Notch signaling in lymphocyte development and function

Current Opinion in Immunology

Volumn 16, Issue 3, 2004, Pages 360-366

  Robey, Ellen A ^a   Bluestone, Jeffery A ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

antigen presenting cell; APC; B cell receptor; BCR; CD4+CD8+ double positive; CD4 CD8 double negative; core binding factor 1, suppressor of hairless, Lag1; CSL; DN; DP; hairy enhancer of split homolog; HES; HPC

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; NOTCH RECEPTOR;

ANTIGEN PRESENTING CELL; B LYMPHOCYTE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; NONHUMAN; REVIEW; T LYMPHOCYTE; THYMOCYTE;

EID: 2342551482     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2004.03.009     Document Type: Article

References (58)

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8. Izon D.J., Aster J.C., He Y., Weng A., Karnell F.G., Patriub V., Xu L., Bakkour S., Rodriguez C., Allman D., et al. Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. Immunity. 16:2002;231-243 Enforced expression of Deltex1 in HPCs leads to a block in T-cell development and ectopic B-cell development in the thymus, similar to the phenotype seen for a deletion of Notch1. These data suggest that Deltex1 is acting as a negative regulator of Notch signaling in the thymus, a surprising result in light of indications that Deltex acts as a positive effector of Notch signaling in other systems.
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13. ••], these data suggest that the expression of Notch ligands is the crucial property of thymic epithelial cells that endows them with the ability to promote T-cell development.
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17. - DN4 population. These results suggest that Notch1 signaling in DN thymocytes promotes TCRβ rearrangement and also affects another, as yet undefined, process.
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26. •], this study provides the first evidence for the involvement of Notch2 in B1 B-cell development. In contrast to earlier studies with the intracellular domain of Notch1, moderate levels of Notch2 intracellular domain did not block the earliest stages of B-cell development, but instead blocked the pro-B to pre-B transition.
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29. + T cells. In addition to providing evidence that Notch promotes T-cell development at multiple stages, this study also introduces a robust in vitro system for thymic development that may be a useful tool for investigating other aspects of T-cell development.
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32. ••], these data show that CSL-dependent Notch2 signaling plays a critical role in MZ B-cell development.
33. •], this study provides the first evidence for the involvement of Notch2 in B1 B-cell development.
34. Tanigaki K., Han H., Yamamoto N., Tashiro K., Ikegawa M., Kuroda K., Suzuki A., Nakano T., Honjo T. Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol. 3:2002;443-450 A B-cell specific deletion of CSL, a central effector of Notch signaling, leads to a dramatic loss of MZ B cells and a corresponding increase in follicular B cells, implicating Notch2 as a regulator of the MZ versus follicular B-cell fate. This study was the first to implicate Notch/CSL signaling in B-cell development.
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42. Huang YH, Li DL, Winoto A, Robey EA: Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals. Proc Natl Acad Sci USA 2004, in press.
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44. Yvon E.S., Vigouroux S., Rousseau R.F., Biagi E., Amrolia P., Dotti G., Wagner H.J., Brenner M.K. Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells. Blood. 102:2003;3815-3821 In this paper, the investigators provide evidence that engagement of Notch by its ligand, Jagged 1 can induce the differentiation of regulatory T cells.
45. Vigouroux S., Yvon E., Wagner H.J., Biagi E., Dotti G., Sili U., Lira C., Rooney C.M., Brenner M.K. Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes. J Virol. 77:2003;10872-10880 This study provides further evidence in human T cells that Notch ligation leads to the induction of regulatory T cells.
46. Wong K.K., Carpenter M.J., Young L.L., Walker S.J., McKenzie G., Rust A.J., Ward G., Packwood L., Wahl K., Delriviere L., et al. Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism. J Clin Invest. 112:2003;1741-1750 This study is an extension of previous work by this group, demonstrating the immunoregulatory effects of Notch ligand expression of allogeneic tissue. The study suggests a role for IL-10 in the immunosuppressive effects induced by Notch activation.
47. ••], is the first demonstration that Notch activity can promote mature T-cell activation by enhancing sensitivity to IL-2.
48. ••], is the first demonstration that Notch activity can promote mature T-cell activation by enhancing sensitivity to IL-2.
49. Maekawa Y., Tsukumo S., Chiba S., Hirai H., Hayashi Y., Okada H., Kishihara K., Yasutomo K. Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells. Immunity. 19:2003;549-559 This study demonstrates that T-cell differentiation can be regulated by Notch activation. The finding suggests that activation of Notch3 leads to induction of the critical Th1 transcription factor T-bet, which promotes Th1 differentiation.
50. Ellisen L.W., Bird J., West D.C., Soreng A.L., Reynolds T.C., Smith S.D., Sklar J. TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell. 66:1991;649-661
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52. ••], provides compelling evidence that pre-TCR signaling is required for Notch3 induced leukemogenesis.
53. Reizis B., Leder P. Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. Genes Dev. 16:2002;295-300 This paper provides evidence that the preTa gene, which encodes an essential component of the pre-TCR signaling complex, is a direct target of Notch/CSL signaling.
54. ••], provides compelling evidence that pre-TCR signaling is required for Notch3-induced leukemogenesis.
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57. lck in the anti-apoptotic effects of Notch in T-cell lines. They also provide evidence for a physical association between Notch and lck.
58. Eagar TN, Tang Q, Wolfe M, He Y, Pear WS, Bluestone JA: Notch 1 signaling regulates peripheral T cell activation. Immunity 2004, 324: in press.