;L173-180.
41. Zhou H., Hammonds R.G. Jr., Findlay D.M., Martin T.J., Ng K.W. Differential effects of transforming growth factor-βl and bone morphogenetic protein 4 on gene expression and differentiated function of preosteoblasts. J. Cell. Physiol. 155:1993;112-119.
42. Zhou L., Dey C.R., Wert S.E., Whitsett J.A. Arrested lung morphogenesis in transgenic mice bearing an SP-C-TGF-beta 1 chimeric gene. Dev. Biol. 175:1996;227-238.